Organoids and organoid extracellular vesicles-based disease treatment strategies by Guangyin Zhou, Ruiyang Li, Shihao Sheng, Jingtao Huang, Fengjin Zhou, Yan Wei, Han Liu, Jiacan Su

“…Abstract Organoids are “mini-organs” that self-organize and differentiate from stem cells under in vitro 3D culture conditions, mimicking the spatial structure and function of tissues in vivo. …”
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Modelling hair follicle growth dynamics as an excitable medium. by Philip J Murray, Philip K Maini, Maksim V Plikus, Cheng-Ming Chuong, Ruth E Baker

“…Expressions are derived, in terms of parameters representing molecular regulation, for the time spent in the different functional phases of the cycle, a formalism that allows the model to be directly compared with a previous cellular automaton model and experimental measurements made at the single follicle scale. …”
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Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing. by Tim Thijs, Katleen Broos, Stefaan J Soenen, Aline Vandenbulcke, Karen Vanhoorelbeke, Hans Deckmyn, Isabelle I Salles-Crawley

“…In conclusion, we here report the successful use of miRNA technology to silence a platelet protein in megakaryoblastic cells and demonstrate its usefulness in functional assays. Hence, we believe that artificial miRNAs are suitable tools to unravel the role of a protein of interest in stem cells, megakaryocytes and platelets, thereby expanding their application to novel fields of basic and translational research.…”
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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…We also comment on how mapping the interactomes of the different cardiac ion channels may help advance research into LQTS and other cardiac diseases. …”
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Notch2 Deletion Compromises Epithelial Integrity and Enamel Formation in Rodent Incisors by Argyro Lamprou, Cristina Porcheri, Thimios A. Mitsiadis

“…The evolutionarily conserved Notch signalling pathway regulates the fate, proliferation and differentiation of cells in most developing organs, thus affecting their morphogenesis and function. Here, we investigated the role of the Notch2 receptor in the generation and function of epithelial cells of the continuously erupting rodent incisors. …”
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Crossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators by Vieri Failli, Stephen M. Strittmatter, Martin E. Schwab, Aileen J. Anderson, Angela Ruban, Hassan Al-Ali, Armin Curt, Adrien Cohen, Jane T.C. Hsieh

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Impact of continuous cropping on tobacco growth, stress resistance, and soil microecological structure by Shikang Yu, Huizhan Gu, Jixian He, Fucheng Li, Weijie Liu, Qi Chen, Yu Lai, Bo Zhu

“…Prediction of the potential functions of soil samples with different continuous cropping years revealed that the Z-scores of each pathway in noncontinuous cropping soil samples ranged from 1.12 to 0.078, while those in 33-year continuous cropping samples decreased from −0.10 to −1.41. …”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

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The role of non-coding RNAs in the regulation of cell death pathways in melanoma by Yekta Metanat, Maria Sviridova, Bareq N. Al-Nuaimi, Fateme Janbazi, Mahtab Jalali, Nogol Ghalamkarpour, Elnaz Khodabandehloo, Ehsan Ahmadi

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Comparative Analysis of Ratoon-Competent and Ratoon-Deficient Sugarcane by Hormonal and Transcriptome Profiling by Liping Zhao, Maoyong Ran, Jing Zhang, Peifang Zhao, Fenggang Zan, Jun Zhao, Wei Qin, Qibin Wu, Jiayong Liu, Xinlong Liu

“…This study elucidates the physiological and molecular mechanisms underlying the sugarcane ratooning ability observed in ratoon-competent GuiTang 29 (GT29) and ratoon-deficient Badila cultivars following stem excision. Through integrated hormonal profiling and transcriptome analysis, we identified significant differences in hormone levels and gene expression patterns. …”
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Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy by YongBo Lv, Dashuai Zhu, Junlang Li, Yuan Li, Chao Lu, Jianing Bi, Ke Huang, Shiqi Hu, Shuo Liu, Na Yan, Ke Cheng, Juan Wang

