The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues by Claire A. Shaw, Claire A. Shaw, Margo Verstrate, Kinga Graniczkowska, Katie R. Risoen, Katie R. Risoen, Pouya Dini, Bart C. Weimer, Bart C. Weimer

“…Interactions with the host microbiome and infections can both significantly impair tissue regeneration and compromise the function of stem cell–derived therapies. Therefore, a comprehensive understanding of how pathogens and the microbiome interact with stem cells and organoids is relevant for developing safe and effective regenerative medicine interventions. …”
Get full text

Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…The objectives of this study are to define a robust and consistent method for the differentiation of induced pluripotent stem cells (iPSCs) into macrophages that can address these needs for recurrent studies with high yields and the potential for gene editing. …”
Get full text

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…The review specifically focuses on how immunological stressors modulate different signaling pathways that impact hematopoiesis. …”
Get full text

Identification of GRAS Gene Family in Paper Mulberry and Analysis of Its Expression in Stem Development by Tanxing CHEN, Huannan LI, Pinsheng WANG, Yajun JIANG, Jinbin XIAO, Lingmin YAN, Yang WANG, Yi FAN

“…【Method】HMM was used to identify GRAS family genes in the whole genome of paper mulberry, and the expression patterns of GRAS genes in paper mulberry stem tissues (T1-T3) with different lignification degrees were analyzed through bioinformatics methods and RNA-Seq data.…”
Get full text

Effects of combined hypoxia and irradiation on mouse bone marrow hematopoietic cells by YANG Xinhai, CHEN Fang, QUAN Yong

Get full text

Preparation and Characterization of Activated Carbon Obtained from Plantain (Musa paradisiaca) Fruit Stem by O. A. Ekpete, A. C. Marcus, V. Osi

“…When comparing the results obtained from CPPAC to that of CPZAC, CPPAC was more preferable for adsorption due to its low bulk density, low ash content, and high iodine value, signifying thus that the activating agents both reacted differently with the plantain stem.…”
Get full text

Tumor-associated mesenchymal stem cells in chemically-induced breast cancer in Wistar rats by A. P. Lykov, A. V. Kabakov, N. A. Bondarenko, O. V. Poveshchenko, T. V. Rayter, O. V. Kazakov, D. N. Strunkin, M. A. Surovtseva, A. F. Poveshchenko, V. I. Konenkov

“…Morphologic and functional differences in mesenchymal stem cells obtained from mammary breast tissue and tumor tissue require further studies.…”
Get full text

Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases by Nikhil Raj Selvaraj, Durga Nandan, Bipin G. Nair, Vipin A. Nair, Parvathy Venugopal, Rajaguru Aradhya

“…Mitochondrial dynamics further illustrate these differences: enhanced function in CSCs supports adaptability and survival, whereas impairments in neurons heighten vulnerability. …”
Get full text

The impact of viral infections on the results of hemopoietic stem cell transplantation in patients with hematologic malignancies by T. V. Antonova, O. E. Pobegalova, M. S. Nozhkin, M. A. Romanova, O. V. Gorchakova

“…There were no significant differences between the group with reactivation of herpesviruses infections without clinical manifestation and the group with manifest herpesviruses infections.Conclusion: Significant impact of herpesviruses infections, including those without clinical manifestation, and HCH with minor symptoms and normal liver functions on one-year survival in patients with hematologic malignancies justifies wider use of antiviral therapy in patients requiring HSCT.…”
Get full text

Molecular and electrophysiological features of spinocerebellar ataxia type seven in induced pluripotent stem cells. by Richard J Burman, Lauren M Watson, Danielle C Smith, Joseph V Raimondo, Robea Ballo, Janine Scholefield, Sally A Cowley, Matthew J A Wood, Susan H Kidson, Leslie J Greenberg

“…To this end, we have generated induced pluripotent stem cells (iPSCs) from a cohort of SCA7 patients in South Africa. …”
Get full text

