Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts by Huarong Wu, Daikun Lei, Xiaoling Zhang, Mengfei Wang, Yuanyuan Wang, Jie Xia, Fan Chen, Bei Chen, Yanming Tian

“…High efficiency and specificity small interference RNA (siRNA) plasmid vector was constructed, its inhibitory effect on fibroblast proliferation was determined by CCK-8 assay, and the appropriate concentration was selected as the siRNA concentration for subsequent experiments. …”
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Phosal^® Curcumin-Loaded Nanoemulsions: Effect of Surfactant Concentration on Critical Physicochemical Properties by Joanna Czerniel, Aleksandra Gostyńska, Tomasz Przybylski, Maciej Stawny

“…The effect of Kolliphor HS15 on emulsion physicochemical properties such as mean droplet diameter (MDD), polydispersity index (PDI), zeta potential (ZP), osmolality (OSM), and pH, as well as encapsulation efficiency (EE) and retention rate (RR) of curcumin, were determined. …”
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An Experimental Design Approach for Producing Curcumin-Loaded Solid Lipid Nanoparticles by Ongun Mehmet Saka, Cemre İrem Aygüler, Neval Sevinç Özdemir, Bilge Sürücü, Egemen Çakırlı, Emirhan Nemutlu, Gülen Melike Demirbolat

“…The optimum formulation was determined with the help of experimental design. The SLNs were characterized in terms of the particle size and distribution, zeta potential, shape, entrapment efficiency, drug loading capacity, and drug release. …”
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Heterogeneity in diabetic distal neuropathy and differential approach to its treatment by Oksana Evgen'evna Khutornaya, Vadim Borisovich Bregovskiy, A G Demina, I A Karpova

“…MATERIALS AND METHODS: 4494 outpatient subjects participated in this study. …”
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Benefits, harms, and cost-effectiveness of risk model-based and risk factor-based low-dose computed tomography screening strategies for lung cancer: a systematic review by Yin Liu, Qingchao Geng, Xin Lin, Chenxi Feng, Youlin Qiao, Shaokai Zhang

“…Conclusion Risk model-based LDCT screening strategies present a more sensitive and potentially more efficient approach for lung cancer detection. Future research should explore optimal risk thresholds for broader applicability, with attention to sex-specific criteria and individual risk factor dynamics.…”
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Out-of-hospital Cardiac Arrest in the Republic of Crimea: Analysis of Epidemiology and Practice of Care by A. A. Birkun, L. P. Frolova, G. N. Buglak, S. S. Olefirenko

“…Introduction. Efficient organization of measures aimed at decreasing mortality from out-of-hospital cardiac arrest (OHCA) warrants a clear understanding of OHCA epidemiology and performance of the prehospital care system in such cases. …”
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Mini-cutting technique for the propagation of a Eucalyptus camaldulensis clone selected in a semiarid region by Francisco Emerson F. de Felice, Poliana C. Dias-Araujo, Ewerton S. Pinheiro, Carlos Vergara

“…These results confirm the mini-cutting technique as an efficient and practical solution for large-scale propagation, offering valuable applications in commercial forestry under challenging environmental conditions. …”
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Remote clinical decision support tool for Parkinson’s disease assessment using a novel approach that combines AI and clinical knowledge by Harel Rom, Ori Peleg, Yovel Rom, Anat Mirelman, Gaddi Blumrosen, Inbal Maidan

“…Methods Facial image of 67 PD patients and 52 healthy-controls (HCs) were collected via standard video recording. …”
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The Impact of Health Belief Model-Based Education on Self-Care Behaviors of Hypertensive Patients by Parisa Kasmaei, Pegah Yousefi, Rabiollah Farmanbar, Saeed Omidi, Mahmood Karimy, Sedighe Bab Eghbal, Maryam Shakiba, Morvarid Molaee

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Current applications of indocyanine green fluorescence angiography in trauma patients and its potential impact: a systematic review by Falco Hietbrink, Karlijn van Wessem, Eline Anna Breuking, Emma J de Fraiture, David D Krijgh, Ivar GJM de Bruin, Jetske Ruiterkamp

“…All studies reported beneficial effects such as necrosis detection, determination of resection/debridement margins and reduction of debridement procedures. …”
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Nurse prescribing right: a bibliometric analysis by Yingying Wang, Yingying Wang, Ruixiao Jia, Su Gu, Zihan Wang, Liqun Zhu, Shaoyong Ma

