Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression. by Lilach Soreq, Hannah Bird, Wael Mohamed, John Hardy

“…Astrocytes and microglia displayed the greatest transcriptomic impacts, with the induction of both shared and distinct gene programs.…”
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Host influence on the eukaryotic virome of sympatric mosquitoes and abundance of diverse viruses with a broad host range. by Côme Morel, Patricia Gil, Antoni Exbrayat, Etienne Loire, Florian Charriat, Baptiste Prepoint, Celine Condachou, Geoffrey Gimonneau, Assane Gueye Fall, Biram Biteye, Momar Talla Seck, Marc Eloit, Serafin Gutierrez

“…Viromes significantly differed by mosquito species but not by habitat. Differences were largely due to changes in relative abundance of shared taxa. …”
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Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts by Fulin Liu, Christine Rouault, Mickael Guesnon, Wencan Zhu, Karine Clément, Séverine A. Degrelle, Thierry Fournier

“…EVCTs and VCTs were purified from human chorionic villi, cultured in vitro, and treated with rosiglitazone. The transcriptomes of both types of cells were then quantified using microarray profiling. …”
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Combined systems approaches reveal highly plastic responses to antimicrobial peptide challenge in Escherichia coli. by Justyna Kozlowska, Louic S Vermeer, Geraint B Rogers, Nabila Rehnnuma, Sarah-Beth T A Amos, Garrit Koller, Michael McArthur, Kenneth D Bruce, A James Mason

“…Selecting structurally and physically related AMPs but with expected differences in bactericidal strategy, we monitored changes in bacterial metabolomes, morphological features and gene expression following AMP challenge at sub-lethal concentrations. …”
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ATP6V1A deletion leads to impaired clearance of septic cardiac resident macrophages by YANG Shunxin, ZHOU Yuanqun, XIANG Xinming

“…Cardiac resident macrophages were extracted for transcriptomic sequencing to determine the functional changes of the cells after sepsis. …”
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Identifying KL-6-Associated Immune Cell Signatures and Key Genes in Emphysematous COPD by Xiao X, Guo W, Li N, Chen N, Zhang Q

“…Pearson analyses revealed that the serum KL-6 concentration was positively correlated with eosinophil count. Transcriptomic analysis revealed 237 differentially expressed genes (DEGs) between patients with high and low levels of KL-6. …”
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Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder by Shengjie Xiong, Lixin Liao, Meng Chen, Qing Gan

“…This study aimed to investigate the molecular pathways involved in MDD using a transcriptomic analysis approach.MethodsTranscriptomic data related to MDD were obtained from public databases. …”
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Unraveling the key drivers of bacterial progesterone degradation by Gabriel Hernández-Fernández, Juan Ibero, José L. García, Beatriz Galán

“…The activity redundancy can be explained by the difference in substrate specificity of each enzyme.…”
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Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons by Nimmy Varghese, Leonora Szabo, M. Zameel Cader, Imane Lejri, Amandine Grimm, Anne Eckert

“…The study concludes that aged iPSCsNs may differ in transcriptomics and the aging-associated glycolytic shift but can be a valuable tool for studying specific feature of mitochondrial neuronal aging in vitro alongside aged iNs.…”
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Network spreading and local biological vulnerability in amyotrophic lateral sclerosis by Asa Farahani, Justine Y. Hansen, Vincent Bazinet, Golia Shafiei, D. Louis Collins, Mahsa Dadar, Sanjay Kalra, Alain Dagher, Bratislav Misic

“…Finally, individual differences in epicenter location correspond to individual differences in clinical and cognitive symptoms and differentiate patient subtypes.…”
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Single-nucleus neuronal transcriptional profiling of male C. elegans uncovers regulators of sex-specific and sex-shared behaviors by Katherine S. Morillo, Jonathan St. Ange, Yifei Weng, Rachel Kaletsky, Coleen T. Murphy

