Human Bone Marrow Mesenchymal Stem/Stromal Cells Exposed to an Inflammatory Environment Increase the Expression of ICAM-1 and Release Microvesicles Enriched in This Adhesive Molecu... by Juan J. Montesinos, Lucero López-García, Víctor A. Cortés-Morales, Lourdes Arriaga-Pizano, Ricardo Valle-Ríos, Guadalupe R. Fajardo-Orduña, Marta E. Castro-Manrreza

“…Bone marrow mesenchymal stem/stromal cells (BM-MSCs) have immunoregulatory capacity; therefore, they have been used in different clinical protocols in which it is necessary to decrease the immune response. …”
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A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. by Ewa Bielczyk-Maczyńska, Jovana Serbanovic-Canic, Lauren Ferreira, Nicole Soranzo, Derek L Stemple, Willem H Ouwehand, Ana Cvejic

“…Only a quarter of those genes, however, are known regulators of hematopoiesis. To determine function of the remaining genes we performed a medium-throughput genetic screen in zebrafish using antisense morpholino oligonucleotides (MOs) to knock down protein expression, followed by histological analysis of selected genes using a wide panel of different hematopoietic markers. …”
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Mechanisms, diagnosis, and treatment of olfactory dysfunction in rhinosinusitis by Hai Zhu, Siyuan Qu, Mengdan Gong, Yizhen Xiang, Shengqi Gan, Yaoshu Teng, Dong Ye

“…Future research should focus on understanding the dynamic changes in olfactory bulb volume and the functional transition of olfactory neuroepithelial stem cells. …”
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Making cells inter-connected for signaling communication: a developmental view of cytonemes by Jiayue Ma, Honglin Yu, Shuo Yao, Yan Yan, Zhaoyu Gu, Ziqi Wang, Hai Huang, Di Chen

“…In this review, we summarize the latest advances of cytoneme research across different model organisms by focusing on the regulatory mechanisms and functional roles in stem cells and developmental disorders. …”
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Change in Viability and Function of Pancreatic Islets after Coculture with Mesenchymal Stromal Cells: A Systemic Review and Meta-Analysis by Xiaohang Li, Hongxin Lang, Baifeng Li, Chengshuo Zhang, Ning Sun, Jianzhen Lin, Jialin Zhang

“…There is no clear consensus on the effect of coculture of islets with mesenchymal stem cells (MSCs) on islet function and viability. …”
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Leaf isoprene and monoterpene emissions vary with fast-slow carbon economics strategies in central Amazon woody species by Michelle Robin, Michelle Robin, Eliane Gomes Alves, Eliane Gomes Alves, Tyeen C. Taylor, Tyeen C. Taylor, Débora Pinheiro Oliveira, Sérgio Duvoisin, José Francisco C. Gonçalves, Jochen Schöngart, Florian Wittmann, Maria T. F. Piedade, Susan Trumbore, Juliana Schietti, Juliana Schietti

“…We measured leaf-level isoprene and monoterpene emission capacity (Ec; emission measured under standard conditions of photosynthetically active radiation of 1000 µmol m-2 s-1 and leaf temperature of 30 ˚C), and 12 leaf and four stem functional traits for 91 trees from 31 species of angiosperm distributed across different vegetation types: non-flooded upland, white sand, and ancient non-flooded river terrace forests. …”
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Assessment of ultra-structure, viability and function of lipopolysaccharides-stimulated human dermal fibroblasts treated with chrysin and exosomes (in vitro study) by Rabab Hassan, Dina Sabry, Amany A. Rabea

“…Bone marrow mesenchymal stem cell (BM-MSC) exosomes have regenerative ability in different tissues. …”
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The development of functional glutamatergic and GABAergic synaptic connections between vestibulo-ocular projection neurons and oculomotor motoneurons in the chicken embryo by Hiraku Mochida, Joel C. Glover

“…Responses were recorded from the dorsal surface in different regions of interest (ROIs) deployed along the mediolateral axis, which allowed us to distinguish responses in IR, MR+IO and SR MNs. …”
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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity by Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Prabhat Sharma, Nikhil N Kulkarni, Louis R Ghanem, Natalie A Terry, Joan M O'Brien, Yadav Wagley, Kurt D Hankenson, Ashley Jermusyk, Jason Hoskins, Laufey T Amundadottir, Mai Xu, Kevin Brown, Stewart Anderson, Wenli Yang, Paul Titchenell, Patrick Seale, Klaus H Kaestner, Laura Cook, Megan Levings, Babette S Zemel, Alessandra Chesi, Andrew D Wells, Struan FA Grant

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Isogenic induced pluripotent stem cell line ICGi036-A-1 from a patient with familial hypercholesterolaemia, derived by correcting a pathogenic variant of the gene LDLR c.530C>T by A. S. Zueva, A. I. Shevchenko, S. P. Medvedev, E. A. Elisaphenko, A. A. Sleptcov, M. S. Nazarenko, N. A. Tmoyan, S. M. Zakian, I. S. Zakharova