“…BackgroundThe concept of nurse prescribing rights is undergoing rapid evolution, and there is increasing interest in academic circles regarding research on this topic.ObjectiveThis study aims to conduct a comprehensive bibliometric analysis of nurses’ prescribing rights to understand the research background, emerging trends, and relevant academic impacts in this field, so as to provide valuable insights for the formulation of health policies and the promotion of more equitable and efficient healthcare services.MethodsWe conducted a bibliometric analysis of the articles on nurses’ prescribing rights from the establishment of the database until 6 December 2023. …”
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Investigating the Soil Hardness on Personal Subsidiary and Individual Peasant Farms by Aleksandr S. Ulanov, Vladimir F. Kupryashkin, Nikolay I. Naumkin, Dmitry A. Naumkin

“…Analyzing the soil hardness on personal subsidiary and individual peasant farms in the post-harvest period is a relevant task for optimal functioning of tillers, namely, it will allow operators to use the most efficient modes for tillage that will increase the tillage unit performance. …”
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The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo by Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, Dag Sehlin, Stina Syvänen, Ken G. Andersson

“…Therefore, the aim was to evaluate the independent effects of valency and affinity on TfR-mediated brain delivery at different doses. Methods Affinity variants of antibody 8D3 were produced by introducing alanine point mutations into the complementarity-determining regions. …”
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Comparison of farmacodynamic properties of three different aspirin formualtions in patients with stable coronary disease by Antić Ana, Stanojković Zoran, Vučić Miodrag, Lazarević Milan, Vacić Nebojša

“…Different ASA preparations observed in this study showed different efficiency on the platelet function as measured by the method of impedance aggregometry.…”
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Optimization of CO2 water-alternating-gas injection parameters based on an improved hunger game search algorithm by WU Gongyi, SUN Yuxin, SUN Xiaofei, JI Hongming, ZHANG Yanyu

“…Traditional reservoir numerical simulation methods for determining optimal injection parameters are time-consuming, labor-intensive, and costly, and may be unfeasible in large oilfields with complex multi-well injection parameter combinations. …”
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Machine Learning for the Early Prediction of Delayed Cerebral Ischemia in Patients With Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis by Haofuzi Zhang, Peng Zou, Peng Luo, Xiaofan Jiang

“… BackgroundDelayed cerebral ischemia (DCI) is a primary contributor to death after subarachnoid hemorrhage (SAH), with significant incidence. Therefore, early determination of the risk of DCI is an urgent need. Machine learning (ML) has received much attention in clinical practice. …”
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From In Vitro Cytotoxicity to In Vivo Zebrafish Assays: A Study on 3,3-Dichloro β-, γ- and δ-Lactams and Their Biological Activity Profiles by Faïza Diaba, María del Carmen Morán, Elisabet Teixidó

“…This study aims to evaluate the hemolytic behavior and cytotoxic properties of ten 3,3-dichlorolactams against A431 tumor and 3T3 fibroblast cells, with a particular focus on their selective toxicity. <b>Methods:</b> To achieve this, we assessed the hemocompatibility and cytotoxic effects of the lactams, determining their impact on cell viability through MTT and NRU assays. …”
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Viral kinetics among persons living with HIV (PLWH) on Dolutegravir-based antiretroviral Regimen: A retrospective and prospective analysis from selected HIV clinics in Ghana. by Samuel Badu Nyarko, Joel Adu Twum, Aikins Sarpong Obeng, Helena Dede Djangba, Oksana Ryabinina, Foster Kyei, George Boateng Kyei, Nicholas Ekow Thomford

“…However, monitoring viral kinetics is critical for determining treatment efficacy and making sound judgments. …”
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Antimicrobial Activity of Piper marginatum Jacq and Ilex guayusa Loes on Microorganisms Associated with Periodontal Disease by Fredy Gamboa, Camila-Cristina Muñoz, Gloria Numpaque, Luis Gonzalo Sequeda-Castañeda, Sandra Janeth Gutierrez, Nohemi Tellez

“…Antimicrobial activity from total ethanol extracts and fractions from both plants were evaluated on P. gingivalis ATCC 33277, F. nucleatum ATCC 25586, and P. intermedia ATCC by the well diffusion method with Wilkins–Chalgren agar. Results. Piper marginatum Jacq total ethanol extract presented antimicrobial activity against all three bacteria, whereas Ilex guayusa Loes was only efficient against P. gingivalis ATCC 33277 and P. intermedia ATCC 25611, with inhibition halos from 9.3 to 30 mm. …”
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THE ROLE OF THE MINISTRY OF FINANCE OF UKRAINE IN SHAPING STATE CUSTOMS POLICY: ECONOMIC AND LEGAL ASPECT by Ivan Yaromii

“…Methodology: the study employs both general and specific methods of scientific knowledge, namely, systems analysis, the dialectical method, formal logic, as well as structural and functional approaches. …”
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