Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years by Tiffanie-Marie Borg, Nima Heidari, Ali Noorani, Mark Slevin, Angela Cullen, Stefano Olgiati, Alberto Zerbi, Alessandro Danovi, Adrian Wilson

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Identification and Functional Characterization of Alfalfa (<i>Medicago sativa</i> L.) Expansins in Regulating Arabidopsis Shoot and Root Development by Longxing Hu, Mengran Zhao, Yu Hu, Qian Xu, Rui Lu

“…Furthermore, expression analysis suggested that <i>MsEXP</i> genes exhibited distinct expression patterns among different tissues of alfalfa. Overexpression of <i>MsEXPA3</i> or <i>MsEXPA4</i> promoted the growth of leaves, stems and roots of Arabidopsis, thereby increasing the biomass of plants. …”
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Climate is stronger than you think: Exploring functional planting and TRIAD zoning for increased forest resilience to extreme disturbances. by Clément Hardy, Christian Messier, Yan Boulanger, Dominic Cyr, Élise Filotas

“…It's uncertain whether these results stemmed from the relative lack of small-scale interactions in LANDIS-II through which the effect of functional diversity on stand resilience should occur, or if this effect is small to begin with. …”
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When Genetic Diversity Is Low: The Effects of Ploidy Level on Plant Functional Trait Expression in Spartina Under Global Change by Dirk Granse, Paul Wendt, Sigrid Suchrow, Dieter Hanelt, Jörg Fromm, Morgane Milin, Oscar Lima, Armel Salmon, Malika Aïnouche, Kai Jensen

“…The allopolyploid's comparatively fewer, larger‐diameter stems may affect aboveground ecosystem functions differently, including sediment trapping and the slowing of tidal currents. …”
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Hypoxia-derived mesenchymal stem-cell exosomes delivering naringin enhance osteoblast migration and fracture healing by upregulating integrin β1 via the BDNF-TrkB/ERK1/2 signaling... by RF Yao, YY Luo, HL Tian

“…Background: The paracrine mechanism of mesenchymal stem cells (MSCs) is receiving extensive attention, and exosomes are positioned as the key mediators. …”
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Generation of INS-jGCaMP7f knock-in Ca2+ reporter human embryonic stem cell line, GZLe001-C, using CRISPR/Cas9-based gene targeting by Xin Liu, Feng Zhang, Deqi Chen, Jiaxiang Yin, Zirong Bi, Lihua Chen, Jiawei Yan, Qifei Dong, Wei Peng, Tao Xu, Yanying Guo, Haopeng Lin, Huisheng Liu

“…The reporter cell line not only effectively labelled the insulin-producing cells induced from hESC, but also reflected the cytosolic change of Ca2+ level in response to different stimuli. This reporter cell line is a valuable research tool for studying functional maturation of hESC-derived insulin-producing cells, conducting drug screenings, and exploring the mechanisms of diabetes.…”
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Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis. by Teresa L Ramos, Luis Ignacio Sánchez-Abarca, Beatriz Rosón-Burgo, Alba Redondo, Ana Rico, Silvia Preciado, Rebeca Ortega, Concepción Rodríguez, Sandra Muntión, Ángel Hernández-Hernández, Javier De Las Rivas, Marcos González, José Ramón González Porras, Consuelo Del Cañizo, Fermín Sánchez-Guijo

“…In the current work we have compared the function and gene expression profile of BM-MSC from healthy donors (HD-MSC) and patients with MPN (JAK2V617F), showing no differences in the morphology, proliferation and differentiation capacity between both groups. …”
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Undergraduate Learning Gains and Learning Efficiency in a Focused Open Education Resource by Chrissy Spencer, Aakanksha Angra, Kata Dósa, Abigail Jones

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Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population by Zaigui Wu, Zeshan You, Cai Zhang, Zhuyu Li, Xiumei Su, Xiuming Zhang, Yinguang Li

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Drought Adaptation and Responses of Stipa krylovii Vary Among Different Regions: Evidence From Growth, Physiology, and RNA‐Seq Transcriptome Analysis by Ziqing Gong, Zehang Qu, Yulin Liu, Tao Wang, Baijie Fan, Anzhi Ren, Yubao Gao, Nianxi Zhao

