ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…However, its role across different cancer types is not well understood.MethodsUtilizing multi-omics data, we comprehensively evaluated ITGA4’s expression, clinical relevance, diagnostic and prognostic value, functions, mutations, and methylation status, along with its impact on immunity, mismatch repair (MMR), heterogeneity, stemness, immunotherapy responsiveness, and drug resistance in pan-cancer, with partial validation in gastric cancer (GC) using transcriptomic analysis, single-cell data, western blot (WB), wound-healing assay, flow cytometry and immunohistochemistry (IHC). …”
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Comprehensive analysis of Dof transcription factors in Dendrobium species and functional characterization of DoDof4 in the accumulation of water-soluble polysaccharides by Zhangting Xu, Guihua Zhang, Feixiong Zheng, Xiaoji Deng, Yiming Sun, Jaime A. Teixeira da Silva, Xiaoxia Shen, Xiaoxia Shen, Zhenming Yu, Zhenming Yu

“…Therefore, it is necessary to study the regulatory manner involved in the accumulation of WSPs.MethodsD. officinale were treated with methyl jasmonate (MeJA), and WSPs content was measured at different time points to assess the dynamic accumulation pattern. …”
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Mitochondria-associated programmed cell death: elucidating prognostic biomarkers, immune checkpoints, and therapeutic avenues in multiple myeloma by Gongzhizi Gao, Jiyu Miao, Yachun Jia, Aili He, Aili He, Aili He

“…The risk model stratified patients into high- and low-risk groups with significantly different survival probabilities. Age, gender, ISS stage, and risk score were independent prognostic factors. …”
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Integrating multi-omics and experimental techniques to decode ubiquitinated protein modifications in hepatocellular carcinoma by Haikun Yang, Yuan Chen, Yuan Chen, Zheng Zhou, Yanjing Wang, Peng Li, Yang Li

“…Ubiquitination scores were calculated to categorize these cell types, and survival data, along with spatial transcriptomics, were employed to evaluate how different levels of ubiquitination influence HCC progression. …”
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Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease by Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik

“…These data link the regulation of 2 highly conserved genes, NSA2 and GFM2, connected to ribosomes in two different cellular compartments, cytosol and mitochondria, to kidney disease and shows that their dysregulation may be involved in mitochondrial dysfunction.…”
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Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson’s disease by Junshi Zhang, Tingting Liu, Haojie Wu, Jianshe Wei, Qiumin Qu

“…Subsequently, the distribution of target genes with AUC > 0.7 in different cell types of the brain was analyzed. Finally, molecular docking was performed between the anti-PD drugs entering clinical phase IV and the target genes. …”
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Establishment of a Novel in vitro Model of Sepsis-Induced Myocardial Injury Using Septic Serum: A Comprehensive Comparative Study by Yang H, Feng L, Jiang Z, Deng R, Wu X, Zeng K

“…This study aimed to systematically compare different in vitro models to determine the most appropriate model for studying the pathophysiological mechanisms of sepsis-induced myocardial injury.Materials and Methods: AC16 cardiomyocytes were treated with lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α), or septic serum for 24 hours to induce myocardial injury. …”
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CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…In addition to standard FACS analysis, we used the ‘Timer of Cell Kinetics and Activity’ system, which can analyze the temporal dynamics of different T cell subsets. This immune data was used to inform the selection of ICI for triple combination therapy, the effects of which were then further characterized using transcriptomics.Results Adding BRAFi treatment to HSV improved anti-tumor effects in vivo but not in vitro. …”
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Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC by Xufan Cai, Weihui Guo, Fang Wu, Weilang Xu, Tao Ding, Yizhe Diao, Lei Wang, Zhenyuan Qian, Guangyuan Song

“…The similar conclusion also occurred in the spatial transcriptomic detection. 5-Fluorouracil, Doxorubicin, Etoposide, et al., may be potential sensitive drugs in therapy of high-hnRNPA3 HCC patients. …”
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Selection and Validation of Reference Genes for RT-qPCR in Protonemal Tissue of the Desiccation-Tolerant Moss <i>Pseudocrossidium replicatum</i> Under Multiple Abiotic Stress Condi... by Rosa María Nava-Nolazco, Selma Ríos-Melendez, Santiago Valentín Galván-Gordillo, Angélica C. Martínez-Navarro, Mishael Sánchez-Pérez, Rocio Alejandra Chavez-Santoscoy, Martha Bibbins-Martínez, Ignacio Eduardo Maldonado-Mendoza, Analilia Arroyo-Becerra, Miguel Angel Villalobos-López

“…The moss <i>Pseudocrossidium replicatum</i> is highly tolerant to different types of abiotic stress, such as desiccation. …”
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Genome-wide identification, evolutionary expansion and expression divergence of the AP2/ERF gene family in loquat (Eriobotrya japonica) by Yumeng Liu, Linqi Cai, Xiurun Fan, Huiling Zhang, Minghui Chen, Yue Lin, Junwei Chen, Kai Xu, Boping Wu

