Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation by Pei-Ciao Tang, Seyoung Um, Anderson B. Mayfield, Olena R. Bracho, Christian Del Castillo, Christine T. Dinh, Derek M. Dykxhoorn, Xue Zhong Liu

“…Although the exactly molecular mechanism mediating NF2-driven schwannomatosis is not fully understood, it is known that defective Merlin protein functionality leads to abnormal cell proliferation. Methods Herein, we utilized a human induced pluripotent stem cell (hiPSC)-based Schwann cell (SC) model to investigate the role of Merlin in human SCs. …”
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ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

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Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage by Aurora Bernal, Vincent Cuminetti, Marc Serulla, Adrian Florit, Joanna Konieczny, Golnaz Golnarnik, Yimeng Chen, Marc Ferré, Samuel Geiseler, Anders Vik, Randi Olsen, Lorena Arranz

“…Abstract The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. …”
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PrPC Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging by Wenduo Liu, Thi Thu Trang Kieu, Zilin Wang, Hyun‐Jaung Sim, Seohyeong Lee, Jeong‐Chae Lee, Yoonjung Park, Sang Hyun Kim, Sung‐Ho Kook

“…Methods This study investigated the change in PrPC expression during muscle formation using C2C12 cells and evaluated muscle function in Prnp wild‐type (WT) and knock‐out (KO) mice at different ages (1, 9 and 15 months). …”
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Comparative Metabolomic Analysis of Three Medicinal <i>Paphiopedilum</i> Species Reveals Divergence in Antioxidant Capacity and Functional Compound Profiles by Jinhan Sang, Yishan Yang, Kanghua Xian, Jiang Su, Jianmin Tang, Chuanming Fu, Fengluan Tang, Xiao Wei

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Influence of matrix nature on the functional efficacy of biomedical cell product for the regeneration of damaged liver (experimental model of acute liver failure) by S. V. Gautier, M. Yu. Shagidulin, N. A. Onishchenko, I. M. Iljinsky, V. I. Sevastianov

“…A statistically significant difference was found between the functional efficacy of the BMCP studied based on BNCM and BMCH matrices. …”
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Trait-mediated insect colonization of newly established grassland strips in agricultural landscapes by Maria Peer, Sophie Kratschmer, Raja Imran Hussain, Manuela Bürgler, Bea Maas, Dominik Rabl, Ronnie Walcher, Tobias Schernhammer, Norbert Schuller, Nora Vogel, Matthias Heer, Simon Zwatz, Bernhard Krautzer, Dietmar Moser, Thomas Frank

“…We applied a trait-based approach to investigate the functional insect richness of newly established grassland strips (NG) compared to adjacent permanent, semi-natural “old” grasslands (OG) over a six-year time span in an agricultural landscape in Austria. …”
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Engineered iNKNKG2A KO cells possess HLA-E specific anti-tumor activity by QIAO Wenhua, XU Yi, DONG Peng, HE Wei, CHEN Hui, ZHANG Jianmin

“…Objective To target at the NKG2A-HLA-E inhibitory axis, a pluripotent stem cell(iPSC)-derived genetically engineered natural killer cells(NK cells) with NKG2A knockout (NKG2A KO-iNK) were prepared and then their tumor-killing efficacy was evaluated in vitro. …”
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Chemical compounds, FTIR and <i>in vitro</i> antibacterial analyses of the acetone stem bark extract of <i>Ziziphus mucronata</i> subsp. <i>mucronata</i> (Buffalo Thorn) against po... by Morenike Olutumbi Adeoye-Isijola, Aderonke Ariyike Olajuyigbe, Kehinde Oluwakemi Fagbemi, Kubendran Kista Naidoo, Roger Murugas Coopoosamy, Olufunmiso Olusola Olajuyigbe

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Insights into the role of GhCYP and GhTPS in the gossypol biosynthesis pathway via a multiomics and functional-based approach in cotton by Teame Gereziher Mehari, Marijana Skorić, Hui Fang, Kai Wang, Fang Liu, Tesfay Araya, Branislav Šiler, Dengbing Yao, Baohua Wang

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Global characterization of GH3 family glycoside hydrolase genes in Fusarium verticillioides and functional analysis of FvGH3-6 by Xiaojie Zhang, Xiaojie Zhang, Pengliang Duan, Pengliang Duan, Shaoqi Shi, Shaoqi Shi, Manli Sun, Manli Sun, Ning Liu, Ning Liu, Zhiyan Cao, Zhiyan Cao, Jingao Dong, Jingao Dong

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Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality by Keke Fang, Lianjie Niu, Baohong Wen, Liang Liu, Ya Tian, Huiting Yang, Ying Hou, Shaoqiang Han, Xianfu Sun, Wenzhou Zhang

“…However, the clinical heterogeneity, likely stemming from diverse neurobiological disturbances, complicates findings from standard group comparison methods. …”
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The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis by Dai-Hong Xie, Jun Wang, Kai Sun, Zong-Yan Shi, Ya-Zhe Wang, Yan Chang, Xiao-Ying Yuan, Yan-Rong Liu, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin

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CLSTM-MT (a Combination of 2-Conv CNN and BiLSTM Under the Mean Teacher Collaborative Learning Framework): Encryption Traffic Classification Based on CLSTM (a Combination of 2-Conv... by Xiaozong Qiu, Guohua Yan, Lihua Yin

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DIFFERENCES IN AGRICULTURAL RETURNS IN SESAME PRODUCTION: AN EMPIRICAL EVIDENCE OF EFFICIENCY IN FACTOR INPUT ALLOCATION IN RINGIM LOCAL GOVERNMENT AREA, JIGAWA STATE, NIGERIA by Tohib Oyeyode OBALOLA, Abdullahi Abbas YAKUBU

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Why the gaze behavior of expert physicians and novice medical students differ during a simulated medical interview: A mixed methods study. by Rie Yamada, Kuangzhe Xu, Satoshi Kondo, Makoto Fujimoto

“…In natural interactions, gaze behavior serves two functions: signal transmission and information gathering. …”
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STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
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Cripto-1 and Cripto-3 differential expression pattern in human placenta, umbilical cord and fetal tissues suggests new functions for these proteins by Josune García-Sanmartín, Judit Narro-Íñiguez, María José Puente, Frank Cuttitta, Alfredo Martínez

“…Abstract Cripto-1 (CR1) is an oncofetal protein involved in EGF/TGFβ signal transduction, with important functions in development, stem cell biology and cancer. …”
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Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulationResearch in context by Xuguang Li, Nobuaki Shiraki, Takami Watanabe, Rikako Fukui, Kyohei Furukawa, Yusuke Kato, Yuri Nakahara, Shoen Kume, Akashi Taguchi, Youichiro Wada, Dwina Juliana Warman, Kenji Saito, Haruyo Nakajima-Adachi, Satoshi Hachimura, Hisanori Kato, Huijuan Jia

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Social Participation of Frail Older People with Functional Limitations Ageing Alone in Place in Italy, and Its Impact on Loneliness: An Urban–Rural Comparison by Maria Gabriella Melchiorre, Marco Socci, Giovanni Lamura, Sabrina Quattrini

“…The results also indicate some different nuances regarding urban and rural sites. (4) Conclusions: Despite the fact that this exploratory study did not have a representative sample of the target population, and that only general considerations can be drawn from results, these findings can offer some insights to policymakers who aim to develop adequate interventions supporting the social participation of older people with functional limitations ageing in place alone. …”
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