PLS-α-GalCer: a novel targeted glycolipid therapy for solid tumors by Jay A Berzofsky, Shweta Tiwary, Julian Burks, David M Stevens, Sarah L Skoczen, Ruvanthi N Kularatne, Stephan T Stern

“…As a parenteral dendritic cell-targeted alternative, we demonstrate that poly(L-lysine succinylated) (PLS)-α-GalCer, a novel scavenger receptor-A1 targeted α-GalCer prodrug has enhanced antitumor activity compared with α-GalCer.Methods To compare the antitumor activity of PLS-α-GalCer and α-GalCer, we used mouse syngeneic subcutaneous pancreatic and cervical tumor models using Panc02 and TC-1 cells, respectively. …”
Get full text

Принципи ергодизайнерського забезпечення проектування авіаційних систем та заходи з їх реалізації... by Anatoly Rubtsov, Vladimir Svirko, Ivan Otroumov

“…It specifies the aim of the article: identification of the basic principles of the ergdesign and operation of aircraft systems and ways of their implementation. Methods of comparative analysis, organi-zational and structural ergodesign assessment, and computer modeling of unmanned aerial systems (UAS) components design are used to specify the importance of ergodesign requirements and parameters during an aviation system designing, importance of their control at different stages of these products life cycle, performing a design process on a human-centric basis, in which the operator is considered as a main integrated component of aviation system during creation efficient, environmentally friendly, and comfortable aviation system. …”
Get full text

STUDY OF THE PHARMACOLOGICAL ACTIVITY OF NOVEL EPOR/CD131 HETERORECEPTOR AGONISTS IN MICE WITH ENDOTHELIAL-SPECIFIC EXPRESSION OF MUTANT POLG GENE by М. В. Korokin, M. V. Kubekina, A. V. Deykin, O. V. Antsiferov, V. M. Pokrovskii, L. V. Korokina, N. L. Kartashkina, V. A. Soldatova, E. V. Kuzubova, A. I. Radchenko, M. V. Pokrovskii

“…(UEQLERALNCS), EP-11-3 (UEQLERALNTS).Materials and methods. The study was conducted on 96 C57Bl/6J male double transgenic Polgmut/mut/Cdh5-CRE mice. …”
Get full text

Optimization Design and Test Analysis of Rice Electric Binder Knotter Based on ADAMS by Difa Bao, Jufei Wang, Zhi Liang, Chongcheng Chen, Wuxiong Weng, Shuhe Zheng, Jinbo Ren

“…At present, rice binders still face the issues of a low bundling efficiency and quality, which affect the progress of rice harvesting during the harvest season. …”
Get full text

Possibilities of Complex Ultrasound Examination in the Assessment of Hemodynamic and Structural Features of Retinal Capillary Hemangioma by V. V. Neroev, T. N. Kiseleva, P. A. Ilyukhin, K. A. Ramazanova, M. A. Ryabina, A. Y. Novikova

“…Purpose: to study the possibilities of complex ultrasound examination in the assessment of hemodynamic and structural features of retinal capillary hemangioma (RCH).Patients and methods. 26 patients (35 eyes) with RCHs at the age of 11 to 53 years (mean 26.6 ± 9.4 years) were examined. …”
Get full text

Estimating the optimal cutoff for the IGT‐AD Distress subscale adapted for amyloid PET results disclosure by Dianxu Ren, Kim Jeong Eun, Joshua D. Grill, Jennifer H. Lingler

“…METHODS We adapted the IGT‐AD instrument by replacing reference to genetic testing with reference to amyloid PET testing. …”
Get full text

Komparasi Machine Learning Berbasis Pso Untuk Prediksi Tingkat Keberhasilan Belajar Berbasis E-Learning by Elin Panca Saputra, Siti Nurajizah, Mawadatul Maulidah, Nadiyah Hidayati, Taufik Rahman

“…While the attributes that have an influence to determine the algorithm on the level of accuracy are Practice Questions, Quizzes, Mid-Semester Exams, and Final Exams. it is evident from our previous studies that the PSO-based neural network algorithm does have a very good advantage. based on ANN is a method that has calculations that build several units of interconnected connectivity, the ANN method with predictive accuracy can be an efficient and good tool for forecasting and classification research in the field of education. …”
Get full text

Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…The analysis of the test diagnostic efficiency showed that the area under the ROC curve (AUC) was 0.85 ± 0.05, 95 % CI 0.75–0.94, the sensitivity of the method was 83 %, its specificity was 77 %. …”
Get full text

Optimizing water-nitrogen management enhances productivity for peanut (Arachis hypogaea L.) with drip-irrigated under mulched in Northwest of China by Jianshu Dong, Xiaojun Shen, Xiaopei Zhang, Junwei Chen, Haiming Li, Qiang Li, Jiaqi He, Hongguang Liu

“…After comprehensively evaluating 130 scenarios using the Entropy Weight Method-Technique for Order Preference by Similarity to an Ideal Solution method, the optimal irrigation and nitrogen application regime for peanut production under drip irrigation with plastic mulch was determined as follows: irrigation of 45 mm from sowing to emergence, 7-day intervals with 40.5 mm each during the flowering-pegging and pod-setting stages, and 10-day intervals with 40.5 mm per irrigation during the pod-filling stage, along with the application of 100 kg·ha−1 nitrogen. …”
Get full text