“…Our data provide a rich resource for discovering sex-specific transcriptomic differences and the molecular basis of sex-specific behaviors.…”
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Integrating single-cell RNA-seq and bulk RNA-seq to construct a neutrophil prognostic model for predicting prognosis and immune response in oral squamous cell carcinoma by Jinhang Wang, Zifeng Cui, Qiwen Song, Kaicheng Yang, Yanping Chen, Shixiong Peng

“…Drug sensitivity analysis highlighted differences in drug responsiveness between high- and low-risk groups. …”
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Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species by Julie D. De Schutter, Anyi Zhang, Pieter-Jan Serneels, Lieve Moons, Luca Masin, Steven Bergmans

“…Understanding species-specific differences in neuronal resilience is critical for identifying key survival mechanisms and potential neuroprotective targets. …”
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Molecular changes in Opisthorchis viverrini (Southeast Asian liver fluke) during the transition from the juvenile to the adult stage. by Aaron R Jex, Neil D Young, Jittiyawadee Sripa, Ross S Hall, Jean-Pierre Scheerlinck, Thewarach Laha, Banchob Sripa, Robin B Gasser

“…Most notable are differences among the C13 and cathepsin L-like cysteine peptidases, which play key roles in tissue migration, immune evasion and feeding, and, thus, represent potential drug and/or vaccine targets. …”
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Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer by Xinya Jia, Qiang Zhang, Zhe Wang, Jianliang Cao, Anran Song, Chao Lan, Yuepeng Hu

“…Utilizing single-cell transcriptomic data from the GSE205049 dataset, this study analyzed the variation in GSH metabolic signaling intensity across distinct cell types within the tumor microenvironment of PC. …”
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From herbarium to life: Implications of reviving historical fungi for modern plant pathology and agriculture by Dagan Sade, Gilli Breuer, Ksenia Juravel, Weronika Jasinska, Aviel Arzi, Nir Sade, Yariv Brotman, Yael Meller Harel, Shay Covo, Maggie Levy, Gila Kahila Bar-Gal

“…In this study, we revived two Botrytis cinerea strains from the early 1940s and performed phenotypic, genomic, transcriptomic, and metabolomic analyses. Comparisons with modern strains revealed significant differences, including adaptations likely driven by fungicide use and environmental pressures such as host-specific pathogenicity and pH tolerance. …”
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A Comparison of Computational Approaches for Intron Retention Detection by Jiantao Zheng, Cuixiang Lin, Zhenpeng Wu, Hong-Dong Li

“…We discuss key principles and features of existing approaches and outline their differences. This systematic analysis provides helpful guidance for interrogating transcriptomic data from the point of view of IR.…”
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Aromatase inhibitors can improve the semen quality of aged roosters by up regulating genes related to steroid hormone synthesis by Xuliang Luo, Xuelian Li, Zi Mei, Haobo Zhou, Yan Chen, Haoxing Wang, Ping Qiu, Yanzhang Gong

“…The results indicated that semen volume, sperm motility, sperm density, MMP, testosterone (T) and gonadotropin releasing hormone (GnRH) in letrozole treatment group (LET) were significantly increased than those in control group (CN) (P<0.05); estradiol (E2) and ROS in LET were significantly lower than those in CN (P<0.05). Through transcriptomic and proteomic analysis, we identified 189 differently expressed genes (DEGs) and 64 differentially expressed proteins (DEPs) in the comparison of LET and CN. …”
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Effects of cold environment exposure on female reproductive health and its regulatory mechanisms by Hongyi Sun, Qianqian Zhao, Xiaolan Liang, Yalun He, Yangshuo Li, Jin Yu, Jie Ding, Chaoqin Yu

“…Ovarian and uterine tissues were collected via surgical procedures, and transcriptomic sequencing was performed to explore potential regulatory mechanisms. …”
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Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

“…Detailed immunophenotyping of peripheral blood, ascites, and tumors revealed that durable treatment responses were associated with reversal of myeloid cell-induced immune suppression, which resulted in enhanced anti-tumor activity by T cells. Single cell transcriptomic analysis further demonstrated striking differences in the phenotype of myeloid cells from mice treated with IL12 in combination with dual-ICI. …”
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