Validation of an LC-MS/MS Method for the Simultaneous Intracellular Quantification of the CDK4/6 Inhibitor Abemaciclib and the EZH2 Inhibitors GSK126 and Tazemetostat by Stefan Senekowitsch, Thomas Freitag, Daniel Dubinski, Thomas M. Freiman, Claudia Maletzki, Burkhard Hinz

“…Overall, the developed method provides a valuable approach for characterizing interactions at the transport level and for predicting the efficiency of both anticancer substance classes in different cell lines.…”
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Experimental Study on UAV-Assisted Pollination in Hybrid Rice by Le Long, Jinlong Lin, Muhua Liu, Xiongfei Chen, Peng Fang, Liping Xiao, Yihan Zhou, Xiaoya Dong

“…To address challenges in hybrid rice seed production—specifically labor dependence, low uniformity of pollen distribution, and low operational efficiency—which collectively drive up large-scale production costs, technological innovations are critical. …”
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The role of titanium dioxide in enhancing low-emission properties of cementitious materials by Agnieszka Ślosarczyk, Izabela Klapiszewska, Patryk Jędrzejczak, Marta Thomas, Bartosz Gapiński, Marcin Janczarek, Łukasz Klapiszewski

“…These systems also showed the best phenol degradation efficiency, due to the photocatalytic properties of TiO2 enhanced by the presence of calcium carbonate. …”
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A General Framework for Accelerator Management Based on ISA Extension by Elham Cheshmikhani, Biagio Peccerillo, Andrea Mondelli, Sandro Bartolini

“…Thanks to the promised improvements in performance and energy efficiency, hardware accelerators are taking momentum in many computing contexts, both in terms of variety and relative weight in the silicon area of many chips. …”
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Goal-directed dehydration therapy in sepsis and acute respiratory distress syndrome guided by volumetric hemodynamic monitoring by N. O. Khromacheva, E. V. Fot, V. V. Kuzkov, M. Yu. Kirov

“…The baseline characteristics of the patients did not differ between the groups. By 48 hours, the target fluid balance was achieved in both groups. …”
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Obtaining Lignin from Nutshells under Mild Extraction Conditions and Its Use as a Biostimulant in Tomato Seedlings by José Alejandro Díaz-Elizondo, Azrrael Ayala-Velazco, Adalberto Benavides-Mendoza, Francisco Javier Enriquez-Medrano, Julia Medrano-Macías

“…Subsequently, lignin solutions were prepared at different concentrations, 0, 10, 50, and 100 ppm, and applied via foliar weekly to tomato seedlings. …”
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Fractional Optimal Control Problem and Stability Analysis of Rumor Spreading Model with Effective Strategies by Hegagi Mohamed Ali, Saud Owyed, Ismail Gad Ameen

“…We derive the necessary optimality conditions (NOCs) by applying Pontryagin’s maximum principle (PMP). Different optimal control strategies are proposed to reduce the negative effects of rumor spreading and achieve the maximum social benefit. …”
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Metagenomic and Metabolomic Perspectives on the Drought Tolerance of Broomcorn Millet (<i>Panicum miliaceum</i> L.) by Yuhan Liu, Jiangling Ren, Binhong Yu, Sichen Liu, Xiaoning Cao

“…These community-level changes can enhance element cycling efficiency, optimize symbiotic interactions between broomcorn millet and rhizosphere microorganisms, and ultimately improve the crop’s drought adaptability. …”
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DualTransAttNet: A Hybrid Model with a Dual Attention Mechanism for Corn Seed Classification by Fei Pan, Dawei He, Pengjun Xiang, Mengdie Hu, Daizhuang Yang, Fang Huang, Changmeng Peng

“…Varietal purity is a critical quality indicator for seeds, yet various production processes can lead to the mixing of seeds from different varieties. Consequently, seed variety classification is an essential step in seed production. …”
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Reducing power ripple for multi-rotor wind energy systems using FOPDPI controllers by Habib Benbouhenni, Ilhami Colak, Z. M. S. Elbarbary, Shaik Mohammad Irshad

“…The designed technique was verified using MATLAB, comparing the results obtained in the case of different wind speed profiles with those using the DPC-PI approach. …”
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Advanced Computational Methods for Mitigating Shock and Vibration Hazards in Deep Mines Gas Outburst Prediction Using SVM Optimized by Grey Relational Analysis and APSO Algorithm by Xiang Wu, Zhen Yang, Dongdong Wu

