BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…We considered boosting natural killer (NK) cell tumor immunosurveillance, as melanoma cells express stress-induced molecules and activate NK cell lysis.Methods Here we have generated vemurafenib (a BRAF inihibitor)-resistant (R) cells from BRAFV600E SK28 and M14-sensitive (S) melanoma cell lines and investigated how resistance interferes with immunogenicity to NK cells. …”
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ASSOCIATION OF BLOOD GENE EXPRESSIONS IN RHEUMATOID ARTHRITIS PATIENTS WITH CLINICAL AND LABORATORY PARAMETERS BEFORE AND AFTER METHOTREXATE THERAPY by E. V. Chetina, N. V. Demidova, D. E. Karateev, G. A. Markova, M. A. Makarov, V. V. Kolomatsky, A. L. Logunov, E. A. Naryshkin, M. M. Lipina, S. A. Makarov, A. N. Kuzin

“…The genes, the high basic expression of which indicates the efficiency of methotrexate (MTX) therapy in relieving joint inflammation and destruction in patients with rheumatoid arthritis (RA), have been defined.Objective: to find an association between the initial expression of the genes: mTOR (mammalian target of rapamycin), a major regulator of cell growth and proliferation; ULK1 (an autophagy marker 1); p21 (a cyclin-dependent kinase inhibitor); kaspase-3 (an apoptosis activity indicator); MMP-9 (matrix metalloproteinase 9), and cathepsin K, which are involved in joint destruction, and the cytokines: TNF-α (tumor necrosis factor-α), TGFβ1 (transforming growth factor β1) and Runx2 (Runt-related transcription factor 2) in the blood of RA patients with disease activity and joint destruction before and after MTX therapy during 24 months.Subjects and methods. …”
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Molecular characteristics of hepatitis B virus among students and pregnant women in Chad by Nalda Debsikréo, Nafissatou Leye, Gora Lo, Maire Dehainsala, Odan Debsikréo, Ndeye Aminata Diaw, Diao Ba, Diabou Diagne, Abdoulaye Souare, Ndeye Dieynaba Diouf, N’da Kouamé Nazaire Kouadio, Isaac Darko Otchere, Ali Mahamat Moussa, Ndèye Coumba Toure-Kane, Françoise Lunel-Fabiani

“…Methods Venous blood samples were collected from pregnant women and students in the capital of Chad between April and August 2021. …”
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Pneumatic Compliant End-effector Using Multi-compensation Integrated Nonlinear Active Disturbance Rejection Control by ZHANG Shuzhong, WU Qianxin, DAI Fuquan, WANG Yabing, ZHANG Gong

“…Therefore, the performance of this control directly affects the quality and efficiency of the polishing process. Among various end-effector mechanisms, the pneumatic type is widely adopted due to its lightweight structure, low cost, robustness, and ease of maintenance. …”
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Power Distribution in Transmissions of Forestry and Transport Wheeled Vehicles by Roman Yu. Dobretsov, Svetlana B. Dobretsova, Sergey A. Voinash, Viktoria A. Sokolova

“…The principles for determining the main external parameters of the mechanism have been proposed. …”
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Operability as an academic subject by Albert A. Abrosimov

“…Targets and goals of academic subject are formulated, being aimed at education in methods of maintaining a high level of operability, as a part of increasing efficiency of work activity.…”
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Endoscopic transpapillary interventions in treatment of patients with biliary hypertension of various genesis by V. M. Durleshter, S. A. Gabriel’, A. Ya. Guchetl’, V. Yu. Dyn’Ko

“…OBJECTIVE. The study determined the efficacy of endoscopic transpapillary methods in diagnostics and treatment of patients with obstructive jaundice of different etiology. …”
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Correlation of Serum Cystatin C with Glomerular Filtration Rate in Patients Receiving Platinum-Based Chemotherapy by Ernesta Cavalcanti, Vittoria Barchiesi, Dionigio Cerasuolo, Flaviano Di Paola, Monica Cantile, Sabrina Chiara Cecere, Sandro Pignata, Alessandro Morabito, Raffaele Costanzo, Massimo Di Maio, Francesco Perrone

“…The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy. …”
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The definition of operating costs depending on the change of quality indicators of operation of infrastructure facilities by I. A. Chukhlomina

“…And revealed the necessity of applying the methods of individual expenditure rates, consolidated expenditure rates, as well as methods for determining the factors of influence, depending on changes in the cost of qualitative use of the rolling stock. …”
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GWO and WOA variable step MPPT algorithms-based PV system output power optimization by Abderrahim Zemmit, Abdelouadoud Loukriz, Khaled Belhouchet, Yahya Z. Alharthi, Muhannad Alshareef, Prabhu Paramasivam, Sherif S. M. Ghoneim