Proteomics and lipidomics of human umbilical cord mesenchymal stem cells exposed to ionizing radiation by Dongmei Han, Li Ding, Xiaoli Zheng, Sheng Li, Hongmin Yan, Jing Liu, Hengxiang Wang

“…However, whether ionizing radiation affects the functions of human umbilical cord mesenchymal stem cells (hucMSCs) remains unclear. …”
Get full text

The Role of Protein Kinase C During the Differentiation of Stem and Precursor Cells into Tissue Cells by Oliver Pieles, Christian Morsczeck

“…Furthermore, PKC is capable of directly phosphorylating transcription factors with pivotal function for a certain developmental process. Ultimately, profound knowledge about the role of distinct PKC isoforms and the involved signaling pathways during differentiation constitutes a promising tool to improve the use of stem cells in regenerative therapies by precisely manipulating the activity of PKC or downstream effectors.…”
Get full text

Role of p57KIP2 in Stem and Progenitor Leydig Cells of Mouse Testes by Seung Hyun Park, Kyung Noh Yoon, Yang Xu, Myung Chan Gye

“…To understand mechanism for ALC development, functional expression of p57KIP2 (cdkn1c) was investigated in the stem Leydig cells (SLCs) and progenitor Leydig cells (PLCs) in mice. …”

Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (... by Nikola Sprigg, Rebecca O'Connor, Lisa Woodhouse, Kailash Krishnan, Timothy J England, Louise A Connell, Marion F Walker, Philip M Bath

“…Only a minority (23%) of participants completed all physiotherapy sessions, a large proportion of sessions (114 of 540, 21%) were cancelled due to patient (94, 17%) and therapist factors (20, 4%). No significant differences in functional outcomes were detected in either the G-CSF or physiotherapy group at day 90 or 365.…”
Get full text

Some methodological dilemmas in comparative tax law by Popović Dejan, Ilić-Popov Gordana

“…Assuming that method in comparative law can be identified by techniques of comparisons, the authors considered dilemma whether the starting point for comparisons is praesumptio similitudinis or presumption of difference. Stemming from diversities of these assumptions, two methodological approaches in the comparative (tax) law have developed - functionalism (based on presumption of similarities) and cultural differences approach, from which critical approach subsequently emerged. …”
Get full text

On strictly convex and strictly 2-convex 2-normed spaces II by C.-S. Lin

Get full text

The QCML dataset, Quantum chemistry reference data from 33.5M DFT and 14.7B semi-empirical calculations by Stefan Ganscha, Oliver T. Unke, Daniel Ahlin, Hartmut Maennel, Sergii Kashubin, Klaus-Robert Müller

“…The QCML dataset systematically covers chemical space with small molecules consisting of up to 8 heavy atoms and includes elements from a large fraction of the periodic table, as well as different electronic states. Starting from chemical graphs, conformer search and normal mode sampling are used to generate both equilibrium and off-equilibrium 3D structures, for which various properties are calculated with semi-empirical methods (14.7 billion entries) and density functional theory (33.5 million entries). …”
Get full text

Total daily energy expenditure and elevated water turnover in a small-scale semi-nomadic pastoralist society from Northern Kenya by Amanda McGrosky, Zane S. Swanson, Rebecca Rimbach, Hilary Bethancourt, Emmanuel Ndiema, Rosemary Nzunza, David R. Braun, Asher Y. Rosinger, Herman Pontzer

“…Daasanach TEEs and WTs were compared to those of other small-scale and industrialised populations.Results When modelled as a function of fat-free-mass, fat-mass, age, and sex, TEE did not differ between Daasanach communities. …”
Get full text

Feasibility of coronary flow velocity reserve during semi-supine exercise echocardiography: a single center study of 3,014 patients by Angela Zagatina, Ogulleyla Hanjykova, Ekaterina Petrova, Irina Begidova, Elena Kalinina

Get full text

Assessment of functional safety of blood forming organs in research of toxicological properties of medicinal products (Review). Part 1. Features of the hematopoietic organs of labo... by N. M. Faustova, A. E. Saloponova, M. V. Miroshnikov, M. N. Makarova, V. G. Makarov

Get full text