THE FIRST RUSSIAN STRATEGIC STUDY OF PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS (REMARCA TRIAL): RESULTS OF 12-MONTH TREATMENT IN 130 PATIENTS by D. E. Karateev, E. L. Luchikhina, N. V. Demidova, G. S. Gridneva, M. A. Kanonirova, Yu. V. Muravyev, G. V. Lukina, Yu. A. Olyunin, K. A. Kasumova, E. N. Aleksandrova, A. A. Novikov, A. A. Avdeeva, T. V. Popkova, D. S. Novikova, A. V. Smirnov, A. V. Volkov, E. L. Nasonov

“…To introduce treat-to-target recommendations is an important task of modern rheumatology; however, there is still a diversity of serious problems relating to a scientific rationale and a clinical one for this strategy and to the possibilities of its implementation in real clinical practice, in the rheumatology service of the Russian Federation in particular, by taking into account the specific features of funding for high-tech medical care.Objective: to determine the efficiency and safety of combined therapy with subcutaneous methotrexate (MT) and biological agents (BA) when using the treat-to-target strategy in patients with active early and extended-stage rheumatoid arthritis (RA) who have risk factors for a poor prognosis.Subjects and methods.The results of the REMARCA (Russian InvEstigation of MethotrexAte and biologicals in eaRly aCtive inflammatory Arthritis) trial of 130 patients followed up for 12 months or more were given. …”
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THE FIRST RUSSIAN STRATEGIC STUDY OF PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS (REMARCA TRIAL): RESULTS OF 12-MONTH TREATMENT IN 130 PATIENTS by D. E. Karateev, E. L. Luchikhina, N. V. Demidova, G. S. Gridneva, M. A. Kanonirova, Yu. V. Muravyev, G. V. Lukina, Yu. A. Olyunin, K. A. Kasumova, E. N. Aleksandrova, A. A. Novikov, A. A. Avdeeva, T. V. Popkova, D. S. Novikova, A. V. Smirnov, A. V. Volkov, E. L. Nasonov

“…To introduce treat-to-target recommendations is an important task of modern rheumatology; however, there is still a diversity of serious problems relating to a scientific rationale and a clinical one for this strategy and to the possibilities of its implementation in real clinical practice, in the rheumatology service of the Russian Federation in particular, by taking into account the specific features of funding for high-tech medical care. Objective: to determine the efficiency and safety of combined therapy with subcutaneous methotrexate (MT) and biological agents (BA) when using the treat-to-target strategy in patients with active early and extended-stage rheumatoid arthritis (RA) who have risk factors for a poor prognosis. …”
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The Effect of Iron Deficiency Stress on the Relative Expression of ZIP3, ZIP6, and ZIP7 Genes in Bread Wheat (Triticum aestivum L.) Cultivars by Saeed Rezaei Musa Dargh, Babak Abdollahi Mandoulakani, Raheleh Ghasemzadeh

“…Considering the important role of ZIP proteins in iron uptake efficiency, investigating the expression of the ZIP genes in Fe-efficient and -inefficient bread wheat cultivars can be effective in improving Fe-efficient cultivars in this valuable crop. …”
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Exploration and morphological characteristics evaluation of a tetraploid seedling from periclinal graft chimera Hongrou Huyou (Citrus unshiu + C. aurantium) by JIANG Nan, WANG Gang, ZHANG Xiaoqin, CHEN Xiang, ZHANG Min, ZHANG Chi

“…Flow cytometry (FCM) was used to determine the ploidy level of the seedlings of Hongrou Huyou using a diploid species Hongrou Huyou as control. …”
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Automated long-term monitoring of stereotypical movement in polar bears under human care using machine learning by Matthias Zuerl, Philip Stoll, Ingrid Brehm, Jonas Sueskind, René Raab, Jan Petermann, Dario Zanca, Ralph Simon, Lorenzo von Fersen, Bjoern Eskofier

“…This work advances the field of animal welfare research by introducing a scalable, efficient method for the long-term, automated detection and monitoring of stereotypical behaviour, paving the way for its application across various settings and species that can be continuously monitored with cameras. …”
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Rapid prediction of poly(butylene adipate-co-terephthalate)/poly(glycolic acid) (PBAT/PGA) agricultural films based on UV-accelerated aging tests with applicability to the environm... by Zihan Jia, Minglong Li, Bo Wang, Dongsheng Li, Peng Guo, Mingfu Lyu, Zhiyong Wei, Lin Sang

