Implementation of Priority Measures to Eliminate the Accumulated Environmental Damage Caused by Chemical Enterprises in the City of Usolye-Sibirskoye, Irkutsk Region by S. A. Maltsev, E. V. Veber, V. A. Inozemtsev, M. V. Tsapok, P. Y. Belyakov, V. A. Kovtun, A. A. Antokhin

“…A difficult situation, close to an environmental disaster, had been developing in the town of UsolyeSibirskoye, Irkutsk Region, since the 90s of the ХХ century. …”
Get full text

Parsimonious and explainable machine learning for predicting mortality in patients post hip fracture surgery by Fouad Trad, Bassel Isber, Ryan Yammine, Khaled Hatoum, Dana Obeid, Mohammad Chahine, Rachid Haidar, Ghada El-Hajj Fuleihan, Ali Chehab

“…Abstract Hip fractures among the elderly population continue to present significant risks and high mortality rates despite advancements in surgical procedures. …”
Get full text

The prevalence of metabolic syndrome in patients with non-alcoholic fatty liver disease in primary care clinics at King Saud University Medical City, Riyadh, Saudi Arabia by Alanoud Maan Alyousef, Alanoud Maan Alyousef, Doaa Zeinhom Mekawy, Doaa Zeinhom Mekawy, Yaser Yousef Bashumeel, Saleh Magdy Mohamed, Turky H. Almigbal, Turky H. Almigbal, Mohammed A. Batais, Mohammed A. Batais, Abdullah A. Alrasheed, Abdullah A. Alrasheed

“…BackgroundMetabolic syndrome is present in a subset of individuals harboring a constellation of metabolic risk factors that heightens their likelihood of developing coronary artery disease. Non-alcoholic fatty liver disease (NAFLD) manifests through the incremental accumulation of fat within liver cells in the absence of secondary causes. …”
Get full text

Diagnosis of the risk, or existence of immunodeficiency state in children associated with sub-atrophy and petrification of the thymus by Yu. I. Rovda, A. V. Vedernikova, A. V. Shabaldin, I. K. Khalivopulo, M. L. Filipenko, N. N. Minyailova, O. V. Shmakova, G. A. Otstavnov, T. M. Vakulova, O. S. Bukhtoyarova, N. V. Krasnova, T. A. Anchikova, R. A. Mukhamadiyarov, V. V. Dadonov, M. V. Katanakhova, A. V. Torgunakova

“…Timely diagnosis of immunodeficiency states (IDS) in children still presents significant issues, especially, when they develop due to failure of the thymus. Thymus pathology may be caused not only by fetogenetic reasons, but also by premature age-related involution caused by the impact of “excessive” stress factors such as infection, continuous hunger, chemotherapy, radiation exposure (including X-ray studies), prolonged hypoxia, tuberculosis infection, tumor growth, etc. …”
Get full text

TIGIT blockade in the context of BCMA-CART cell therapy does not augment efficacy in a multiple myeloma mouse model by Aina Oliver-Caldes, Joan Mañe Pujol, Anthony M. Battram, Lorena Perez-Amill, Mireia Bachiller, Hugo Calderon, Maria Castella, Judit Carpio, Sergi V. Salsench, Natalia Tovar, Oriol Cardus, Alvaro Urbano-Ispizua, David F. Moreno, Luis Gerardo Rodríguez-Lobato, Ester Lozano, Laura Rosiñol, Manel Juan, Beatriz Martín-Antonio, Carlos Fernández de Larrea

“…BCMA-directed CAR-T therapies have shown promising results in multiple myeloma (MM). However, patients continue to relapse. T cell exhaustion with increased TIGIT expression is a resistance mechanism which was confirmed in CAR-T cells from ARI0002h trial, an academic CAR-T developed in our institution. …”
Get full text

Impact of the SARS-COV-2 pandemic on access to health services in Angola: a focus on diagnosis and treatment services for tuberculosis by Susanna Caminada, Roberto Benoni, Roberto Benoni, Roberto Benoni, Maria Grazia Dente, Claudia Robbiati, Claudia Robbiati, Joaquim Tomas, Giulia Natali, Luca De Simeis, Nsuka Da Silvia, Neusa Lazary, Paulo Siene Tienabe, Giovanni Putoto, Marianna Costanzo, Fabio Manenti, Maria Elena Tosti

