A molecular dynamics protocol for rapid prediction of EGFR overactivation and its application to the rare mutations S768I, S768N, D761N by Julian Behn, R.N.V. Krishna Deepak, Jiancheng Hu, Hao Fan

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Identification and characterization of grape VAP27 gene family and their roles in disease resistance by Ruonan Li, Bianbian Wang, Mingxiu Zha, Kangzhuang Zhang, Min Li, Linjiao Xie, Xinyu Chen, Yan Xu, Guotian Liu

“…Additionally, we compared the transcriptional levels and subcellular localizations of the VvVAP27 family members across different plant tissues (flower, leaf, seed, root, fruit, tendril, and stem), indicating site-specific functionalities for different gene members. …”
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Investigation of hypoglycemic and antidiarrheal activity on mice model and in vitro anthelmintic study of Macropanax dispermus (Blume) Kuntze (Araliaceae): a promising ethnomedicin... by Syeda Rubaiya Afrin, Mohammad Rashedul Islam, Sayeda Saima Didari, Sarah Waddun Jannat, Ummah Tasnim Nisat, Mohammed Kamrul Hossain

“…This study also identified the functional groups present in MDML which could correlate the presence of different phytochemicals responsible for biological activities. …”
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Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration by Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou

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Dual action of pyrimidine derivatives: Targeting tamoxifen resistance in breast cancer by Jie Yuan, Geng Wang, Narasimha M. Beeraka, Hua Zhang, Qun Wang, Danfeng Zhang, Minghua Wang, Akshay Ravish, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Vladimir N. Nikolenko, Basappa Basappa, Li Yang

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Comprehensive review of macrophage models: primary cells and immortalized lines across species by Tiansong Ding, Yuhan Du, Bin Yang, Wenfan Tian, Jiapei Li, Jinghong Xie

“…As a consequence, macrophage cultivation in vitro has emerged as a crucial biological technique for mimicking the microenvironment of different disease models. Primary macrophage models and immortalized macrophage models are two distinct types of macrophage models, each with unique origins, functions, benefits, and drawbacks. …”
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Immunological microenvironment and targeted therapeutics in multiple sclerosis: new insights in crosstalk between immune niches and CNS by Xiaodi Sun, Feng Zhang, Luojinyun Wang, Gyeore Lee, Sibo Yang, Daqiang Zhou, Bohao Chang, Bo Hu, Yifan Zhou

“…., T/B cells, myeloid cells and microglia) in disease progression, highlighting their functional heterogeneity across different MS subtypes. …”
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Plasticity in the Neonatal Brain following Hypoxic-Ischaemic Injury by Eridan Rocha-Ferreira, Mariya Hristova

“…In term infants HI causes selective damage to sensorimotor cortex, basal ganglia, thalamus, and brain stem. Even though the immature brain is more malleable to external stimuli compared to the adult one, a hypoxic-ischaemic event to the neonate interrupts the shaping of central motor pathways and can affect normal developmental plasticity through altering neurotransmission, changes in cellular signalling, neural connectivity and function, wrong targeted innervation, and interruption of developmental apoptosis. …”
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Immunomodulatory Activity of Granulocyte Colony-Stimulating Factor and its Therapeutic Effect on Liver Failure by Jinhua Hu, Zijian Sun, Jingjing Tong, Jing Chen, Zifeng Liu, Haijuan Wang

“…Liver failure is characterized by the rapid deterioration of liver function, often accompanied by ascites, coagulation dysfunction, hepatic encephalopathy, and other critical complications. …”
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Unravelling the conundrum of nucleolar NR2F1 localization using antibody-based approaches in vitro and in vivo by Michele Bertacchi, Susanne Theiß, Ayat Ahmed, Michael Eibl, Agnès Loubat, Gwendoline Maharaux, Wanchana Phromkrasae, Krittalak Chakrabandhu, Aylin Camgöz, Marco Antonaci, Christian Patrick Schaaf, Michèle Studer, Magdalena Laugsch