“…However, research on the degradation behaviors of biodegradable films remains relatively nascent, which is a crucial determinant in applications. Ultraviolet accelerated aging method offers an effective approach to simulate the outdoor or field degradation in a shortened period. …”
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A Dual-Technology Approach: Handheld NIR Spectrometer and CNN for <i>Fritillaria</i> spp. Quality Control by Fengling Li, Wen Lei, Juan Li, Xiaoting Wang, Jingyu Su, Tangnuer Sahati, Xiahenazi Aierkenjiang, Ruyi Tian, Weihong Zhou, Jixiong Zhang, Jingjing Xia

“…., a handheld near-infrared spectrometer was combined with a convolutional neural network (CNN) to establish an efficient and convenient quality assessment method. …”
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The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine by Kiyoumars Roushangar, Mohammad Hosseini, Saman Shahnazi

“…Since intelligent methods are applied for various rivers with different flow conditions, it is necessary to evaluate the accuracy of these methods in quantification of bed load under varied hydraulic conditions. …”
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Estimation of soil free Iron content using spectral reflectance and machine learning algorithms by Wanzhu Ma, Hongkui Zhou, Hao Hu, Zhiqing Zhuo, Kangying Zhu, Guangzhi Zhang

“…An accurate and efficient determination of soil free iron content is important. …”
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Prevalence and screening of hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Yemeni blood donors by Mohammed A.W. Almorish, Ahmed M. E. Elkhalifa, Elsharif. A. Bazie, Elsadig Mohamed Ahmed, Isameldin Mohamed Abdalla Hamad, Omer M. Aburaida, Rabei M. Elbadry, Yasir S. Kaloda, Tarig Babikir Algak Khalid

“…Hemoglobinopathies and Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency pose significant health threats in Yemen, which can be alleviated through robust preventive strategies, highlighting the importance of implementing a cost-effective and efficient blood donor screening method to facilitate early diagnosis and management of erythrocyte disorders, ultimately improving both donor safety and patient health outcomes.Objectives This study aimed to determine the prevalence of total blood cell abnormalities, hemoglobinopathies and G6PD deficiency and evaluate the efficacy of red blood cell (RBC) indices, mentzer index (MI) and naked-eye single tube red cell osmotic fragility (NESTROF) test as screening tools for diagnosis of β thalassemia trait among Yemeni blood donors.Methods A cross-sectional study was conducted with 106 volunteer blood donors who met the national standard criterion of blood donation. …”
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Penentuan Musim Penangkapan Ikan Ekor Kuning (Blonch, 1791): Studi Perairan Karimunjawa, Indonesia by Pranata Candra Perdana Putra, Setyo Tri Wahyudi, Abu Bakar Sambah, Aida Sartimbul

“…This study aims to determine the optimal yellowtail fishing season index using the moving average method based on time series analysis to optimize fishing sustainably. …”
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Presidential elections of 1997: a comparative analysis of electoral provisions and stereotypes by Lauras Bielinis

“…Priorities of the politicians can be interpreted by using statistical methods, that is—studying the texts (political declarations, programmes and rules, interviews, etc.). …”
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Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells by Ki-Beom Moon, Ji-Sun Park, Han-Gyeul Kim, Jae-Heung Jeon, Tae-Ho Kwon, Kyung-Sook Chung, Hyo-Jun Lee, Hyun-Soon Kim

“…Abstract Molecular farming for producing biopharmaceuticals in plants is considered an excellent method to replace some of the production methods currently used, and a significant number of recombinant proteins have already shown the potential to facilitate this. …”
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Understanding crystallinity indexes benchmarking concept from optimized parametric ionic liquid pretreatment using 1-ethyl-3-methylimidazolium Acetate [EMIM]Ac on oil palm biomass by Amizon Azizan, Rosmaria Abu Darim, Intan Suhada Azmi, Rafidah Jalil, Shareena Fairuz Abdul Manaf

