Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems by Amar J. Azad, Alessandro Bentivogli, Henrike Germar, Dana Wörz, Elena Lizunova, Max J. Cumberland, January Weiner, Sarah Hedtrich

“…Fibroblasts exhibit significant heterogeneity, with distinct subtypes playing critical roles in organ function and integrity. This study investigates whether iFBs can acquire tissue-specific transcriptional profiles through co-culture with cells from different germ layers, including skin (keratinocytes), heart (cardiomyocytes), gut (intestinal cells), and lung (bronchial epithelial cells). …”
Get full text

miRNA-125b-5p-rich exosomes derived from fibro-adipogenic progenitors promoting muscle regeneration through inducing pro-regenerative macrophages by Meng-meng Yang, Jing-ya Luo, Jia Cai, Jin Qian, Xiao-yan Zhu, Hui-zhen Zou, Gao-ming Li, Jing Dai, Huang Zhu, Wei Li, Li-dan Zhang, Xia Kang

Get full text

KRT5high TP63-expressing urothelial basal cells act as a driver to bladder urothelium regeneration in rabbit by Jiasheng Chen, Mingming Yu, Lin Wang, Hua Xie, Yiqing Lv, Yichen Huang, Yue Hong, Fang Chen

“…Results Via single-cell RNA sequencing (scRNA-seq), it has been confirmed that the cluster of KRT5high TP63-expressing cells possesses a ‘‘stemness’’ signature which can give rise to lineage cell types sequentially. …”
Get full text

DMSO-free cryopreservation of hiPSC-derived cardiomyocytes: low temperature characterization and protocol development by Akshat S. Mallya, Tessa Burrows, Jeanne Hsieh, Troy Louwagie, James R. Dutton, Brenda M. Ogle, Allison Hubel

“…Abstract Background Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have attracted significant interest for use in disease modeling, drug discovery and potential therapeutic applications. …”
Get full text

Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids by Eleonora Mello, Stefano Sorrentino, Alessio Bucciarelli, Ermanno Cordelli, Elisa De Luca, Haakon Nygaard, Stefan Wendt, Alberto Rainer, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Pamela Mozetic

“…This is even more exacerbated in case of pluripotent stem cell (PSC) derived spheroids, which remain challenging to standardize. …”
Get full text

DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy by Jinjin Ma, Xinyu Wang, Dalei Sun, Jiali Chen, Linyi Zhou, Kaiao Zou, Xinxin Ni, Hongting Jin, Jun Lin

“…Notably, synovitis and its macrophage component represent a target of interest for developing treatments. Dental pulp stem cells (DPSCs) are derived from the neural crest, coincidentally with maxillofacial tissues, thus attracting significant interest in situ maxillofacial regenerative medicine. …”
Get full text

ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors by Jean Pierre Bikorimana, Nehme El-Hachem, Gabrielle A. Mandl, Daniela Stanga, Jamilah Abusarah, Roudy Farah, Marina P. Gonçalves, Perla Matar, Malak Lahrichi, Sebastien Talbot, Moutih Rafei

Get full text

Harnessing the angiogenic potential of adipose-derived stromal vascular fraction cells with perfusion cell seeding by Gregory Reid, Giulia Cerino, Ludovic Melly, Deborah Fusco, Chunyan Zhang, Oliver Reuthebuch, Giulia Milan, Anna Marsano

Get full text

Any closer to successful therapy of multiple myeloma? CAR-T cell is a good reason for optimism by Faroogh Marofi, Safa Tahmasebi, Heshu Sulaiman Rahman, Denis Kaigorodov, Alexander Markov, Alexei Valerievich Yumashev, Navid Shomali, Max Stanley Chartrand, Yashwant Pathak, Rebar N. Mohammed, Mostafa Jarahian, Roza Motavalli, Farhad Motavalli Khiavi

Get full text

Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn by Ellen Donohoe, Aoife Canning, Eanna Johnston, Seyedmohammad Moosavizadeh, Jiemin Wang, Martin Leahy, Oliver Treacy, Aideen E. Ryan, Thomas Ritter