“…Cis-element analysis showed that most of the AP2/ERF genes in loquat had multiple cis-elements related to stress response, plant hormone signal transduction, and plant growth and development. Transcriptomic data indicated that the expression patterns of AP2/ERF genes exhibited diversity in different loquat cultivars during fruit development and ripening. …”
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Tumor microenvironment assessment-based signatures for predicting response to immunotherapy in non-small cell lung cancer by Jiani Wu, Yuanyuan Wang, Zhenhua Huang, Jingjing Wu, Huiying Sun, Rui Zhou, Wenjun Qiu, Zilan Ye, Yiran Fang, Xiatong Huang, Jianhua Wu, Jianping Bin, Yulin Liao, Min Shi, Jiguang Wang, Wangjun Liao, Dongqiang Zeng

“…IKCscore is a robust biomarker predicting response to immunotherapy, and its predictive capacity was confirmed from public datasets across different cancer types (N = 892), including OAK, POPLAR, IMvigor210, GSE135222, GSE126044, and Kim cohorts. …”
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Astragaloside IV accelerates hematopoietic reconstruction by improving the AMPK/PGC1α-mediated mitochondrial function in hematopoietic stem cells by Ling Zhang, Wanqi Xu, Yueying Zeng, Long Wang, Jiesi Luo, Xiaogang Zhou, Qibing Mei, Dalian Qin, Anguo Wu, Jianming Wu, Feihong Huang

“…In vivo studies involved a 4.0 Gy total body irradiation mouse model treated with different doses of AS-IV (50 mg/kg and 100 mg/kg). …”
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Degradation of PARP1 by MARCHF3 in tumor cells triggers cCAS-STING activation in dendritic cells to regulate antitumor immunity in hepatocellular carcinoma by Qian Wang, Rui Peng, Chi Zhang, Jun Cao, Bingbing Su, Daoyuan Tu, Qiangwei Deng, Guoqing Jiang, Shengjie Jin, Dou-Sheng Bai

“…Our aim was to clarify the role of membrane-associated ring-CH-type finger 3 (MARCHF3) in HCC within the framework of anti-programmed cell death protein-1 (PD-1) therapy.Methods MARCHF3 was identified in the transcriptomic profiles of HCC tumors exhibiting different responses to ICIs. …”
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Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro‐Angiogenic Macrophage Polarization via Activation of the PI3K‐Akt Signaling Pathway by Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng, Fuping You, Mingming Xu, Xuliang Deng, Xuehui Zhang

“…Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF‐TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO3 nanoparticles (homogeneous surface potential distribution, HOPD) to 1D BaTiO3 nanofibers (heterogeneous surface potential distribution, HEPD). …”
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A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma by Kuo Kang, Hui Nie, Weilu Kuang, Xuanxuan Li, Yangying Zhou

“…Furthermore, we observed differences in IC50 values among nine chemotherapeutic drugs across different TRG risk subtypes which partially confirmed our model’s predictive efficacy for immunotherapy. …”
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Short‐chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice by Chaoran Liu, Pui Yan Wong, Qianjin Wang, Hei Yuet Wong, Tao Huang, Can Cui, Ning Zhang, Wing Hoi Cheung, Ronald Man Yeung Wong

“…Results Aged SAMP8 mice had different microbiota composition, and lower serum butyric acid compared with SAMR1 mice (P < 0.05). …”
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Brachyury co-operates with polycomb protein RYBP to regulate gastrulation and axial elongation in vitro by Lilla Kokity, Lilla Kokity, Zsolt Czimmerer, Bernadett Benyhe-Kis, Bernadett Benyhe-Kis, Anna Poscher, Anna Poscher, Emese Belai, Emese Belai, Gábor Steinbach, Zoltan Lipinszki, Zoltan Lipinszki, Melinda Katalin Pirity

“…During gastrulation, three germ layers form, giving rise to different cell lineages and organs. This process is regulated by transcription factors and epigenetic regulators, including non-canonical polycomb repressive complex 1s (ncPRC1s). …”
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Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

“…This study sought to address the knowledge gap by integrating transcriptomic and metabolomic analyses to elucidate the intricate mechanisms. …”
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Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis by Alice Tata, Guillaume Rocha, Marguerite Hureaux, Alice S. Serafin, Esther Porée, Lucie Menguy, Nicolas Goudin, Nicolas Cagnard, Lilian Gréau, Marc Fila, Luis Briseño-Roa, Jean-Philippe Annereau, Sophie Saunier, Alexandre Benmerah

“…Results: Eupatilin partially rescued NPHP1-associated ciliogenesis defects. Transcriptomic analyses pointed out that cell cycle progression was inhibited by Eupatilin, likely explaining its broad effects on cilia assembly. …”
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