Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis. by Teresa L Ramos, Luis Ignacio Sánchez-Abarca, Beatriz Rosón-Burgo, Alba Redondo, Ana Rico, Silvia Preciado, Rebeca Ortega, Concepción Rodríguez, Sandra Muntión, Ángel Hernández-Hernández, Javier De Las Rivas, Marcos González, José Ramón González Porras, Consuelo Del Cañizo, Fermín Sánchez-Guijo

“…In the current work we have compared the function and gene expression profile of BM-MSC from healthy donors (HD-MSC) and patients with MPN (JAK2V617F), showing no differences in the morphology, proliferation and differentiation capacity between both groups. …”
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Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population by Zaigui Wu, Zeshan You, Cai Zhang, Zhuyu Li, Xiumei Su, Xiuming Zhang, Yinguang Li

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Intravenous injection of BMSCs modulate tsRNA expression and ameliorate lung remodeling in COPD mice by Ting Jin, Xianyang Liu, Guoan Li, Shenghua Sun, Lihua Xie

“…Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by lung remodeling induced by chronic inflammation, presenting challenges for effective treatment. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have shown promise in mitigating inflammation and tissue repairing in various diseases, including COPD. …”
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch by Mohammad Izadifar, Mohammad Massumi, Kacey J. Prentice, Tatiana Oussenko, Biao Li, Judith Elbaz, Mira Puri, Michael B. Wheeler, Andras Nagy

“…Subsequently we evaluated and confirmed the functionality of the drug-inducible kill-switch in FSβiPLCs at different ganciclovir (GCV) concentrations using our PDMS-based transcapillary microfluidic system. …”
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Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives by Jie Yang, Donghui Zhang, Wei Jiang

“…In this review, we have analyzed the features of overlapping, proximal, and desert lncRNAs, classified by genomic location, in pluripotent stem cells (PSCs) and the differentiation derivatives. …”
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Targeting pivotal amino acids metabolism for treatment of leukemia by Jiankun Hong, Wuling Liu, Xiao Xiao, Babu Gajendran, Yaacov Ben-David

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Epigenetic regulation of organ-specific functions in Mikania micrantha and Mikania cordata: insights from DNA methylation and siRNA integration by Yatong Sang, Yitong Ma, Ruonan Wang, Zhen Wang, Ting Wang, Yingjuan Su

“…However, the role of DNA methylation in regulating the organ-specific functions of the invasive weed Mikania micrantha remains unknown. …”
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Functions of developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) in bovine preimplantation embryo development and their potential mechanisms by QIU Jinlong, LUO Lei, HU Bingjie, DANG Yanna, LI Shuang, SHI Yan, WANG Shaohua, ZHANG Kun

“…Developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) are important regulators of genome activation in 2-cell-like embryonic stem cells (2CL ESCs), meanwhile, they can regulate the proliferation of ESCs. …”
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Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation by Pei-Ciao Tang, Seyoung Um, Anderson B. Mayfield, Olena R. Bracho, Christian Del Castillo, Christine T. Dinh, Derek M. Dykxhoorn, Xue Zhong Liu

“…Although the exactly molecular mechanism mediating NF2-driven schwannomatosis is not fully understood, it is known that defective Merlin protein functionality leads to abnormal cell proliferation. Methods Herein, we utilized a human induced pluripotent stem cell (hiPSC)-based Schwann cell (SC) model to investigate the role of Merlin in human SCs. …”
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ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

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Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage by Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik, Randi Olsen, Lorena Arranz

“…Abstract The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. …”
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PrPC Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging by Wenduo Liu, Thi Thu Trang Kieu, Zilin Wang, Hyun‐Jaung Sim, Seohyeong Lee, Jeong‐Chae Lee, Yoonjung Park, Sang Hyun Kim, Sung‐Ho Kook

“…Methods This study investigated the change in PrPC expression during muscle formation using C2C12 cells and evaluated muscle function in Prnp wild‐type (WT) and knock‐out (KO) mice at different ages (1, 9 and 15 months). …”
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Comparative Metabolomic Analysis of Three Medicinal <i>Paphiopedilum</i> Species Reveals Divergence in Antioxidant Capacity and Functional Compound Profiles by Jinhan Sang, Yishan Yang, Kanghua Xian, Jiang Su, Jianmin Tang, Chuanming Fu, Fengluan Tang, Xiao Wei

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Influence of matrix nature on the functional efficacy of biomedical cell product for the regeneration of damaged liver (experimental model of acute liver failure) by S. V. Gautier, M. Yu. Shagidulin, N. A. Onishchenko, I. M. Iljinsky, V. I. Sevastianov

“…A statistically significant difference was found between the functional efficacy of the BMCP studied based on BNCM and BMCH matrices. …”
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Engineered iNKNKG2A KO cells possess HLA-E specific anti-tumor activity by QIAO Wenhua, XU Yi, DONG Peng, HE Wei, CHEN Hui, ZHANG Jianmin

“…Objective To target at the NKG2A-HLA-E inhibitory axis, a pluripotent stem cell(iPSC)-derived genetically engineered natural killer cells(NK cells) with NKG2A knockout (NKG2A KO-iNK) were prepared and then their tumor-killing efficacy was evaluated in vitro. …”
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Chemical compounds, FTIR and <i>in vitro</i> antibacterial analyses of the acetone stem bark extract of <i>Ziziphus mucronata</i> subsp. <i>mucronata</i> (Buffalo Thorn) against po... by Morenike Olutumbi Adeoye-Isijola, Aderonke Ariyike Olajuyigbe, Kehinde Oluwakemi Fagbemi, Kubendran Kista Naidoo, Roger Murugas Coopoosamy, Olufunmiso Olusola Olajuyigbe

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Insights into the role of GhCYP and GhTPS in the gossypol biosynthesis pathway via a multiomics and functional-based approach in cotton by Teame Gereziher Mehari, Marijana Skorić, Hui Fang, Kai Wang, Fang Liu, Tesfay Araya, Branislav Šiler, Dengbing Yao, Baohua Wang

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Global characterization of GH3 family glycoside hydrolase genes in Fusarium verticillioides and functional analysis of FvGH3-6 by Xiaojie Zhang, Xiaojie Zhang, Pengliang Duan, Pengliang Duan, Shaoqi Shi, Shaoqi Shi, Manli Sun, Manli Sun, Ning Liu, Ning Liu, Zhiyan Cao, Zhiyan Cao, Jingao Dong, Jingao Dong

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Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality by Keke Fang, Lianjie Niu, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Ying Hou, Shaoqiang Han, Xianfu Sun, Wenzhou Zhang

“…However, the clinical heterogeneity, likely stemming from diverse neurobiological disturbances, complicates findings from standard group comparison methods. …”
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The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis by Dai-Hong Xie, Jun Wang, Kai Sun, Zong-Yan Shi, Ya-Zhe Wang, Yan Chang, Xiao-Ying Yuan, Yan-Rong Liu, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin

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