Uncovering functional deterioration in the rhizosphere microbiome associated with post-green revolution wheat cultivars by Monique E. Smith, Vanessa N. Kavamura, David Hughes, Rodrigo Mendes, George Lund, Ian Clark, Tim H. Mauchline

“…Results We found distinct taxonomic and functional differences between heritage and modern wheat rhizosphere communities and identified that modern wheat microbiomes were less distinct from the communities in the surrounding soil. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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Numerical simulation of plant root system stress response to coal mining disturbances in semiarid mining areas by Ying LIU, Weihao PEI, Yong GUO, Xiaoyang CHEN, Shaogang LEI, Dongjiang PAN, Chuangang GONG, Huiling TAO, Hang CHEN

“…State response functions of root stress to different mining depths, advance rates, coal seam depths, and coal seam thicknesses are then constructed. …”
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Human Comfort and Environmental Sustainability Through Wetland Management: A Case Study of the Nawabganj Wetland, India by Kirti Avishek, Pranav Dev Singh, Abhrankash Kanungo, Pankaj Kumar, Shamik Chakraborty, Suraj Kumar Singh, Shruti Kanga, Gowhar Meraj, Bhartendu Sajan, Saurabh Kumar Gupta

“…This study aims to evaluate the temperature regulation function of the Nawabganj Wetland, Uttar Pradesh (India), a Ramsar site designated in January 2020, located in a semi-arid region vulnerable to increasing heat waves. …”
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Unraveling the impact of congenital deafness on individual brain organization by Lenia Amaral, Xiaosha Wang, Yanchao Bi, Ella Striem-Amit

“…To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. …”
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Contrasting Patterns of Plants, Bees, Hoverflies and Spiders in Different Habitats in a Central European Agricultural Landscape by Flóra Vajna, Raoul Pellaton, Csaba Molnár, Zoltán Soltész, Nikolett Gallé‐Szpisjak, Áron Domonkos Bihaly, András Báldi

“…We aimed to compare three different habitats (i.e., sown wildflower fields (WFF), semi‐natural road verges and adjacent crop fields) in terms of their species and individual numbers and assemblage compositions to reveal differences between primary producers (plants), pollinators (bees and hoverflies) and predators (spiders). …”
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Trade-Offs Between Hydraulic Efficiency and Safety in Cotton (<i>Gossypium hirsutum</i> L.) Stems Under Elevated CO₂ and Salt Stress by Qing Zhao, Jinliang Chen, Jian Kang, Shaozhong Kang

“…This study aims to investigate the effects of elevated CO₂ and salt stress on the hydraulic traits and xylem anatomical structures of cotton stems. Potted cotton plants were exposed to different CO₂ concentrations (aC: 400 ppm; eC: 800 ppm) and salinity levels (aS: 0‰ soil salinity; eS: 6‰ soil salinity). …”
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Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in... by Fengyun Zhao, Mengting Chen, Tianjiao Wu, Mingfang Ji, Fugui Li

“…Gene Set Variation Analysis (GSVA) identified potential biological functions in different clusters. The TSCMS model was constructed using Lasso-Cox regression, and its prognostic value was assessed through Kaplan–Meier, Cox regression, and receiver-operating characteristic (ROC) curve analyses. …”
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Understanding the structure–function relationship in selected dairy food matrices using material science approaches* by Prateek Sharma, Pragya Choudhary

“…The theoretical basis for functionality in each food matrix is derived from the multiple layers of food structure and the way different molecules interact with one another at different length scales. …”
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Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns by Kourosch C. Elahi, Gerd Klein, Meltem Avci-Adali, Karl D. Sievert, Sheila MacNeil, Wilhelm K. Aicher

“…This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies.…”
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Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway by Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho

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IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration by Cheng Zhou, Shunlai Shang, Jing Zhao, Yunzhao Yang, Meihan Shi, Ping Li, Qinggang Li, Jian Zhang, Wenge Li, Chuyue Zhang, Xue-Yuan Bai