“…This highlights the urgent need for health systems to develop robust contingency plans to ensure the continuity of TB services during and after public health crises and to maintain essential healthcare services by supporting the healthcare workforce and addressing barriers to patient access.…”
Get full text

VA's EHR transition and health professions trainee programs: Findings and impacts of a multistakeholder learning community by Julian Brunner, Ellen A. Ahlness, Ekaterina Anderson, Brianne K. Molloy‐Paolillo, Alexandre Braga, Sarah L. Cutrona, Christian D. Helfrich, Deborah Levy, Erin Matteau, Edward Walton, George Sayre, Seppo T. Rinne

“…In this study, we describe the findings of this learning community and the practices and policies developed in response. Methods In the qualitative study designed and executed by our learning community, we conducted 51 interviews with HPTs, program leaders, and preceptors before and multiple times after an EHR transition site's go‐live (February 16, 2022 to April 7, 2023). …”
Get full text

DMP-PUNet: A novel network for two-dimensional InSAR phase unwrapping under severe noise and complex fringes conditions by Yu Chen, Shuai Wang, Yandong Gao, Yanjian Sun, Jinqi Zhao, Kun Tan, Peijun Du

“…Traditional methods, based on the assumption of phase continuity, often struggle with abrupt terrain changes and the influence of severe noise, leading to poor performance or failure. …”
Get full text

Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis by Lihui Liu, Lihui Liu, Yisong He, Yisong He, Gang Huang, Yangxi Zeng, Yangxi Zeng, Jiaan Lu, Ru He, Haiqing Chen, Yuheng Gu, Qingwen Hu, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan

“…Thus, there is an urgent need to develop adaptive public health measures against the dual health risks from extreme temperatures. …”
Get full text

Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 Neisseria meningitidis isolates causing invasive meningococcal disease in Argentina in 2010–2014 by Adriana Efron, Alessandro Brozzi, Alessia Biolchi, Margherita Bodini, Maria Giuliani, Silvia Guidotti, Federico Lorenzo, María Alicia Moscoloni, Alessandro Muzzi, Florencia Nocita, Mariagrazia Pizza, Rino Rappuoli, Sara Tomei, Gabriela Vidal, Carla Vizzotti, Josefina Campos, Cecilia Sorhouet Pereira

“…Estimated coverage by gMATS (61.3%; prediction interval: 55.5%, 66.7%) was consistent with the infant hSBA assay results. Continued genomic surveillance is needed to evaluate the persistence of major MenB CCs in Argentina.…”
Get full text

Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples by Dong Hwan Lee, Jae Ha Lee, Ji Hoon Jang, Yong Kyun Kim, Gaeun Kang, So Young Jung, Minyoung Her, Hang Jea Jang

“…On the other hand, in the ECMO model, the Imax for aPTT reduction was 43.6%, with an IC50 of 581 μg/L.ConclusionThe PK/PD models developed from samples collected from both the patient and the ECMO circuit indicate significant differences in PD. …”
Get full text

Intranasal Human-Recombinant Nerve Growth Factor Enhances Motor and Cognitive Function Recovery in a Child with Severe Traumatic Brain Injury by Lorenzo Di Sarno, Lavinia Capossela, Serena Ferretti, Luigi Manni, Marzia Soligo, Susanna Staccioli, Eleonora Napoli, Riccardo Burattini, Antonio Gatto, Antonio Chiaretti

“…After intensive care and rehabilitation, the child exhibited gradual improvements in consciousness and motor functions but continued to face challenges, particularly with left-sided hemiparesis. …”
Get full text

Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

“…New logistic regression models were further developed to predict the probability of recurrence. …”
Get full text

Effect of luseogliflozin on liver fibrosis differs depending on alcohol consumption in patients with type 2 diabetes by Hiroyuki Ito, Ryota Someya, Tomoko Koyanagi, Chiaki I, Shun Miura, Suzuko Matsumoto, Hideyuki Inoue, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane

“…Methods A total of 192 patients with type 2 diabetes who continued luseogliflozin therapy for over 12 months were retrospectively investigated. …”
Get full text

