STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
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Cripto-1 and Cripto-3 differential expression pattern in human placenta, umbilical cord and fetal tissues suggests new functions for these proteins by Josune García-Sanmartín, Judit Narro-Íñiguez, María José Puente, Frank Cuttitta, Alfredo Martínez

“…Abstract Cripto-1 (CR1) is an oncofetal protein involved in EGF/TGFβ signal transduction, with important functions in development, stem cell biology and cancer. …”
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulationResearch in context by Xuguang Li, Nobuaki Shiraki, Takami Watanabe, Rikako Fukui, Kyohei Furukawa, Yusuke Kato, Yuri Nakahara, Shoen Kume, Akashi Taguchi, Youichiro Wada, Dwina Juliana Warman, Kenji Saito, Haruyo Nakajima-Adachi, Satoshi Hachimura, Hisanori Kato, Huijuan Jia

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Identification of functional pathways and hub genes associated with the heterochronic development of sugarcane axillary buds and sett roots through multi-omics analysis by Jiabao Zheng, Xiaoyu Huang, Yanli Wei, Wenyan Li, Baoshan Chen, Baoshan Chen, Wenlan Li, Wenlan Li

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Hypomethylation of GCNT2 isoform A correlates with transcriptional expression and is associated with poor survival in acute myeloid leukemia by De-hong Wu, De-hong Wu, Hong-chun Qiu, Jing Xu, Jiang Lin, Jun Qian

“…BackgroundThe function of GCNT2 has been documented to act as an oncogenic driver or tumor suppressor in different types of tumor, but the role of GCNT2 and the epigenetic regulation mechanism in AML, however, has not yet been clarified. …”
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Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration by Wenshuai Li, Qichen Shen, Tong Tong, Hongsen Tian, Xiaowei Lian, Haoli Wang, Ke Yang, Zhanqiu Dai, Yijun Li, Xianhua Chen, Qingqing Wang, Dan Yang, Feng Wang, Feng Hao, Linfeng Wang

“…In vitro, the NPVs regulated lipid metabolism in bone marrow mesenchymal stem cells (BMSCs), reprogramed the fate of BMSCs by activating the PI3K/AKT and MAPK/ERK positive feedback pathways, and increased BMSC functions, including proliferation, migration and proangiogenic potential. …”
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Aberrant white matter and subcortical gray matter functional network connectivity associated with static and dynamic characteristics in subjects with temporal lobe epilepsy by Sukesh Kumar Das, George B. Hanna, Hai Sun, Bharat B. Biswal

“…This altered connectivity categorizes TLE as a network disorder, highlighting the need to investigate functional network connectivity (FNC) in WM areas. Dynamic functional connectivity (dFC) measures time-varying correlations between two or multiple regions of interest and derives clusters highlighting functional networks (FNs) where connectivity among regions behaves in a similar fashion. …”
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Phosphoinositide Signaling and Actin Polymerization Are Critical for Tip Growth in the Marine Red Alga <i>Pyropia yezoensis</i> by Ryunosuke Irie, Koji Mikami

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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…Results sAD and HS hiPSCs displayed similar stemness features and genomic stability. However, they differed in neuronal differentiation and function. sAD-derived neurons (sAD-hNs) displayed increased levels of AD-related proteins, including Aβ and phosphorylated tau. …”
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Generic Models of Willow (genus Salix L.) Tree Phytomass: a Meta-Analysis by Andrey А. Paramonov, Vladimir A. Usoltsev, Sergey V. Tretyakov, Ilya V. Tsvetkov, Ivan S. Tsepordey

“…In the course of the work, the models have been constructed for assessing the aboveground phytomass of trees both in diameter at the stem base and in diameter at breast height, the information content of which is close to functional, and the biases are only about 2 %. …”
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Injectable elastin-like recombinamer hydrogels with layered degradation rates for osteochondral regeneration in a rabbit model by Desiré Venegas-Bustos, Gonzalo Martínez-Municio, S. Martínez-Páramo, Israel González de Torre, F. Lamus, M.I. Alonso, A. Gato, A.J. Álvarez-Barcia, A. Vega-Castrillo, Mercedes Alberca, J.C. Rodríguez-Cabello

