Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation by Thi Thuy Duong Pham, Su-Young Choi, Jeong Suk Koh, Bu-Yeon Heo, Sang-Woo Lee, Myung-Won Lee, Wonhyoung Seo, Yunseon Jang, Jung-Hyun Park, Deog-Yeon Jo, Seungyeul Yoo, Jaeyul Kwon, Ik-Chan Song

“…Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in patients with hematologic malignancies. …”
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Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. L... by L. Yu. Grivtsova, O. E. Popovkina, N. N. Dukhova, O. A. Politiko, V. V. Yuzhakov, L. A. Lepekhina, S. Sh. Kalsina, S. A. Ivanov, A. D. Kaprin

“…With the introduction of molecular and cell biology into medical practice, today, stem cell therapy can become an alternative method of nonsurgical restoration of myocardial functions. …”
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Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice by Wenyi Chen, Xinyi Chen, Feiqiong Gao, Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Guanghua Ma, Jintao Gong, Qian Li, Yunhua Chen, Lee Wei Lim, Ilia Stambler, Georgina M. Ellison-Hughes, Brun Ulfhake, Robert Chunhua Zhao, Hongcui Cao

“…Here, we develop a novel human liver multilineage organoid (Mulorg) model combined with Mdr2−/− mice to investigate the pro-fibrotic role of T helper 17 cells (Th17) and the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (EVMSC) for PSC, particularly periductal fibrosis. …”
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Wnt-signaling pathway in pathogenesis of glioblastoma multiforme by Yu. D. Vasilets, N. E. Arnotskaya, I. A. Kudryavtsev, V. E. Shevchenko

“…The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in different kinds of tumor, including multiform glioblastoma. …”
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Collagen-based biomaterials: recent advances on regulating cell migration and correlated biomedical applications by Qinghe Zhang, Minghuan Dou, Xinyi Su, Zelong Yu, Benmei Wei, Lian Zhu, Juntao Zhang, Haibo Wang

“…The discussion primarily focuses on three pivotal cell types: stem cells, immune cells, and cancer cells. By shedding light on the functions, mechanisms, and therapeutic potential of collagen in cell migration, this review will contribute to the development of innovative collagen-based biomaterials with applications in wound healing and tissue regeneration. …”
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Cellular crosstalk in the bone marrow niche by Zeqi Huang, Zoya Iqbal, Zhe Zhao, Jianquan Liu, A. M. Alabsi, Maryam Shabbir, Ayesha Mahmood, Yujie Liang, Wencui Li, Zhiqin Deng

“…Abstract The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial cells, and helps maintain their characteristic functions. …”
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Cryopreservation and culture strategies for testicular tissue and cells in small and large animals by Valeria Vurchio, Martina Colombo, Rolando Pasquariello, Gaia Cecilia Luvoni

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Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex by Ying-Wen Wang, Ching-Wei Luo

“…In vivo adipogenesis and ex vivo culture of bone explants were used to verify the functions of different SMAD complexes. Ingenuity Pathway Analysis, and analysis of transcriptomic datasets from human BM-MSCs in combination with hierarchical clustering and STRING assay were used to decipher the interplaying co-repressors. …”
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Liposomal ellagic acid enhances the regenerative potential of ADMSC-laden nanofibrous PCL scaffolds in a rat model of spinal cord injury by Arman Abroumand Gholami, Shokoufeh Rahmani, Payam Moharreri, Esmael Amirazodi, Amir Mahdi Molavi, Tahere Mokhtari, Fatemeh Tahmasebi, Amirhossein Rabiei Rad, Hamideh Babaloo

“…Scaffolds were created through the electrospinning of a PCL/functionalized multi-walled carbon nanotube (f-MWCNTs) composite, which was then coated with liposomal ellagic acid (EA@lip) and seeded with adipose-derived mesenchymal stem cells (ADMSCs). …”
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Cell therapy efficacy and safety in treating tendon disorders: a systemic review of clinical studies by Seyed Peyman Mirghaderi, Zahra Valizadeh, Kimia Shadman, Thibault Lafosse, Leila Oryadi‐Zanjani, Mir Saeed Yekaninejad, Mohammad Hossein Nabian

