Comparative efficacy of different doses of platelet-rich plasma injection in the treatment of knee osteoarthritis: a systematic review and network meta-analysis by Majid Khalilizad, Seyedeh Tahereh Emadian, Mobin Marzban Abbas Abadi

“…Methods We searched published data in Embase, PubMed, Scopus, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov, with no language restrictions from the inception to 30 September 2024. …”
Get full text

Clinical observation of hemodialysis in the treatment of elderly type Ⅱ cardiorenal syndrome by YANG Sheng-xi, MA Hong

“…Objective To compare the therapeutic effect of intermittent hemodialysis(IHD) vs.sustained low-efficiency hemodialysis(SLED) in elderly patients with type Ⅱ cardiorenal syndrome(CRS).Methods The clinical data of 62 elderly patients with type Ⅱ CRS in our hospital were retrospectively analyzed.All the patients accepted the hemodialysis with central venous catheters via the right femoral vein.According to the therapies,the patients were divided into two groups:IHD and SLED,with treatment for one week.During treatment,the patients were avoided to suffer excessive ultrafiltration.Before and after treatment,central venous pressure(CVP) and heart rate(HR) were measured,BUN and SCr were determined by Beckman Olympus AU2700 automatic biochemical Analyzer,N-terminal Pro Brain Natriuretic Peptide(NT-proBNP) was detected by ReLIA multifunctional immune detection instrument,and left ventricular ejection fraction(LVEF) and pulmonary arterial pressure(PAP) wer examined by Philips IE33 ultrasound scanner.Results There was significant difference in age between two groups(P<0.05).After treatment,BUN,SCr and NT-proBNP were all significantly reduced,and LVEF was significantly increased in both two groups(P<0.01).After treatment,HR,CVP and PAP were significantly reduced in IHD group(P<0.05).After treatment,HR,CVP and PAP were significantly reduced in SLED group(P<0.01).After treatment,HR,CVP and PAP were reduced in both two groups.Moreover,the changes in SLED group were reduced more obviously than in IHD group(P<0.01).Conclusions Both IHD and SLED have satisfactory treatment effects on elderly patients with type II CRS.SLED removes excess fluids in the body slowly and maintains the balance of internal environment It can remove the extra heart toxicity from kidney medulla continually,such as renin,and it also can keep the balance of water,electrolyte and pH.SLED can obtain more stable hemodynamics than IHD.For elderly patients with type E CRS,SLED can clear toxin quickly and adjust the unbalance of electrolyte and pH.Furthermore,SLED can obtain better hemodynamic stabilization and save the medical resources.In conclusion,the treatment effect of SLED is better than IHD.…”
Get full text

Repeated assessments of informed consent comprehension among HIV-infected participants of a three-year clinical trial in Botswana. by Lelia H Chaisson, Nancy E Kass, Bafanana Chengeta, Unami Mathebula, Taraz Samandari

“…<h4>Conclusions</h4>Administration of a comprehension quiz at enrollment and during follow-up was feasible in a large, international collaboration and efficiently determined IC comprehension by trial participants. …”
Get full text

Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts by Huarong Wu, Daikun Lei, Xiaoling Zhang, Mengfei Wang, Yuanyuan Wang, Jie Xia, Fan Chen, Bei Chen, Yanming Tian

“…High efficiency and specificity small interference RNA (siRNA) plasmid vector was constructed, its inhibitory effect on fibroblast proliferation was determined by CCK-8 assay, and the appropriate concentration was selected as the siRNA concentration for subsequent experiments. …”
Get full text

Phosal^® Curcumin-Loaded Nanoemulsions: Effect of Surfactant Concentration on Critical Physicochemical Properties by Joanna Czerniel, Aleksandra Gostyńska, Tomasz Przybylski, Maciej Stawny

“…The effect of Kolliphor HS15 on emulsion physicochemical properties such as mean droplet diameter (MDD), polydispersity index (PDI), zeta potential (ZP), osmolality (OSM), and pH, as well as encapsulation efficiency (EE) and retention rate (RR) of curcumin, were determined. …”
Get full text

