Pathogenic KCNH2-G53S variant in the PAS domain influences the electrophysiological phenotype in long QT syndrome type 2 by Dasom Mun, Ji-Young Kang, Malgeum Park, Gyeongseo Yoo, Nuri Yun, YouMi Hwang, YouMi Hwang, Boyoung Joung

“…BackgroundLong QT syndrome type 2 (LQT2) is an arrythmia caused by loss-of-function mutations in KCNH2, leading to impaired Kv11.1 channel function.ObjectiveTo better understand LQT2, we examined the electrophysiological differences related to the G53S variant, which is located within the PAS domain of KCNH2, using patient-specific human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs).MethodsWe generated hiPSC-CMs from a patient harboring the KCNH2G53S variant and a healthy control using non-integrative Sendai virus-mediated reprogramming. …”
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The Feasibility of Using Tartary Buckwheat as a Se-Containing Food Material by Aleksandra Golob, Vekoslava Stibilj, Ivan Kreft, Mateja Germ

“…The aim of this investigation was thus to determine the concentration of Se in different edible parts of Tartary buckwheat treated with different concentrations of Na selenate using different techniques. …”
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Genome wide identification of AGC kinase genes and their expression in response to heat and cold stresses in barley by Zohreh HAJIBARAT, Abbas SAIDI

“…Identifying overlaps between orthologous clusters can enable us to study the function and evolution of proteins in different species. …”
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Resistance Exercise With Herbal Supplements Improving the Sperm Status of Infertile Men by Amir Delshad, Fereshte salimi, Hoda Fazaeli, Atefeh Verdi, Leila Naserpour, Mehdi Azadpour, Elham Asa

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AI-assisted 3D versus conventional 2D preoperative planning in total hip arthroplasty for Crowe type II–IV high hip dislocation: a two-year retrospective study by Zhenbao Lu, Cuihua Yuan, Qingshan Xu, Yuhua Feng, Qiujin Xia, Xiaolu Wang, Jianfu Zhu, Jinqing Wu, Tihui Wang, Jiliang Chen, Xu Wang, Qijin Wang

“…Results At 24 months, both groups demonstrated significant improvements in functional outcomes. Compared to the 2D X-ray group, the AI-3D group showed higher accuracy in implant size prediction (acetabular cup: 59.18% vs. 30.23%; femoral stem: 65.31% vs. 41.86%; both p < 0.05), a greater proportion of cups placed within the Lewinnek and Callanan safe zones (p < 0.05), shorter operative time, reduced intraoperative blood loss, and more effective correction of leg length discrepancy (all p < 0.05). …”
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Effects of light intensity and nitrogen supply on the dynamic characteristics of leaf SPAD value of rice canopy by He Junjun, Yang Jingping, Yang Hu, Zhao Xing, Ye Xinyi

“…Improving nitrogen level had positive effect on increasing the SPAD values of functional leaves. However, less-light condition made an inhibitory effect on the positive role of nitrogen. …”
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The efficacy of core decompression combined with regenerative therapy in early femoral head necrosis: a systematic review and meta-analysis involving 954 subjects by Haiwei Tang, Tingxian Ling, Enze Zhao, Mingke You, Xi Chen, Gang Chen, Kai Zhou, Zongke Zhou

“…Secondary outcomes (VAS, HHS, WOMAC score and Lequesne index) showed improved results when CD was combined with other regenerative agents, such as bone mesenchymal stem cells (BMSCs) and bone morphogenetic proteins (BMPs), etc. …”
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Ambisemy of Linguistic Term (by Example of Russian Linguistic Terminology of 18th - early 20th Сenturies) by E. A. Sherstyannikova

“…It is shown that as long as the varying part of the semantics of the term is not be formed as a categorical value, the term can function with different content volume. The author argues that ambisemy is an essential, natural characteristic of linguistic terminology under its formation. …”
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Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery by Tijana Stanković, Tanja Ilić, Branka Divović Matović, Milos Petkovic, Vladimir Dobričić, Ivan Jančić, Biljana Bufan, Kristina Jezdić, Jelena Đoković, Ivana Pantelić, Danijela Randjelović, Dishary Sharmin, James M. Cook, Miroslav M. Savić, Snežana Savić

“…The quantification of CW-02-79 in plasma/brain homogenate and calculated pharmacokinetic parameters confirmed good systemic and brain availability after intravenous administration. There were subtle differences in the pharmacokinetic parameters in favor of a dual surface-functionalized nanoemulson containing the glucose transporter-1-targeting ligand (mannose). …”
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Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells by You Li, Ankit Gupta, Brian N. Papas, David Aponte-Diaz, Jayden M. Harris, Ichiro Misumi, Jason K. Whitmire, Craig E. Cameron, Marcos Morgan, Stanley M. Lemon

