Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations by Frédéric A. Dreyer, Constantin Schneider, Aleksandr Kovaltsuk, Daniel Cutting, Matthew J. Byrne, Daniel A. Nissley, Henry Kenlay, Claire Marks, David Errington, Richard J. Gildea, David Damerell, Pedro Tizei, Wilawan Bunjobpol, John F. Darby, Ieva Drulyte, Daniel L. Hurdiss, Sachin Surade, Newton Wahome, Douglas E.V. Pires, Charlotte M. Deane

“…We present a computational pipeline for the discovery and design of therapeutic antibody candidates, which incorporates physics- and AI-based methods for the generation, assessment, and validation of candidate antibodies with improved developability against diverse epitopes, via efficient few-shot experimental screens. We demonstrate that these orthogonal methods can lead to promising designs. …”
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A Convenient and Efficient Strategy for Improving Separation Ability of Capillary Electrophoresis Through Tilting Capillary as Needed by Wenhui Jia, Pingyi Zheng, Yuchen Cui, James J. Bao, Yanmei Xu, Youxin Li

“…It significantly improved separation efficiencies of some small molecules, chiral compounds, macromolecules and cells when the tilt angles of the capillary were adjusted to a special range predicted through the fitting curve. …”
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INFLUENCE VALUATION OF ASYNCHRONOUS MOTOR CONSTRUCTIVE MODIFICATIONS WITHOUT TOOTH AREA CORRECTION ON ITS ENERGY EFFICIENCY by Irina Romanenko, Maksim Danilov

“…For various combinations of these parameters were received rated and maximum efficiency and rated power factor. It was found the optimal combination of simulated changes, which differs from the original design solution.…”
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SPEMix: a lightweight method via superclass pseudo-label and efficient mixup for echocardiogram view classification by Shizhou Ma, Yifeng Zhang, Delong Li, Yixin Sun, Zhaowen Qiu, Lei Wei, Suyu Dong

“…IntroductionIn clinical, the echocardiogram is the most widely used for diagnosing heart diseases. Different heart diseases are diagnosed based on different views of the echocardiogram images, so efficient echocardiogram view classification can help cardiologists diagnose heart disease rapidly. …”
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Toward an Efficient Differentiation of Two <i>Diaporthe</i> Strains Through Mass Spectrometry for Fungal Biotyping by Kathleen Hernández-Torres, Daniel Torres-Mendoza, Gesabel Navarro-Velasco, Luis Cubilla-Rios

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Improving efficiency of road transport through the use of hydrodiodes in hydraulic systems taking into account cavitation phenomena by K. N. Sokirko, E. A. Pavliuchenko, E. A. Lysenko

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A study on an efficient citrus Huanglong disease detection algorithm based on three-channel aggregated attention by Yizong Wang, Zhengrong Xiao, Hong Wang, Fei Li, Jiya Tian

“…Background Aiming at the problems of complex and diverse field symptoms of citrus Huanglong disease (HLB), low efficiency and insufficient recognition accuracy of traditional detection methods, this study proposes an efficient detection algorithm based on improved You Only Look Once (YOLO)v8. …”
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EFFICIENT INTRODUCTION OF COMPLEMENTARY FOODS FOR CHILDREN WITH ATOPIC DERMATITIS AND PREDISPOSITION TO ALLERGIC REACTIONS FOR PREVENTION OF ATOPIC MARCH by A.V. Kamaev

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Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat by Dipendra Shahi, Jia Guo, Md Ali Babar, Sumit Pradhan, Muhsin AVCI, Jordan McBreen, Zhao Liu, Guihua Bai, Paul St. Amand, Amy Bernardo, Matthew Reynolds, Gemma Molero, Sivakumar Sukumaran, John Foulkes, Jahangir Khan

“…Abstract Background Grain number (GN) is one of the key yield contributing factors in modern wheat (Triticum aestivum) varieties. Fruiting efficiency (FE) is a key trait for increasing GN by making more spike assimilates available to reproductive structures. …”
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Anaerobic Co-Digestion of Dairy Manure and Cucumber Residues: Methane Production Efficiency and Microbial Community Characteristics by Yanqin Wang, Yan Li, Yumeng Qi, Longyun Fu, Guangjie Li, Zhaodong Liu, Luji Bo, Yongping Jing