Coproduction in Social Prescribing Initiatives: Protocol for a Scoping Review by Madeline Dougherty, Tamara Tompkins, Elaine Zibrowski, Jesse Cram, Maureen C Ashe, Le-Tien Bhaskar, Kiffer George Card, Christina Godfrey, Paul Hebert, Ron Lacombe, Caitlin Muhl, Kate Mulligan, Gillian Mulvale, Michelle L A Nelson, Myrna Norman, Bobbi Symes, Gary Teare, Vivian Welch, Anita Kothari

“…We anticipate this review will guide clients, communities, stakeholders, and policy makers in further developing SP practice within health care systems. …”
Get full text

Sudanese medical students’ satisfaction with online learning and its association with their psychological distress: a cross-sectional study by Muhannad Bushra Masaad Ahmed, Ahmed Balla M. Ahmed, Moram Elfadel Abdelrhaman Gasmalha, Olla Zuhair Elamin Abdalla, Safinat Hassan Mohammed Ahmed, Blsam Abdelmoneam Ahmed Mohammed, Rabaa Alamein Omer Ebrahim, Maab Hisham Saeed Abdeen, Esraa Obeid Mohammed Babiker, Tasneem Abdelgader Abdelrhman Ahmed, Alkhansa Ahmed Osman Ahmed, Doaa Salaheldin Mohamed Ahmed, Muhammad Mubashir, Sohaib Mohammed Mokhtar Ahmed

“…Abstract Background Online learning has emerged as an alternative to continuing higher education during the ongoing conflict in Sudan. …”
Get full text

Bacillus spore showcasing key antigens of African swine fever potentializes a promising oral vaccine candidate by Xiaohua Wang, Baochao Fan, Tao Zhu, Hanwen Shen, Lian Li, Sihan Wang, Xiulian Yin, Baoxia Tian, Jinfeng Zhang, Bin Li, Chuping Luo

“…In recent years, Bacillus spores have been developed into effective vaccine carriers. Here, Bacillus amyloliquefaciens spores from strain CPLK1314 were used as a vaccine delivery system to display three highly antigenic proteins, p72, p30, and p54 of ASF, and their immune responses in BALB/c mice were evaluated. …”
Get full text

Laser directed energy deposition of heteroarchitected Ti6Al4V composites: In-situ TiB/TiC network engineering for multi-mechanistic strength-ductility synergy by Shenghao Hu, Chengfang Chai, Shuai Guo, Fengxian Li, Yichun Liu, Jianhong Yi, Jie Yu, Jürgen Eckert

“…This work establishes LDED-enabled heterostructuring as a transformative pathway for developing damage-tolerant TMCs, achieving an unprecedented combination of specific strength and damage absorption capacity.…”
Get full text

Analysis of risk characteristics related to ICU and death in children with severe HFMD in Guangxi by LAN Qiyuan, JU Yu, PAN Peijiang, ZHENG Zhigang, LU Zhenwei, FENG Juntan, PENG Yuanjun, LIAO Yanyan, WANG Hailong, ZHOU Lijuan, LIANG Hao, CHEN Minmei, YE Li

“…Methods Between 2014 and 2018, a continuous case survey was conducted on severe HFMD children of hospitalization in various counties (cities and districts) of Guangxi through on-site investigation. …”
Get full text

Atogepant for migraine prevention: a meta-analysis of safety and efficacy in adults by Adarsh Raja, Rabia Asim, Muhammad Hamza Shuja, Sandesh Raja, Tazheen Saleh Muhammad, Simran Bajaj, Abdul Hadi Ansari, Hamza Ali, Iffat Ambreen Magsi, Muhammad Hammad Faridi, Hamza Ali Hasnain Sheikh, Muhammad Junaid Imran, Muhammad Ahmed, Muhammad Sohaib Asghar, Muhammad Sohaib Asghar

“…Statistical analyses were carried out using RevMan, utilizing risk ratios for dichotomous outcomes and mean differences for continuous outcomes, and a random-effects model.ResultsOur primary outcome was the change in MMDs over 12 weeks, which showed a significant reduction with atogepant at dosages of 10, 30, and 60 mg. …”
Get full text