“…However, transfecting exogenous hsRNA into TENT4-depleted cells failed to rescue HAV replication, leaving the functional role of hsRNA unresolved. These findings reveal a novel picornaviral subgenomic RNA species while highlighting mechanistic differences in the manner in which HAV and HBV exploit the host ZCCHC4-TENT4 complex for their replication.…”
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The Expression of Innate Immunity Responsible Genes in Human Macrophages Encountering Mycobacterium Tuberculosis by Farhang Babamahmoodi, Hadiseh Saberi, Farzaneh Rabiae, Hossein Jalali, Mohammad Reza Mahdavi

“…The extracted cells were counted using a cell counter and cultured in StemSpan medium supplemented with 2 ml of lipid cholesterol and 5 ml of Pen/Strep (10x) per 500 ml of culture medium. …”
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Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort by Cynthia B. deMedeiros, Iska Moxon‐Emre, Nadia Scantlebury, David Malkin, Vijay Ramaswamy, Alexandra Decker, Nicole Law, Toshihiro Kumabe, Jeffrey Leonard, Josh Rubin, Shin Jung, Seung‐Ki Kim, Nalin Gupta, William Weiss, Claudia C. Faria, Rajeev Vibhakar, Lucie Lafay‐Cousin, Jennifer Chan, Johan M. Kros, Laura Janzen, Michael D. Taylor, Eric Bouffet, Donald J. Mabbott

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Unveiling Salt Tolerance Mechanisms and Hub Genes in Alfalfa (<i>Medicago sativa</i> L.) Through Transcriptomic and WGCNA Analysis by Fengdan Wang, Hanfu Wu, Mei Yang, Wen Xu, Wenjie Zhao, Rui Qiu, Ning Kang, Guowen Cui

“…Additionally, the variety-specific DEGs were also enriched in the same KEGG pathways and GO functions, indicating that the differences between the two varieties stem from their unique stress-responsive DEGs, while their overall mechanisms for coping with stress remain similar. …”
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A Linguistic Landscape Analysis of Pannon Egyetem Utca. 12. Through a Multilingual Lens. by Ibrahim Rawshdeh, Hala Saed

“…Its location is hypothesized to have an impact on the street's multilingual nature, especially since the existence of a student dormitory on the street attracts international students with different linguistic and cultural backgrounds. This investigation is based on a corpus of 53 images that will be analyzed according to the function of signs as well as the taxonomy of types of the multilingual information arrangement provided by Reh (2004), namely: duplicating, fragmentary, overlapping, and complementary. …”
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Psychological implications of early marriages: the unhealed wombs and shattered dreams by Shezah Khalid, Abdul Wahab Yousafzai

“…These approaches aim to alleviate symptoms and improve overall functioning. Timely recognition and management are crucial in mitigating the impact of BPD on the lives of affected individuals.8   All member states of the European Union have established a minimum age for sexual consent. …”
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Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4 by Aizhong Xu, Jianjun Liu, Li Tong, Tingting Shen, Songlin Xing, Yujie Xia, Bosen Zhang, Zihao Wu, Wenkang Yuan, Anhai Yu, Zijie Kan, Wenqi Yang, Chao Zhang, Chong Zhang

“…Molecular subtypes in thymoma (THYM), thyroid carcinoma (THCA), and kidney chromophobe (KICH) showed significant differences in tumor cell stemness among different subtypes. …”
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Construction and validation of a prognostic model based on cuproptosis-related genes in patients with multiple myeloma by KANG Zhongmin, KANG Zhongmin, LI Licheng

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Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression by Sara Huerta-Yepez, Thomas G Graeber, Neda A Moatamed, Po-Chun Chen, Sanaz Memarzadeh, Subramaniam Malarkannan, Ao Mei, Kawaljit Kaur, Yash Jain, Tanya Singh, Favour Esedebe, Yi Jou Liao, Gabriella DiBernardo, Anahid Jewett

“…Unlike primary interleukin (IL)-2-activated NK cells, sNK cells effectively lysed OVCAR8 ovarian poorly differentiated cancer stem-like cells (PDCSCs) and well-differentiated OVCAR4 tumours. …”
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Genetic analysis and gene mapping of a rice spikelet degradation mutant (spd-hp73) by REN Sanjuan, SUN Chu, TONG Chuan, ZHAO Fei, SHU Qingyao, SHEN Shengquan

“…Furthermore, the branches were twisted at different degrees, and the secondary branch was longer than hp73. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

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