“…The microbial community structure changed with different TS levels. This study offers valuable scientific insights for enhancing biogas production efficiency in co-digestion systems.…”
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Efficient Online Recruitment of Patients With Depressive Symptoms Using Social Media: Cross-Sectional Observational Study by Carolin Haas, Lisa Klein, Marlene Heckl, Marija Kesić, Ann-Katrin Rueß, Jochen Gensichen, Karoline Lukaschek, Tobias Kruse

“…Although some studies have investigated the advantages and disadvantages of using social media for recruitment, a considerable gap still exists in understanding the precise mechanisms and factors that make different social media platforms most effective and cost-efficient for patient recruitment in mental health studies. …”
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Experimental Study and Optimization of Shredding Speed to Improve the Efficiency of Small-Sized Disc Shredder for Plant Residues by Vitaliy V. Krasovskiy, Yuriy B. Gerber

“…The experimental data have confirmed the importance of optimizing small-sized shredders to increase their efficiency and reduce energy consumption. The results of the work can be used to develop more economical and efficient shredder models, which will have a positive impact on the environmental and economic situation in agriculture.…”
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POLYMORPHISM OF THE GENE OF β2-ADRENERGIC RECEPTOR AND EFFICIENCY OF THE BRONCHOLYTIC THERAPY AMONG CHILDREN WITH BRONCHIAL ASTHMA by O.N. Bryantseva, E.E. Tikhomirov, N.V. Zhurkova, N.I. Voznesenskaya, G.M. Bayazutdinova, N.S. Aver'yanova, I.I. Balabolkin, V.G. Pinelis

“…The objective of our research was to evaluate the significance of ADRβ2 gene polymorphism in the 16th amino acid position in the efficiency of broncholytic therapy by β2-agonists agonists among children with bronchial asthma. …”
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Mesoporous Silica Supported Au Nanoparticles with Controlled Size as Efficient Heterogeneous Catalyst for Aerobic Oxidation of Alcohols by Xuefeng Chu, Chao Wang, Liang Guo, Yaodan Chi, Xiaohong Gao, Xiaotian Yang

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Optimizing HVAC&R System Efficiency and Comfort Levels Using Machine Learning-Based Control Methods by Suroor M. Dawood, Raad Z. Homod, Alireza Hatami

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Optimizing energy use efficiency and environmental performance in cotton and canola production using the Imperialist Competitive Algorithm by Mousa Mirmoradi, Mohammad Gholami Parashkoohi, Hamed Afshari, Ahmad Mohammadi

“…This study focuses on optimizing energy efficiency and environmental performance in the production of cotton and canola through the application of the Imperialist Competitive Algorithm (ICA). …”
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Scoping Opportunities for Nitrogen Use Efficiency Among Productive Agricultural Forage Grasses With Diverse Rooting Systems by N. P. K. Muhandiram, M. W. Humphreys, R. Fychan, J. W. Davies, M. B. Scott, J. Harper, A. Thomas, H. Powell, R. Sanderson, C. L. Marley

“…ABSTRACT For forage production to be efficient and environmentally sustainable, the extent and timing of nitrogen fertiliser applications should match the uptake and growth capabilities of a grass crop. …”
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METHODS FOR THE CHOOSING THE RATIONAL COMBINATION AND COMPARISON OF THE CHARACTERISTICS AND FACTORS OF THE EFFICIENCY OF THE PRODUCTION PROCESSES AND TECHNOLOGIES OF THE BOREHOLE D... by V. V. Kulikov

“…The paper considers the methods for choosing the rational combination and comparison of the measured characteristic sand factors, used during decisions making, designing and assessment the efficiency of the production processes and boreholes drilling technologies. …”
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Dynamic Topology Optimization of Constrained Damping Plates considering Frequency and Temperature Characteristics Based on an Efficient Strategy by Fan Wu, Pu Xue

“…The findings indicated that a positive compromise between accuracy and efficiency can be achieved, and the computational time can be significantly reduced while ensuring the accuracy of the results. …”
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ANALYSIS OF THE EFFICIENCY OF THE IMPLEMENTATION OF FINANCING PROGRAMS FROM THE EUROPEAN SOCIAL FUND ON EDUCATION IN THE RURAL ENVIRONMENT IN ROMANIA by Mihaela GRECU (FRĂȚEA), Constantin Adrian SURLEANU, Ovidiu GUȘAN, Dragos Ion SMEDESCU, George VLAD, Răzvan PANAIT, Valentina Constanța TUDOR

“…In conclusion, recommendations will be proposed to optimize the efficiency of the implementation of ESF financing programs, for the purpose of rural education and supporting sustainable rural development.…”
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