An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…Here, we introduce a systemic MPRA (sysMPRA) to address these challenges through systemic intravenous AAV viral delivery.Results: We demonstrate successful transduction of the MPRA library into diverse mouse tissues, efficiently identifying tissue specificity in candidate enhancers and aligning well with predictions from machine learning models. …”
Get full text

Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues by Mohsen Safaei, Seyedeh Somayeh Rajabi, Mahtab Tirgar, Najmeh Namdar, Mahsa Dalfardi, Farnia Mohammadifar, Arash Goodarzi, Ahmad Reza Farmani, Vahid Ramezani, Zahra Abpeikar

“…However, the potential of exosomes can be used by engineering them and considering different therapeutic approaches to overcome tumors. …”
Get full text

Pulsed field ablation using a circular electrode array catheter in patients with atrial fibrillation: A workflow optimization study evaluating the role of mapping by Melanie A. Gunawardene, Jens Hartmann, Jannis Dickow, Rahin Wahedi, Tim Harloff, Johanna Jezuit, Eike P. Tigges, Mario Jularic, Borislav Dinov, Nele Gessler, Stephan Willems

“…Pre- and post-ablation hemoglobin (14.4 ± 1.4 vs. 13.5 ± 1.2 g/dl, p = 0.0169) and LDH (188 ± 39 vs. 210 ± 29 U/l, p = 0.0007) were different. Conclusion: The cPFA-catheter allows for fast and efficient PVI. …”
Get full text

COOLFACADE by Alejandro Prieto Hoces

“…In order to achieve the research goal and comprehensively assess the façade integration potential of solar technologies and discuss current barriers, different aspects must be acknowledged. These distinct aspects are addressed through several research questions, which in turn define the different chapters of the dissertation. …”
Get full text

Effects of Salinity on the Growth Performance and Nutritional Composition of Artemia by Xiaodong JIANG, Ying WANG, Hongyan LI, Xinfeng ZHANG, Xiao FENG, Chen ZHONG, Yuanqin SUN

“…Artemia was cultured under four different salinities (30, 60, 90, and 120) for 14 days. …”
Get full text

Planning with self‑organised initiatives by Igor Tempels Moreno Pessôa

“…Although this process differs from region to region, rapid urbanisation has created many challenges for countries in the Global South. …”
Get full text

Major Sorghum Production Constraints and Coping Mechanisms: The Case of Anthracnose (Colletotrichum sublineolum) by Kebede Dessalegn Lemu, Peter Ogbonna, Christian Agbo, Dagnachew Lule

“…Recent advancement of molecular breeding and bio-informatics tools are playing a significant role in efficiencies and precisions of resistance breeding. QTLs or genomic area for resistance were identified using traditional molecular markers and recent research results revealed discoveries of specific gene and locus using high throughput markers like SNPs using GWAS approach. …”
Get full text

Application of QVP Method to Winter Precipitation Observation Based on Polarimetric Radar by Guan Li, Dai Jianhua, Tao Lan, Yin Chunguang, Meng Fanwang

“…In 3 different synoptic system governing snow cases affecting Shanghai, the QVPs retrieved from dual-polarization radars at elevations of 19.5ånd 9.9åre demonstrated to successfully monitor the evolution of melting layer and Bergeron process. …”
Get full text

Atomic-scale Simulation Study of Creep Behavior in Nanocrystalline Mo by NI Weixuan, JIA Lixia, DOU Yankun, HE Xinfu, CAO Jinli, WANG Dongjie, YANG Wen

“…Given that experimental creep tests require long durations, molecular dynamics (MD) simulation offers an efficient alternative for studying atomic-scale processes at grain boundaries. …”
Get full text

ABCB1 confers resistance to carboplatin by accumulating stem-like cells in the G2/M phase of the cell cycle in p53null ovarian cancer by Danbi Lee, Hyun-Seok Jeong, Sun-Young Hwang, Yu-Gyeong Lee, Youn-Jung Kang

“…However, the molecular mechanisms of action behind acquired drug resistance, particularly in relation to different TP53 mutation types, have not been fully elucidated. …”
Get full text

