DEVELOPMENT OF AN AUTOMATED FLUORESCENCE MICROSCOPY ASSAY FOR QUANTIFYING FACTORS AFFECTING RED BLOOD CELL (RBC) SICKLING IN SICKLE CELL DISEASE (SCD) by ML Arrojo, ACS Pinto, SK Haddad, RA Panepucci

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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…Wnt signalling pathways govern a myriad of stem cell processes during embryogenesis and drive tumorigenesis in adult tissues in animals. …”
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The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy by Eleonora Catricalà, Pasquale A. Della Rosa, Paola Ortelli, Valeria Ginex, Alessandra Marcone, Daniela Perani, Stefano F. Cappa

“…Posterior cortical atrophy (PCA) is an uncommon presentation of Alzheimer's disease (AD), characterised by prevalent anatomo-functional involvement of posterior cortical areas. …”
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Construction of genetic transformation system mediated by Agrobacterium rhizogenes in Vaccinium corymbosum by WU Tingting, LIU Liangqin, JIANG Yanqin, GE Chunfeng, TIAN Liangliang, LIU Mengxi, ZENG Qilong, YU Hong

“…Inspired by the RAPID method, we established an Agrobacterium rhizogenes transformation system for blueberry (Vaccinium corymbosum) stem segments. [Methods] The stem segments from current-year green shoots of field-grown Lanmei 1 blueberry plants were used as explants. …”
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Surface morphology segmentation and evaluation of diamond lapping pad based on improved Mask R-CNN by Wenlong SUO, Yanfen LIN, Congfu FANG

“…Dilated convolution is introduced in stage 3, and each residual block in stage 3 is improved into a residual block using dilated convolution to expand the receptive field, enhance the model's ability to extract deep semantic features of abrasive particles and pore targets of smaller scales on the surface of the lapping pad, and improve segmentation performance for abrasive grain and pore targets of different scales. The loss function and mean average precision (mAP) of Mask R-CNN are used to comprehensively reflect the performance of the model. …”
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Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes by Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng

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Screening for cold tolerance resources in maize seedlings and analysis of leaf cell responses by Mengting Hu, Mengting Hu, Dan Zhang, Dan Zhang, Wentao Du, Wentao Du, Huijuan Tian, Huijuan Tian, Ying Hao, Ying Hao, Shuqi Ding, Shuqi Ding, Kaizhi Yang, Kaizhi Yang, Ruohang Xu, Ruohang Xu, Lei Zhang, Lei Zhang

“…The results of the experiment indicate that: (1) Different maize varieties exhibit variations in cold tolerance during the seedling stage, and the extent to which various measurement indicators are affected by low-temperature stress differs. (2) The comparative analysis of phenotypic traits and physiological indexes showed that low temperature stress inhibited the growth of plant height and stem diameter, and had a great impact on leaf width and leaf area. …”
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Karate Sports Disciplines from the Spotlight of the Paradigm Shift of Japanese Combat Systems: Analytical Study by Anatoliy Lozovyy Anatoliy

“…The differences between them stem from the differences between the forms of karate from which they arose. …”
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Measuring Optical Scattering in Relation to Coatings on Crystalline X-Ray Scintillator Screens by Matthias Diez, Simon Zabler

“…This model assumes an additive exponential kernel with a certain scattering length to the system’s point spread function. This assumption was confirmed, and the scatter length was estimated from three new different kinds of experiments (hgap, rect, and LSF) on the BM18 beamline of the European synchrotron. …”
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Preclinical Performance of Customized Polycaprolactone-Based Hybrid Bone Grafts by Ildefonso Serrano-Belmonte, Javier Montero, Ángel Román-Maciá, Virginia Pérez-Fernández, Luis M. Rodríguez-Lorenzo, Nieves Cubo-Mateo, Angélica Lara-Nuñez, Ascensión Martínez-Cánovas

“…The main objective of this work was to evaluate the biocompatibility and cytotoxic effects that different combinations of PCL with nanohydroxyapatite and strontium could produce on periodontal ligament stem cells (PDLSC). (2) Materials and Methods: PDLSCs were seeded in six 96-well plates. …”
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Role of Translationally Controlled Tumor Protein in Cancer Progression by Tim Hon Man Chan, Leilei Chen, Xin-Yuan Guan

