Phase I-IIa clinical trial to evaluate the safety, feasibility and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft p... by Ingrid Garzón, Antonio Campos, Miguel Alaminos, Gloria Carmona, Antonio España-López, Ricardo Fernández-Valadés, Elisa Cubiles, Miguel Angel Martin-Piedra, Víctor Carriel, Fernando Campos, Adoración Martínez-Plaza, Daniel Vallejo, Esther Liceras-Liceras, Jesús Chato-Astrain, Oscar Dario García-García, David Sánchez-Porras, Paula Ávila-Fernández, Miguel Etayo-Escanilla, Blanca Quijano, Elisabet Aguilar

“…This trial aims to evaluate the potential of a bioengineered artificial palate mucosa, created through tissue engineering with autologous stromal and epithelial cells and nanostructured fibrin–agarose biomaterials, to enhance treatment outcomes for patients with unilateral cleft lip and palate.Methods and analysis This phase I-IIa clinical trial aims to evaluate the feasibility and biosafety of a procedure involving grafting bioartificial palate mucosa onto the areas of denudated bone in patients undergoing uranostaphylorrhaphy. …”
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A Disposable SWCNTs/AuNPs-Based Screen-Printed ISE at Different Temperatures to Monitor Ca²⁺ for Hypocalcemia Diagnosis by Zhixue Yu, Hui Wang, Yue He, Ruipeng Chen, Xiangfang Tang, Benhai Xiong

“…Therefore, the development of an economical and swift detection method holds paramount importance for facilitating early diagnosis and subsequent treatment. …”
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Automated long-term monitoring of stereotypical movement in polar bears under human care using machine learning by Matthias Zuerl, Philip Stoll, Ingrid Brehm, Jonas Sueskind, René Raab, Jan Petermann, Dario Zanca, Ralph Simon, Lorenzo von Fersen, Bjoern Eskofier

“…This work advances the field of animal welfare research by introducing a scalable, efficient method for the long-term, automated detection and monitoring of stereotypical behaviour, paving the way for its application across various settings and species that can be continuously monitored with cameras. …”
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Independensi Aparat Pengawas Intern Pemerintah Guna Pelaksanaan Good Governance Berbasis CACM Di Lingkungan Pemerintah Daerah by Herlin Angela Dewi

“…This normative juridical research show that CACM are tools that are expected to support the implementation of audits in order to produce effective and efficient audits. The research method used is normative juridicial. …”
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A Dual-Technology Approach: Handheld NIR Spectrometer and CNN for <i>Fritillaria</i> spp. Quality Control by Fengling Li, Wen Lei, Juan Li, Xiaoting Wang, Jingyu Su, Tangnuer Sahati, Xiahenazi Aierkenjiang, Ruyi Tian, Weihong Zhou, Jixiong Zhang, Jingjing Xia

“…., a handheld near-infrared spectrometer was combined with a convolutional neural network (CNN) to establish an efficient and convenient quality assessment method. …”
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Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs by Jun Li, Cuiyun Zhang, Yuping Guan, Siyu Wang, Jiawen Zheng, Junnan Feng, Sile Han, Ruijuan Ma, Pengfei Ren, Shasha Li, Harry J. M. Groen, Klaas Kok, Anke van den Berg, Bing Wei, Jie Ma, Hongle Li, Yongjun Guo

“…Material and methods Targeted sequencing covering the hotspot regions of eight LUAD driver genes was performed across 853 treatment-naive LUAD patients admitted in Henan Cancer Hospital (HNCH cohort). …”
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Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised... by John Norrie, Stephen Morris, Daniel Francis McAuley, Bronagh Blackwood, Paul Dark, Matt P Wise, Anthony C Gordon, Kalliopi Kydonaki, Timothy Simon Walsh, David Hope, Christopher Weir, Gavin Perkins, Nazir I Lone, Benedict Creagh-Brown, Julia Boyd, Michael Reade, Richard Anthony Parker, Leanne M Aitken, Valerie J Page, Alasdair MacLullich, Cathrine A McKenzie, Alix Macdonald, Annabel Giddings, Lydia Emerson, Robert Glen

