Quantification of Total and Unbound Selinexor Concentrations in Human Plasma by a Fully Validated Liquid Chromatography-Tandem Mass Spectrometry Method by Suhyun Lee, Seungwon Yang, Hyeonji Kim, Wang-Seob Shim, Eunseo Song, Seunghoon Han, Sung-Soo Park, Suein Choi, Sungpil Han, Sung Hwan Joo, Seok Jun Park, Beomjin Shin, Donghyun Kim, Hyeon Su Kim, Kyung-Tae Lee, Eun Kyoung Chung

“…Unbound selinexor was separated using ultrafiltration, and selinexor was efficiently extracted from 50 μL of plasma by liquid–liquid extraction. …”
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Machine learning-guided field site selection for river classification by Zhihao Wang, Gregory Brian Pasternack, Yufang Jin, Costanza Rampini, Serena Alexander, Nikhil Kumar, Rune Storesund, K. Martin Perales, Christopher Lim, Stephanie Moreno, Igor Lacan

“…Machine learning has been recognized for discovering and extracting streams’ geomorphic patterns efficiently and accurately from data, but its application in field site sampling design is still in its infancy. …”
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Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases by Yiovana Verónica Okraine, María Belén de la Vega, Sofía Venerus Arbilla, Ginette Moyano, Agostina P. Bertolin, Horacio M. Pallarés, Lisa Wiesmüller, Sabrina F. Mansilla, Vanesa Gottifredi

“…This strategy is demonstrably valid to enhance the cancer cell killing by different DNA-damaging agents.…”
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Long term proliferation and physiological response of embryogenic callus in Slash pine (Pinus Elliottii Engelm) by Zishan Cheng, Cangfu Jin, Min Yi, Jinwen Xie, Meng Lai, Xiujing Xiao, Lu Zhang

“…The optimized long-term proliferation culture system for EC in slash pine provides an efficient approach to enhance the production of EC and SE.…”
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Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets by Xinjin Liu, Jiangpeng Feng, Qiuhan Zhang, Dong Guo, Lu Zhang, Tao Suo, Wenjia Hu, Ming Guo, Xin Wang, Zhixiang Huang, Yong Xiong, Guozhong Chen, Yu Chen, Ke Lan

“…Different primers/probes sets have been developed all over the world for the nucleic acid detection of SARS-CoV-2 by quantitative real time polymerase chain reaction (qRT-PCR) as a standard method. …”
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Comparative analysis of duck Tembusu virus Cluster 1 and Cluster 2.1 in Culex tritaeniorhynchus: Insights into viral characteristics, infectivity, and innate immune response by Chalida Sri-in, Duangduean Prakairungnamthip, Kanana Rungprasert, Aunyaratana Thontiravong, Lyric C. Bartholomay, Sonthaya Tiawsirisup

“…Interestingly, DTMUV2.1 was more efficient than DTMUV1 in inducing the production of mRNAs for macroglobulin complement-related factor, thioester-containing protein, and antimicrobial peptides (cecropin family) within the mosquito salivary gland. …”
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Biostimulant Effect and Antioxidant Responses of Carrot Extract and the Viability of Rice Seeds Under Salt Stress by Sheila Bigolin Teixeira, Stefânia Nunes Pires, Caroline Hernke Thiel, Cristiane Deuner, Diogo da Silva Moura, Natalia da Silva Garcia, Filipe Selau Carlos, Fernanda Reolon de Souza, Te Ming Tseng, Sidnei Deuner

“…Aqueous extracts of carrot roots at concentrations of 0% (water), 25%, 50%, and 100% were used to soak rice seeds for 48 h, which were then subjected to different concentrations of NaCl (0, 25, 75, and 150 mM). …”
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Bright Luminal Sign on High b-Value Diffusion-Weighted Magnetic Resonance Enterography Imaging as a New Biomarker to Predict Fibrotic Strictures in Crohn’s Disease Patients: A Retr... by Luca Pio Stoppino, Stefano Piscone, Ottavia Quarta Colosso, Sara Saccone, Paola Milillo, Nicola Della Valle, Rodolfo Sacco, Alfonso Reginelli, Luca Macarini, Roberta Vinci

“…These findings indicate that DWI hyperintensity can be considered as a good non-invasive indicator for the detection of severe intestinal fibrosis and may provide an efficient and accurate method for assessing fibrotic strictures. …”
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Microwave-assisted extraction of essential oils from basil leaves (Ocimum basilicum L.) and coriander seeds (Coriandrum sativum L.): A comparative study on chemical composition, an... by G.M. Masud Rana, Subarna Sandhani Dey, Bijoy Chandra Ghos, Md. Jasim Uddin, Tahmina Akter Chowdhury, Md. Tariqul Islam, Toufikur Rahman, Md. Jobayear Hossain, Jaytirmoy Barmon, Mst. Sarmina Yeasmin

“…Microwave-assisted extraction (MAE) has emerged as a green, efficient and rapid technique for extracting EOs from plant sources. …”
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3-O-trans-p-coumaroyl esterification enhances the anti-inflammatory effects of tormentic acid by targeting NF-κB signaling by Mara Heckmann, Lea Karlsberger, Bernhard Blank-Landeshammer, Gerald Klanert, Nadiia Sadova, Verena Stadlbauer, Georg Sandner, Theresa Gramatte, Simone Kasis, Julian Weghuber