“…The primary advantage of these methods lies in their adaptive step-size optimization, leveraging multiple criteria to determine the optimal step size. …”
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Early Study on Visible (Vis) and Short-Wave Infrared (SWIR) Spectroscopy for Assessing Water Content in Olive Fruits: Towards Sustainable Land and Agricultural Practices by Giuseppe Bonifazi, Riccardo Gasbarrone, Davide Gattabria, Eugenio Lendaro, Luciana Mosca, Roberto Mattioli, Silvia Serranti

“…The obtained results indicate that portable Vis-SWIR spectrophotometers provide a rapid and efficient alternative to conventional drying and weighing methods, facilitating early detection of olive fruit quality. …”
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Sustainability Measurement of Farming System in Isfahan Agricultural Sector (Smallholders-Rural Production Cooperatives- Farm Corporation) by Saedali Nekooei Naenii, Yosef Ghanbari, Hamid Barghi

“…Indeed, this capacity is also determined by analysis or stability measurement. Stability Analysis is the basis and criteria to determine environmental standards in order to show the utilization of resources and control screw. …”
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Synthesis and characterization of hematite nanomaterials imprinted with acetone, ethanol and methanol for AI-Based IoT gas sensor arrays by Rana M. Abdelghani, Abd El-Hady B. Kashyout, Iman Morsi, Taha Elsayed Taha, Naglaa F. Soliman, Walid El-Shafai

“…Regression analysis further demonstrated that the RF-GB model achieved an ideal coefficient of determination (R2 = 1) across all three gases, with RF and RF-GB-NN yielding R2 values of 0.999. …”
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Investigation on the interaction force measurement between bubble and particle in flotation based on resistance strain cantilever beam by Xibing REN, Lijuan SUN, Qinshan LIU, Yulong CHENG, Xiahui GUI, Yaowen XING

“…The interaction force between bubble and particle directly determine the efficiency of bubble-particle mineralization and serve as a crucial window into the microscopic mechanism of flotation. …”
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Experimental approaches to creating a tissue-specific matrix for a bioartificial liver by A. M. Grigoriev, Yu. B. Basok, A. D. Kirillova, L. A. Kirsanova, N. P. Shmerko, A. M. Subbot, E. A. Nemets, I. A. Miloserdov, M. Yu. Shagidulin, V. I. Sevastyanov

“…Biochemical screening included the determination of DNA quantity in the test samples. Efficiency of surfactant washing was assessed by the cytotoxicity of the matrix in the NIH 3T3 fibroblast culture. …”
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Sparstolonin B potentiates the antitumor activity of nanovesicle-loaded drugs by suppressing the phagocytosis of macrophages in vivo by Yuefeng Zhang, Zuo Mou, Wei Song, Xiaoqin He, Qin Yi, Zhekai Wang, Xietong Mao, Wei Wang, Yangtao Xu, Yang Shen, Peng Ma, Kaihuan Yu

“…Macrophages (Mφs) in the liver and spleen contribute to the rapid depletion of NVs, but the underlying mechanism is unclear. Methods By collecting the supernatant of PANC-1 cells and squeezing PANC-1 cells, EVs and ENVs derived from PANC-1 cells were prepared via ultracentrifugation. …”
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Continuum topological derivative - A novel application tool for segmentation of CT and MRI images by Viswanath Muthukrishnan, Sandeep Jaipurkar, Nedumaran Damodaran

“…Results clearly demonstrate that the combination of CTD denoising and segmentation outperforms the other three established methods in terms of both efficiency and accuracy in delineating diseased or affected areas, as evidenced by the various case studies conducted in this research. …”
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Digital vs. conventional instructor-led midwifery training in Benue State, Nigeria: a randomized non-inferiority trial by Fanan Ujoh, Anja Dzunic-Wachilonga, Rafat Noor, Victoria Gusa, Roseline Ape-aii, Isaac Ohene, Rajan Bola, Jan Christilaw, Stephen Hodgins, Ronald Lett

“…In this study, the Midwifery Active Digitization Empowerment Initiative (MADE-I) program was tested to determine if digital delivery of the Fundamental Interventions, Referral and Safe Transfer (FIRST) course is at least equally effective for training midwifery students compared to conventional small-group delivery.MethodsA non-inferiority randomized controlled trial design was used, enrolling 130 s-year students from 2 midwifery schools in Benue State, Nigeria. …”
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Agricultural Electrostatic Spraying Electrode Corrosion Degradation Mechanisms: A Multi-Parameter Coupling Model by Yufei Li, Anni Zou, Jun Hu, Changxi Liu, Shengxue Zhao, Qingda Li, Wei Zhang, Yafei Wang

“…Theoretical analysis indicates that the Fermi level and work function of electrode materials fundamentally determine charge transfer efficiency, while corrosion resistance emerges as a key parameter affecting system durability. …”
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Integrating Artificial Intelligence in urban redesign: A collaborative approach to post-war design phases by I. Alshafei, R. Almashhour

“…It compares conventional methods of urban revival with innovative Artificial Intelligence-supported methods to determine the advantages of utilizing Artificial Intelligence in post-war urban re-design. …”
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