Research status and prospects of exosomes in the treatment of intervertebral disc degeneration by Feihong HUANG, Hua JIANG

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Bioinformatic Prediction of Novel microRNAs Encoded in Krüppel-like Factor 4 Gene by Mina Zahiri, Maryam Hassanlou, Amir-Reza Javanmard, Nooshin Bijari

“…Krüppel-like factor 4 (KLF4) is a transcription factor that has different regulatory functions, and it plays a role in various cellular processes. …”
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Preparation and Characterization of Red Dragon Fruit (Hylocereus polyrhizus) Starch as Solid Medicinal Additive by Melisa Nia Alfiona, Intan Martha Cahyani, Wulan Kartika Sari

“…FTIR analysis showed that red dragon fruit stem starch contains starch functional groups. Based on the results of the red dragon fruit stem characterization test, the best treatment was obtained, namely 1 hour soaking, producing starch with physical characteristics suitable for solid preparation additives.…”

Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta by Nobuyuki Hamada, Ki-ichiro Kawano, Seiko Hirota, Farina Mohamad Yusoff, Takaharu Nomura, Yusuke Saito, Ayumu Nakashima, Shinji Yoshinaga, Yukihito Higashi

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Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles by Sónia Castanheira, Juan J. Cestero, Francisco García-del Portillo, M. Graciela Pucciarelli

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Targeting the Cargo Receptor TMED9 as a Therapeutic Strategy Against Brain Tumors by Alaa Daoud Sarsour, Sara Kinstlinger, Rephael Nizar, Naama Amos, Narkis Arbeli, Gila Kazimirsky, Irena Bronshtein-Berger, Iris Fried, Ron Unger, Chaya Brodie, Moran Dvela-Levitt

“…This is the first time, to the best of our knowledge, that TMED9 has been shown to play a major role in the function and tumorigenesis of brain tumor cancer stem cells. …”
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Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells by Yu Zhang, Yueda Lu, Xinyue Hu, Mengxing Jiang, Zhixiu Chen, Lingkun Jin, Min Li, Chen Chen, Jianye Wang

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Impact of Excipient and Cell Concentration on the Viability, Proliferation, and Adhesion of Mesenchymal Stem Cells: Future Relevance for the Development of a New Advanced Therapy M... by Ester Moñivas, Concepción Aguayo, Beatriz Rodera, Mercedes Zurita

“…Evaluating various excipients to optimize MSC conservation and functionality is essential. <b>Methods</b>: Five excipients with different proportions of human platelet lysate (hPL) and Hypothermosol were evaluated at two different cell concentrations (0.1 × 10⁶ MSC/μL and 0.008 × 10⁶ MSC/μL). …”
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Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minima... by Gergana Mincheva, Victoria Moreno-Manzano, Vicente Felipo, Marta Llansola

“…Treatment with extracellular vesicles (EV) from mesenchymal stem cells (MSC) reduces neuroinflammation and improves cognitive impairment in different animal models of neurological diseases. …”
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Equine Adipose-Derived Mesenchymal Stromal Cells Release Extracellular Vesicles Enclosing Different Subsets of Small RNAs by Stefano Capomaccio, Katia Cappelli, Cinzia Bazzucchi, Mauro Coletti, Rodolfo Gialletti, Franco Moriconi, Fabrizio Passamonti, Marco Pepe, Stefano Petrini, Samanta Mecocci, Maurizio Silvestrelli, Luisa Pascucci

“…The miRNA target pathway analysis revealed the presence of “signaling pathways regulating pluripotency of stem cells” coherent with the source of the samples. …”
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Evolution of HD-ZIP transcription factors and their function in cabbage leafy head formation by Ju Zhang, Ju Zhang, Can Chen, Can Chen, Qihang Yang, Jie Xu, Zizhuo Han, Wei Ma, Xiaomeng Zhang, Kedong Xu, Jianjun Zhao, Xueping Chen

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Large Pore Ion and Metabolite-Permeable Channel Regulation of Postnatal Ventricular Zone Neural Stem and Progenitor Cells: Interplay between Aquaporins, Connexins, and Pannexins? by Leigh E. Wicki-Stordeur, Leigh Anne Swayne

“…The birth of new neurons from unspecialized neural stem and progenitor cells surrounding the lateral ventricles occurs throughout postnatal life. …”
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Multilayer Membranes of Glycosaminoglycans and Collagen I Biomaterials Modulate the Function and Microvesicle Release of Endothelial Progenitor Cells by Bingyan Dai, Qunwen Pan, Zhanghua Li, Mingyan Zhao, Xiaorong Liao, Keng Wu, Xiaotang Ma

