Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

“…Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by insulin resistance and impaired beta-cell secretory function. Since existing treatments often present side effects based on different mechanisms, alternative therapeutic options are needed. …”
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Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis by Tarsha Ward, Sarah U. Morton, Gabriela Venturini, Warren Tai, Min Young Jang, Joshua Gorham, Dan Delaughter, Lauren K. Wasson, Zahra Khazal, Jason Homsy, Bruce D. Gelb, Wendy K. Chung, Benoit G. Bruneau, Martina Brueckner, Martin Tristani‐Firouzi, Steven R. DePalma, Christine Seidman, J. G. Seidman

“…We constructed isogenic induced pluripotent stem cells with heterozygous or homozygous loss‐of‐function and missense SMAD2 variants identified in CHD probands. …”
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Identification of biomarkers associated with proliferation and differentiation of mesenchymal stem cells in pulmonary adenocarcinoma and establishment of prognostic models by Xin-Xin Zeng, Ke-Xin Xian, Jie-Lun Wen, Qi-Zhe Wang, Xin-Yu Wang, Li-Yue Sun

“…Abstract Background Mesenchymal stem cells (MSCs) hold potential as therapeutic agents in cancer, but their mechanisms in lung adenocarcinoma (LUAD) remain poorly understood. …”
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Role of bone marrow-derived mesenchymal stem cells on the parotid glands of streptozotocin induced diabetes rats by Mona Denewar, Laila E. Amin

“…Immunohistochemical examination of aquaporin-5 showed significant difference between the two groups. Conclusion: bone marrow derived stem cell treatment considers as an improved methods in prevention and treatment of diabeticinduced hyposalivation.…”
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Meta-Analysis of the Therapeutic Effects of Stem Cell-Derived Extracellular Vesicles in Rodent Models of Hemorrhagic Stroke by Conglin Wang, Bo Yan, Pan Liao, Fanglian Chen, Ping Lei

“…Background. Stem cell-derived extracellular vesicles (SCEVs) have emerged as a potential therapy for hemorrhagic stroke. …”
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A Carbon-Based Nanomaterial with Dichotomous Effects: Antineoplastic on Oral Cancer Cells and Osteoinductive/Chondroinductive on Dental Pulp Stem Cells by Milica Jaksic Karisik, Nataša Jović Orsini, Jelena Carkic, Milos Lazarevic, Dijana Mitić, Bojan Jokanovic, Vukoman Jokanović, Jelena Milasin

“…To examine the pro-regenerative capacity of CBN/PVP, dental pulp stem cell cultures (DPSCs) were treated with the nanomaterial and subjected to osteo- and chondro-induction. …”
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Effects and Mechanisms of Extracellular Vesicles in Different Models of Acute Kidney Injury by Weidong Wang, Jingyu Wang, Dan Liao

“…Acute kidney injury (AKI) is a rapid decline in renal function caused by ischemia/reperfusion (I/R), renal toxic injury, and sepsis. …”
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Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes by Yize Zhang, Samira Musah