“…Pro-inflammatory cytokine production in LPS-stimulated THP-1 macrophages was analyzed through cytokine arrays and multiplex immunoassays, while NF-κB activation was examined in both TLR4-dependent and -independent models using HEK-Blue reporter cells. Uptake efficiencies into Caco-2 enterocytes were measured via LC-MS. …”
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Performance Analysis and Computational Interface for <italic>X &#x2013; R</italic> Intuitionistic Fuzzy Control Chart by Amanda Dos Santos Mendes, Tulio S. Almeida, Marcela A. G. Machado, Paloma Maria Silva Rocha Rizol

“…This work showed that intuitionistic fuzzy control charts are efficient at detecting special causes, and that the computer interface developed is capable of performing the proposed functions.…”
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Multiple-omics analysis of three novel haloalkaliphilic species of Kocuria revealed that the phenolic acid-degrading abilities are ubiquitous in the genus by Lian Xu, Lian Xu, Rui-Qi Sun, Jia-Hui Zeng, Hua-Mei Wei, Biao Shen, Ji-Quan Sun

“…All five Kocuria strains could efficiently degrade ferulic acid (FA) and cinnamic acid (CA) under saline-alkaline conditions. …”
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Cardioattentionnet: advancing ECG beat characterization with a high-accuracy and portable deep learning model by Youfu He, Youfu He, Youfu He, Yu Zhou, Yu Zhou, Yu Qian, Jingjie Liu, Jinyan Zhang, Debin Liu, Qiang Wu, Qiang Wu

“…This situation highlights the necessity for an automated, efficient, and real-time detection method aimed at enhancing diagnostic accuracy and improving patient outcomes.MethodsThe present study is centered on the development of a portable deep learning model for the detection of arrhythmias via electrocardiogram (ECG) signals, referred to as CardioAttentionNet (CANet). …”
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Equalizer Design: HBOA-DE-trained radial basis function neural networks by Santosh Kumar Das, Satya Ranjan Pattanaik, Pradyumna Kumar Mohapatra, Saroja Kumar Rout, Abdulaziz S. Almazyad, Muhammed Basheer Jasser, Guojiang Xiong, Ali Wagdy Mohamed

“…Both BOA and DE are advantageous in the proposed algorithm, which permits it to produce efficient results by balancing exploration and exploitation. …”
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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy by Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer, Ulrich Brinkmann

“…We demonstrate that targeted on-cell prodrug conversion is more efficient than nonspecific activation in-solution. …”
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Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of <i>Mycobacterium tuberculosis</i> by Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan

“…<i>Background and Objective</i>: ATP-binding cassette (ABC) transporters are prominent drug targets due to their highly efficient trafficking capabilities and their significant physiological and clinical roles. …”
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A Comparison of Tests for Detecting Prior Exposure to <i>Coxiella burnetii</i> for Use with Q-VAX in Australian Human Q Fever Vaccination by Stephen Graves, Jennifer Robson, Anja Scholzen, Richard Dzeng, Francisca Powell-Romero, Jennifer Evans, John Stenos, Meg Jeppesen, Milou L. C. E. Kouwijzer, Jordi Lankhof, Susan Raju Paul, Tatiana Proboste Ibertti, Lauren Ball, Helen Powell, Stephanie Wilkinson, Evi van Schuppen, Willemijn J. Anker-Op den Brouw, Rowland Cobbold, Anja Garritsen, Mark C. Poznansky, Ann E. Sluder

“…The week-long interval for skin test assessment limits efficient vaccination. This study evaluated a standardized interferon-γ release assay (IGRA) as a potential skin test alternative. …”
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Optimization of Mangiferin extraction from Mangifera Indica leaves Peruvian Criollo variation using ultrasound assisted surface response methodology by Elena Sofia Espinoza Rodríguez, Stephanie Elena Sosa Pulcha, Naysha Y. M․ Elguera, Abdel Alejandro Portocarrero Banda, Hugo Guillermo Jiménez Pacheco

“…These findings confirm that UAE is an efficient technique for extracting mangiferin while minimizing solvent use and processing time. …”
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Characterization of key spike RBD residues influencing SARS-CoV-2 variant adaptation to avian ACE2 by Weitong Yao, Yujun Li, Huize Sun, Danting Ma, Xiaojuan Tang, Xiaojuan Tang, Aiping Zeng, Fang Huang

“…IntroductionThe beta-coronavirus SARS-CoV-2 has been revealed to infect mammals and other species, which potentially promotes the virus adaptation to broader species and the emergence of new variants. The host range of different SARS-CoV-2 variants are mainly determined by the affinity of the receptor-binding domain (RBD) of the spike protein to the host receptor angiotensin-converting enzyme 2 (ACE2). …”
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Research on horizontal multi-step cavity construction for salt cavern gas storage based on experiments by Jiasong CHEN, Xuefeng BAI, Guijiu WANG, Lianbin ZHAO, Jun LU, Lilin FAN, Haosheng LIU, Luokun XIAO

“…ObjectiveGiven that most salt rock strata in China consist of thin-layered salt formations, conventional single-well and single-cavity construction technologies are no longer adequate for the efficient construction of large-size salt cavities. …”
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