“…Hence, we studied this phenomenon employing various in vitro and in vivo models using different antibody-dependent approaches. Examination of seven commonly used anti-NR2F1 antibodies in different human cancer and stem cells as well as in wild type and null mice revealed that NR2F1 nucleolar localization is artificial and has no functional role. …”
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The influence of 6-Benzylaminopurine (BAP) on yield responses and photosynthetic physiological indices of soybean by Xinglong Lian, Shuang Liu, Aatika Sikandar, Zongli Kang, Yaxing Feng, Lanyuwen Jiang, Yuanyuan Wang

“…In the current investigation, spraying different concentrations of BAP had no significant effect on the soybean yield. …”
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Autonomic dysfunction in multiple system atrophy: from pathophysiology to clinical manifestations by Yuqi Luo, Nan Yang, Wanlin Yang, Baoling Chen, Shuzhen Zhu, YihRu Wu, Qing Wang

“…The deposition of α-synuclein in highly interconnected neuronal networks with different neurochemistry properties in different regions of the cortex, diencephalon, brain stem and spinal cord leads to early onset and extensive autonomic dysfunction in MSA. …”
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Overcoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles by Jun Deng, Hui Ke

“…Loss-of-function assays were conducted to investigate the biological functions of EVs/siCD38 in HCC cells. …”
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Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids by Cong-Yi Shen, Qi-Rong Zhou, Xiang Wu, Xin-Yu Han, Qin Zhang, Xiao Chen, Yu-Xiao Lai, Long Bai, Ying-Ying Jing, Jian-Hua Wang, Cheng-Long Wang, Zhen Geng, Jia-Can Su

“…Organoids, miniature three-dimensional (3D) tissue structures derived from the directed differentiation of stem or progenitor cells, mimic the structure and function of natural organs. …”
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Global Transcriptome and Correlation Analysis Reveal Cultivar-Specific Molecular Signatures Associated with Fruit Development and Fatty Acid Determination in Camellia oleifera Abel by Shaofeng Peng, Jia Lu, Zhen Zhang, Li Ma, Caixia Liu, Yongzhong Chen

“…The transcriptomics was conducted to perform a comprehensive and system-level view on dynamic gene expression networks for different developmental stages. Short Time-series Expression Miner (STEM) analysis of XL106 (the 6 time points) and XL210 (8 time points) was performed to screen related fatty acid (FA) gene set, from which 1041 candidate genes related to FA were selected in XL106 and 202 related genes were screened in XL210 based on GO and KEGG enrichment. …”
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How short peptides interact with oral cells? A systematic review by Giulia Tetè, Aleksandr Trofimov, Natasha Cinta Vinskid, Giuseppe Tafuri, Fabia Profili, Bruna Sinjari

“…Results 8 in vitro studies dealing with different short peptides with different biological functions against oral cavity cells and tissues were included. 4 articles highlighted the ability of short peptides to positively influence the proliferation of cells in the oral cavity. 2 articles highlighted the antitumour activity of short peptides. 1 article highlighted the antimicrobial activity of the peptide DJK-15. …”
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Effects of PPARγ Ligands on Leukemia by Yoko Tabe, Marina Konopleva, Michael Andreeff, Akimichi Ohsaka

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Neutrophils: The Gatekeepers to Candidal Infection by Aliyu, M. , Muhammed, Y. , Azeez-Akande, O. and Jibril, M.*

“…Subpopulations of PMNs exist in different tissues carrying specialized functions. Understanding the various roles of PMN in candidiasis can aid in the development of immunotherapy as the current antifungal therapy recorded a colossal setback.…”
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CHD1 contributes to intestinal resistance against infection by P. aeruginosa in Drosophila melanogaster. by Johanna Sebald, Stefano Morettini, Valerie Podhraski, Cornelia Lass-Flörl, Alexandra Lusser

“…We found a fraction of genes that were misregulated in Chd1 mutants to be functionally linked to Drosophila immune and stress response. …”
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Silencing NEDD4L Effectively Inhibits the Malignant Behaviors of Hepatocellular Carcinoma by Dai J, Zhu T, Wan J, Liu R, Song Y, Zhang D, Wang X, Zhang H, Li W, Lin J, Zhu X, Liu Y

“…Single-cell sequencing analysis revealed that NEDD4L was notably enriched in cancer stem cell populations across different HCC developmental stages and immune states, with subgroups exhibiting high NEDD4L expression sharing substantial co-expressed genes with stem cell subpopulations. …”
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