RITUXIMAB THERAPY MONITORING IN PATIENTS WITH RHEUMATOID ARTHRITIS HROUGH PERIPHERAL BLOOD GENE EXPRESSION ANALYSIS by E. V. Chetina, A. V. Pivanova, K. Kh. Kuzikyants, A. Yu. Devyataikina, G. V. Lukina, E. Yu. Samarkina, A. P. Aleksankin, E. N. Aleksandrova

“…Objective: to determine the predictors of the efficiency of rituximab (RTM) therapy through analysis of blood gene expressions in patients with rheumatoid arthritis (RA). …”
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Adalimumab in Focus: Evaluating Effectiveness and Safety in Non-Infectious Uveitis at a Tertiary Referral Center in Türkiye by Berru Yargı Özkoçak, Çiğdem Altan, Burcu Kemer Atik, Berna Başarır

“…BCVA was monitored at baseline and subsequent months to determine the onset of functional efficiency of ADA treatment. …”
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Intelligent algorithm-based model for predicting mass transfer performance in CO2 absorption within a rotating packed bed by Wei Zhang, Hao Chen, Ke Huang, Xing Shu, Cheng Fu, Bin Huang

“…The findings of this study suggest that the integration of intelligent optimization algorithms with LSSVM offers a promising alternative to conventional methods for predicting the mass transfer coefficient in RPB systems, thereby enhancing the efficiency and reliability of CO2 absorption processes.…”
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Unplanned re-attendance to emergency department of patients with systemic inflammatory response syndrome: a situational analysis by Siwapon Srikeaw, Ketsarin Utriyaprasit, Wanlaya Thampanichawat, Siriorn Sindhu, Chukiat Viwatwongkasem, Thitipong Tankumpuan

“…Methods This study employed a cross-sectional and prospective cohort study design. …”
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Ethanol consumption during gestation promotes placental alterations in IGF-1 deficient mouse placentas [version 3; peer review: 1 approved, 2 approved with reservations, 1 not appr... by Mario Bermúdez De León, Diego Rodríguez-Mendoza, Carolina Zertuche-Mery, Inma Castilla-Cortázar, Oscar R Fajardo-Ramírez, Fabiola Castorena-Torres, Marcela Galindo-Rangel, Patricio Gómez-Álvarez, Irene Martín-Estal, Andrea Leal López

“…Methods Wild type (WT, Igf1 +/+) and heterozygous (HZ, Igf1 +/-) female mice were given 10% ethanol in water during 14 days as an acclimation period and throughout pregnancy. …”
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Evaluating spectral indices for water extraction: Limitations and contextual usage recommendations by Chuanwu Zhao, Haishuo Wei, Gudina Legese Feyisa, Thiaggo de Castro Tayer, Gelilan Ma, Hanyi Wu, Yaozhong Pan

“…Currently, various technologies have been applied to water information monitoring, with remote sensing-based spectral index methods being widely used due to their simplicity, low cost, and large-scale observation capabilities. …”
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AI-powered machine learning models for monitoring and optimization of biodrying process by Abhisit Bhatsada, Panida Payomthip, Tanik Itsarathorn, Ye Nyi Nyi Lwin, Eka Wahyanti, Sirintornthep Towprayoon, Suthum Patumsawad, Chart Chiemchaisri, Komsilp Wangyao

“…Among all models tested, deep learning methods demonstrated superior accuracy, with Long Short-Term Memory (LSTM) achieving the highest predictive performance (R² = 0.988 training, R² = 0.987 testing). …”
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Programmatic mapping and size estimation of people who inject drugs to plan targeted HIV prevention and harm reduction programs in iran, a nationwide study by Nima Ghalekhani, Ahmad Hajebi, Ebrahim Ghodusi, Behnaz Beygi, Toktam Khojasteh Bojnordi, Mohammad Farooq Mashhour, Fatemeh Rezaei Sharif, Farzaneh Rajabzadeh, Hooriyeh Khoshdel, Hamid Reza Fathi, Hamid Sharifi

