Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis by E. Mormone, L. Savastano, G. Rossi, F. Maruccia, G. Di Maggio, N. P. Sinisi, M. Sandri, M. Copetti, E. De Santis, V. Guerra, G. Biancofiore, C. Cisternino, E. Caradonna, P. Graziano, F. L. Gorgoglione

“…Surprisingly, despite these differences in cells number, the improvement in early pain and function scores, after each treatment, were statistically significant within each of the three arms. …”
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Molecular Beacons: Powerful Tools for Imaging RNA in Living Cells by Ricardo Monroy-Contreras, Luis Vaca

“…Despite the fact that fixed cells offer the possibility to observe the spatial distribution of RNA, assays with capability to real-time monitoring RNA transport into living cells are needed to further understand the role of RNA dynamics in cellular functions. Molecular beacons (MBs) are stem-loop hairpin-structured oligonucleotides equipped with a fluorescence quencher at one end and a fluorescent dye (also called reporter or fluorophore) at the opposite end. …”
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Neural differentiation modulates the vertebrate brain specific splicing program. by Alicia Madgwick, Philippe Fort, Peter S Hanson, Philippe Thibault, Marie-Claude Gaudreau, Georges Lutfalla, Tarik Möröy, Sherif Abou Elela, Bill Chaudhry, David J Elliott, Christopher M Morris, Julian P Venables

“…Alternative splicing patterns are known to vary between tissues but these patterns have been found to be predominantly peculiar to one species or another, implying only a limited function in fundamental neural biology. Here we used high-throughput RT-PCR to monitor the expression pattern of all the annotated simple alternative splicing events (ASEs) in the Reference Sequence Database, in different mouse tissues and identified 93 brain-specific events that shift from one isoform to another (switch-like) between brain and other tissues. …”
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Transcriptomic Analysis Reveals the Biosynthesis Mechanism of Coixol Under Salicylic Acid Treatment by Yao Wang, Hanli Ye, Xuqin Luo, Ziwei Li, Chuanqi Zheng, Dali Sun

“…Methods: In this study, different dosages of salicylic acid (SA) were applied to coix plants, and the contents of coixol from different parts were detected by an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). …”
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Neurorehabilitation and white matter repair in traumatic spinal cord injury: a dialogue between clinical and preclinical studies by Vito Antonio Baldassarro, Ilaria Baroncini, Laura Calzà, Francesca Ciardulli, Luca Lorenzini, Francesco Giuseppe Materazzi, Francesca Merighi, Corinne Quadalti, Lucia Ricci, Francesca Serafino, Laura Simoncini

“…OPCs are generated during development, are widely distributed across both white and gray matter, and remain quiescent until appropriate stimuli, such as functional requests or injuries, arise. Under these conditions, endogenous OPCs, as well as new OPCs derived from the proliferation and differentiation of endogenous neural stem cells, migrate toward axons and differentiate into mature OLs capable of wrapping axons and forming the myelin sheaths. …”
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Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice. by Jinhong Meng, Carl F Adkin, Shi-wen Xu, Francesco Muntoni, Jennifer E Morgan

“…<h4>Background</h4>Stem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche in the majority of the patient's skeletal muscles. …”
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THE PHENOMENON OF NEUROPLASTICITY IN THE MECHANISMS OF REFLEXOTHERAPY by G. M. Karimova, L. G. Mindubaeva, A. R. Abashev, A. Sh. Bilalova, A. A. Zinnatullina

“…The therapeutic effects of reflexotherapy are realized through the formation of a local and background sensory flow, and their interaction at different levels of the nervous system. Afferent flow is processed at the peripheral, spinal-segmental, stem, subcortical levels, as well as at the level of the cortex. …”
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A Review of 3D Bioprinting Technologies in the Reconstruction of Human Nasal Cartilaginous Tissue by Hosein Rostamani, Omid Fakhraei, Fatemeh Toosizadeh Khorasani, Narges Kelidari

“…Objective This study investigates the ability of different three-dimensional bioprinting methods to repair defects in the nose area. …”
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The Invisible World of Images. From “Nonhuman” to “Undigital” Photography in Joanna Zylinska’s Reflections by Piotr Zawojski

