‘They don’t squeal, ‘Disabled’.’: using qualitative interviews to explore user perceptions of ‘stylish’ grab rails intended to promote healthy ageing in place in England... by Katie Brittain, Kate Gibson, Sarah Dickson, Andrew Kingston, Mitra Cheraghi

“…However, some participants were unaware that the grab rails had been designed with a duality of purpose or were apprehensive towards the functionality of these grab rails. This apprehension may have stemmed from the home adaptations being provided by a large energy provider, or because the discreet design of the grab rails made their intended purpose less overt.Conclusions While home adaptations with a discreet and stylish aesthetic are valued by older people, our findings highlight that there are issues with commodifying home adaptations. …”
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Invited review: Ruminal acidosis and its definition—A critical review by H.M. Golder, I.J. Lean

“…ABSTRACT: Ruminal acidosis occurs as a continuum of disorders, stemming from ruminal dysbiosis and disorders of metabolism, of varying severity. …”
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Accelerated cassava varietal turnover in Tanzania, a direct result of cassava seed system interventions by Jessey A. Msami, Mathias Ndalahwa, Jonas Nickas, Maria Arbogast, James Nkwabi, Nsajigwa Mwakyusa, Ambilikile Mwenisongole, Dwasi Matondo, P. Lava Kumar, James P. Legg

“…The cassava seed system has been historically neglected resulting in the widespread propagation of poor quality and diseased planting materials (stems/cuttings). Recently there have been ongoing efforts to modernise cassava breeding and improve seed delivery in Tanzania which have resulted in the creation of a functional and commercially sustainable cassava seed system. …”
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Identification of matrix stiffness-related molecular subtypes in HCC via integrating multi-omics analysis and machine learning algorithms by Hanqi Li, Jiayi Zhang, Yu Shi, Huanhuan Wang, Ruida Yang, Shaobo Wu, Yue Li, Xue Yang, Qingguang Liu, Liankang Sun

“…Furthermore, increased matrix stiffness was found to upregulate PPARG expression, promoting cell proliferation, activating lipid metabolism, and enhancing the stemness of HCC cells through the MAPK signaling pathway. …”
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Genome-wide identification of the P4ATPase gene family and its response to biotic and abiotic stress in soybean (Glycine max L.) by Jingjing Wei, Gaoyang Zhang, Huanhuan Lv, Saidi Wang, Xingyu Liu, Yanli Qi, Zhongke Sun, Chengwei Li

“…Tissue-specific expression profiles revealed that GmALAs were differentially expressed in roots, stems, seeds, flowers, nodules and leaves. The expression pattern of these genes appeared to be diverse in the different developmental tissues. …”
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Analyzing the Influence of Accounting Information Quality on Debt Concentration: Moderating Effects of Financial Constraints and Managerial Risk Aversion by Mohsen Rashidi

“…This approach of centralization is a function of the company's financial situation and managers' risk-taking. …”
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Effects of DCM Leaf Extract of Gnidia glauca (Fresen) on Locomotor Activity, Anxiety, and Exploration-Like Behaviors in High-Fat Diet-Induced Obese Rats by Wycliffe Makori Arika, Cromwell Mwiti Kibiti, Joan Murugi Njagi, Mathew Piero Ngugi

“…Obesity is the main component of metabolic syndromes involving distinct etiologies that target different underlying behavioral and physiological functions within the brain structures and neuronal circuits. …”
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Exploring urban garden ponds: considering chemical pollution as a limiting factor for insect diversity in cities by Johanna Bock, Marie Neske, Martin Krauss, Andrea Dombrowski, Jörg Oehlmann

“…Likely, the increased benzothiazole derivative concentrations stemmed from the installation of ethylene propylene diene monomer (EPDM) rubber pond liner. …”
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Single-cell RNA sequencing reveals the role of GTF2F2 in ovarian cancer oncogenesis and progression by Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si

“…The interaction patterns between different malignant subpopulations and immune/stromal cells were analyzed using cell-to-cell communication analysis. …”
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Effects of foliar selenium spraying on the growth and selenium content and morphology of rice by Wenxia Pei, Mengya Dai, Sheng Shi, Yuan Zhang, Daxia Wu, Cece Qiao, Yafei Sun, Jianfei Wang

“…Spatial partitioning analysis further confirmed reduced Se retention in stems and husks alongside elevated accumulation in leaves under foliar treatments. …”
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Genome-wide identification of MYBL2 in Brassicaceae, with a focus on the expression pattern of regulating anthocyanin synthesis in Brassica crops by Chenchen Wang, Qi Zhang, Yi Liu, Wenjie Shen, Shubei Wan, Lunlin Chen, Chen Tan, Daozong Chen