“…In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. …”
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Extracellular vesicles: innovative cell-free solutions for wound repair by Hanne Eerdekens, Elke Pirlet, Sarah Willems, Annelies Bronckaers, Paula M. Pincela Lins, Paula M. Pincela Lins

“…This review comprehensively summarizes the latest research on the function of EVs from endogenous cell types during the different phases of wound healing, thereby presenting interesting therapeutic targets. …”
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Free-Form Rapid Prototyped Porous PDMS Scaffolds Incorporating Growth Factors Promote Chondrogenesis by Andrés Díaz Lantada, Hernán Alarcón Iniesta, Beatriz Pareja Sánchez, Josefa Predestinación García-Ruíz

“…We include a comparative study of PDMS sponges obtained by different simple processes. Final in vitro assessment is carried out using hMSCs (bone marrow-derived human mesenchymal stem cells), cultured onto porous PDMS scaffolds functionalized with aminopropyltriethoxysilane (APTS) and equilibrated with a trophic factors medium produced by the cells. …”
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Advancements in phytomass-derived activated carbon for applications in energy storage systems by Palanichamy Kalyani, Rangachari Banuprabha Thakku, Jayavel Sridhar, Dhandapani Aravind, Natarajan Varagunapandiyan

“…This article intricately reviews the recent advancements in phytomass-derived activated carbon (PAC), chiefly for the supercapacitor electrodes and notably, phytomass including different parts of the plants limited to, stem, leaf, flower, seed, fruit, and root for deriving PACs bestowed with excellent electrochemical performance have been considered. …”
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Embryonic Origins of Cancer: Insights from Double Homeobox 4 Regulation by Bo Fu, Hong Ma, Liang Wang, Zhenhua Guo, Fang Wang, Di Liu, Dongjie Zhang

“…DUX4 is involved in the activation of the zygote genome and then facilitates the establishment of totipotency in pre-implantation embryos, whereas the misexpression of DUX4 is associated with different types of cancer. Taken together, this indicates that DUX4 performs analogous functions in these two processes and connects embryogenesis and tumorigenesis. …”
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Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model by Yinmin Wang, Wenxiao Qi, Shun Yu, Xianyu Zhou, Xiuxia Wang, Fei Liu, Fei Liu, Rui Jin, Xusong Luo, Qiangliang Ma, Lin Lu, Jun Yang

“…Moreover, Tpm1, Sfrp1, and Notch1 were highly expressed in all epithelial and stem cell subgroups.ConclusionsThe hub genes, Notch1, Tpm1 and Sfrp1, and their associated signaling pathways such as Notch and Wnt signaling and functions in key cell subsets highlight prospective therapeutic strategies to enhance skin growth under mechanical expansion. …”
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Transcriptomic Profiling Reveals Lysine-Mediated Proliferative Mechanisms in Mongolian Horse Myogenic Satellite Cells by Yumeng Liu, Yuanyi Liu, Dongyi Bai, Manglai Dugarjaviin, Xinzhuang Zhang

“…Skeletal muscle satellite cells are muscle stem cells that play an important role in the growth, development, and repair of skeletal muscle as well as in the locomotor performance of the animal body. …”
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Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation. by Stephanie Dumon, David S Walton, Giacomo Volpe, Nicola Wilson, Emilie Dassé, Walter Del Pozzo, Josette-Renee Landry, Bryan Turner, Laura P O'Neill, Berthold Göttgens, Jon Frampton

“…Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. …”
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Sediment stability is optimized by manipulating planting design during coastal marsh establishment by Christine B. Rohal, Xiao Yu, Jesse Mason Crawford, Ollie Montgomery, Laura K. Reynolds, Carrie Reinhardt Adams

“…Abstract Seaside communities increasingly harness the shoreline protection functions of coastal ecosystems by constructing nature-based infrastructure. …”
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Deep crypt secretory cells shape region-specific mucin glycosylation patterns in the mouse colon. by Daisuke Sugahara, Hayato Kawakami, Yoshihiro Akimoto

“…Although DCS cells are implicated in supporting the stem cell niche, their involvement in mucin production was unclear. …”
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