AI-Based Noise-Reduction Filter for Whole-Body Planar Bone Scintigraphy Reliably Improves Low-Count Images by Csaba Csikos, Sándor Barna, Ákos Kovács, Péter Czina, Ádám Budai, Melinda Szoliková, Iván Gábor Nagy, Borbála Husztik, Gábor Kiszler, Ildikó Garai

“…<b>Background/Objectives</b>: Artificial intelligence (AI) is a promising tool for the enhancement of physician workflow and serves to further improve the efficiency of their diagnostic evaluations. This study aimed to assess the performance of an AI-based bone scan noise-reduction filter on noisy, low-count images in a routine clinical environment. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…The analysis of the test diagnostic efficiency showed that the area under the ROC curve (AUC) was 0.85 ± 0.05, 95 % CI 0.75–0.94, the sensitivity of the method was 83 %, its specificity was 77 %. …”
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CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia by Xinzhe Du, Wei Hu, Xinrong Li, Yao Gao, Junxia Li, Xiaodong Hu, Xiao Wang, Wentao Zhao, Long Cheng, Xiaohua Cao, Hongbao Cao, Zhiyong Ren, Yu Zhang, Yong Xu, Sha Liu

“…Here, we constructed circRNA-miRNA-mRNA networks of EVs, and examined their diagnostic efficiency in FOS. Methods The expression levels of circRNAs, miRNAs and mRNAs in EVs derived from 10 FOS patients and 10 healthy controls (HC) were determined by high-throughput sequencing. …”
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7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas by Aleksandra Ellert-Miklaszewska, Paulina Pilanc, Katarzyna Poleszak, Adria-Jaume Roura, Salwador Cyranowski, Mitrajit Ghosh, Szymon Baluszek, Maria Pasierbinska, Bartłomiej Gielniewski, Julian Swatler, Yuliana Hovorova, Kamil Wojnicki, Bozena Kaminska

“…We determined the impact of 7aaRGD, administered as a monotherapy or combined with PD-1 blockade, on tumor growth, GAMs accumulation and phenotypes, arginase-1 levels and neovasculature in experimental gliomas. …”
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Myocardial work in electrical dyssynchrony due to left bundle branch block by E. M. Rimskaya, S. V. Dobrovolskaya, E. V. Kukharchuk, S. Yu. Kashtanova, N. A. Mironova, G. S. Tarasovsky, A. E. Komlev, T. E. Imaev, M. A. Saidova, S. P. Golitsyn

“…To evaluate myocardial function in different groups of patients with left bundle branch block (LBBB) and the LBBB "model" — right ventricular pacing (RVP).Material and methods. Global longitudinal strain (GLS) and myocardial function parameters, such as global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE), were measured in 25 patients with dilated cardiomyopathy (DCM) and LBBB (DCM-LBBB group), 20 patients with DCM and a narrow QRS complex (DCM-nonLBBB group), 15 patients with LBBB developed after transcatheter aortic valve implantation (TAVI LBBB group), 12 patients with idiopathic LBBB (I-LBBB group), 27 patients with permanent RVP, and 10 healthy volunteers (HVs). …”
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Pharmacoeconomic aspects of the targeted drugs use in psoriatic arthritis in context of the Russian healthcare system by O. I. Ivakhnenko, T. V. Korotaeva, T. V. Dubinina, A. M. Lila

“…A low CpR value was determined in cases of ADA 40 mg and UPA 15 mg use for the treatment of patients with PsA who had not previously received bDMARDs. …”
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The effectiveness of cardiac resynchronization therapy in patients with chronic heart failure of various origin depending on the structural myocardial injury in cardiac magnetic re... by O. V. Stukalova, N. A. Mironova, M. D. Utsumueva, S. Yu. Kashtanova, E. A. Butorova, V. N. Shitov, G. S. Tarasovsky, S. P. Golitsyn, S. K. Ternovoy

“…To assess the effect of the size and pattern of myocardial structural injury, determined by magnetic resonance imaging (MRI), on response to cardiac resynchronization therapy (CRT) in patients with ischemic and non-ischemic heart failure (HF).Material and methods. …”
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Development and study of mucoadhesive microcapsules for the nasal levodopa delivery by D. S. Gordeeva, V. V. Khutoryanskiy, R. I. Moustafine

“…A method for MC preparation was developed, the device parameters and the optimal composition of microparticles were selected. …”
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Combined exercise training and dietary interventions versus independent effect of exercise on ectopic fat in individuals with overweight and obesity: a systematic review, meta‐anal... by Fatemeh Kazeminasab, Motahareh Mohebinejad, Mohammad Hossein Mahboobi, Maedeh Nojoumi, Saba Belyani, Reza Bagheri, Fred Dutheil

“…Additional investigation is required to delve into the processes behind these findings and to pinpoint treatments that efficiently focus on reducing ectopic fat.…”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Uptake of fluorescent labelled sEVs by hCMEC/D3 cell layers was determined by flow cytometry, barrier integrity was measured by transendothelial electrical resistance (TEER). …”
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Exploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in ch... by Yadong Li, Mingjie Li, Chenye Lin, Wentao Tang, Qiuyu Tang, Feng Cheng