“…Finally, quantitative reverse transcription PCR (qRT-PCR) analysis of B. napus leaves, stems, and petals indicated that four MYBL2 homologous genes were significantly up-regulated in leaves and petals, with expression patterns consistent with those of ABGs. …”
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FBXO42 promotes hepatocellular carcinoma progression via mediating p57Kip2 ubiquitination and degradation by Bing Zhou, Shasha Wu, Shengqian Hong, Han Li, Zhi Jiang, Yong Sun, Jiannan Qiu, Lei Qin

“…The studies on the role of FBXO42 in different diseases are inadequate, especially in HCC. …”
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Genome-Wide Characterization of the Heat Shock Transcription Factor Gene Family in <i>Begonia semperflorens</i> Reveals Promising Candidates for Heat Tolerance by Zhirou Liu, Nan Lin, Qirui Wang, Enkai Xu, Kaiming Zhang

“…Finally, through real-time quantitative PCR, we examined the expression patterns of the 37 <i>BsHSFs</i> in different plant tissues (roots, stems, leaves, and flowers) and their expression levels under heat stress treatment. …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Margetuximab administration also enhances HER2-specific B cell and T cell–mediated responses ex vivo in samples from patients treated with prior lines of HER2 antibody-based therapies. Stemming from these observations, a worthwhile future goal in the treatment of HER2+ breast cancer is to promote combinatorial approaches that better eradicate HER2+ cancer cells via enhanced immunological mechanisms.…”
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The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases by Yezhou Ding, Mingyang Feng, Wanqing Chi, Xiaoyin Wang, Baoyan An, Kehui Liu, Shike Lou, Xiaolin Wang, Hui Wang

“…An array of bioinformatics methods was employed to explore the potential oncogenic roles of METTL17, including analyzing its related prognosis, mutation, landscapes, tumor stemness index, immune cell infiltration, and other factors among different tumors. …”
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Biodegradable Liquid Slow-Release Mulch Film Based on Bamboo Residue for Selenium-Enriched Crop Cultivation by Chaoqi Chen, Zhaoshuang Li, Kuaile Yin, Lei Li, Zhen Zhang, Xu Xu, He Liu, Yan Qing, Xingong Li, Yiqiang Wu

“…Optimal rhizome growth of pak choi seedlings was observed under the PVA@CMC/QL cover, as demonstrated by the planting of both pak choi seedlings and weeds. Roots and stems increased by 3.8 ± 0.3 and 1.2 ± 0.3 cm, respectively. …”
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ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…However, its role across different cancer types is not well understood.MethodsUtilizing multi-omics data, we comprehensively evaluated ITGA4’s expression, clinical relevance, diagnostic and prognostic value, functions, mutations, and methylation status, along with its impact on immunity, mismatch repair (MMR), heterogeneity, stemness, immunotherapy responsiveness, and drug resistance in pan-cancer, with partial validation in gastric cancer (GC) using transcriptomic analysis, single-cell data, western blot (WB), wound-healing assay, flow cytometry and immunohistochemistry (IHC). …”
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Identification and validation of a lenvatinib resistance-related prognostic signature in HCC, in which PFKFB4 contributes to tumor progression and lenvatinib resistance by Jinfeng Wang, Jianfei Shi, Lili Mi, Ning Li, Xin Han, Man Zhao, Xiaoling Duan, Guangjie Han, Jiaojiao Hou, Fei Yin

“…Mutation signatures, therapeutic response, functional enrichment, and immune profile analyses were performed in the two groups. …”
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Identification of intratumoral microbiome-driven immune modulation and therapeutic implications in diffuse large B-cell lymphoma by Zheng Yijia, Xiaoyu Li, Lina Ma, Siying Wang, Hong Du, Yun Wu, Jing Yu, Yunxia Xiang, Daiqin Xiong, Huiting Shan, Yubo Wang, Zhi Wang, Jianping Hao, Jie Wang

“…Pseudo-time analysis further revealed distinct differentiation trajectories of B cells, highlighting their potential heterogeneity across different immune environments. Metabolic pathway analysis showed significant differences in the average expression levels of metabolic pathways among B-cell subgroups, suggesting functional specialization. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…PERSONAL PERSPECTIVE As someone who has voluntarily been admitted to a psychiatric health facility twice to treat manic episodes stemming from Bipolar I Disorder, I recognize the autonomy-persevering utility of psychiatric advance directives on a theoretical and experiential level. …”
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