“…Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as physical and biochemical signals. …”
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Functional composition of the Amazonian tree flora and forests by Hans ter Steege, Lourens Poorter, Jesús Aguirre-Gutiérrez, Claire Fortunel, William E. Magnusson, Oliver L. Phillips, Edwin Pos, Bruno Garcia Luize, Chris Baraloto, Juan Ernesto Guevara, María-José Endara, Tim R. Baker, Maria Natalia Umaña, Masha van der Sande, Maihyra Marina Pombo, Matt McGlone, Freddie C. Draper, Iêda Leão do Amaral, Luiz de Souza Coelho, Florian Wittmann, Francisca Dionízia de Almeida Matos, Diógenes de Andrade Lima Filho, Rafael P. Salomão, Carolina V. Castilho, Marcelo de Jesus Veiga Carim, Maria Teresa Fernandez Piedade, Daniel Sabatier, Jean-François Molino, Layon O. Demarchi, Juan David Cardenas Revilla, Jochen Schöngart, Mariana Victória Irume, Maria Pires Martins, José Renan da Silva Guimarães, José Ferreira Ramos, Olaf S. Bánki, Adriano Costa Quaresma, Nigel C. A. Pitman, Carlos A. Peres, Domingos de Jesus Rodrigues, Joseph E. Hawes, Everton José Almeida, Luciane Ferreira Barbosa, Larissa Cavalheiro, Márcia Cléia Vilela dos Santos, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Eduardo Martins Venticinque, Angelo Gilberto Manzatto, Neidiane Farias Costa Reis, John Terborgh, Katia Regina Casula, Euridice N. Honorio Coronado, Abel Monteagudo Mendoza, Juan Carlos Montero, Cintia Rodrigues De Souza, Marcus Vinicio Neves de Oliveira, Flávia R. C. Costa, Julien Engel, Ted R. Feldpausch, Nicolás Castaño Arboleda, Flávia Machado Durgante, Charles Eugene Zartman, Timothy J. Killeen, Beatriz S. Marimon, Ben Hur Marimon-Junior, Rodolfo Vasquez, Bonifacio Mostacedo, Rafael L. Assis, Dário Dantas do Amaral, Hernán Castellanos, John Ethan Householder, Marcelo Brilhante de Medeiros, Marcelo Fragomeni Simon, Ana Andrade, José Luís Camargo, Susan G. W. Laurance, William F. Laurance, Lorena Maniguaje Rincón, Gisele Biem Mori, Juliana Schietti, Thaiane R. Sousa, Emanuelle de Sousa Farias, Maria Aparecida Lopes, José Leonardo Lima Magalhães, Henrique Eduardo Mendonça Nascimento, Helder Lima de Queiroz, Caroline C. Vasconcelos, Gerardo A. Aymard C, Roel Brienen, Pâmella Leite de Sousa Assis, Darlene Gris, Karoline Aparecida Felix Ribeiro, Pablo R. Stevenson, Alejandro Araujo-Murakami, Bruno Barçante Ladvocat Cintra, Yuri Oliveira Feitosa, Hugo F. Mogollón, Miles R. Silman, Leandro Valle Ferreira, José Rafael Lozada, James A. Comiskey, José Julio de Toledo, Gabriel Damasco, Roosevelt García-Villacorta, Aline Lopes, Marcos Rios Paredes, Alberto Vicentini, Ima Célia Guimarães Vieira, Fernando Cornejo Valverde, Alfonso Alonso, Luzmila Arroyo, Francisco Dallmeier, Vitor H. F. Gomes, William Nauray Huari, David Neill, Maria Cristina Peñuela Mora, Daniel P. P. de Aguiar, Flávia Rodrigues Barbosa, Yennie K. Bredin, Rainiellen de Sá Carpanedo, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth J. Feeley, Rogerio Gribel, Torbjørn Haugaasen, Janaína Costa Noronha, Marcelo Petratti Pansonato, John J. Pipoly, Jos Barlow, Erika Berenguer, Izaias Brasil da Silva, Joice Ferreira, Maria Julia Ferreira, Paul V. A. Fine, Marcelino Carneiro Guedes, Carolina Levis, Juan Carlos Licona, Boris Eduardo Villa Zegarra, Vincent Antoine Vos, Carlos Cerón, Émile Fonty, Terry W. Henkel, Isau Huamantupa-Chuquimaco, Marcos Silveira, Juliana Stropp, Raquel Thomas, Doug Daly, Kyle G. Dexter, William Milliken, Guido Pardo Molina, Toby Pennington, Bianca Weiss Albuquerque, Wegliane Campelo, Alfredo Fuentes Claros, Bente Klitgaard, José Luis Marcelo Pena, Luis Torres Montenegro, J. Sebastián Tello, Corine Vriesendorp, Jerome Chave, Anthony Di Fiore, Renato Richard Hilário, Luciana de Oliveira Pereira, Juan Fernando Phillips, Gonzalo Rivas-Torres, Tinde R. van Andel, Patricio von Hildebrand, William Balee, Edelcilio Marques Barbosa, Luiz Carlos de Matos Bonates, Hilda Paulette Dávila Doza, Ricardo Zárate Gómez, George Pepe Gallardo Gonzales, Therany Gonzales, Bruce Hoffman, André Braga Junqueira, Yadvinder Malhi, Ires Paula de Andrade Miranda, Linder Felipe Mozombite Pinto, Adriana Prieto, Agustín Rudas, Ademir R. Ruschel, Natalino Silva, César I. A. Vela, Egleé L. Zent, Stanford Zent, Angela Cano, Yrma Andreina Carrero Márquez, Diego F. Correa, Janaina Barbosa Pedrosa Costa, Bernardo Monteiro Flores, David Galbraith, Milena Holmgren, Michelle Kalamandeen, Guilherme Lobo, Tony Mori Vargas, Marcelo Trindade Nascimento, Alexandre A. Oliveira, Hirma Ramirez-Angulo, Maira Rocha, Veridiana Vizoni Scudeller, Geertje van der Heijden, Emilio Vilanova Torre, Cláudia Baider, Henrik Balslev, Sasha Cárdenas, Luisa Fernanda Casas, William Farfan-Rios, Reynaldo Linares-Palomino, Casimiro Mendoza, Italo Mesones, Germaine Alexander Parada, Armando Torres-Lezama, Daniel Villarroel, Roderick Zagt, Miguel N. Alexiades, Edmar Almeida de Oliveira, Riley P. Fortier, Karina Garcia-Cabrera, Lionel Hernandez, Walter Palacios Cuenca, Susamar Pansini, Daniela Pauletto, Freddy Ramirez Arevalo, Adeilza Felipe Sampaio, Elvis H. Valderrama Sandoval, Luis Valenzuela Gamarra, Aurora Levesley, Georgia Pickavance