PictureGuard: Enhancing Software-Defined Networking–Internet of Things Security with Novel Image-Based Authentication and Artificial Intelligence-Powered Two-Stage Intrusion Detect... by Hazem (Moh’d Said) Hatamleh, As’ad Mahmoud As’ad Alnaser, Said S. Saloum, Ahmed Sharadqeh, Jawdat S. Alkasassbeh

“…When integrated with the Internet of Things (IoT), SDN addresses critical challenges such as security and efficient network management, positioning the SDN-IoT paradigm as an emerging and impactful technology in modern networking. …”
Get full text

Eukfinder: a pipeline to retrieve microbial eukaryote genome sequences from metagenomic data by Dandan Zhao, Dayana E. Salas-Leiva, Shelby K. Williams, Katherine A. Dunn, Jason D. Shao, Andrew J. Roger

“…Compared to other workflows, Eukfinder offers the potential to recover high-quality, near-complete genomes of diverse eukaryotes, including different Blastocystis subtypes, without relying on a reference genome. …”
Get full text

Unraveling Burkholderia cenocepacia H111 fitness determinants using two animal models by Sarah Paszti, Stefano Gualdi, Marta Torres, Luis Augusto, Freya Harrison, Leo Eberl

“…Our results highlight the power of the transposon sequencing approach to identify new targets for infection treatment and show the importance of using different infection models.…”
Get full text

Research note: Comparison of live attenuated and non-attenuated Eimeria vaccines on safety following overdose administration using the European pharmacopoeia monograph model by Marc Pagès, Andreu Albó, Gregori Bech-Sàbat, Roser Morató, Joan Molist-Badiola, Martina Dardi

“…Birds receiving the attenuated vaccine showed significantly increased mean body weight at day 14 (P < 0.001), without differences from the control group. Feed consumption was similar and lower in the control and attenuated vaccine groups, while was higher in the non-attenuated vaccine groups (from day 6 to day 14), indicating a more efficient feed conversion ratio (not significant). …”
Get full text

Preparation and Physicochemical Properties of High-purity Isomaltooligosaccharides by Sequential Simulated Moving Bed Chromatography by Shenghui RUAN, Xiqun ZHENG, Xiaolan LIU, Liangyu LI

“…The separation degree of different types of cation exchange resin on isomaltooligosaccharides, monosaccharides and disaccharides mixture was compared, ZG106 K+ resin was selected as the suitable separation medium. …”
Get full text

Assessment of textile sludge pyrolysis behaviour through advance predictive models for bioenergy production by Arslan Khan, Asif Hussain Khoja, Salman Raza Naqvi, Waheed Miran, Imtiaz Ali

“…This study investigates the pyrolysis of textile sludge through thermogravimetric analysis (TGA) conducted from ambient temperature to 1000 °C at three different heating rates of 2.5, 5 and 7.5 °C/min in an inert environment. …”
Get full text

Remaining Useful Life Prediction for Rolling Bearings Based on TCN–Transformer Networks Using Vibration Signals by Xiaochao Jin, Yaping Ji, Shiteng Li, Kailang Lv, Jianzheng Xu, Haonan Jiang, Shengnan Fu

“…In addition, a new RUL prediction method, TCN–Transformer, is developed which can efficiently learn and integrate local and global features of vibration signals, addressing the long time series prediction problem in RUL prediction. …”
Get full text

Biodegradation mechanisms of p-nitrophenol and microflora dynamics in fluidized bed bioreactors by Xin Zheng, Yongjie Zhang, Yongjie Zhang, Zhiheng Ye, Zhiyan Pan

“…This study highlights an efficient, sustainable and cost-effective approach for PNP removal from agricultural and industrial wastewater.…”
Get full text

MISTIC: a novel approach for metastasis classification in Italian electronic health records using transformers by Livia Lilli, Mario Santoro, Valeria Masiello, Stefano Patarnello, Luca Tagliaferri, Fabio Marazzi, Nikola Dino Capocchiano

“…Furthermore, MISTIC demonstrates strong generalization across different data sources, reinforcing its potential as a scalable and transparent solution for clinical text classification. …”
Get full text

Preparing Lawyers for the Twenty-First Century by William Twining

“…Whether we are doing so as efficiently, as imaginatively or as professionally as we might is another matter. …”
Get full text