A comparative bench scale study of oxygen transfer dynamics using micro-nano bubbles and conventional aeration in water treatment systems by Mohamed Ibrahim kizhisseri, Marwa Sakr, Munjed Maraqa, Mohamed M. Mohamed

“…The findings of this study suggest that MNB aeration, with its enhanced mass transfer characteristics, offers a more energy-efficient alternative to conventional aeration methods, with the potential for higher oxygen transfer rates and improved wastewater treatment performance. …”
Get full text

Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains by Ana C. B. Terzian, Sasha R. Azar, Cassia F. Estofolete, Mauricio L. Nogueira, Nikos Vasilakis

“…Their functional differences in the neutralization profiles are not known. <b>Methods</b>: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. …”
Get full text

Preparation, characterization and antioxidative activity analysis of recombinant humanized collagen type III-loaded liposomes by Mengxing Du, Chuanxiu Chen, Yuxin Zhou, Yixuan Song, Shan Wang, Shanshan Tang, Jia Yang, Xia Yang, Enli Liu, Yufeng Yu

“…Abstract To improve the bioavailability and biological activity of recombinant type III humanized collagen (rhCol III), we optimized the preparation process of recombinant type III humanized collagen-loaded liposomes (rhCol III-LIPS) using the film dispersion and periplasmic extrusion methods, with the encapsulation rate as the response value. …”
Get full text

Short-term Outcomes of Intracorporeal Versus Extracorporeal Totally Stapled Anastomosis after Laparoscopic Colectomy: A Propensity Score-matched Cohort Study by Yoshiaki Fujii, Kenji Kobayashi, Hirozumi Sawai, Seiya Yamamoto, Shuhei Uehara, Hirotaka Miyai, Hiroki Takahashi, Shuji Takiguchi

“…Methods: In total, 59 consecutive patients who underwent laparoscopic colectomy between June 2018 and August 2021 were retrospectively assessed. …”
Get full text

An Experimental Design Approach for Producing Curcumin-Loaded Solid Lipid Nanoparticles by Ongun Mehmet Saka, Cemre İrem Aygüler, Neval Sevinç Özdemir, Bilge Sürücü, Egemen Çakırlı, Emirhan Nemutlu, Gülen Melike Demirbolat

“…The optimum formulation was determined with the help of experimental design. The SLNs were characterized in terms of the particle size and distribution, zeta potential, shape, entrapment efficiency, drug loading capacity, and drug release. …”
Get full text

Heterogeneity in diabetic distal neuropathy and differential approach to its treatment by Oksana Evgen'evna Khutornaya, Vadim Borisovich Bregovskiy, A G Demina, I A Karpova

“…MATERIALS AND METHODS: 4494 outpatient subjects participated in this study. …”
Get full text

Benefits, harms, and cost-effectiveness of risk model-based and risk factor-based low-dose computed tomography screening strategies for lung cancer: a systematic review by Yin Liu, Qingchao Geng, Xin Lin, Chenxi Feng, Youlin Qiao, Shaokai Zhang

“…In this review, we provide an overview of the benefits, harms, and cost-effectiveness of these two strategies in lung cancer screening application, as well as discussing possible future research directions. Methods Following the PRISMA guidelines, a comprehensive literature search was conducted across PubMed, Web of Science, Cochrane libraries, and EMBASE from January 1994 to April 2024. …”
Get full text

Out-of-hospital Cardiac Arrest in the Republic of Crimea: Analysis of Epidemiology and Practice of Care by A. A. Birkun, L. P. Frolova, G. N. Buglak, S. S. Olefirenko

“…The study was aimed at performing respective analysis and identifying the ways for improving prehospital management of OHCA in the Republic of Crimea.Material and methods. Annual data from the Crimean OHCA and Resuscitation Registry for 2018 were utilized. …”
Get full text

