Molecular Genetic Analysis of Human Endometrial Mesenchymal Stem Cells That Survived Sublethal Heat Shock by A. E. Vinogradov, M. A. Shilina, O. V. Anatskaya, L. L. Alekseenko, I. I. Fridlyanskaya, A. Krasnenko, A. Kim, D. Korostin, V. Ilynsky, A. Elmuratov, O. Tsyganov, T. M. Grinchuk, N. N. Nikolsky

“…Although heat shock is a well-studied biological phenomenon, hyperthermia response of stem cells is poorly understood. Previously, we demonstrated that sublethal heat shock induced premature senescence in human endometrial mesenchymal stem cells (eMSC). …”
Get full text

Age-related changes in the proteome and mitochondrial metabolism of rabbit adipose-derived stromal/stem cells by Alicia Toto Nienguesso, Juliane-Susanne Jung, Marie Alfes, Maria Schindler, Luisa Täubert, Carla Schmidt, Anne Navarrete Santos

“…Abstract Adipose tissue is continuously regenerated by stromal mesenchymal stem cells throughout life. This study hypothesises that early age-related changes in the proteome and metabolic properties of subcutaneous (s) and visceral (v) adipose tissue-derived stromal/stem cells (ASCs) from young and old rabbits contribute to a loss of stem cell plasticity and function. …”
Get full text

Investigation of the stemness and wound-healing potential of long-term cryopreserved stromal vascular fraction cells by Naoki Inafuku, Yoshihiro Sowa, Tsunao Kishida, Seiji Sawai, Edward Hosea Ntege, Toshiaki Numajiri, Kenta Yamamoto, Yusuke Shimizu, Osam Mazda

“…Non-parametric statistical tests analyzed the differences between groups. Results: L-SVF exhibited significantly lower stemness compared to S-SVF. …”
Get full text

A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors by Katsuhito Watanabe, Takashi Nakamura, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma

“…Therefore, the aim of this study was to generate GNAS -mutated disease-specific induced pluripotent stem cells as a model for these diseases. We then analyzed the functionality of this induced pluripotent stem cell model and differentiated epithelial cells. …”
Get full text

Functional traits mediate the elevational patterns of functional diversity and community structure of mosses in a tropical mountain area by Liqin Fu, Chengxiu Zhan, Haozhe Wang, Shikai Song, Peng Xu, Lina Zhang, Jiancheng Zhao, De Gao

“…We applied and compared boosted regression trees (BRT) without considering functional traits and piecewise structural equation modelling (SEM) mediated with functional traits to relate environmental variables with functional diversity and functional community structure, respectively. …”
Get full text

EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells by Yang Li, Dazhuang Lu, Fanqing Xu, Jun Yang, Dong Li, Chenlong Yang, Xin Chen, Xu Wang, Jia Qing, Hui Zhang, Yingfei Zhang, Fuchou Tang, Jie Qiao, Ophir D. Klein, Ping Zhang, Yongsheng Zhou

“…Abstract Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. …”
Get full text

The impact of active sport tourism experiencescape perception on tourists’ psychological recovery: the mediating role of flow experience by Hengyi Song, Dongqi Wang, Teng Ma

Get full text

A comparative analysis of Zambian and newly industrialised country manufacturing finance models by Wiza Ng’ambi, Getrude B. Mwanza, Lubinda Haabazoka

Get full text

Different sources of sucrose in water kefir fermentation by Ana Luíza Barbosa de Carvalho Lima, Letícia Reis Pinheiro, Bruno Jhosef Freires de Souza, Alexandre Fontes Pereira

“…The results showed differences in the use of sugar, concluding that there was a greater difference in relation to refined sugar and the others. …”
Get full text

Impacts of Hematopoietic Stem Cell Transplantation on Quality of Life and Behavioral Outcomes in Pediatric Patients with Leukemia and Thalassemia by Aysun Kara Uzun, Sevilay Yıldız Akkuş, Ayça Koca Yozgat, Fadime Yüksel, Özlem Arman Bilir, Hüsniye Neşe Yaralı, Namık Yaşar Özbek

“…Background: This study aimed to investigate the effects of allogeneic hematopoietic stem cell transplantation (HSCT) on quality of life and behavioral problems in children diagnosed with leukemia and β-thalassemia major, with a focus on post-transplant diagnosis-specific differences in psychosocial adjustment. …”
Get full text