“…The regeneration of osteochondral defects remains a significant challenge due to the distinct structural and functional requirements of cartilage and subchondral bone. …”
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Functional outcome, revision rates and mortality after primary total hip replacement--a national comparison of nine prosthesis brands in England. by Mark Pennington, Richard Grieve, Nick Black, Jan H van der Meulen

“…<h4>Conclusions</h4>Functional outcomes were better with cementless cups and revision rates were lower with cemented stems, which underlies the good overall performance of hybrids. …”
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Phenotypic and transcriptomic analysis reveals key genes associated with plant height in rubber tree and functional characterization of the candidate gene HbFLA11 by Baoyi Yang, Yuanyuan Zhang, Weiguo Li, Xiao Huang, Xinsheng Gao, Juncang Qi, Xiangjun Wang

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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…In this work, we have set up a human cellular disease model of AL cardiac amyloidosis (AL-CA) in the form of cardiac spheroids, to study the cytotoxic effects of amyloidogenic LCs with regard to contractile function and calcium handling. To mimic the disease in a reconstituted system, soluble amyloidogenic LCs purified from urine of AL-CA patients were added to a mixture of induced pluripotent stem cell-issued human cardiomyocytes (hiPSC-CM) and human primary cardiac fibroblasts, which resulted in formation of spheroids within 7 days. …”
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Home settings are associated with less functional decline among older adults compared to community-care foster homes and skilled nursing facilities in Hawaii. by Hua Zan, Yanyan Wu, Yan Luo, John P Barile, Joshua R Holmes, Joy Agner

“…To increase comparability despite these differences, we matched older adults (n = 852) on baseline functional status, age, sex, marital status, and race/ethnicity using propensity score matching and performed sensitivity analyses on cognitive status. …”
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Assessing the Success of Ferula assa-foetida L. Plantation Restoration Operations in Semi-Steppe Rangelands by Linking Plant Functional Traits to Species Diversity by Esfandiar Jahantab, Azam Khosravi Mashizi, Mohsen Sharafatmandrad

“…The canopy cover and density of plant species were recorded in every plot. Functional traits (growth form, life form, palatability, life span, leaf life span, root depth, woodiness, flowering start, length of flowering period, height, and stem density) were measured according to literature (1, 2, 3, 4, 6, 10, 11). …”
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Characterization of bovine and ovine basal-out and apical-out ileum organoids by Ambre F. Chapuis, Tanith Harte, Daniel R. G. Price, Marc N. Faber, William M. Anderson, Barbara Shih, Jayne C. Hope, Jo Moore, David Smith

“…Organoids are three-dimensional stem cell-derived structures that differentiate into multiple cell types. …”
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Optogenetic approaches for neural tissue regeneration: A review of basic optogenetic principles and target cells for therapy by Davletshin Eldar, Sufianov Albert, Ageeva Tatyana, Sufianova Galina, Rizvanov Albert, Mukhamedshina Yana

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Genome-wide identification of SWEET gene family and functional analysis of BcSWEET1-2 associated with flowering in flowering Chinese cabbage (Brassica campestris) by Xinmin Huang, Liming He, Yuyao Chen, Yin Liu, Jinfeng Liu, Guangyuan Lu, Riyuan Chen, Yunna Zhu, Shiwei Song, Qinqin He

“…BcSWEET1-2 has been confirmed to be localized in the cell membrane and to function as a hexose transporter. Overexpression of BcSWEET1-2 in Arabidopsis promotes stem carbohydrate accumulation, upregulates flowering gene expression, enhances Arabidopsis stem elongation, and advances flowering time. …”
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Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer by Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Da Li, Da Li, Da Li, Da Li, Chao Quan, Chao Quan, Zhu Yu, Zhu Yu, Zhu Yu, Yue Feng, Yue Feng, Yue Feng, Yue Feng, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Yong Li, Yong Li, Yong Li, Yong Li, Tongtong Qi, Tongtong Qi, Tongtong Qi, Tongtong Qi, Junqiang Chen, Junqiang Chen, Junqiang Chen, Junqiang Chen

“…Additionally, single-cell analysis was employed to examine FZD2 expression levels across different cell types. To investigate the functional impact of FZD2, loss-of-function experiments were carried out in gastric cancer cell lines using siRNA-mediated knockdown. …”
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