Uncovering functional deterioration in the rhizosphere microbiome associated with post-green revolution wheat cultivars by Monique E. Smith, Vanessa N. Kavamura, David Hughes, Rodrigo Mendes, George Lund, Ian Clark, Tim H. Mauchline

“…Results We found distinct taxonomic and functional differences between heritage and modern wheat rhizosphere communities and identified that modern wheat microbiomes were less distinct from the communities in the surrounding soil. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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Amine-functionalized cellulose-silica composites for the remediation of hexavalent chromium (Cr IV) in contaminated water by Mayenzeke Trueman Mazibuko, Stanley Chibuzor Onwubu, Phumlane Selby Mdluli, Vimla Paul, Mokhena Clement Teboho, Mokhothu Thabang

“…We employed the in-situ sol–gel method to create cellulose-silica silane functionalized composites, analyzing them through different characterization techniques such as Attenuated total reflectance- Fourier transform infrared spectroscopy (ATR-FTIR), X-ray Diffraction Analysis (XRD), Thermo gravimetric analysis (TGA)/differential thermogravimetric (DTG), Brunauer–Emmett–Teller (BET), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM) techniques. …”
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Unraveling the impact of congenital deafness on individual brain organization by Lenia Amaral, Xiaosha Wang, Yanchao Bi, Ella Striem-Amit

“…To address this question, we examined the individual differences in functional connectivity (FC) from the deprived auditory cortex. …”
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Effects of Nitrogen Addition on Leaf Functional Traits of Dominant Species in Bayanbulak Grassland, Xinjiang, China by Xiaoyu Ding, Junjie Liu, Yao Wang, Juan Wang, Chao Liu, Mengtian Qin, Yujiao Xu, Yonggang Ma, Jianjun Yang, Zhonglin Xu

“…The results were as follows: (1) LA and leaf length (LL) of Poaceae changed significantly (<i>p</i> < 0.05) under different N addition gradients, and leaf nutrient contents of Poaceae, Rosaceae and Fabaceae showed significant changes under different N addition gradients. (2) Pearson correlation analyses showed that total nitrogen (TN), total carbon (TOC) and leaf width (LW) of Rosaceae leaves had a significant positive correlation, and the TOC and total phosphorus (TP) of Fabaceae leaves showed a significant negative correlation. (3) SEM of the three plant functional groups showed direct and indirect effects of N addition on leaf dry matter content of Poaceae and Rosaceae, and only indirect effects on Fabaceae.…”
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Trade-Offs Between Hydraulic Efficiency and Safety in Cotton (<i>Gossypium hirsutum</i> L.) Stems Under Elevated CO₂ and Salt Stress by Qing Zhao, Jinliang Chen, Jian Kang, Shaozhong Kang

“…This study aims to investigate the effects of elevated CO₂ and salt stress on the hydraulic traits and xylem anatomical structures of cotton stems. Potted cotton plants were exposed to different CO₂ concentrations (aC: 400 ppm; eC: 800 ppm) and salinity levels (aS: 0‰ soil salinity; eS: 6‰ soil salinity). …”
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Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in... by Fengyun Zhao, Mengting Chen, Tianjiao Wu, Mingfang Ji, Fugui Li

“…Gene Set Variation Analysis (GSVA) identified potential biological functions in different clusters. The TSCMS model was constructed using Lasso-Cox regression, and its prognostic value was assessed through Kaplan–Meier, Cox regression, and receiver-operating characteristic (ROC) curve analyses. …”
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Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns by Kourosch C. Elahi, Gerd Klein, Meltem Avci-Adali, Karl D. Sievert, Sheila MacNeil, Wilhelm K. Aicher

“…This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies.…”
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Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway by Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho

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Removal characteristics for nine species of per-and poly-fluoroalkyl substances using different types of anion exchange by Heejong Son, Byungryul An, Jeongwoo Shin

“…Methods IRA900-Cu and A860-Cu were synthesized from two commercial AIXs(IRA900 and A860) using a 1% CuCl2·2H2O solution. SEM-EDS analysis and Cu2+ extraction experiments were conducted to evaluate surface characteristics under different matrices and their modification. …”
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IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration by Cheng Zhou, Shunlai Shang, Jing Zhao, Yunzhao Yang, Meihan Shi, Ping Li, Qinggang Li, Jian Zhang, Wenge Li, Chuyue Zhang, Xue-Yuan Bai