“…The alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B) trial aims to determine whether clonidine or dexmedetomidine (or both) are clinically and cost-effective in MV ICU patients compared with usual care.Methods and analysis Adult ICU patients within 48 hours of starting MV, expected to require at least 24 hours further MV, are randomised in an open-label three arm trial to receive propofol (usual care) or clonidine or dexmedetomidine as primary sedative, plus analgesia according to local practice. …”
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Measurement report: Optical and structural properties of atmospheric water-soluble organic carbon in China – insights from multi-site spectroscopic measurements by H. Chen, C. Yan, C. Yan, C. Yan, L. Huang, L. Huang, L. Du, L. Du, Y. Yue, X. Wang, Q. Chen, M. Xie, J. Liu, F. Wang, S. Fang, Q. Yang, H. Niu, M. Zheng, Y. Wu, L. Xue

“…<p>To understand the spatial variation of optical and structural properties of water-soluble brown carbon and its influencing factors in China, the light absorption, fluorescence, and Fourier transform infrared (FTIR) spectrum of water-soluble organic carbon (WSOC) in different regions of China are measured following the same analytical methods. The average light absorption coefficients and mass absorption efficiencies of WSOC at 365 nm (Abs<span class="inline-formula">₃₆₅</span> and MAE<span class="inline-formula">₃₆₅</span>) rank from high to low as northwest China <span class="inline-formula">&gt;</span> southwest China <span class="inline-formula">&gt;</span> north China <span class="inline-formula">&gt;</span> east China <span class="inline-formula">&gt;</span> regional site, with higher values in northern China than southern China and regional sites and higher values in inland areas than coastal areas. …”
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Error performance of multi-branch dual-hop PF cooperative systems by Guangqiu LI, Jiayun DONG, Tao JIANG

“…Design of multi-branch dual-hop phase-only forward(PF)cooperative systems with continuous phase frequency shift keying(CPFSK)modulation needs to determine the number of branch and modulation index.The usual solution of determining the above parameters is the time-consuming and inefficient computer simulation.An efficient solution of determining these parameters is theoretical analysis method.Semi-analytical expressions for the average bit error rate(ABER)of multi-branch dual-hop PF cooperative systems in conjunction with discrimination detection CPFSK over time-selective Rayleigh fading channels was presented.Two cases with and without antenna selection at the relays and maximum-ratio combining(MRC)receive diversity at the destination were considered.The simulation results show that numerical calculation results and simulation results for the ABERs of PF，discrimination detection,CPFSK cooperative systems are consistent and show that the above ABER theory results of CPFSK cooperative systems can be used to design PF cooperative systems.…”
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Technology of automated video observation of a drogue-sensor basket in the problem of autonomous aerial refueling by A. V. Gaidenkov, M. I. Kanevskiy, A. S. Ostrovskiy, O. I. Ganyak, N. Yu. Chizhov

“…The technology is based on the use of a passive optoelectronic system and incorporates the logic of automated refueling observation of a refueling process using algorithms for the automatic detection and tracking of a drogue-sensor, a methodical apparatus for suboptimal linear filtering of the observed process under the conditions of spatial and temporary non-stationarity of the refueling process, algorithms for automatic correlation detection and tracking of a drogue-sensor using suboptimal filtering. …”
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Evolution of the activities of states as reflected in legal and political Teachings by A. A. Klishin

“…The return of the law to its traditional, system-level basics that are clear to everyone taking part in the social relations is often facilitated by crises, such as the one in place today when the existing challenges and problems are complemented by the objective force majeure events like the virus attack in 2020 which the amorphous “network-based” instruments or not entirely just and efficient elements of the “international legal order” cannot cope with, as opposed to the active governmental and legal mechanisms of sovereign states capable of ensuring the balance of legal instruments and administrative levers of management in crisis situations.MATERIALS AND METHODS. …”
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Optimizing Small Cell Performance: A New MIMO Paradigm With Distributed ASTAR-RISs by Shakil Ahmed, Ahmed E. Kamal, Mohamed Y. Selim, Md Akbar Hossain, Saifur Rahman Sabuj

“…Additionally, we use the dual method to determine the optimal ON/OFF status of the ASTAR-RIS. …”
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Evaluation of SSM-Wheat Model in Simulating the Growth and Development of Wheat (Triticum aestivum L.) Cultivars in Different Planting Densities by Ali Rahemi karizki, Faramarz Sayyedi, Habib allah Soghi, Arazqlych Marfy, Mojtaba Salehi SHaikhi, Saeed Bagherikia

