Longitudinal Digital Phenotyping of Multiple Sclerosis Severity Using Passively Sensed Behaviors and Ecological Momentary Assessments: Real-World Evaluation by Zongqi Xia, Prerna Chikersal, Shruthi Venkatesh, Elizabeth Walker, Anind K Dey, Mayank Goel

“…ObjectiveWe aimed to develop and evaluate a machine learning (ML)–based digital phenotyping approach to monitor the severity of clinically-relevant MS symptoms. …”
Get full text

Clinical manifestations of COVID-19 infection and its impact on the outcome in children and adolescents with benign and malignant hematological disease in Egypt: a single-center ex... by Fatma Soliman Elsayed Ebeid, Aya Mostafa, Sondos M. Magdy, Haidy Moahmed Abd El Kader, Amal Abdel Azim Lotfy, Nihal Hussien Aly

“…Few reports describe the clinical manifestations and outcomes of COVID-19 infection in children and adolescents with benign and malignant hematological disease with a large sample size from our Egyptian population. Aim As a preliminary step in developing a national registry for children and adolescents with hemato-oncological disease who were diagnosed with COVID-19 infection, in this study we aimed to determine (a) the frequency of COVID-19 infection in children with hematological disease, (b) the presenting clinical manifestations, and (c) the associated underlying disease outcome and its clinical determinants. …”
Get full text

Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
Get full text

Combined Esculentin-2CHa Fusion Protein-Coated Au Nanoparticles for Effective Against Non-Alcoholic Fatty Liver Disease in Mice Model by Amatya R, Joseph A, Roh GS, Moon C, Benmokadem Y, Kim D, Min KA, Shin MC

“…In this research, a long-acting esculentin-2CHa(1-30)-coated AuNPs (ESC-ABD-AuNPs) was developed and the applicability was evaluated for their use in the treatment of non-alcoholic fatty liver disease (NAFLD).Methods: ESC-ABD-AuNPs were synthesized by adopting a 1-step reduction process and the successful preparation of the nanoparticles (NPs) was assessed by various physical characterizations including transmission electron microscopy (TEM), ultraviolet-visible (UV-VIS) absorption spectra, dynamic light scattering (DLS), and Fourier Transform Infrared Spectroscopy (FT-IR). …”
Get full text

Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement by Li J, Leung SSY, Chan EHY, Jiang C, Ho ETY, Zuo Z

“…In the current study, formulation strategies and routes of administration were assessed to enhance systemic and brain uptake of piperine.Methods: Formulation of piperine nanoparticles (PIP NPs) was developed to enhance its solubility. PIP NPs were prepared using flash nanoprecipitation via a four-stream Multi-Inlet Vortex Mixer, employing an aqueous solution of poloxamer 188 and an ethanolic solution containing piperine and Eudragit L100-55. …”
Get full text

Internally Catalyzed Hydrogen Atom Transfer (<i>I-CHAT</i>)—A New Class of Reactions in Combustion Chemistry by Rubik Asatryan, Jason Hudzik, Venus Amiri, Mark T. Swihart

“…The current paradigm of low-T combustion and autoignition of hydrocarbons is based on the sequential two-step oxygenation of fuel radicals. The key chain-branching occurs when the second oxygenation adduct (OOQOOH) is isomerized releasing an OH radical and a key <i>ketohydroperoxide</i> (KHP) intermediate. …”
Get full text

Unraveling natural carbonate variability in Narragansett Bay, RI using multiple high temporal resolution pH time series by Abigail Baskind, Georgia Ahumada, Kristofer Gomes, Heather Stoffel, Shuai Gu, Andrew J Davies, Andrew J Davies, Hongjie Wang

“…OA is well-studied in open ocean environments; however, understanding the unique manifestation of OA in coastal ecosystems presents myriad challenges due to considerable natural variability resulting from concurrent and sometimes opposing coastal processes—e.g. eutrophication, changing hydrological conditions, heterogeneous biological activity, and complex water mass mixing. Developing a mechanistic understanding of carbonate chemistry variability and its drivers across different time scales is a critical first step in identifying the anthropogenic OA signal against background variability and predicting future OA in coastal systems. …”
Get full text

30 Years of Research in Brand Personality: Mapping Knowledge and Analyzing the Thematic Structure by a Scientometrics Approach by Mohammad Rahim Esfidani, Mohsen Nazari, Shahriar Gharibzadeh, Nakisa Rezaie

“…The methodology involves a five-step literature review process: identification, selection, eligibility, and inclusion. …”
Get full text

Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental... by Kaeley M. Simpson, Robert J. W. McHardy, J. Grace Zhou, Sydney Levasseur-Puhach, Cynthia M. Côté, Millie Braun, Fiona Clement, Anna L. MacKinnon, Nathan Nickel, Tracie O. Afifi, Gerald F. Giesbrecht, Ryan Giuliano, Laurence Y. Katz, Lauren E. Kelly, Terry P. Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M. Hensel, James M. Bolton, Jo Ann M. Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E. Roos

“…In response, we developed the Building Emotional Awareness and Mental Health (BEAM) program, an innovative mobile health (mHealth) solution for parents of young children. …”
Get full text