“…Besides, PCT presented the highest diagnostic efficiency among the single-item detections, with an AUC of 0.862 (95% CI: 0.819–0.906). …”
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Experience with long-term infliximab therapy in patients with ankylosing spondylitis by Oksana Alekseevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov, Oksana Alekseyevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov

“…The duration of continuous use of infliximab is more than 8 years in patients with ankylosing spondylitis (AS). The efficiency of the drug persists in most patients during its long-term regular therapy. …”
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INVESTIGATION OF IMMUNOGENICITY AND SAFETY OF 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS by G. M. Tarasova, B. S. Belov, D. V. Bukhanova, M. V. Cherkasova, S. K. Solovyev, E. A. Aseeva, T. M. Reshetnyak, T. V. Popkova

“…The overall clinical efficiency of vaccination was 93.3%. Conclusion. Thus, PPV-23 shows a good tolerability and a sufficient immunogenicity in patients with SLE. …”
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Robot-assisted laparoscopic ureteropelvic junction plasty in children using the da Vinci Xi robotic system: a Russian first experience by V. V. Sizonov, A. G. Makarov, S. M. Pakus, D. G. Kvaratskhelia, E. V. Orlova, S. G. Piskunova, M. I. Kogan

“…This prior expertise facilitates the optimization of console time duration and enables the rapid attainment of the performance plateau, achieving optimal surgical efficiency in the shortest possible timeframe.…”
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CHANGES OF CYTOKINE LEVELS DURING THERAPY WITH METHOTREXATE AND ADALIMUMAB IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS (REMARCA STUDY) by A. S. Avdeeva, A. A. Novikov, E. N. Aleksandrova, D. E. Karateev, E. L. Luchikhina, E. L. Nasonov

“…Serum cytokine concentrations were determined using the xMAP multiplexing technology before and 12 and 24 weeks after therapy. …”
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Anti-Virulence Efficacy of Chinese Dragon&amp;rsquo;s Blood Against Pseudomonas aeruginosa Isolated from Wound Infections by Shen Y, Gu Z, Li Y, Zhou H, Zhu S, Sheng L, Qiang X, Zheng X

“…Antimicrobial susceptibility profiles were determined using the agar dilution method. Biofilm formation and eradication assays, quantitative real-time PCR (RT-qPCR), and bacterial motility assays were performed to evaluate the efficacy of CDB on biofilm formation, mature biofilm eradication, and motility ability of P. aeruginosa isolates.Results: Minimal inhibitory concentration (MIC) values of CDB against P. aeruginosa isolates were ≥ 1024 μg/mL. …”
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Microbiological Evaluation of the Effectiveness of Sewage Sludge Sanitization with Solar Drying Technology by Zbigniew Paluszak, Krzysztof Skowron, Małgorzata Sypuła, Karolina Jadwiga Skowron

“…The number of reisolated microorganisms was determined with MPN method and the percentage of invasive A. suum eggs—with the microscope counting. …”
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Nash Bargaining-Based Coordinated Frequency-Constrained Dispatch for Distribution Networks and Microgrids by Ziming Zhou, Zihao Wang, Yanan Zhang, Xiaoxue Wang

“…The effectiveness of the proposed method in enhancing the operational security and economic efficiency of the distribution networks is validated through simulation analysis.…”
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Understanding adaptations in a community-vetted COVID-19 testing program by Breanna J. Reyes, Stephenie Tinoco Calvillo, Angel Lomeli, Angel Lomeli, Arleth A. Escoto, Maria Linda Burola, Kelli L. Cain, Linda Salgin, Linda Salgin, Maria Balbuena-Bojorquez, Anne-Marie Engler, Marva Seifert, Louise C. Laurent, Nicole A. Stadnick, Nicole A. Stadnick, Nicole A. Stadnick, Borsika A. Rabin, Borsika A. Rabin

“…Each adaptation was evaluated to determine whether it increased, decreased, had no effect, or not applicable to the RE-AIM outcomes. …”
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In vitro activity of seven antifungal agents against Fusarium oxysporum and expression of related regulatory genes. by Dafeng Xu, Kun Wang, Tingchun Li, Jingjing Wang, Shiji Wang, Fanna Kong, Jie Dai, Yuguo Liu, Banfeng Ruan, Benguo Zhou

“…In this study, the aims were to screen highly effective pesticides for F. oxysporum, reduce peasants' misunderstandings about pesticide application, improve disease control levels, and enhance economic efficiency. The toxicity of seven fungicides (carbendazim, pyraclostrobin, epoxiconazole, tricyclazole, azoxystrobin, difenoconazole, quintozene) on F. oxysporum were determined by the mycelium growth rate and the spore germination method, and single and compound fungicides with effective inhibitory effects on mycelial growth were screened. …”
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