Mini-cutting technique for the propagation of a Eucalyptus camaldulensis clone selected in a semiarid region by Francisco Emerson F. de Felice, Poliana C. Dias-Araujo, Ewerton S. Pinheiro, Carlos Vergara

“…Area of study: Mossoró, located in the state of Rio Grande do Norte, Brazil. Material and methods: The mini-stumps of the E. camaldulensis clone were subjected to five consecutive prunings and the shoots were analyzed for their adventitious rooting capacity by testing the IAA and IBA auxins at four doses (0 -control; 1,000; 2,000; and 4,000 mg.L-1). …”
Get full text

Current applications of indocyanine green fluorescence angiography in trauma patients and its potential impact: a systematic review by Falco Hietbrink, Karlijn van Wessem, Eline Anna Breuking, Emma J de Fraiture, David D Krijgh, Ivar GJM de Bruin, Jetske Ruiterkamp

“…Exclusion criteria were use of ICG for treatment of burn wounds, traumatic brain injury or reconstructive surgery, absence of an English or Dutch full-text and non-primary study design.Data extraction and synthesis Two independent reviewers performed the search and screening process according to standardised methods. Risk of bias was assessed using the Methodological Index for Non-Randomised Studies. …”
Get full text

Nurse prescribing right: a bibliometric analysis by Yingying Wang, Yingying Wang, Ruixiao Jia, Su Gu, Zihan Wang, Liqun Zhu, Shaoyong Ma

“…BackgroundThe concept of nurse prescribing rights is undergoing rapid evolution, and there is increasing interest in academic circles regarding research on this topic.ObjectiveThis study aims to conduct a comprehensive bibliometric analysis of nurses’ prescribing rights to understand the research background, emerging trends, and relevant academic impacts in this field, so as to provide valuable insights for the formulation of health policies and the promotion of more equitable and efficient healthcare services.MethodsWe conducted a bibliometric analysis of the articles on nurses’ prescribing rights from the establishment of the database until 6 December 2023. …”
Get full text

Investigating the Soil Hardness on Personal Subsidiary and Individual Peasant Farms by Aleksandr S. Ulanov, Vladimir F. Kupryashkin, Nikolay I. Naumkin, Dmitry A. Naumkin

“…The study is aimed at identifying the hardness of medium-loamy gray forest soil on different soil horizons typical for growing fruits and vegetables in personal subsidiary and individual peasant farms. Materials and Methods. To measure the soil hardness, there are used different types of penetrometers: percussion, statically loaded and forcibly pressing a deformer (cone, cy­linder, and ball) into the soil. …”
Get full text

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo by Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, Dag Sehlin, Stina Syvänen, Ken G. Andersson

“…Therefore, the aim was to evaluate the independent effects of valency and affinity on TfR-mediated brain delivery at different doses. Methods Affinity variants of antibody 8D3 were produced by introducing alanine point mutations into the complementarity-determining regions. …”
Get full text

Machine Learning for the Early Prediction of Delayed Cerebral Ischemia in Patients With Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis by Haofuzi Zhang, Peng Zou, Peng Luo, Xiaofan Jiang

“…ObjectiveThe aim of this study was to synthesize the prediction accuracy of ML models for DCI to provide evidence for the development or updating of intelligent detection tools. MethodsPubMed, Cochrane, Embase, and Web of Science databases were systematically searched up to May 18, 2023. …”
Get full text

From In Vitro Cytotoxicity to In Vivo Zebrafish Assays: A Study on 3,3-Dichloro β-, γ- and δ-Lactams and Their Biological Activity Profiles by Faïza Diaba, María del Carmen Morán, Elisabet Teixidó

“…This study aims to evaluate the hemolytic behavior and cytotoxic properties of ten 3,3-dichlorolactams against A431 tumor and 3T3 fibroblast cells, with a particular focus on their selective toxicity. <b>Methods:</b> To achieve this, we assessed the hemocompatibility and cytotoxic effects of the lactams, determining their impact on cell viability through MTT and NRU assays. …”
Get full text