“…Despite these progresses, predicting the gas outburst more accurately and efficiently still remains a great challenge. In this work, an algorithm based on grey relational analysis and SVM using adaptive particle swarm optimization (APSO-SVM) for gas outburst prediction is proposed. …”
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Surface adsorption of malachite green dye from aqueous solution using novel synthesized adsorbent ZnO, Zn1-xFexO and Zn1-xCuxO nanoparticles by Masome Naseri Tekyeh, Dariush Mehrparvar, Rostam Moradian, Shahriar Mahdavi

“…The variation in qmax values among the different nanoparticles suggests that the composition and structure of the nanoparticles play a crucial role in their adsorption performance. …”
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The Importance of Copy Number Variant Analysis in Patients with Monogenic Kidney Disease by Laura R. Claus, Robert F. Ernst, Martin G. Elferink, Hanneke W.M. van Deutekom, Bert van der Zwaag, Albertien M. van Eerde

“…We highlight the efficiency of exome-based CNV calling, which reduces the need for additional diagnostic tests. …”
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Would the CBAM promote greener African-EU agri-food trade? Insights from a joint economic—legal assessment by Christian Häberli, Bodo Steiner, Mari Carlson

“…The review and analysis in this paper focus on the potential impacts of different conceptualisations of the CBAM, especially on African countries, from a joint economic and legal perspective that includes issues related to World Trade Organisation rules and trade and investment treaties. …”
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Contributing to a value-based health care framework for lung cancer patients in Switzerland - A methodological approach to merge routinely collected hospital data. by Michaela Carla Barbier, Katya Galactionova, Mark Lambiris, Leonel Oliveira, Florian Rüter, Dominik Glinz, Jessica Thürmer, Flurina Pletscher, Benjamin Kasenda, Tobias Finazzi, David König, Didier Lardinois, Larissa Conrad, Leonie Mutz, Matthias Schwenkglenks

“…It is reproducible and scalable across other conditions and hospitals, enabling the development of lung cancer treatments towards greater value and efficiency.…”
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Economic viability and CO2 emissions of hydrogen production for ammonia synthesis: A comparative analysis across Europe by Alessandro Magnino, Paolo Marocco, Massimo Santarelli, Marta Gandiglio

“…Process models for the three plant layouts are developed, incorporating heat integration between different components. The economic results are presented in terms of the levelised cost of ammonia, which accounts for both capital and operating expenses over the plant's lifetime. …”
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Development of wrench-based system for occlusal force analysis: a biomechanical approach to evaluate dental occlusion by Ittetsu Uchigasaki, Yoshinori Hattori

“…In addition, the system provided consistent outcomes in biomechanical analyses across different examiners.…”
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West Nile Fever in the Russian Federation in 2024, Forecast for 2025 by E. V. Putintseva, S. K. Udovichenko, D. N. Nikitin, N. V. Boroday, A. Yu. Koloskova, A. S. Antonov, O. S. Bondareva, A. V. Toporkov

“…The incidence and clinical course structure of WNF in 2024 did not differ significantly compared to the average long-term values and those in 2023. …”
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To evaluate the EASE intervention for reducing anxiety and depression among adolescents in Pakistan: a protocol for a mixed methods study, including a cluster-randomised controlled... by Fenglin Cao, Lubna Ghazal, Naixue Cui

“…In addition, adapting interventions from high-income countries to LMICs raises concerns about efficiency. The LMIC-tailored Early Adolescent Skills for Emotions (EASE) intervention, integrating cognitive-behavioural principles, group sessions, non-specialist delivery and parental involvement, provides a promising solution. …”
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RESULTS OF EVALUATING THE EFFICACY OF SECUKINUMAB VERSUS ADALIMUMAB IN TREATING PSORIATIC ARTHRITIS BY USING THE MATCHING-ADJUSTED INDIRECT COMPARISON METHOD by T. V. Korotaeva

“…To date there have been no results of a direct comparison of the efficiency of using tumor necrosis factor-α inhibitors, secukinumab (SCM) and adalimumab (ADA) in particular, to treat psoriatic arthritis (PsA). …”
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