“…Lupus nephritis is recognized as a common and severe complication of systemic lupus erythematosus, without an optimal therapeutic strategy currently available. While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy varies substantially, likely due to their plasticity and capacity to adopt pro-inflammatory (MSC1) or anti-inflammatory (MSC2) functional states in response to different microenvironments. …”
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Impacts of different types of straw returning on soil physicochemical properties, microbial community structure, and pepper quality by Xiapu Gai, Biao Chen, Shijuan Xiong, Qingqing Zhou, Yuan Yuan, Yumei Mou

“…MS treatment increased amino acids (59.6%) and crude fat (6.3%), which was related to the different metabolic pathways caused by the difference in carbon-nitrogen ratio. …”
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Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells by Francesca Mancuso, Mario Calvitti, Giovanni Luca, Claudio Nastruzzi, Tiziano Baroni, Stefania Mazzitelli, Ennio Becchetti, Iva Arato, Carlo Boselli, Monique D. Ngo Nselel, Riccardo Calafiore

“…Starting from isolated neonatal porcine pancreatic islets (NPIs), we have obtained cell monolayers that were exposed to microencapsulated monolayered Sertoli cells (ESCs) for different time periods (7, 14, 21 days). To assess the development of the cocultured cell monolayers, we have studied either endocrine cell phenotype differentiation markers or c-kit, a hematopoietic stem cell marker, has recently been involved with growth and differentiation of β-cell subpopulations in human as well as rodent animal models. …”
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Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer by Chiara M. S. Herzog, Elisa Redl, James Barrett, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Julia Tevini, Roland Lang, Barbara Kofler, Martin Widschwendter

“…Epigenetic alterations such as DNA methylation (DNAme) changes are a hallmark of aging and form the basis of so-called epigenetic clocks, yet their functional relevance and directionality in different organs during disease development is often unclear. …”
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Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats by Daniel Kwame Afriyie, Elvis Ofori Ameyaw, Isaac Tabiri Henneh, George Asare, Ebenezer Ofori-Atta, Seth Kwabena Amponsah, Regina Appiah-Opong

“…The objective of this study was to determine the acute oral toxicity of the aqueous stem extract of Croton membranaceus (CMASE) in male Sprague–Dawley (S-D) rats. …”
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FOXO1 and FYN Expression Trends in Breast Cancer Stem Cells: An Integrative Study of Single Nucleotide Polymorphism (SNP) Array and Quantitative PCR (qPCR) Analysis by Ay Ly Margaret, Septelia Inawati Wanandi, Fadilah Fadilah, Rafika Indah Paramita

“…BACKGROUND: Currently, identification of breast cancer stem cells (BCSCs) commonly relies on CD24-/CD44+ expression profiles. …”
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Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study by Hadi Sayedyousef, Onur Yilmaz, Cagla Ozturk, Becen Demir, Hilal Uslu Toygar, Nur Balci

“…Abstract Background Aging is a progressive decline in physiological & immunological functions, leading to an increased risk of chronic diseases. …”
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Phenology analysis for trait prediction using UAVs in a MAGIC rice population with different transplanting protocols by Shoji Taniguchi, Toshihiro Sakamoto, Haruki Nakamura, Yasunori Nonoue, Di Guan, Akari Fukuda, Hirofumi Fukuda, Kaede C. Wada, Takuro Ishii, Jun-Ichi Yonemaru, Daisuke Ogawa

“…However, whether CH parameters are applicable to other rice populations and to different cultivation methods, and whether vegetation indices such as the chlorophyll index green (CIg) can function for phenotype prediction remain to be elucidated. …”
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Allometric Growth of Annual <i>Pinus yunnanensis</i> After Decapitation Under Different Shading Levels by Pengrui Wang, Chiyu Zhou, Boning Yang, Jiangfei Li, Yulan Xu, Nianhui Cai

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