“…Two spectra of global plant form and function have been identified: a size spectrum from small to tall species with increasing stem tissue density, leaf size, and seed mass; a leaf economics spectrum reflecting slow to fast returns on investments in leaf nutrients and carbon. …”
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Expression of innate immunity genes in human hematopoietic stem/progenitor cells – single cell RNA-seq analysis by Justyna Jarczak, Kannathasan Thetchinamoorthy, Diana Wierzbicka, Kamila Bujko, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Magdalena Kucia

“…BackgroundThe complement system expressed intracellularly and known as complosome has been indicated as a trigger in the regulation of lymphocyte functioning. The expression of its genes was confirmed also in several types of human bone marrow-derived stem cells: mononuclear cells (MNCs), very small embryonic-like stem cells (VSELs), hematopoietic stem/progenitor cells (HSPCs), endothelial progenitors (EPCs) and mesenchymal stem cells (MSCs). …”
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The efficacy and safety of stem cell therapy for ischemic stroke: a systematic review and network meta-analysis study by Wanpeng Chang, Xuejun Ma, Huawei Zhang, Hongli Xu, Shuai Liu, Binhong Du, Yanwen Xu, Yan Huang

“…Abstract Background and aim Using a network meta-analysis, this study evaluates the clinical efficacy and safety of different types of stem cell therapy in regard to the recovery of neurological function, motor function, and daily living ability in ischemic stroke patients. …”
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Matrix-free human lung organoids derived from induced pluripotent stem cells to model lung injury by Bettina Budeus, Chiara Kroepel, Lisa Marie Stasch, Diana Klein

