Retrospective evaluation of the short-term effectiveness of non-enzymatically isolated stromal vascular fraction cells in patients with knee osteoarthritis by Aytan Safarli, Berkay Kirnaz, Derin Kumcuoglu, Vusal Mahmudov, Ziya Karimov, Afig Berdeli

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Estimation of impact of remodeling and microbial factors on the results of total endoprosthesis of a knee joint in patients, suffering rheumatoid arthritis by S. І. Gerasymenko, М. V. Pоlulyakh, L. М. Panchenko, О. B. Lyutko, А. М. Babko, А. S. Gerasymenko, E. М. Аvtomeyenko

“…High level of contamination of predominantly gram-positive microorganisms of the bone operative material, obtained while primary TEP of a knee joint in 82.8% patients, suffering RA, have a strong (almost a functional one) linear adverse correlation (coefficient r = -0.98) with osteogenic аctivity of the stem stromal cells in the bone marrow, which form a knee joint, what necessitates overestimation of approaches, concerning preparation and performance of surgical intervention for guaranteeing the efficacy of orthopedic treatment and standards of the protocols.…”
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FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila by Navneeta Kaul, Sarala J. Pradhan, Nathan G. Boin, Madeleine M. Mason, Julian Rosales, Emily L. Starke, Emily C. Wilkinson, Erich G. Chapman, Scott A. Barbee

“…Specific target RNAs play critical roles in neurodevelopment, including the regulation of neurite morphogenesis, synaptic plasticity, and cognitive function. The different biological functions of FMRP are modulated by its cooperative interaction with distinct sets of neuronal RNA and protein-binding partners. …”
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Subcellular localization and tissue expression pattern of SlMAPK7 gene in tomato by Guan Xiaoyan, Chen Lifei, He Yanjun, Wang Jie, Lu Gang

“…Therefore, this study aimed to characterize the temporal and spatial expression profiles of tomato SlMAPK7, analyze the cis-elements in its promoter sequences, and to confirm the subcellular localization of SlMAPK7 protein.The expression profiles of SlMAPK7 in the roots, stems, leaves, calyxes, petals, stamens, pistils, and fruits from flowering tomato plants were characterized by real-time fluorescent quantitative reverse transcription polymerase chain reaction (qRT-PCR), as well as the flower buds ranging from 2 mm to 8.5 mm in length, representing in different floral development periods. …”
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Reaction dynamics and nuclear structure of light exotic nuclei by Di Pietro Alessia

“…Results of reactions induced by neutron-halo and proton-halo nuclei are compared, highlighting differences in the reaction dynamics that stem from variations in nuclear structure. …”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…These findings suggest that different metabolic pathways play a critical role at different stages of cellular development, each contributing to diverse cellular functions.DiscussionOur study demonstrates the efficacy of the MetaboLINK approach in analyzing NMR-based longitudinal metabolomic datasets, highlighting key metabolic shifts during cellular transitions. …”
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Bone Fillers with Balance Between Biocompatibility and Antimicrobial Properties by Bogdan Valeriu Sorca, Durmuş Alpaslan Kaya, Madalina Georgiana Albu Kaya, Marius Enachescu, Daniela-Madalina Ghetu, Laura-Bianca Enache, Iulian Boerasu, Alina Elena Coman, Laura Cristina Rusu, Rodica Constantinescu, Irina Titorencu

“…This study aims to develop and characterize novel biomimetic bone fillers which have simultaneously both antimicrobial properties and biocompatibility with human bone marrow—derived mesenchymal stem cells (BMSCs). Type I collagen and calcium triphosphate in a ratio of 1:1 were used as a control, according to our previous studies, and ZnO, functionalized with different percentages of <i>Satureja thymbra</i> L. essential oils, was added as an antimicrobial, promoting bone growth, mineralization, and formation. …”
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Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer’s disease and related Tau pathologies by Alice Alessandra Galeotti, Lorenzo Santucci, Jennifer Klimek, Jennifer Klimek, Mohamed Aghyad Al Kabbani, Mohamed Aghyad Al Kabbani, Hans Zempel, Hans Zempel, Vittoria Raffa

“…Alzheimer’s disease (AD) and related tauopathies such as frontotemporal dementia (FTD) or traumatic brain injury (TBI) are neurodegenerative disorders characterized by progressive loss of memory and cognitive function. The main histopathological features of AD are amyloid-β plaques and Tau neurofibrillary tangles, suggested to interfere with neuronal function and to cause microtubule (MT) destabilization. …”
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Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol by Daniel Oros, Jon Schoorlemmer, Cristina Paules, Jesús Gonzalez, Marta Fabre, Sara Ruiz-Martínez, Lina Youssef, Natalia Abadía-Cuchí, Marcos Clavero-Adell, Ana Medel-Martinez, Ariadna Ayerza-Casas, Juan Lerma-Irureta, Pilar Maestro-Quibus, Jesús Rodriguez-Calvo, Diego Lerma