“…In this study, to explore the drought adaptation and responses of the dominant species in the semi‐arid Eurasian Steppes and their differences among the different regions in terms of growth, physiology, and RNA‐seq transcriptome, Stipa krylovii was chosen as the study material, and a seed source (three regions: eastern, middle, and western regions) × soil moisture treatment (three treatments: control, light drought, and heavy drought) two‐factor experiment was conducted. (1) Four growth traits for individuals from the western region were significantly lower than those from the other two regions. …”
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Medication safety analysis of elderly inpatients based on improved functional resonance analysis method (FRAM): a mixed methods study by Jing Yang, Xuwen Yin, Yue Xu, Zejuan Gu, Tingru Li, Yanhong Yan, Qiaoling Jiang, Ting Lu, Yangyang Fu, Yan Yu, Zhongyan Hou

“…The functional resonance analysis method and decision-making trial and evaluation laboratory (DEMATEL) method were introduced to graphically model the medication administration process in elderly inpatients and identify safety issues affecting the complex interactions of functions. …”
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Cognitive function changes during a course of electroconvulsive therapy in patients with various psychiatric illnesses: A prospective observational study by Harita Patel, Parth Patel, Roshani Patel, Nilesh Kanaujiya, Kalpesh Chandrani, Yogesh Murugan

“…Aim: To assess cognitive function changes during ECT in patients with various psychiatric illnesses. …”
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Intravenous injection of BMSCs modulate tsRNA expression and ameliorate lung remodeling in COPD mice by Ting Jin, Xianyang Liu, Guoan Li, Shenghua Sun, Lihua Xie

“…Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by lung remodeling induced by chronic inflammation, presenting challenges for effective treatment. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have shown promise in mitigating inflammation and tissue repairing in various diseases, including COPD. …”
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Ventricular function assessment using an ultrafast spoiled gradient echo sequence with an intravascular blood pool contrast agent in pediatric patients. by Tayaba Miah, Rithvik Gunda, Gerald Greil, Mohammad Hussain, Qing Zou

“…<h4>Results</h4>Ventricular function assessment via volumetric data analysis resulted in no statistically significant differences (P > 0.05), and high R2 values. …”
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Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch by Mohammad Izadifar, Mohammad Massumi, Kacey J. Prentice, Tatiana Oussenko, Biao Li, Judith Elbaz, Mira Puri, Michael B. Wheeler, Andras Nagy

“…Subsequently we evaluated and confirmed the functionality of the drug-inducible kill-switch in FSβiPLCs at different ganciclovir (GCV) concentrations using our PDMS-based transcapillary microfluidic system. …”
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Long noncoding RNA as an emerging regulator of endoderm differentiation: progress and perspectives by Jie Yang, Donghui Zhang, Wei Jiang

“…In this review, we have analyzed the features of overlapping, proximal, and desert lncRNAs, classified by genomic location, in pluripotent stem cells (PSCs) and the differentiation derivatives. …”
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INCREASING THE INDUSTRIAL POTENTIAL OF A REGION AS A FACTOR OF IMPROVING THE REGION’S COMPETITIVENESS by L. V. Shamray

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Targeting pivotal amino acids metabolism for treatment of leukemia by Jiankun Hong, Wuling Liu, Xiao Xiao, Babu Gajendran, Yaacov Ben-David

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Epigenetic regulation of organ-specific functions in Mikania micrantha and Mikania cordata: insights from DNA methylation and siRNA integration by Yatong Sang, Yitong Ma, Ruonan Wang, Zhen Wang, Ting Wang, Yingjuan Su

“…However, the role of DNA methylation in regulating the organ-specific functions of the invasive weed Mikania micrantha remains unknown. …”
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Functions of developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) in bovine preimplantation embryo development and their potential mechanisms by QIU Jinlong, LUO Lei, HU Bingjie, DANG Yanna, LI Shuang, SHI Yan, WANG Shaohua, ZHANG Kun

“…Developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) are important regulators of genome activation in 2-cell-like embryonic stem cells (2CL ESCs), meanwhile, they can regulate the proliferation of ESCs. …”
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