“…With this optimization data route, the challenge of determining which highly efficient ionic liquid is costly during pretreatment on any biomass can be shortened by preliminary CrI value benchmarking.…”
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Gluten Contamination of Labelled Gluten-Free Food Products Marketed in China by Yanjun Li, Qing Liu, Samuel Godefroy, Jingguang Li, Yan Chen

“…A rigorous gluten-free diet is recognized as the only safe and efficient coeliac disease therapy. This study intended to use the enzyme-linked immunosorbent assay (ELISA) R5 Méndez method to determine gluten contamination in labelled gluten-free food products marketed in China and to evaluate the performance of two ELISA platforms (the Neogen Veratox^® R5 and the Romer Labs AgraQuant^® G12) for analyzing gluten, using R5 Méndez as the reference. …”
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Open-Source High-Throughput Phenotyping for Blueberry Yield and Maturity Prediction Across Environments: Neural Network Model and Labeled Dataset for Breeders by Jing Zhang, Jerome Maleski, Hudson Ashrafi, Jessica A. Spencer, Ye Chu

“…In this study, we developed and shared a high-throughput phenotyping method using neural networks to predict blueberry time to maturity and to provide a proxy for yield, overcoming the labor constraints of obtaining high-frequency data. …”
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Data-Driven Distributionally Robust Optimization for Solar-Powered EV Charging Under Spatiotemporal Uncertainty in Urban Distribution Networks by Tianhao Wang, Xuejiao Zhang, Xiaolin Zheng, Jian Wang, Shiqian Ma, Jian Chen, Mengyu Liu, Wei Wei

“…The results offer practical insights for city-scale planners seeking to enable the reliable and efficient electrification of mobility infrastructure under uncertainty.…”
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Reconstructed hyperspectral imaging for in-situ nutrient prediction in pine needles by Yuanhang Li, Yuanhang Li, Jun Du, Jun Du, Chuangjie Zeng, Chuangjie Zeng, Yongshan Wu, Yongshan Wu, Junxian Chen, Junxian Chen, Teng Long, Teng Long, Yongbing Long, Yongbing Long, Yubin Lan, Yubin Lan, Xiaoliang Che, Tianyi Liu, Jing Zhao, Jing Zhao

“…However, its high cost and complexity hinder practical field applications.MethodsTo overcome these limitations, we propose a deep-learning-based method to reconstruct hyperspectral images from RGB inputs for in situ needle nutrient prediction. …”
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Effects of Fagopyrum dibotrys rhizoma meal supplementation on productive performance, egg quality, egg nutritional value, and serum biochemical parameters of Shanma laying ducks by Pingwen Xiong, Pingwen Xiong, Pingwen Xiong, Gaoxiang Ai, Gaoxiang Ai, Jiang Chen, Jiang Chen, Wenjing Song, Wenjing Song, Weide Su, Weide Su, Dongyou Yu, Qiongli Song, Qiongli Song, Chuanhui Xu, Chuanhui Xu, Zhiheng Zou, Zhiheng Zou, Qipeng Wei, Qipeng Wei, Xiaolian Chen, Xiaolian Chen, Lizhen Hu, Lizhen Hu

“…This experiment was conducted to assess the impacts of FDRM supplementation in Shanma laying ducks diet by determining productive performance, egg quality, egg nutritional value, and serum biochemical parameters.MethodsWith similar laying performance (80.88 ± 5.17%) and body weight (1.24 ± 0.02 kg), 512 healthy 32-week-old Shanma laying ducks were randomly assigned to four groups consisting of eight replicates (16 ducks per replicate). …”
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Effectiveness of drainage, depressurization and gas production of coalbed methane wells based on production data: A case study of the Zhijin Block in Western Guizhou by Chen GUO, Kang SHI, Yong QIN, Hang YUAN, Zhenlong CHEN, Wei GAO, Lingling LU, Houqiang LI, Xuyang ZHANG, Xiang WANG, Hongbin HE, Runhan ZHANG

“…Discriminating the effectiveness of the two steps based on the analysis of production data and identifying the main constraints on gas production are of great significance for promoting the economic and efficient development of CBM. An analysis method was constructed for the effectiveness of CBM recovery based on three relationship curves: cumulative water production and bottom-hole flow pressure, cumulative gas production and bottom-hole flow pressure, and cumulative water production and cumulative gas production. …”
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