Rapidly Manufactured CAR-T with Conserved Cell Stemness and Distinctive Cytokine-Secreting Profile Shows Improved Anti-Tumor Efficacy by Shih-Ting Tsao, Mingyuan Gu, Qinghui Xiong, Yingzhi Deng, Tian Deng, Chengbing Fu, Zihao Zhao, Haoyu Zhang, Cuicui Liu, Xiong Zhong, Fang Xiang, Fei Huang, Haiying Wang

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Generation of a KDM5D knockout human embryonic stem cell line with CRISPR/Cas9 technology by Ouhui Li, Yuting Zhen, Chao Sun, Yanlin Ma, Qi Li, Luan Wen

“…We successfully generated a KDM5D knockout human embryonic stem cells using CRISPR/Cas9 technology. This knockout cell line provides a valuable model for studying KDM5D’s function in spermatogenesis and its influence on sex differences in various diseases.…”
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Hemiarthroplasty in Proximal Humerus Fractures: Does Modular Metaphyseal Stem Design Lead to Better Results? An Analysis of 24 Cases by Periklis Godolias MD, Jonathan Plümer MD, Charlotte Cibura MD, Julius R Gerstmeyer MD, Maria A Bernstorff MD, Hansjörg Heep MD, Marcel Dudda PhD, Thomas A Schildhauer MD, PhD, Matthias Königshausen MD, PhD

“…There was no significant difference in functional outcome on average between patients with healed tubercles (CS = 57) and resorbed tubercles (CS = 51). …”
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Efficacy of mesenchymal stem cells and platelet-rich plasma therapies on wound healing: A Systematic Review and meta-analysis by Yunqing Sun, Ming Zhu, Lianmei Qiu

“…Background: Wound healing is a complex physiological process essential for maintaining tissue integrity and function. This meta-analysis aims to evaluate the efficacy of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP), and their combination in enhancing wound healing. …”
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The Efficacy of Mesenchymal Stem Cells loaded in Acacia Gum Hydrogel and Acacia Gum Hydrogel on Skin Wounds Healing in Rats by Wissam Abdullah Alhayani

“… Cutaneous wound healing processes start at the beginning of the trauma leading to impairment of physical and functional tissue continuity. The present work aimed to clarify the efficacy of stem cells loaded in acacia gum hydrogel and acacia gum hydrogel on skin wound healing in rats. …”
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Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation by Soo-Jin Lee, Ji-Woong Shin, Mee-Ae Kwon, Ki Baek Lee, Hyo-Jun Kim, Jin-Haeng Lee, Heun-Soo Kang, Jong Kwan Jun, Sung-Yup Cho, In-Gyu Kim

“…In this study, we report a new function of TG2 in the regulation of MSC redox homeostasis. …”
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Maintenance of pluripotency and osteogenic differentiation of human mesenchymal stem cells on acrylate-based substrates exhibiting gelatin or heparin grafting by María Noel Tamaño-Machiavello, Juan Carlos Marín Payá, Silvia Flores, Lourdes Cordón, Amparo Sempere, Roser Sabater i Serra, José Luis Gómez Ribelles

“…Abstract This study investigated the in vitro biological behaviour of human mesenchymal stem cells grown on acrylate-based substrates functionalized with biomolecules that play a significant role in the extracellular matrix, specifically gelatin (derived from collagen) and heparin. …”
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Intra-articular administration of autologous adipose-derived stem cells in hip osteoarthritis: Longitudinal treatment trajectories and prognostic factors by Masaki Hatano, Hisatoshi Ishikura, Tomohiro Terao, Taro Kasai, Ryota Yamagami, Junya Higuchi, Shuichi Yoshida, Yusuke Arino, Ryo Murakami, Masashi Sato, Yuji Maenohara, Yuma Makii, Tokio Matsuzaki, Keita Inoue, Shinsaku Tsuji, Sakae Tanaka, Taku Saito

“…Introduction: Evidence regarding the effectiveness of mesenchymal stem cells in improving hip function in patients with hip osteoarthritis (OA) remains inconsistent. …”
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Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells by David Estève, Jean Galitzky, Anne Bouloumié, Caroline Fonta, René Buchet, David Magne

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Team Survivors: Preliminary Analysis of an Innovative Intervention to Promote Physical Activity in Survivors of Childhood Cancer and Hematopoietic Stem Cell Transplant by Meghan K. Flannery, Jocelyn Morin, Katrina O’Malley, Debra Schmidt, Jennifer A. Hoag

