Tissue Engineering for Rotator Cuff Repair: An Evidence-Based Systematic Review by Nicola Maffulli, Umile Giuseppe Longo, Mattia Loppini, Alessandra Berton, Filippo Spiezia, Vincenzo Denaro

“…The three studies found no difference in clinical rating scales and functional outcomes between PRP and control groups. …”
Get full text

CD14 and ALPK1 Affect Expression of Tight Junction Components and Proinflammatory Mediators upon Bacterial Stimulation in a Colonic 3D Organoid Model by Pascal Brooks, Talke zur Bruegge, Erin C. Boyle, Stefan Kalies, Santiago Nahuel Villarreal, Andrea Liese, André Bleich, Manuela Buettner

“…Intestinal barrier integrity can be influenced by CD14, whereas to date, the role of ALPK1 in maintaining barrier function remains unknown. We used colon-derived 3D organoids, first characterised for growth, proliferation, stem cell markers, and expression of tight junction (TJ) components using qPCR and immunohistochemistry. …”
Get full text

The Regulatory Role of Ferroptosis in Bone Homeostasis by Yuan Xiong, Lang Chen, Ze Lin, Yiqiang Hu, Adriana C. Panayi, Wu Zhou, Yun Sun, Faqi Cao, Guodong Liu, Guangdong Dai, Bobin Mi, Guohui Liu

“…Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. …”
Get full text

The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal by Wen Du, Wei Du, Haiyang Yu

“…This review discusses the role of FGF signaling in these mineralized tissues, trying to separate its different functions and highlighting the crosstalk between FGFs and other signaling pathways.…”
Get full text

Stimuli-Responsive Graphene Nanohybrids for Biomedical Applications by Dinesh K. Patel, Yu-Ri Seo, Ki-Taek Lim

“…Numerous surface functionalizations are possible for the graphene structure with different functional groups, which can be used to alter the properties of native materials. …”
Get full text

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy by Marie-Luce Vignais, Andrés Caicedo, Jean-Marc Brondello, Christian Jorgensen

“…TNTs allow the cell-to-cell transfer of various cellular components, including proteins, RNAs, viruses, and organelles, such as mitochondria. Mesenchymal stem cells (MSCs) are both naturally present and recruited to many different tissues where their interaction with resident cells via secreted factors has been largely documented. …”
Get full text

Advances in MicroRNA-Mediated Reprogramming Technology by Chih-Hao Kuo, Shao-Yao Ying

“…Soon after the discovery of embryonic-stem-cell- (ESC-) specific miRNAs, researchers began to investigate their functions in embryonic development and differentiation, as well as their potential roles in somatic cell reprogramming (SCR). …”
Get full text

Vessel Wall-Derived Mesenchymal Stromal Cells Share Similar Differentiation Potential and Immunomodulatory Properties with Bone Marrow-Derived Stromal Cells by Zoltán Veréb, Anett Mázló, Attila Szabó, Szilárd Póliska, Attila Kiss, Krisztina Litauszky, Gábor Koncz, Zoltán Boda, Éva Rajnavölgyi, Attila Bácsi

“…For comparative analysis, the expression of different stemness, proliferation, and differentiation-related genes was determined by Affymetrix gene array. …”
Get full text

Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model by M. Koch, A. Lemke, C. Lange

Get full text

Exosomes for Intramyocardial Intercellular Communication by Elisabetta Cervio, Lucio Barile, Tiziano Moccetti, Giuseppe Vassalli

Get full text

Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2 by Nina Härting, Katarzyna A. Ludwik, Regina Jahn, Frank J. Kaiser, Harald Stachelscheid

Get full text

Role of Primary Cilia in Skeletal Disorders by Xinhua Li, Song Guo, Yang Su, Jiawei Lu, Donghua Hang, Shao Cao, Qiang Fu, Ziqing Li

“…In addition, the intact of primary cilium is essential to osteogenic/chondrogenic induction of mesenchymal stem cells, regarded as a promising target for clinical intervention for skeletal disorders. …”
Get full text

Endothelial Plasticity: Shifting Phenotypes through Force Feedback by Guido Krenning, Valerio G. Barauna, José E. Krieger, Martin C. Harmsen, Jan-Renier A. J. Moonen

Get full text

Genome Editing Redefines Precision Medicine in the Cardiovascular Field by Elda Dzilic, Harald Lahm, Martina Dreßen, Marcus-André Deutsch, Rüdiger Lange, Sean M. Wu, Markus Krane, Stefanie A. Doppler

“…In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. …”
Get full text

Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies by Juçara Gastaldi Cominal, Maira da Costa Cacemiro, Belinda Pinto-Simões, Hans-Jochem Kolb, Kelen Cristina Ribeiro Malmegrim, Fabíola Attié de Castro

“…Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, maintaining, and regulating the functions and fate of haematopoietic stem cells. Despite the great potential of MSC for cell therapy in several diseases due to their regenerative, immunomodulatory, and anti-inflammatory properties, they can also contribute to modulate tumor microenvironment. …”
Get full text

Study of the Structure and Properties of ZnS Utilized in a Fluorescence Biosensor by Y. Ren, H. Zhou, X. Wang, Q. W. Liu, X. D. Hou, G. F. Zhang

“…ZnS materials have been widely used in fluorescence biosensors to characterize different types of stem cells due to their excellent fluorescence effect. …”
Get full text

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect by Wenqian Jiang, Youwen Tan, Mengjie Cai, Ting Zhao, Fei Mao, Xu Zhang, Wenrong Xu, Zhixin Yan, Hui Qian, Yongmin Yan

“…Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. …”
Get full text

Reliability and Validity Measures of the Patellofemoral Subscale KOOS-PF in Greek Patients with Patellofemoral Pain by Ioannis Moros, Eleni C. Boutsikari, George Plakoutsis, Elefterios Paraskevopoulos, George A. Koumantakis, Maria Papandreou

Get full text

Three Growth Factors Induce Proliferation and Differentiation of Neural Precursor Cells In Vitro and Support Cell-Transplantation after Spinal Cord Injury In Vivo by Alexander Younsi, Guoli Zheng, Moritz Scherer, Lennart Riemann, Hao Zhang, Mohamed Tail, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger

“…Stem cell therapy with neural precursor cells (NPCs) has the potential to improve neuroregeneration after spinal cord injury (SCI). …”
Get full text

Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes by Nikunj Satani, Kaavya Giridhar, Chunyan Cai, Natalia Wewior, Dominique D. Norris, Jaroslaw Aronowski, Sean I. Savitz

Get full text