“…Methods A cross-sectional key informant-driven mapping and enumeration methodology was used to identify hotspots of illicit drug use in 82 cities across 24 provinces in Iran from August 2020 to March 2021. …”
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Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction by Anurak Muangsanguan, Warintorn Ruksiriwanich, Pipat Tangjaidee, Korawan Sringarm, Chaiwat Arjin, Pornchai Rachtanapun, Sarana Rose Sommano, Korawit Chaisu, Apinya Satsook, Juan Manuel Castagnini

“…This study compared three extraction methods—maceration (MAC), screw pressing (SC), and supercritical fluid extraction (SFE)—to determine their efficiency in recovering bioactive compounds and their effects on androgenetic alopecia (AGA)-related pathways. …”
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Arbuscular mycorrhizal fungi symbiosis enhances growth, nutrient uptake, and oil quality in sunflower–pumpkin under intercropping systems by Aisha A. M. Alayafi, Basmah M. Alharbi, Basmah M. Alharbi, Awatif M. Abdulmajeed, Taghreed S. Alnusaire, Ayshah Aysh ALrashidi, Siham M. AL-Balawi, Hanan Khalaf Anazi, Suliman M. S. Alghanem, Omar Mahmoud Al zoubi, Mona H. Soliman, Mona H. Soliman

“…IntroductionThis study evaluated the effects of Funneliformis mosseae, an arbuscular mycorrhizal (AM) fungus, on nutrient uptake, biomass production, and oil quality in sunflower (Helianthus annuus) and pumpkin (Cucurbita pepo) under both sole and intercropping field systems.MethodsA factorial experimental design was conducted over two growing seasons (2023 and 2024), involving three cropping systems: sunflower monoculture, pumpkin monoculture, and additive sunflower–pumpkin intercropping. …”
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Predictive value of resting-state fMRI graph measures in hypoxic encephalopathy after cardiac arrest by Puck Lange, Marlous Verhulst, Anil Man Tuladhar, Prejaas Tewarie, Hanneke Keijzer, Catharina J.M. Klijn, Cornelia Hoedemaekers, Michiel Blans, Bart Tonino, Frederick J.A. Meijer, Rick C. Helmich, Jeannette Hofmeijer

“…Introduction: Current multimodal prediction models can determine the prognosis of about half of comatose cardiac arrest patients. …”
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Research on nitrogen transformation pathways of a thermophilic heterotrophic nitrifying bacterial consortium GW7 by Yongqi Ma, Jiali Wang, Yindi Zhang, Wenping Guan, Wenrui Qi, Xisheng Tai, Dong Lin, Rong He, Likun Sun, Aiwen Zhang

“…The study aims to isolate and characterize a high-temperature-tolerant heterotrophic nitrifying bacterial consortium to enhance nitrogen transformation during aerobic composting.MethodsAn excellent high-temperature-tolerant heterotrophic nitrifying bacterial consortium, designated GW7, was enriched from compost samples at elevated temperatures. …”
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Effect of transcriptional coactivator with PDZ-binding motif on proliferation and migration of breast cancer cells and its mechanism by WANG Lin, ZHAO Gaoxiang

“…Colony-forming assay (CFA) and Transwell assay were used to determine plating efficiency and migration rate in groups A-F and a-f. …”
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Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models by Atziri Corin Chavez Alvarez, Chahrazed Bouzriba, Vincent Ouellette, Mathieu Gagné-Boulet, Alexandre Patenaude, Sylvie Pilote, René C.-Gaudreault, Chantale Simard, Sébastien Fortin