“…For Achilles tendinopathies, only one randomized controlled trial (RCT) found that both cell therapy and control groups showed significant pain reduction and functional improvement with no statistical differences at the 6 months follow‐up, but the cell therapy group had improved faster at earlier follow‐ups. …”
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Genome-wide identification and functional analysis of the GRAS gene family in Medicago lupulina L by Li Fan, Ruimiao Wang, Pedro García-Caparrós, Lihua Meng, Xudong Sun

“…To further predict the potential functions of MlPAT1s genes, we performed molecular cloning and transcriptional activation assays on MlGRAS3/31/35/62/65. …”
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Development and analysis of scaffold-free adipose spheroids by Jesse Liszewski, Aloysious Klingelhutz, Edward A. Sander, James Ankrum

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Comparative Analysis of Endophytic <i>Curtobacterium</i> Species Reveals Commonalities and Adaptations by Annabel Arhin, Sydney Wiegand, Isabella Foriska, Kiersten Brown, Kylee Crayne, Kaitlyn Stroscio, Rajinikanth Mohan

“…<i>Curtobacterium</i> species are increasingly recognized as plant pathogens and soil decomposers, but their prevalence and function as plant endophytes in aerial organs are less clear. …”
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Bioinformatics-Based Analysis of Ferroptosis-Related Biomarkers and the Prediction of Drugs Affecting the Adipogenic Differentiation of MSCs by Jiahao Jin, Zihao Yuan, Xinglang Wang, Quanfeng Li, Yunhui Zhang, Yibin Zhang, Pengfei Ji, Yanfeng Wu, Peng Wang, Wenjie Liu

“…<b>Background</b>: The imbalance between the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) is a key factor in the progression of osteoporosis; therefore, it is crucial to study the regulatory mechanisms that maintain this balance. …”
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Uncovering functional deterioration in the rhizosphere microbiome associated with post-green revolution wheat cultivars by Monique E. Smith, Vanessa N. Kavamura, David Hughes, Rodrigo Mendes, George Lund, Ian Clark, Tim H. Mauchline

“…Results We found distinct taxonomic and functional differences between heritage and modern wheat rhizosphere communities and identified that modern wheat microbiomes were less distinct from the communities in the surrounding soil. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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Unraveling the impact of congenital deafness on individual brain organization by Lenia Amaral, Xiaosha Wang, Yanchao Bi, Ella Striem-Amit

“…To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. …”
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Trade-Offs Between Hydraulic Efficiency and Safety in Cotton (<i>Gossypium hirsutum</i> L.) Stems Under Elevated CO₂ and Salt Stress by Qing Zhao, Jinliang Chen, Jian Kang, Shaozhong Kang

“…This study aims to investigate the effects of elevated CO₂ and salt stress on the hydraulic traits and xylem anatomical structures of cotton stems. Potted cotton plants were exposed to different CO₂ concentrations (aC: 400 ppm; eC: 800 ppm) and salinity levels (aS: 0‰ soil salinity; eS: 6‰ soil salinity). …”
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Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in... by Fengyun Zhao, Mengting Chen, Tianjiao Wu, Mingfang Ji, Fugui Li

“…Gene Set Variation Analysis (GSVA) identified potential biological functions in different clusters. The TSCMS model was constructed using Lasso-Cox regression, and its prognostic value was assessed through Kaplan–Meier, Cox regression, and receiver-operating characteristic (ROC) curve analyses. …”
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Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns by Kourosch C. Elahi, Gerd Klein, Meltem Avci-Adali, Karl D. Sievert, Sheila MacNeil, Wilhelm K. Aicher

“…This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies.…”
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