Radiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance by Fatemeh Yazarlou, Ivan Martinez, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich, Leonard Lipovich

“…Given that patients respond differently to RT, it is imperative to understand the molecular mechanisms underlying these differences. …”
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Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration by Shishuo Li, Zhentao Man, Kangqing Zuo, Linbo Zhang, Taixing Zhang, Guiyong Xiao, Yupeng Lu, Wei Li, Ningbo Li

“…However, developing the smart implants with ideal osteogenesis-related multi-functions remains challenging, as the effects of physicochemical properties of implant materials on intracellular signaling, stem cell niches, and tissue regeneration are not yet fully understood. …”
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Combination application of microbial agent and lime application improves soil nutrients and soil fungi community, producing good quality tobacco by Jingtao Zhang, Chao Li, Kai Xia, Kaikai Cheng, Shanhu Guo, Wenzheng Pan, Lingling Liu, Ke Wang, Li Wen, Haiming Tang

“…An explicit enrichment of saprotrophic fungi in T4 is predicated by the FUNGuild function. Soil nutrients were extremely significant and relevant in relation to the fungal community structure. …”
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klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. by Peter Novodvorsky, Oliver Watson, Caroline Gray, Robert N Wilkinson, Scott Reeve, Carl Smythe, Richard Beniston, Karen Plant, Richard Maguire, Alexander M K Rothman, Stone Elworthy, Fredericus J M van Eeden, Timothy J A Chico

“…Targeted genome editing is an increasingly applied method for functional assessment of candidate genes. We therefore generated a stable klf2a mutant zebrafish and characterised its cardiovascular and haematopoietic development.…”
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ZF-HD gene family in rapeseed (Brassica napus L.): genome-wide identification, phylogeny, evolutionary expansion and expression analyses by Xinrui Xu, Hui Zhou, Qiaohui Yang, Yuyao Yang, Xiaobin Pu

“…For example, BnZHD37, BnZHD53, and BnZHD55 may be sensitive to different hormones. Under different stresses, the expression of BnZHD3, BnZHD4, BnZHD7, BnZHD38, BnZD45, and BnZHD53 significantly increased in roots, stems, and leaves within 24 h. …”
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Pupillary manifolds: uncovering the latent geometrical structures behind phasic changes in pupil size by Elvio Blini, Roberto Arrighi, Giovanni Anobile

“…In other words, pupillometry provides an integrated readout of several distinct networks, but it is unclear whether each has a specific fingerprint, stemming from its function or physiological substrate. …”
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Genomewide analysis of the Class III peroxidase gene family in apple (Malus domestica) by Yao Lu, Rongqun Ma, Kunhao Wu, Jilu Sun, Yutong Li, Jiawei Zhao, Zhenbao Qi, Guangli Sha, Hongjuan Ge, Yanjing Shi

“…A set of MdPRXs such as MdPRX27, MdPRX59, and MdPRX90 may affect the ROS status in stem cell niche of the axillary buds and promote the differentiation of branches. …”
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Production and Role of Nitric Oxide in Endometrial Cancer by Seung Geun Yeo, Yeon Ju Oh, Jae Min Lee, Joon Hyung Yeo, Sung Soo Kim, Dong Choon Park

“…NO production is associated with the pathogenesis, development, and prognosis of endometrial cancer, with effects varying based on NO level fluctuations. Differences in NO production and function were observed according to the type of nitric oxide synthase (NOS) involved, control conditions, subtype, grade, and invasiveness of the cancer, as well as the experimental methodologies employed. …”
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Climate Change Risk, Performance, and Value Added in Agricultural Sector by Ramin Amani, Zanko Ghorbani, Zana Mozaffari

“…He considers invisible fixed effects as parameters that are jointly estimated with the effects of auxiliary variables for different quantiles. The unique feature of this method is that it introduces a penalty term in the minimization to address the computational problem of a set of parameters; The parameters are calculated as follows: min(α.β)Σk=1KΣt=1TΣi=1N wkρτkyit-αi-xitTβτk+λΣiNαi                              (6) In equation (6), i represents the number of countries (N), T represents the index for the number of observations of each country, K represents the quantile index, x is the matrix of explanatory variables, and ρτk is the quantile loss function. …”
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The effect of calf muscular vein thrombosis on the prognosis within one year postoperatively of geriatric hip fracture patients: a propensity score-matched analysis by Jiabao Jiang, Fei Xing, Rong Luo, Zhao Chen, Hao Liu, Zhou Xiang, Xin Duan

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Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy by Jinsen Zhang, Rui Sun, Yingying Lyu, Chaxian Liu, Ying Liu, Yuan Feng, Minjie Fu, Peter Jih Cheng Wong, Zunguo Du, Tianming Qiu, Yi Zhang, Dongxiao Zhuang, Zhiyong Qin, Yu Yao, Wei Zhu, Tiannan Guo, Wei Hua, Hui Yang, Ying Mao