“…Translationally controlled tumor protein (TCTP) is a highly conserved and ubiquitously expressed protein in all eukaryotes—highlighting its important functions in the cell. Previous studies revealed that TCTP is implicated in many biological processes, including cell growth, tumor reversion, and induction of pluripotent stem cell. …”
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Proliferation and regeneration of the healthy human urothelium: A multi-scale simulation approach with 16 hypotheses of cell differentiation. by Fabian Siegel, Angelo Torelli, Minca Mattis, Julian Debatin, Philipp Erben, Markus Gumbel

“…The urothelium as a stratified epithelium of the urinary tract is a slow regenerating tissue of different layers and shares similarities with the epidermis. …”
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Unveiling the intricacies of bone homeostasis: Epigenetic regulation, extracellular vesicles, and angiogenesis integration by Célio Junior da Costa Fernandes

“…Extracellular vesicles derived from different cell types, such as osteoblasts, endothelial cells, and mesenchymal stem cells, are also important in bone homeostasis. …”
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The effect of vitamin D3 on CD34 progenitor cells in vitamin D deficiency rickets by Sevgi Yetgin, S Songül Yalçin

“… Vitamin D metabolites have multiple functions not only in calcium homeostasis, but also in hematopoiesis. …”
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Large-Scale Gene Relocations following an Ancient Genome Triplication Associated with the Diversification of Core Eudicots. by Yupeng Wang, Stephen P Ficklin, Xiyin Wang, F Alex Feltus, Andrew H Paterson

“…Different modes of gene duplication including whole-genome duplication (WGD), and tandem, proximal and dispersed duplications are widespread in angiosperm genomes. …”
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Development and application of GlycanDIA workflow for glycomic analysis by Yixuan Xie, Xingyu Liu, Li Yi, Shunyang Wang, Zongtao Lin, Chenfeng Zhao, Siyu Chen, Faith M. Robison, Benson M. George, Carlito B. Lebrilla, Ryan A. Flynn, Benjamin A. Garcia

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Myelodysplastic Neoplasms (MDS): Pathogenesis and Therapeutic Prospects by Xuefeng Li, Chaoyu Zou, Xinrong Xiang, Lei Zhao, Mengran Chen, Chenlu Yang, Yu Wu

“…Myelodysplastic neoplasms (MDS) are a group of hematological malignancies originating from hematopoietic stem cells (HSCs), characterized by distinct clinical and/or molecular heterogeneity across different MDS subtypes. …”
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Generation of mouse and rat xenogeneic ovaries in vitro for production of mouse oocyte by Si Won Jang, Ye Rim Kim, Jae Ho Han, Hoon Jang, Hyun Woo Choi

“…The system forming ovarian follicles is developed to investigate in vitro folliculogenesis in a confined environment to obtain functional oocytes. Several studies have reported the successful generation of fully functional oocytes using mouse-induced pluripotent stem cells (iPSCs) and mouse female germline stem cells (fGSCs) as sources of stem cells for in vitro gametogenesis models. …”
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The dynamic brain: from spiking neurons to neural masses and cortical fields. by Gustavo Deco, Viktor K Jirsa, Peter A Robinson, Michael Breakspear, Karl Friston

“…Macroscopic models can inform us about whole brain dynamics and interactions between large-scale neural systems such as cortical regions, the thalamus, and brain stem. Each level of description relates uniquely to neuroscience data, from single-unit recordings, through local field potentials to functional magnetic resonance imaging (fMRI), electroencephalogram (EEG), and magnetoencephalogram (MEG). …”
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BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis by Yijin Chen, Dawei Huo, Ye Meng, Jie Zhang, Mengmeng Huang, Qian Luo, Yulin Xu, Haiqiong Zheng, Yingli Han, Xiangjun Zeng, Yanjuan Liu, Yunfei Liu, Rui Wen, Delin Kong, Ruxiu Tie, Shanshan Pei, Nan Liu, Pengxu Qian, He Huang, Meng Zhang

“…Results We identified that inhibitors of the bromodomain protein BRD4, an epigenetic reader and transcriptional activator together with CDK9, promoted terminal erythropoiesis from hematopoietic stem/progenitor cells and embryonic stem cells, and enhanced enucleation. …”
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