“…Lupus nephritis is recognized as a common and severe complication of systemic lupus erythematosus, without an optimal therapeutic strategy currently available. While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy varies substantially, likely due to their plasticity and capacity to adopt pro-inflammatory (MSC1) or anti-inflammatory (MSC2) functional states in response to different microenvironments. …”
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Impacts of different types of straw returning on soil physicochemical properties, microbial community structure, and pepper quality by Xiapu Gai, Biao Chen, Shijuan Xiong, Qingqing Zhou, Yuan Yuan, Yumei Mou

“…MS treatment increased amino acids (59.6%) and crude fat (6.3%), which was related to the different metabolic pathways caused by the difference in carbon-nitrogen ratio. …”
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Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells by Francesca Mancuso, Mario Calvitti, Giovanni Luca, Claudio Nastruzzi, Tiziano Baroni, Stefania Mazzitelli, Ennio Becchetti, Iva Arato, Carlo Boselli, Monique D. Ngo Nselel, Riccardo Calafiore

“…Starting from isolated neonatal porcine pancreatic islets (NPIs), we have obtained cell monolayers that were exposed to microencapsulated monolayered Sertoli cells (ESCs) for different time periods (7, 14, 21 days). To assess the development of the cocultured cell monolayers, we have studied either endocrine cell phenotype differentiation markers or c-kit, a hematopoietic stem cell marker, has recently been involved with growth and differentiation of β-cell subpopulations in human as well as rodent animal models. …”
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Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer by Chiara M. S. Herzog, Elisa Redl, James Barrett, Sepideh Aminzadeh-Gohari, Daniela D. Weber, Julia Tevini, Roland Lang, Barbara Kofler, Martin Widschwendter

“…Epigenetic alterations such as DNA methylation (DNAme) changes are a hallmark of aging and form the basis of so-called epigenetic clocks, yet their functional relevance and directionality in different organs during disease development is often unclear. …”
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Acute Oral Toxicological Profile of Croton membranaceus Mull. Arg. Aqueous Stem Extract, a Herbal Treatment for Benign Prostate Hyperplasia, in Male Sprague–Dawley Rats by Daniel Kwame Afriyie, Elvis Ofori Ameyaw, Isaac Tabiri Henneh, George Asare, Ebenezer Ofori-Atta, Seth Kwabena Amponsah, Regina Appiah-Opong

“…The objective of this study was to determine the acute oral toxicity of the aqueous stem extract of Croton membranaceus (CMASE) in male Sprague–Dawley (S-D) rats. …”
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FOXO1 and FYN Expression Trends in Breast Cancer Stem Cells: An Integrative Study of Single Nucleotide Polymorphism (SNP) Array and Quantitative PCR (qPCR) Analysis by Ay Ly Margaret, Septelia Inawati Wanandi, Fadilah Fadilah, Rafika Indah Paramita

“…BACKGROUND: Currently, identification of breast cancer stem cells (BCSCs) commonly relies on CD24-/CD44+ expression profiles. …”
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Experimental and Numerical Studies on Permeability Properties of Thermal Damaged Red Sandstone under Different Confining Pressures by Zhenlong Zhao, Hongwen Jing, Guangping Fu, Qian Yin, Xinshuai Shi, Yuan Gao

“…To reveal the flow behavior of fluid in thermal damaged rock, first, a rock seepage testing system was applied to study the permeability properties of red sandstone specimens after different high-temperature treatments from 200 to 800°C under different confining pressures of 10 to 30 MPa. …”
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Functionalities of Octenyl Succinic Anhydride Wheat Starch and Its Effect on the Quality of Model Dough and Noodles by Hongxue Ma, Liai Yang, Dunhe Zhang, Huijing Chen, Jianquan Kan

“…Scanning electron microscopy (SEM) observations indicated that the surface of OSA-modified wheat starch granules became rougher. …”
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Functional trait response to aridity based on leaf trait network analysis in the Hexi Corridor, China by Yingxiang Miao, Haifeng Liu, James F. White, Guoqiang Wu, Shanjia Li

“…A leaf trait network (LTN) was constructed to study how leaf trait tradeoff strategies differ between the two areas. Structural equation modeling (SEM) was used to identify the direct and indirect effects of aridity and functional diversity (as measured by community weighted means and functional dispersion) on leaf nutrient concentration. …”
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Beyond chronological age: exploring how different future time perspective influences the health tourism intention by Caisheng Liao, Huiqing Xiao, Zhao Li, Yuki Todo

“…The study employed the structural equation modeling (SEM) to test the proposed hypotheses. Results The effect of different dimensions of future time perspective on health tourism intention differed. …”
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