“…Through a detailed investigation of metabolic pathways guided by our proteomic findings, dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP) emerge as potential prognostic biomarkers linked to the reprogramming of nucleotide metabolism. Functional validation in patient-derived glioma stem cells and animal models highlights nucleotide metabolism as a promising therapy target for gliomas. …”
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Atmospheric Pollutant Flow and Precipitation: Modeling Effects on the Vegetation Ecosystem by Allag Fateh, Saddek Bouharati, Lamri Tedjar, Mohamed Fenni

“…Since artificial neural networks have the capacity to treat different complex parameters, their application in this domain is adequate. …”
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A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method by Yuki Kobayashi, Honoka Hashizume, Sotaro Takiguchi, Jiajue Ji, Ryuji Kawano, Keiichiro Koiwai, Haru Yamamoto, Mohamed Elbadawy, Tsutomu Omatsu, Amira Abugomaa, Masahiro Kaneda, Tatsuya Usui, Kazuaki Sasaki

“…Abstract Organoids are stem cell-derived three-dimensional tissue cultures composed of multiple cell types that recapitulate the morphology and functions of their in vivo counterparts. …”
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Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing by Yongfen Huang, Ping Yi, Ping Yi, Yixuan Wang, Lingling Wang, Yongqin Cao, Jingbo Lu, Kun Fang, Kun Fang, Yuexin Cheng, Yuqing Miao, Yuqing Miao

“…This study aims to construct a novel risk model for AML patient through comprehensive analysis of scRNA and bulk RNA data to optimize the precise treatment strategies for patients and improve prognosis.Methods and ResultsscRNA-seq classified cells into nine clusters, including Bcells, erythrocyte, granulocyte-macrophage progenitor (GMP), hematopoietic stem cell progenitors (HSC/Prog), monocyte/macrophagocyte (Mono/Macro), myelocyte, neutrophils, plasma, and T/NK cells. …”
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Targeted proteomics for absolute quantification of glucose transporter 1 in mammalian brain cells using liquid chromatography-mass spectrometry by Yash Mehta, Dhavalkumar Patel, Iqra Pervaiz, Ulrich Bickel, Abraham Jacob Al-Ahmad

“…Furthermore, we used such a method to provide absolute GLUT1 quantification in various brain endothelial cells, showing differences in protein expression. Finally, we also used this method to assess changes in GLUT1 protein levels during the differentiation of induced pluripotent stem cells (iPSCs) into astrocyte-like cells (iAstros) and brain microvascular endothelial cell-like cells (iBMECs). …”
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Black tea rich in polygonatum sibiricum polysaccharides inhibits osteoporosis in ovariectomized mice through immune regulation and gut microbiota suppression by Shiyu Gao, Yikang Yu, Jialu shu, Biqian Yang, Baiqiao Zhang, Jinhao Xu, Zhenwei Wang

“…This impact is postulated to stem from certain bioactive constituents within CBT that act via immune regulation and gut microbiota modulation.…”
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Effects of bacterial wilt on community composition and diversity of culturable endophytic fungi in Alpinia galanga by Jiahui Liu, Yuanyuan Wu, Jinru Lin, Mengxia Xie, Likai Chen, Liguo Wang

“…The RA of HDK_J leaves was 78.08% higher than that of stems. All diversity indices for HDK_J were higher than those for HDK_B, with significant differences. …”
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LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES

“…We have optimized a simple flow cytometry method, which, avoiding any pre-enrichment step, allows the identification, classification, enumeration, and separation, by fluorescence activated cell sorting, circulating EVs stemming from different parental cells. This protocol takes advantage of a lipophilic cationic dye (LCD) able to probe EVs, which has been combined with fluorescent phalloidin to exclude damaged elements and different mixes of specific monoclonal antibodies. …”
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Immunosuppressive role of CD11b+CD33+HLA‐DR− myeloid‐derived suppressor cells‐like blast subpopulation in acute myeloid leukemia by Shin Young Hyun, Eun Jung Na, Ji Eun Jang, Haerim Chung, Soo Jeong Kim, Jin Seok Kim, Jee Hyun Kong, Kwang Yong Shim, Jong In Lee, Yoo Hong Min, June‐Won Cheong

“…Patients with high MDSC‐like blasts at diagnosis showed substantially shorter overall survival and leukemia‐free survival relative to low MDSC‐like blasts patients, with subgroup analysis showing statistically significant differences in patients not receiving allogeneic hematopoietic stem cell transplantation. …”
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Research of subpopulation CD3+ CD4- CD8- double-negative T lymphocytes in kidney transplant recipients by S. V. Zybleva, S. L. Zyblev

“…The first group included patients with the primary graft function and satisfactory late graft function. The second group included patients with the primary function and late graft dysfunction. …”
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