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Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements. by Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar

“…However, expression, regulation and functions of the two isoforms are largely uncharacterized. …”
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Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression by A. Saalbach, M. Stein, S. Lee, U. Krügel, M. Haffner-Luntzer, K. Krohn, S. Franz, J.C. Simon, J. Tuckermann, U. Anderegg

“…RNAseq analysis revealed that MSC from Has-tKO are characterised by decreased expression of genes annotated for bone and organ development, whereas expression of genes associated with chemokine related interactions and cytokine signalling is increased.Taken together, we present a novel mouse model with complete deletion of HA synthases in adult mice which has the potential to study HA function in different organs and during age-related HA reduction. …”
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Genome-Wide Identification and Expression Profiling Analysis of the Mitochondrial Calcium Uniporter Gene Family Under Abiotic Stresses in <i>Medicago sativa</i> by Wanhong Li, Bowei Jia, Jiaxun Sheng, Yang Shen, Jun Jin, Xiaoli Sun, Xiangping Liu, Mingzhe Sun

“…These results provide detailed knowledge of alfalfa <i>MCU</i> genes and suggest their potential functions in abiotic stress response.…”
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Biomedical applications of organoids derived from the digestive system by Zhensheng Xu, Zhongwen Lei, Qiuhua Cheng, Yuanhui Gao, Yang Xiang

“…However, these models fail to fully replicate the complex cellular microenvironment and spatial structure, and are further limited by individual and species differences. Organoid technology, as an emerging in vitro cell culture approach, enables the precise culturing and differentiation of human stem cells to generate highly tissue-specific and functionally intact organoids. …”
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Challenges of in vitro modelling of liver fibrosis by Patricia Ros-Tarraga, Estela Villanueva-Badenas, Estela Villanueva-Badenas, Estela Sanchez-Gonzalez, Estela Sanchez-Gonzalez, Gloria Gallego-Ferrer, Gloria Gallego-Ferrer, M. Teresa Donato, M. Teresa Donato, M. Teresa Donato, Laia Tolosa, Laia Tolosa

“…Primary human cells, human hepatic cell lines and human stem cells-derived hepatic stellate-like cells have been widely used for studying fibrosis pathogenesis. …”
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Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages by Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li, Zhangting Liang, Jianfei Xu, Zhen Xiao, Yu Qiao, Zheng Lin, Katerina Oleynikova, Mobolaji T. Akinwole, Xuemeng Zhou, Alexey Ruzov, Andrew P. Hutchins

“…TEs were thought to have little functional relevance but recent studies report roles in biological processes, including embryonic development. …”
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From Quiescence to Activation: The Reciprocal Regulation of Ras and Rho Signaling in Hepatic Stellate Cells by Saeideh Nakhaei-Rad, Silke Pudewell, Amin Mirzaiebadizi, Kazem Nouri, Doreen Reichert, Claus Kordes, Dieter Häussinger, Mohammad Reza Ahmadian

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HLA-E⁎01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence by Julie Di Cristofaro, Mathieu Pelardy, Anderson Loundou, Agnès Basire, Carine Gomez, Jacques Chiaroni, Pascal Thomas, Martine Reynaud-Gaubert, Christophe Picard

“…HLA-E seems to play a major role in the immune response to different viral infections and to affect transplantation outcome, in Hematopoietic Stem Cell Transplantation, for example. …”
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Effects of Transcutaneous Electroacupuncture Stimulation (TEAS) on Eyeblink, EEG, and Heart Rate Variability (HRV): A Non-Parametric Statistical Study Investigating the Potential o... by David Mayor, Tony Steffert, Paul Steinfath, Tim Watson, Neil Spencer, Duncan Banks

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Characterization of the hepatic flora and metabolome in nonalcoholic fatty liver disease by Hua Jiang, Hui Wang, Yangfan Guo, Yankun Zhu, Hui Dai, Chenchen Liang, Jianpeng Gao, Jianpeng Gao

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Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution by Max Henry Hills, Limei Ma, Ai Fang, Thelma Chiremba, Seth Malloy, Allison R Scott, Anoja G Perera, C Ron Yu

“…Substantial co-expression is found between receptors across clades, from different classes, and between olfactory and VRs, with nearly half from pairs located on the same chromosome. …”
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