“… The article presents the theoretical views and, to a lesser extent, artistic practices of Joanna Zylinska, who in her artistic activity combines epistemological strategies of a researcher and theorist with her activities in the field of art. She develops in different manners an original project of philosophy as photography, or photography as a form of philosophizing. …”
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Microgel-based bioink for extrusion-based 3D bioprinting and its applications in tissue engineering by Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Aparna Jayachandran, Rodney Luwor, Jiao Jiao Li, Haiyan Li

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Regulatory T Cells and Their Prognostic Relevance in Hematologic Malignancies by Giovanni D’Arena, Candida Vitale, Marta Coscia, Agostino Festa, Nicola Matteo Dario Di Minno, Vincenzo De Feo, Michele Caraglia, Gioacchino Calapai, Luca Laurenti, Pellegrino Musto, Giovanni Di Minno, Daniela Fenoglio

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Generation and characterisation of keratin 7 (K7) knockout mice. by Aileen Sandilands, Frances J D Smith, Declan P Lunny, Linda E Campbell, Kirsty M Davidson, Stephanie F MacCallum, Laura D Corden, Lesley Christie, Stewart Fleming, E Birgitte Lane, W H Irwin McLean

“…Keratin 7 (K7) is a Type II member of the keratin superfamily and despite its widespread expression in different types of simple and transitional epithelia, its functional role in vivo remains elusive, in part due to the lack of any appropriate mouse models or any human diseases that are associated with KRT7 gene mutations. …”
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Analysis of interconnections between Lean and QM standards within LCIA framework by Burtseva Tatyana, Mironova Nataliya, Borisova Anzhelika, Mottaeva Asiiat

“…The ubiquitous approaches of lean management and environmental management (lean and green management) stem from the same sentiment, their driving force is of great importance in government and Russian practice, they have different tools and a general view of waste processes. …”
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Multifactorial Control of Autoimmune Insulin-Dependent Diabetes in NOD Mice: Lessons for IBD by Edward H Leiter

“…Genetic susceptibility is transmitted by hemopoietic stem cells, and specific defects in T immunoregulation have been traced to defects in the development and function of marrow-derived antigen presenting cells. …”
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Elavl1 deletion in limb mesenchyme is dispensable for skeletal morphogenesis by Rohini Parsha, Satya K. Kota

“…Our study indicates differential dependency and susceptibility to the loss of Elavl1 in different stem cell lineages, with its functions being dispensable during limb skeletal development.…”
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Microglial colonization routes and their impacts on cellular diversity by Yuki Hattori

“…Unlike other glial cells—such as astrocytes and oligodendrocytes—which originate from neural stem cells alongside neurons, microglia derive from erythromyeloid progenitors that emerge in the yolk sac during early embryonic development. …”
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Unique regulatory properties of mesangial cells are genetically determined in the rat. by Ping-Chin Lai, Ling-Yin Chiu, Prashant Srivastava, Cristina Trento, Francesco Dazzi, Enrico Petretto, H Terence Cook, Jacques Behmoaras

“…Here we have hypothesised that mesangial cells, given their mesenchymal stromal origin, show similar immunomodulatory properties as mesenchymal stem cells (MSCs), by regulating macrophage function associated with glomerular crescent formation. …”
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Extracellular vesicles as novel therapeutic targets and diagnosis markers by Yu Zhang, Weiliang Wu, Xiangbin Pan, Yanli Wang, Chengjie Wu, Lin Lu, Xi-Yong Yu, Yangxin Li

“…EVs contain lipids, proteins, genetic material, and organelles, which can be used as communication carriers between different cells and potential disease biomarkers. EVs secreted by different cells (cancer cells, adipocytes, mesenchymal stem cells, immune cells et al.) play different functions. …”
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Role of oxysterol 4β-hydroxycholesterol and liver X receptor alleles in pre-eclampsia by Lassi Kaartinen, Tiina Jääskeläinen, Eeva Sliz, Gamze Yazgeldi Gunaydin, Satu Wedenoja, Shintaro Katayama, Eero Kajantie, Valtteri Rinne, Seppo Heinonen, Juha Kere, Heta Merikallio, Eeva Sliz, Hannele Laivuori, Janne Hukkanen

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Systemic AL Amyloidosis and Precision Medicine by Axel Rüfer, Rahel Schwotzer

“…The mechanisms behind this organ function impairment are different from plasma-cell myeloma, as are the diagnostic work-up and the treatment strategies. …”
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