Uterine layers hypervascularization in atypical placentation: the comparison of magnetic resonance imaging with vascular pathomorphology by Polina V. Kulabukhova, Natalia V. Nizyaeva, Andrey P. Milovanov, Ksenia A. Artemyeva, Vladimir A. Mhitarov, Vladimir G. Bychenko

“…Also, abnormal vessels location and their wall structure have not been studied with state-of-the-art pathomorphological methods. Aim: To develop a classification for various types of the uterine wall hypervascularization depending on the depth of placental invasion assessed by magnetic resonance imaging (MRI). …”
Get full text

Welfare impacts during and after reproductive procedures for in vivo embryo production and transfer in Holstein dairy heifers by D. Ledoux, A. de Boyer des Roches, P. de Roover, C. Roque, S. Lancelin, B. Deloupy-Dobin, P. Salvetti

“…Acknowledging that some discomfort/pain may be present, it may be welfare-friendly to develop and apply refinement strategies during and after embryo technology procedures.…”
Get full text

On electrochemical corrosion of mechano-activated and thermally processed AlxCryNiz 2D decagonal quasicrystalline structures and crystalline approximants by Meysam Amini, Seyed Ali Tayebifard, Irandokht Jahanian Bahnemiri

“…Both Al72Cr15Ni13 and Al86Cr12Ni2 alloys develop a protective passive film in 0.1 mol/L Na2SO4 electrolyte. …”
Get full text

A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation by Thanh Tai Duong, Danny De Sarno, Hatim Fakir, Glenn Bauman, Martin Martinov, Rowan M. Thomson, Ting-Yim Lee, Ting-Yim Lee, Ting-Yim Lee

“…Our voxel-based approach demonstrates significant dose variations in prostate cancer patients under standard TRT with a one-size-fits-all radioligand dose, enabling pre-treatment dose personalization—a critical step toward precision radiotheranostics.MethodsDynamic PET/CT scans obtained with 18F-DCFPyL over 22 min from six prostate cancer patients were used in this study. …”
Get full text

Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial by Taylor B Thompson, Todd W Rice, Guy N Brock, Jonathan Peters, Elliott D Crouser, Matthew Exline, Sonal R Pannu, Jamie Zimmer, Jeffrey C Horowitz

“…Conversely, arterial oxygen saturation (SaO2) offers accuracy but is costly and invasive. We aim to develop a novel approach to targeted oxygenation that collectively uses the accuracy of SaO2 and the feasibility of SpO2 to mitigate occult hypoxaemia and prevent hyperoxaemia.Methods and analysis The Optimization of Inspired Oxygen during Mechanical Ventilation trial is a pragmatic stepped wedge, open label, cluster-randomised controlled trial of an algorithm-based SpO2-SaO2 electronic alert-based oxygen titration protocol. …”
Get full text

A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case-control study. by Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic

“…At a pre-selected cutoff of >80% SN and SP for the affiliated PancRISK score, we demonstrate a clinically applicable risk stratification tool with a binary output for risk of developing PDAC ('elevated' or 'normal'). PancRISK provides a step towards precision surveillance for PDAC patients, which we will test in a prospective clinical study, UroPanc.…”
Get full text

Análisis de la eficacia del patrocinio de WorldSBK desde la perspectiva de los asistentes en el campeonato de Jerez (Analysis of the efficacy of sponsorship of WorldSBK from the pe... by Marta Visa Carol, Fransesc Xavier de Blas i Foix, Sixte Abadia i Naudí

“…The most significant results indicate that the factors behind the success of sports sponsorship in the WorldSBK are: level of fandom, brand awareness, favourable attitude towards the event, favourable attitude towards the sponsor, and purchase intention.This paper should be the step-in order to develop a methodology to analyze sponsorship. …”
Get full text

A qualitative study on health education knowledge demands of patients after gastric cancer surgery before discharge (胃癌术后患者出院前健康教育知识需求的质性研究)... by LAI Shurong (赖淑蓉), LAI Xiaoning (赖小令), YU Xiaoqing (喻小青), HUANG Xiaoyi (黄小恬)

“…Methods An interview outline was developed based on Maslow's hierarchy of needs theory. …”
Get full text

Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…This model is an important step toward understanding how power errors propagate within a comagnetometer. …”
Get full text

Emisión Acústica y Redes Neuronales para Modelado y Caracterización del Proceso de Soldadura por Fricción Agitación by Emilio Jiménez Macías, Angel Sánchez Roca, Hipólito Carvajal Fals, Julio Blanco Fernández, Juan C. Sáenz-Diez Muro

“…The model obtained can be used to develop the automatic control of the parameters of the FSW process, based on vibro-acoustic signals, which constitutes the following step in this research line. …”
Get full text

Identifying the Antecedents of Humble Leadership for Managers with a Meta-synthesis Approach by Tahereh Mohammadi, Adel Zahedbabelan, Ali Khaleghkhah, Hossein Taghavi Qarabulagh

“…Methods This research employed a qualitative approach, leveraging the seven-step hybrid method developed by Sandelowski and Barroso (2007). …”
Get full text