Get full text

Evaluation of the efficacy of FDG-PET/CT in assessing the effects of BMMSC treatment in aged rhesus monkeys by Yaohui Zhang, Jie Li, Longbao Lü, Yuanyuan Li, Zhiyu Yang, Shici Yang, Xiangqing Zhu, Rui He, Xinghua Pan, Gaohong Zhu

Get full text

ECOLOGICAL APPROACHES OF AGRO-RECREATIONAL LAND USE by Abdurakhman M. Magomedov, Kasum A. Abdulaev

“…Improved combined interzonal use of lands with different natural rhythms of vegetation development contributes, first of all, to maintaining the equilibrium and integrity of the regional ecological system; secondly, to the ecological orientation of pasture-livestock and tourist-recreational land use; and thirdly, to the restoration and the functioning of the quality of natural semi-desert and mountain pasture lands. …”
Get full text

Freedom of movement and health of nursing home residents with dementia: an exploratory cross-sectional study by Suzan P. van Liempd, Sascha R. Bolt, Katrien G. Luijkx

“…Conclusions This exploratory study found no significant differences in health between residents with dementia in semi-open and closed NHs. …”
Get full text

Parler de télévision, parler de soi by André H. Caron, Letizia Caronia

“…As a practice which constitutes the daily life of families, television viewing both structures and is structured by, the dynamics and social organization characteristic of the family. Far from functioning in a deterministic fashion, this role seems rather to be dependant upon the meanings and functions attributed by the different members participating in the activity and of the uses they make of it. …”
Get full text

Derived nominal units in the Russian language: On the way of realization of the semantic and derivational potential by M.Ju. Varlamova

“…The problem faced by linguists consists in search for particular examples proving that nominative units appear in the language as a result of the functioning of derivational affixes, which can shape different relations to what is meant by the stem, as well as without the use of formants during the process of word formation. …”
Get full text

Effectiveness of qigong and Tai Chi for quality of life in patients with cancer: an umbrella review and meta-analysis by Jing Xu, Hong Li, Daniel Man-yuen Sze, Vincent Wan Shing Chan, Angela Wei Hong Yang

Get full text

Global Gender Equality Norm and Trade Unions in Turkey: Local Contestations, Rival Validations, and Discrepant Receptions by Hüsrev Tabak, Muharrem Doğan

“…Nevertheless, this multi-layered process is disrupted by local contestations, with bold consequences for the proper functioning of the equality norms. This paper is a scrutiny on the practice of the contestation on and the interruption of the functioning of the gender equality norm, with a particular focus on trade unions in Turkey. …”
Get full text

Pain Management in Pediatric Burns: A Review of the Science behind It by Bogdan Ciornei, Vlad Laurentiu David, Diana Popescu, Eugen Sorin Boia

“…On the other hand, chronic pain, which persists for an extended period, can have long-lasting effects on physical functioning and quality of life in children. The psychological consequences of burns can persist long after the physical wounds have healed, leading to ongoing emotional distress and impaired functioning. …”
Get full text

Green Supply Chain Risk Network Management and Performance Analysis: Bayesian Belief Network Modeling by Mahdi Shakeri, Azim Zarei, Adel Azar, Morteza Maleki Minbash Razgah

“…These risks alongside their resources disrupt the normal functioning of the GSC and affect its environmental and economic performance. …”
Get full text

Look at My Body: It Tells of Suffering—Understanding Psychiatric Pathology in Patients Who Suffer from Headaches, Restrictive Eating Disorders, or Non-Suicidal Self-Injuries (NSSIs... by Diletta Cristina Pratile, Marika Orlandi, Adriana Carpani, Martina Maria Mensi

“…<b>Methods</b>: Sixty adolescent patients (51 female; mean age = 15.34 ± 1.80) were divided into three groups: headaches, restrictive eating disorders, and NSSI, and assessed for differences in symptoms, cognitive performance, personality, functioning, and illness severity using semi-structured interviews, clinician-based scales, and performance-based tests like the Rorschach inkblot test, according to the Rorschach Performance Assessment System (R-PAS). …”
Get full text