“…In familial hypercholesterolaemia, the function of the receptor is impaired and the uptake of low-density lipoproteins is significantly reduced. …”
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Influência de um protocolo de criopreservação no rendimento in vitro de células-tronco derivadas do tecido adiposo Effect of a cryopreservation protocol on the in vitro yield of ad... by Fernanda Ginani, Diego Moura Soares, Carlos Augusto Galvão Barboza

“…Cryopreservation maintains stem cells in a live state for long periods of time, without impairing their function. …”
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The inconclusive superiority debate of allogeneic versus autologous MSCs in treating patients with HFrEF: a systematic review and meta-analysis of RCTs by Omar T. F. Ahmed, Ziyad Tarek Ahmed, Abdulrahman W. Dairi, Maha Saad Zain Al-Abeden, Mohammed H. Alkahlot, Rana H. Alkahlot, Ghazi I. Al Jowf, Lars M. T. Eijssen, Khawaja Husnain Haider

“…This study delves into mesenchymal stem cells’ promising potential, offering a beacon of hope for the future of heart failure treatment with reduced ejection fraction (HFrEF). …”
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Distinct microbial communities drive methane cycling in below- and above-ground compartments of tropical cloud forests growing on peat by Fahad Ali Kazmi, Ülo Mander, Ramita Khanongnuch, Maarja Öpik, Reti Ranniku, Kaido Soosaar, Mohit Masta, Salla A. M. Tenhovirta, Kuno Kasak, Claudine Ah-Peng, Mikk Espenberg

“…However, no CH4-cycling functional genes were detected in the stem core samples. …”
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Serum indicators in functional high-risk multiple myeloma patients undertaking proteasome inhibitors therapy: a retrospective study by Linquan Zhan, Dai Yuan, Xueling Ge, Mei Ding, Jianhong Wang, Xiangxiang Zhou, Xin Wang

“…An increasing application of autologous stem cell transplantation (ASCT) and anti-myeloma agents represented by proteasome inhibitors (PIs) has improved the response rates and survival of MM patients. …”
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Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years by Tiffanie-Marie Borg, Nima Heidari, Ali Noorani, Mark Slevin, Angela Cullen, Stefano Olgiati, Alberto Zerbi, Alessandro Danovi, Adrian Wilson

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Identification and Functional Characterization of Alfalfa (<i>Medicago sativa</i> L.) Expansins in Regulating Arabidopsis Shoot and Root Development by Longxing Hu, Mengran Zhao, Yu Hu, Qian Xu, Rui Lu

“…Furthermore, expression analysis suggested that <i>MsEXP</i> genes exhibited distinct expression patterns among different tissues of alfalfa. Overexpression of <i>MsEXPA3</i> or <i>MsEXPA4</i> promoted the growth of leaves, stems and roots of Arabidopsis, thereby increasing the biomass of plants. …”
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Climate is stronger than you think: Exploring functional planting and TRIAD zoning for increased forest resilience to extreme disturbances. by Clément Hardy, Christian Messier, Yan Boulanger, Dominic Cyr, Élise Filotas

“…It's uncertain whether these results stemmed from the relative lack of small-scale interactions in LANDIS-II through which the effect of functional diversity on stand resilience should occur, or if this effect is small to begin with. …”
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When Genetic Diversity Is Low: The Effects of Ploidy Level on Plant Functional Trait Expression in Spartina Under Global Change by Dirk Granse, Paul Wendt, Sigrid Suchrow, Dieter Hanelt, Jörg Fromm, Morgane Milin, Oscar Lima, Armel Salmon, Malika Aïnouche, Kai Jensen

“…The allopolyploid's comparatively fewer, larger‐diameter stems may affect aboveground ecosystem functions differently, including sediment trapping and the slowing of tidal currents. …”
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Hypoxia-derived mesenchymal stem-cell exosomes delivering naringin enhance osteoblast migration and fracture healing by upregulating integrin β1 via the BDNF-TrkB/ERK1/2 signaling... by RF Yao, YY Luo, HL Tian

“…Background: The paracrine mechanism of mesenchymal stem cells (MSCs) is receiving extensive attention, and exosomes are positioned as the key mediators. …”
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Generation of INS-jGCaMP7f knock-in Ca2+ reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting by Xin Liu, Feng Zhang, Deqi Chen, Jiaxiang Yin, Zirong Bi, Lihua Chen, Jiawei Yan, Qifei Dong, Wei Peng, Tao Xu, Yanying Guo, Haopeng Lin, Huisheng Liu

“…The reporter cell line not only effectively labelled the insulin-producing cells induced from hESC, but also reflected the cytosolic change of Ca2+ level in response to different stimuli. This reporter cell line is a valuable research tool for studying functional maturation of hESC-derived insulin-producing cells, conducting drug screenings, and exploring the mechanisms of diabetes.…”
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