“…(1) Background: Inadequate physical activity is an ongoing issue for pediatric survivors of childhood cancer and hematopoietic stem cell transplant (HSCT), increasing their risk for chronic health conditions and decreasing quality of life. …”
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Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment by Elisabetta Straface, Lucrezia Gambardella, Francesca Pagano, Francesco Angelini, Barbara Ascione, Rosa Vona, Elena De Falco, Elena Cavarretta, Raffaele La Russa, Walter Malorni, Giacomo Frati, Isotta Chimenti

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Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches by Divya S. Varghese, Thilina Thejinda Alawathugoda, Suraiya A. Ansari

“…Herein, we have tested several combinations of published protocols, for example, growth factor vs. small molecule and different time durations of treatment for definitive endoderm (DE) induction and further hepatocyte differentiation to develop an efficient DE induction and hepatocyte differentiation in a highly reproducible manner based on the stage-specific marker expression and functional analysis.…”
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Viscoelastic properties of differentiating blood cells are fate- and function-dependent. by Andrew E Ekpenyong, Graeme Whyte, Kevin Chalut, Stefano Pagliara, Franziska Lautenschläger, Christine Fiddler, Stephan Paschke, Ulrich F Keyser, Edwin R Chilvers, Jochen Guck

“…Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is incomplete. …”
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Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials by Xiang-Rui Ma, Ya-Ling Tang, Ming Xuan, Zheng Chang, Xiao-Yi Wang, Xin-Hua Liang

“…The bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated great potential as regenerative medicine in different therapeutic applications. …”
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Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells by Sabina Sánchez Hernández, Tobias Wang Bjerg, Ian Helstrup Nielsen, Anders Laustsen, Hai Q Tang, Lars Henning Pedersen, Lars Henning Pedersen, Lars Henning Pedersen, Eynav Klechevsky, Martin R. Jakobsen, Rasmus O. Bak

“…In conclusion, we phenotypically and functionally characterize different cell subsets and modulate their relative frequencies by manipulating TF expression during pDC differentiation. …”
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Doxycycline: An antibiotic with brain protective function in vanadium-intoxicated rats by Negia Emtawel Mohamed, Ezeddin Gassar, Sara Abdulla, Mustafa Elfakhri, Ayyub Patel, Syed Haider

“…Objectives: This research investigates the neuroprotective effects of doxycycline, in different rat brain areas in an animal model intoxicated with vanadium. …”
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Comparative Analysis of Vascular Cell Differentiation From Peripheral Blood Mononuclear Cell- and Urine-Derived Induced Pluripotent Stem Cells by Julia Deinsberger, Silvio Holzner, Sophie Bromberger, Philipp Foessleitner, Dominik Wiedemann, Bernhard Winkler, Natalia Krajic, Sophia Aligianni, Elisabeth Stein, Jennifer Volz, Zahra Mazidi, Regina Grillari, Klaudia Schossleitner, Peter Petzelbauer, Benedikt Weber

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Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells by Jerome Tan, Jiahui Chen, Daniel Roxby, Wai Hon Chooi, Tan Dai Nguyen, Shi Yan Ng, Jongyoon Han, Sing Yian Chew

“…Abstract Background The emergence of induced pluripotent stem cells (iPSCs) offers a promising approach for replacing damaged neurons and glial cells, particularly in spinal cord injuries (SCI). …”
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IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells. by Karoline Fechter, Akaitz Dorronsoro, Emma Jakobsson, Izaskun Ferrin, Valérie Lang, Pilar Sepulveda, Daniel J Pennington, César Trigueros

“…In this study, we show that IFNγ, produced by Vδ2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative feedback mechanism on γδ T cell function ranging from cytokine production to proliferation. …”
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Protocol for real-time measurement of mitochondrial bioenergetics in 3D-cultured brain tumor stem cells using the Resipher system by Cloé Tessier, Maxime Toujas, Antonio C. Pagano Zottola, Andreas Bikfalvi, Thomas Mathivet, Thomas Daubon, Lucie Brisson, Audrey Burban, Ahmad Sharanek

“…Summary: Aberrant mitochondrial function can lead to severe human diseases, including neurodegenerative diseases and cancer. …”
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