“…Our screening program studies of PAIB-SO chemolibraries selected three prototypical PAIB-SOs as antimitotic prodrugs amenable for studies using BC animal models. <b>Methods</b>: Healthy female CD1^® IGS mice were treated with three prototypical PAIB-SOs, namely CEU-835, -934, and -938, for the determination of their toxicity and half-lives. …”
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Genomic Landscape and Prediction of Udder Traits in Saanen Dairy Goats by Xiaoting Yao, Jiaxin Li, Jiaqi Fu, Xingquan Wang, Longgang Ma, Hojjat Asadollahpour Nanaei, Ali Mujtaba Shah, Zhuangbiao Zhang, Peipei Bian, Shishuo Zhou, Ao Wang, Xihong Wang, Yu Jiang

“…This study leveraged genotyping imputation to explore the genetic parameters and architecture of udder traits and assess the efficiency of genomic prediction methods. Using data from 635 Saanen dairy goats, genotyped for over 14,717,075 SNP markers and phenotyped for three udder traits, heritability was 0.16 for udder width, 0.32 for udder depth, and 0.13 for teat spacing, with genetic correlations of 0.79, 0.70, and 0.45 observed among the traits. …”
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MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colit... by Eszter Vámos, Viola Bagóné Vántus, Péter Deák, Nikoletta Kálmán, Eva Maria Sturm, Barsha Baisakhi Nayak, Lilla Makszin, Tamás Loránd, Ferenc Jr Gallyas, Balázs Radnai

“…Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC50 = 5.63 μmol/dm3) in experimental Crohn’s disease in male mice, in leukocyte recruitment and in inflammatory M1 macrophage activation.Methods2,4,6-trinitrobenzenesulfonic acid-(TNBS)-induced colitis was utilized as a CD-model in male mice. …”
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LiDAR Sensor Parameter Augmentation and Data-Driven Influence Analysis on Deep-Learning-Based People Detection by Lukas Haas, Florian Sanne, Johann Zedelmeier, Subir Das, Thomas Zeh, Matthias Kuba, Florian Bindges, Martin Jakobi, Alexander W. Koch

“…Therefore, this paper presents augmentation methods to analyze the influence of the distance, resolution, noise, and shading parameters of a LiDAR sensor in real point clouds for people detection. …”
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Unveiling Functional Impairment in Fabry Disease: The Role of Peripheral vs. Cardiac Mechanisms by Geza Halasz, Chiara Lanzillo, Raffaella Mistrulli, Emanuele Canali, Elisa Fedele, Paolo Ciacci, Federica Onorato, Guido Giacalone, Giovanni Nardecchia, Domenico Gabrielli, Federica Re

“…<b>Methods:</b> Thirty-one patients with genetically confirmed AFD were retrospectively enrolled from two tertiary centers. …”
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Access and coverage of malaria services in Haiti in the context of elimination: a scoping review of the literature by Kenny Moise, Aude Melody Achille, Roubens Duvilaire, Jimmy Fedna, Roody Thermidor, Bertiny Bourdeau, Jessica Maureen Nestor, Gérald Lerebours, Jean Hugues Henrys, Christian Raccurt

“…This scoping review aims to identify the scope of research on access and coverage of malaria surveillance, diagnosis, and treatment in Haiti in the elimination setting. Methods We compiled, analyzed, and synthesized the literature on access and coverage of antimalarial services in Haiti in the elimination setting based on Arksey and O’Malley’s framework for scoping reviews and held a formal meeting with the PNCM leadership and stakeholders of malaria programs in Haiti. …”
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Metabolome and transcriptome analysis reveal the pigments biosynthesis pathways in different color fruit peels of Clausena lansium L. Skeels by Zhichang Zhao, Mark Owusu Adjei, Ruixiong Luo, Huaping Yu, Yali Pang, Jian Wang, Yu Zhang, Jun Ma, Aiping Gao

“…The coloration of the peels was attributed to significant differences in chlorophyll, carotenoid, and anthocyanin content between BP and PP.MethodsThis study investigates the biosynthetic metabolic activities in the brown and purple peels of Clausena lansium L. …”
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