Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells. by Marcela Guzman-Ayala, Kian Leong Lee, Konstantinos J Mavrakis, Paraskevi Goggolidou, Dominic P Norris, Vasso Episkopou

“…The above system and resource provide tools to study morphogen function in development.…”
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RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix by Changjun Li, Gehua Zhen, Yu Chai, Liang Xie, Janet L. Crane, Emily Farber, Charles R. Farber, Xianghang Luo, Peisong Gao, Xu Cao, Mei Wan

“…Abstract Mesenchymal stem cells (MSCs) participate in the repair/remodelling of many tissues, where MSCs commit to different lineages dependent on the cues in the local microenvironment. …”
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Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. by Ana Antonic, Emily S Sena, Jennifer S Lees, Taryn E Wills, Peta Skeers, Peter E Batchelor, Malcolm R Macleod, David W Howells

“…Spinal cord injury (SCI) is a devastating condition that causes substantial morbidity and mortality and for which no treatments are available. Stem cells offer some promise in the restoration of neurological function. …”
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Mesenchymal Stem Cell Plasticity: What Role Do Culture Conditions and Substrates Play in Shaping Biomechanical Signatures? by Marina Danalache, Lena Karin Gaa, Charline Burgun, Felix Umrath, Andreas Naros, Dorothea Alexander

“…Cell functionality, driven by remarkable plasticity, is strongly influenced by mechanical forces that regulate mesenchymal stem cell (MSC) fate. …”
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Do STEM education problem-solving tasks trigger learners’ epistemic curiosity? And why we should be astonished by Sebastian Stuppan, Markus Rehm, Tessa J. P. van Schijndel, Markus Wilhelm

“…Conclusions This study presents new evidence on the complex interactions between different epistemic emotions in STEM problem-solving situations, specifically in confrontation tasks. …”
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Microbial Community Characteristics and Underlying Drivers Along the Streams, Tributaries, and Main Stems of the Yangtze River Source Region by Futing Liu, Luyao Kang, Lele Lin, Sisi Yu

“…A comprehensive examination of the riverine microbial community composition and structure is crucial for understanding the functions of aquatic ecosystems. However, previous studies mainly focused on the spatial distribution of microorganisms in the main stems of rivers, ignoring the shifts in microbial communities along the streams, tributaries, and main stems of rivers. …”
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Probability of allogeneic hematopoietic stem cell transplant failure depending on the recipient's killer immunoglobulin-like receptor genotype by U. V. Maslikova, E. G. Khamaganova, M. Yu. Drokov, I. Yu. Urybin, E. D. Mikhaltsova, L. A. Kuzmina, E. N. Parovichnikova

“…Their role is to recognize "self" cells and block signals aimed at destroying their own cells. Knowledge of the functional activity of natural killers urged to studying the impact of mismatches between the inhibitory receptor gene and the ligand on the development of allogeneic hematopoietic stem cell transplant failure.The aim of research was to study the probability of the graft failure development in allogeneic hematopoietic stem cell transplantation depending on the recipient's killer immunoglobulin-like receptor genotype.Material and methods. …”
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CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity by Kezhe Tan, Hongtao Zhu, Jianfang Zhang, Weili Ouyang, Jianfeng Tang, Youming Zhang, Linlin Qiu, Xueqing Liu, Zhaoping Ding, Xiaoming Deng

“…The results highlight a heterogeneity of the CD73 expression that may be related to its catalytic products on the modulation of the local immune response and thus provide a possible explanation to the inconsistency of the regenerative results when different sources of donor cells were used in stem cell-based therapy.…”
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Clinical application of the tibial extension stem in primary TKA for knee varus deformity combined with tibial bone defect by Fei Yuan, Yankun Li, Xiaogang Shen, Xuepeng Zhu, Li Sun, Youliang Ren, Tao Guo, Bo Li

“…There was no significant difference in HKA Angle between the two groups before and after operation (p > 0.05). …”
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Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…In conclusion, this study revealed the difference of methylated levels during the noninduced and induced osteogenic differentiation of BMSCs and provided useful information for future works to characterize the important function of epigenetic mechanisms on BMSCs’ differentiation.…”
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Investigating combined hypoxia and stemness indices for prognostic transcripts in gastric cancer: Machine learning and network analysis approaches by Sharareh Mahmoudian-Hamedani, Maryam Lotfi-Shahreza, Parvaneh Nikpour