“…The aim of this experiment is to evaluate the SSM-Wheat model under different density conditions and late-season drought stress. Materials and Methods This experiment was conducted in the cropping year 2021-2022 at the Gorgan Agricultural Research Station. …”
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Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes by D. V. Ivashchenko, A. S. Osipov, E. V. Nazarova, M. A. Ovchinnikova, N. I. Buromskaya, V. V. Smirnov, P. V. Shimanov, R. V. Deitch, T. A. Fainshtein, E. N. Shagovenko, K. A. Akmalova, A. A. Kachanova, E. A. Grishina, L. M. Savchenko, Yu. S. Shevchenko, D. A. Sychev

“…The CGAS, PANSS, UKU SERS, SAS, and BARS scales were used to evaluate the efficiency and safety of the therapy on day 14. The activity of CYP3A and CYP2D6 isoenzymes was measured by determining the metabolic ratios of the concentrations of endogenous substrates of the isoenzymes and their metabolites in a morning urine sample on days 1 and 14 of the study. …”
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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and ma... by Leanne J Robinson, Rahel Wampfler, Inoni Betuela, Stephan Karl, Michael T White, Connie S N Li Wai Suen, Natalie E Hofmann, Benson Kinboro, Andreea Waltmann, Jessica Brewster, Lina Lorry, Nandao Tarongka, Lornah Samol, Mariabeth Silkey, Quique Bassat, Peter M Siba, Louis Schofield, Ingrid Felger, Ivo Mueller

“…This study aims to directly determine the contribution of relapses to the burden of P. vivax and P. ovale infection, illness, and transmission in Papua New Guinean children.…”
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Genetic transformation of Lentil (Lens culinaris M.) and production of transgenic fertile plants by Fatemeh zaker tavallaie, Behzad Ghareyazie, Abdorreza Bagheri, Kiran Komar Sharma

“…The objective of this research is gene transformation of lentil using codA gene to enhance its tolerance against abiotic stress especially cold tolerance. Materials and Methods Seeds of lentil (Lens culinaris Medik) variety of Gachsaran (ILL6212) collected from Shiravan Agriculture Research center in Iran were used in this investigation. …”
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The Effect of Deficit Irrigation on Yield and Its Related Traits in Promising Chiti Bean (Phaseolus vulgaris L.) Genotypes under Zanjan Province Climatic Condition by Seyedeh Soudabeh Shobeiri, Ali Akbar Asadi

“…Materials and MethodsIn order to investigate the effects of deficit irrigation on some phenological and yield traits of chiti beans, 14 promising chiti bean genotypes obtained from breeding programs along with Sadri and Kosha control cultivars, in two consecutive crop years from 2022 to 2023, at Kheirabad Zanjan Research Station, in two conditions normal irrigation (irrigation cycle of 5 days) and deficit irrigation (irrigation cycle of 9 days) were investigated. …”
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Evaluation of the effectiveness of combined treatment of coronary heart disease – coronary artery bypass grafting, transplantation of autologous bone marrow mononuclear cells: a ra... by V. V. Komok, N. S. Bunenkov, S. A. Beliy, V. M. Pizin, V. M. Kondratev, A. V. Dulaev, A. E. Kobak, T. S. Maksimova, I. P. Sergienko, E. V. Parusova, L. A. Smirnova, E. V. Babenko, B. V. Afanasev, A. S. Nemkov, G. G. Khubulava

“…Objective: to evaluate the outcome of ABMMC transplantation during coronary artery bypass grafting (CABG) surgery in combined treatment of CHD. Materials and methods. The data of 408 patients admitted to the clinic from 2013 to 2016 for planned surgical treatment of CHD were analyzed. …”
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Comparative efficacy studies of nine Chinese traditional patent medicines for the treatment of post-myocardial infarction heart failure: A Bayesian network by Fuyun Jia, Shengwei Gao, Qiaochu Zhu, Opoku Bonsu Francis, Rui Liu, Yadong Wang, Rui Zhang, Shichuan Chen, Zilian Zhan, Xi Zhang, Qiang Xu

“…This network meta-analysis aimed to assess the effectiveness of nine different Chinese traditional patent medicines (CTPMs) in the treatment of heart failure developing after acute myocardial infarction. Methods: Determine the eligibility criteria for inclusion and exclusion in advance. …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…Data analysis and determination of significant levels were performed using SPSS 16 software and Duncan's statistical test with a confidence level of 95% and One-Way ANOVA test. …”
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