“…Multilayer composite membrane of biomaterials can increase the function of adipose stem cells or osteoprogenitor cells. …”
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CRISPR/Cas9 Genome Editing in LGMD2A/R1 Patient-Derived Induced Pluripotent Stem and Skeletal Muscle Progenitor Cells by Lampros Mavrommatis, Abdul Zaben, Urs Kindler, Marie-Cécile Kienitz, Julienne Dietz, Hyun-Woo Jeong, Pierre Böhme, Beate Brand-Saberi, Matthias Vorgerd, Holm Zaehres

“…Two different strategies to rescue these mutations are devised: (i) on the level of LGMD2A-iPSC, we combined CRISPR/Cas9 genome targeting with a FACS and Tet transactivator-based biallelic selection strategy, which resulted in a new functional chimeric exon 3-4 without the two CAPN3 mutations. …”
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Functional Diversity of Serotonin Neurons in the Dorsal and Median Raphe Nuclei in Emotional Responses by Yu Ohmura, Kazuki Nagayasu

“…These findings suggest that different subpopulations within the serotonergic system may exert opposing effects on emotional functions. …”
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Phenotypic and Proteomic Characteristics of Human Dental Pulp Derived Mesenchymal Stem Cells from a Natal, an Exfoliated Deciduous, and an Impacted Third Molar Tooth by Gurler Akpinar, Murat Kasap, Ayca Aksoy, Gokhan Duruksu, Gulcin Gacar, Erdal Karaoz

“…The cells were isolated from a natal (NDPSCs), an exfoliated deciduous (stem cells from human exfoliated deciduous (SHED)), and an impacted third molar (DPSCs) tooth of three different donors. …”
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Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Tria... by Masahito Kawabori, Yasuaki Karasawa, Jun Suenaga, Hajime Nakamura, Hideaki Imai, Takao Yasuhara, Naoki Tani, Tatsuya Sasaki, Takashi Kawasaki, Kenta Totsuka, Dai Chida, Yoichi M. Ito, Tetsuya Yamamoto, Isao Date, Shota Tanaka, Haruhiko Kishima, Miki Fujimura

“…This study included all Japanese subjects from the STEMTRA trial who were assigned to the cell transplantation group. Functional recovery was assessed by the difference in Fugl–Meyer Motor Scale (FMMS) scores between the screening period and 24 or 48 weeks post-transplantation. …”
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Bisphenol S interrupted axonogenesis on a human embryonic stem cells derived neural differentiation model: Conserved axon guidance and WNT signaling pathway involved by Wanqing Guo, Wei Xiong, Liang Wang, Xiaoya Wang, Yongru Zhou, Yili Chen, Xiaomeng Li, Lishi Zhang, Mengmei Ni, Jinyao Chen

“…In present study, the neuro-differentiating human embryonic stem cells, hESC, was exposed to BPS (0–375 µM) at different stages (the precursor stage, the precursor to maturation stage, and the whole differentiation stage) to assess the potential neurodevelopmental toxicity and its mechanisms. …”
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High NK cell counts at day 90 predict improved survival in event-free patients after T-cell depleted allogeneic stem cell transplantation by Andrej Pešić, Nevena Bešević, Nicolaus Kröger, Dejana Stanisavljević, Dejana Stanisavljević, Nada Kraguljac Kurtović, Zoran Bukumirić, Zoran Bukumirić, Natalija Kecman, Nikola Lemajić, Mihailo Smiljanić, Nada Suvajdžić Vuković, Nada Suvajdžić Vuković, Andrija Bogdanović, Andrija Bogdanović, Ana Vidović, Ana Vidović, Jelena Bila, Jelena Bila, Mirjana Mitrović, Mirjana Mitrović, Danijela Leković, Danijela Leković, Marijana Virijević, Marijana Virijević, Irena Đunić, Irena Đunić, Darko Antić, Darko Antić, Milena Todorović Balint, Milena Todorović Balint

“…However, data on the impact of different lymphocyte subsets influencing outcomes is conflicting. …”
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Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation by D. S. Romaniuk, A. A. Khmelevskaya, M. Yu. Drokov, N. N. Popova, V. A. Vasilieva, L. A. Kuzmina, G. A. Efimov, E. N. Parovichnikova, V. G. Savchenko

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is being widely applied as a therapy for hematological malignancies. …”
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