Metformin pretreatment ameliorates busulfan-induced liver endothelial toxicity during haematopoietic stem cell transplantation. by Balaji Balakrishnan, Raveen Stephen Stallon Illangeswaran, Bharathi Murugan Rajamani, Arun Kumar Arunachalam, Aswin Anand Pai, Ezhilpavai Mohanan, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian

Get full text

MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Abstract Background Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and a high risk of progression to acute myeloid leukemia. …”
Get full text

INDUCED PLURIPOTENT STEM CELL-DERIVED MICROGLIA TO STUDY NLRP3 INFLAMMASOME ACTIVATION IN ALZHEIMER’S DISEASE by Aslı Erdoğan, Cira Dansokho, Jari Koıstınaho, Sarka Lehtonen, Seyhun Solakoğlu, Michael Thomas Heneka

“…Since animal models of AD do not accurately reflect human pathology, in our study, human induced pluripotent stem cells (iPSCs) were differentiated into microglia, and their potential to be used in NLRP3 pathway-related mechanisms in AD was investigated.Material and Method: iPSC cell lines of AD, isogenic, or control genotypes were differentiated into microglia and cells from different stages of the differentiation were characterized by flow cytometry, real time quantintative polymerase chain reaction (RTqPCR), immunocytochemistry, and Western blot. …”
Get full text

The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells by P. F. Muzychenko, Zh. M. Minchenko, T. I. Havrylenko, V. A. Cherniak, S. V. Demidov, N. O. Ryzhkova, O. A. Pidhaina

“…Global trends in the study of stem cells of different origins from the perspective of morphofunctional, molecular-genetic, cytogenetic, immunogenetic and cytological characteristics contribute significantly the development of regenerative medicine in the context of developing new methodological solutions for the use of stem cells and their components, particularly exosomes, for cell therapy of various pathological conditions. …”
Get full text

PPARs Expression in Adult Mouse Neural Stem Cells: Modulation of PPARs during Astroglial Differentiaton of NSC by A. Cimini, L. Cristiano, E. Benedetti, B. D'Angelo, M. P. Cerù

“…PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. …”
Get full text

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Therapy by Shenyuan Chen, Fengtian Sun, Hui Qian, Wenrong Xu, Jiajia Jiang

“…Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing to their multiple differentiation, self-renewal, and immunomodulatory abilities. …”
Get full text

Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator. by Danielle Ciren, Sophia Zebell, Zachary B Lippman

“…Here, we investigated these questions using a plant stem cell regulator conserved in expression pattern and function over ~125 million years. …”
Get full text

Light Exposure as a Tool to Enhance the Regenerative Potential of Adipose-Derived Mesenchymal Stem/Stromal Cells by Kaarthik Sridharan, Tawakalitu Okikiola Waheed, Susanne Staehlke, Alexander Riess, Mario Mand, Juliane Meyer, Hermann Seitz, Kirsten Peters, Olga Hahn

“…Photobiomodulation (PBM) utilizes different wavelengths of light to modulate cellular functions and has emerged as a promising approach in regenerative medicine. …”
Get full text

Mesenchymal stem cell application in pulmonary disease treatment with emphasis on their interaction with lung-resident immune cells by Ali Hazrati, Seyed Mohamad Javad Mirarefin, Kosar Malekpour, Arezou Rahimi, Arezou Khosrojerdi, Ashkan Rasouli, Susan Akrami, Sara Soudi

“…Furthermore, they can secrete exosomes that affect the function of lung cells and immune cells and change their function. …”
Get full text

Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors by Seyyedeh Mina Hejazian, Seyyed Sina Hejazian, Seyyedeh Mina Mostafavi, Seyed Mahdi Hosseiniyan, Soheila Montazersaheb, Mohammadreza Ardalan, Sepideh Zununi Vahed, Abolfazl Barzegari

“…The presence of accumulated senescent cells, whether transiently (acute senescence) or persistently (chronic senescence) plays a dual role in various conditions such as natural kidney aging and different kidney disorders. Elevations in senescent cells and senescence-associated secretory phenotype (SASP) levels correlate with decreased kidney function, kidney ailments, and age-related conditions. …”
Get full text