Analysis of options for using oxygen-helium mixture in complex therapy and rehabilitation of patients with various diseases of the respiratory organs (review of literature) by Yu. A. Khatuntseva, V. M. Manuylov, A. N. Shcherbyuk, Ya. E. Nemstsveridze, A. A. Andrushchenko, G. I. Kurnakin

“…Based on the analysis of literary data, the key mechanisms of the therapeutic effect of CGS were identified: reduction of airway aerodynamic resistance due to transformation of turbulent flow into laminar flow, improvement of ventilation-perfusion relations, optimization of oxygen transport to tissues and increase in the efficiency of carbon dioxide elimination. Promising areas of clinical application of CGS in various pathologies of the respiratory system were determined: obstructive disorders of the upper and lower respiratory tract, acute respiratory distress syndrome, bronchial asthma, COPD, pneumonia of various etiologies, including those associated with COVID-19. …”
Get full text

A power analysis framework to aid the design of robust semi-field vector control experiments by Andrea M. Kipingu, Dickson W. Lwetoijera, Kija R. Ng’habi, Samson S. Kiware, Mafalda Viana, Paul C. D. Johnson

“…As compared to a single intervention, an additional intervention required an increase in the number of chambers, while short and long experiments were similar in terms of key aspects such as the number of chambers per treatment. Conclusion Determining the most efficient experimental design for a semi-field experiment will depend on a balance of design choices and resource constraints. …”
Get full text

Construction of biological control strain of Trichoderma viride and study of their ability to induce plant disease resistance by LIU Shi-wang, GUO Ze-jian

“…Plasmids pCSNTCC and pCSNTCCm were transformed into the protoplasts of T. viride by a Xho I restriction enzyme-mediated integration, with an efficiency of 1-2 transformants per microgram of DNA. …”
Get full text

Injection well site optimization of carbon geological sequestration based on dynamic programming by Bin LIU, Chunsheng SHI

“…Geological storage of carbon dioxide (CO2) is one of the most effective methods for reducing carbon emissions and mitigating the greenhouse effect, critical challenges in combating climate change. …”
Get full text

Developing an Operational Approach to Educational Quality Assurance in Colleges under the Office of the Vocational Education Commission in Thailand by Ch. Chianchana, S. Na Wichian

“…Methodology and research methods. The study participants included college personnel directors, teachers, and staff selected through purposive sampling. …”
Get full text

Factors Affecting Values of Short-Circuit Current Levels in Electrical Power Engineering Systems by F. M. Erkhan

“…They are discretely changeable, depend on a number of factors and have a significant importance while selecting electric equipment, a graph of power network development and voltage levels.Determination of the main factors affecting values of short-circuit currents permits to develop efficient methods with the purpose to limit their increase in power networks with various voltage class.…”
Get full text

Construction of genetic transformation system mediated by Agrobacterium rhizogenes in Vaccinium corymbosum by WU Tingting, LIU Liangqin, JIANG Yanqin, GE Chunfeng, TIAN Liangliang, LIU Mengxi, ZENG Qilong, YU Hong

“…[Methods] The stem segments from current-year green shoots of field-grown Lanmei 1 blueberry plants were used as explants. …”
Get full text

Numerical Study of Complex Heat Transfer in Blown Impassable Channels of Heating Mains by V. A. Sednin, T. V. Bubyr

“…Research of processes of heat exchange between a stream of air and pipelines of network water on the one hand and between a stream of air and walls of the channel on another hand is a determinant for realization of the presented technology of increase of efficiency of operation of the considered heating mains. …”
Get full text

Novel Liposome–Gel Formulations Containing a Next Generation Postbiotic: Characterization, Rheological, Stability, Release Kinetic, and In Vitro Antimicrobial Activity Studies by Halise Betül Gökçe, İsmail Aslan

“…Finally, the antimicrobial activities of the postbiotics and the optimum gel formulation LG1 were evaluated on <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Enterococcus hirae</i>, and <i>Candida albicans</i> strains using disk diffusion and microdilution methods. The optimum liposome formulation L1 was determined to have a particle size of 185.32 ± 0.80 nm, a polydispersity index of 0.206 ± 0.012, a zeta potential of 35.0 ± 0.5 mV, and an encapsulation efficiency of 17.52%. …”
Get full text

Research on Lightweight Technology of Hydraulic Components for Integrated Fast Reactor Main Pump by PU Enshan1, ZHAI Xiao1, GU Jipin1, LIU Simin1, ZHANG Xu2

“…The hydraulic performance of different numbers of suction ports (10, 6, and 4) was analyzed using CFD numerical simulation methods. On the premise of ensuring that the hydraulic performance meets the requirements, the optimization scheme was determined. …”
Get full text

Approximate power flow solutions‐based forecasting‐aided state estimation for power distribution networks by Zhenyu Wang, Zhao Xu, Donglian Qi, Yunfeng Yan, Jianliang Zhang

“…Abstract This paper presents an approximate power flow model‐based forecasting‐aided state estimation estimator for power distribution networks subject to naive forecasting methods and nonlinear filtering processes. To this end, this estimator designs a voltage perturbation vector around the priori‐determined nominal value as the dynamic state variable, which enables more detailed depictions of voltage changes. …”
Get full text