“…Abstract Background Organoids, as near-physiological 3D culture systems, offer new opportunities to study the pathogenesis of various organs in mimicking the cellular complexity and functionality of human organs. Method Here we used a quite simple and very practicable method to successfully generate induced pluripotent stem cell (iPSC)-derived human lung organoids (LuOrg) in a matrix-free manner as an alternative to the widely used preclinical mouse models in order to investigate normal lung damage in detail and as close as possible to the patient. …”
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Stem introducer designs and surgical technique play a significant role in achieving the optimal implant-cement interface by Bernard H. van Duren, Kevin Ilo, Sophie Walker, Mark Higgins, Benjamin V. Bloch, Andrew R. Manktelow, Hemant G. Pandit

“…The aim of this study was to assess movement when using different introducer designs. Methods: We compared four stem introducer designs used with two commonly used PTS stems. …”
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Cell-free regenerative medicine: identifying the best source of mesenchymal stem cells for skin therapy in Systemic Sclerosis by Filomena Napolitano, Valentina Giudice, Valentina Giudice, Vittoria D’Esposito, Nella Prevete, Pasqualina Scala, Amato de Paulis, Amato de Paulis, Carmine Selleri, Carmine Selleri, Pietro Formisano, Pietro Formisano, Francesca Wanda Rossi, Francesca Wanda Rossi, Nunzia Montuori, Nunzia Montuori

“…Understanding of the secretion profile of different MSCs is necessary to identify the most efficient and useful source for SSc treatment.MethodsWe analyzed the content of MSC-conditioned media (MSC-CM) obtained from MSCs isolated from adipose tissue (AT), bone marrow (BM), Wharton’s jelly (WJ), and cord blood (CB) by ELISA method, and their effects on the wound healing process by fibroblast proliferation, migration, and ECM deposition assays, to compare regenerative potential of different MSC populations.ResultsWJ-MSC-conditioned medium (CM) and BM-MSC-CM show a greater regenerative profile, compared to CB-MSC-CM and AT-MSC-CM, due to the abundance of growth factors and immunomodulatory cytokines and the effects on fibroblast functions. …”
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Different storage and freezing protocols for extracellular vesicles: a systematic review by Shahin Ahmadian, Negin Jafari, Amin Tamadon, Alireza Ghaffarzadeh, Reza Rahbarghazi, Mahdi Mahdipour

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Adsorption of Ibuprofen from Water Using Waste from Rose Geranium (<i>Pelargonium graveolens</i>) Stems by Ntaote David Shooto, Patience Mapule Thabede

“…The SEM images showed that the adsorbent had a rough surface with voids and pores. Different functional groups were detected on the surface of SPG with FTIR. …”
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Investigation of important morphological traits and grain yield of lentil under shading and bio-priming by feresteh darabi, Ali Hatami, Mohammad Javad Zarea, Rahim Naseri

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Deciphering transcriptome patterns in porcine mesenchymal stem cells promoting phenotypic maintenance and differentiation by key driver genes by Nadia Khaveh, Nadia Khaveh, René Buschow, Julia Metzger, Julia Metzger

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Equivalents of the neutrophil-to-lymphocyte ratio of circulating pool of stem and immature hematopoietic cells for assessing liver transplant status by A. N. Shutko, O. A. Gerasimova, N. V. Marchenko, I. I. Tileubergenov

“…Blood samples of 19 recipients with satisfactory graft function were examined by flow cytofluorometry at various time periods after LT using hematopoietic stem cell markers CD133, their CD31 derivatives, and alpha-fetoprotein (AFP), compared with the conventional NLR.Results. …”
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The Optimization of a Protocol for the Directed Differentiation of Induced Pluripotent Stem Cells into Liver Progenitor Cells and the Delivery of Transgenes by Irina Panchuk, Valeriia Kovalskaia, Natalia Balinova, Oxana Ryzhkova, Svetlana Smirnikhina

“…Primary human hepatocytes in 2D cultures rapidly dedifferentiate and lose their function, making their use as a reliable cell model challenging. …”
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