“…Results: Hierarchical clustering identified six clusters among 375 TCGA GC patients, with significant survival differences between cluster 1 (low hypoxia, high stemness) and cluster 4 (high hypoxia, high stemness). …”
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Efficacy and safety of stem cell therapy for acute and subacute ischemic stroke: a systematic review and meta-analysis by Toshiya Osanai, Soichiro Takamiya, Yasuhiro Morii, Katsuhiko Ogasawara, Kiyohiro Houkin, Miki Fujimura

“…Abstract The efficacy of stem cell therapy for ischemic stroke in terms of functional outcomes remains unclear. …”
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Efficacy of mesenchymal stem cells in the treatment of peritoneal fibrosis in animal models: a systematic review and meta-analysis by Lingqian Zheng, Wenmin Chen, Kaijin Yao, Yina Xie, Chunling Liao, Yongda Lin, Tianbiao Zhou

“…However, no significant differences were observed in VEGF, D/P of Na, D/P of BUN, D/P of protein, or glucose mass transfer between the MSCs treatment group and the control group.Conclusion MSC therapy significantly improves peritoneal function and attenuates fibrotic and inflammatory responses in animal models. …”
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Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Sota Iwatani, Akemi Shono, Makiko Yoshida, Keiji Yamana, Khin Kyae Mon Thwin, Jumpei Kuroda, Daisuke Kurokawa, Tsubasa Koda, Kosuke Nishida, Toshihiko Ikuta, Kazumichi Fujioka, Masami Mizobuchi, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

“…Although the cell proliferation and differentiation of BM-derived MSCs is known to decline with age, the functional difference between preterm and term UC-MSCs is poorly characterized. …”
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Identification of the early and late responder genes during the generation of induced pluripotent stem cells from mouse fibroblasts. by Jihwan Park, Yoo-Wook Kwon, Seokjin Ham, Chang-Pyo Hong, Seonghye Seo, Moon Kyung Choe, So-I Shin, Choon-Soo Lee, Hyo-Soo Kim, Tae-Young Roh

“…Regardless of the origins of the somatic cells, the fibroblasts induced using the ESC protein extracts appear to be completely reprogrammed into pluripotent cells, although they show unshared marginal differences in their gene expression programs, which may not affect the maintenance of stemness. …”
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The Development of a Human Respiratory Mucosa-on-a-Chip Using Human Turbinate-Derived Mesenchymal Stem Cells by Do Hyun Kim, Sang Hi Park, Mi-Yeon Kwon, Chae-Yoon Lim, Sun Hwa Park, David W. Jang, Se Hwan Hwang, Sung Won Kim

“…<i>Conclusions</i>: We conclude that the human respiratory mucosa-on-a-chip using human turbinate-derived mesenchymal stem cells allows the respiratory differentiation of hNTSCs and shows the difference in gene and cytokine expression, which could serve as an alternative to conventional differentiation for the production of functionally competent hNTSCs for future clinical applications.…”
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Upregulation of mitochondrial function is associated with advanced prostate cancer by Valentin Baumgartner, Thomas Paul Scherer, Ashkan Mortezavi, Niels Rupp, Holger Moch, Peter Wild, Susanne Dettwiler, Miriam Wanner, Dominik Enderlin, Souzan Salemi, Daniel Eberli

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Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity by R. Ramírez-Barrantes, C. Cordova, H. Poblete, P. Muñoz, I. Marchant, F. Wianny, P. Olivero

“…The function of TRPV1 in the brain is under intensive investigation, due to multiple places where it has been detected and its sensitivity for different chemical and physical agonists, and a new role of TRPV1 in brain function is now emerging as a molecular tool for survival and control of neural stem cells.…”
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The combination of odontogenic stem cells and mandibular advancement promotes the length of the mandible in adult rats by facilitating the development of condylar cartilage by Xin Cheng, Liangching Huang, Huijuan Wang, SiLong Lei, Chichong Chan, Xuesong Yang, Yue Huang

“…Abstract Background Mandibular retraction is a prevalent dental and maxillofacial deformity that negatively affects patients' functional health and facial aesthetics. It has been challenging to achieve optimal outcomes for patients who have passed the peak of growth and development using only functional orthopedic treatment. …”
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Blood-Brain Barrier Overview: Structural and Functional Correlation by Abeer Alahmari

“…In this review, we searched in Google Scholar, Pubmed, Web of Science, and Saudi Digital Library for the various cells and components that support the development and function of this barrier, as well as the different pathways to transport the various molecules between blood and the brain. …”
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