Development and Characterization of Trihexyphenidyl Orodispersible Minitablets: A Challenge to Fill the Therapeutic Gap in Neuropediatrics by Camila Olivera, Oriana Boscolo, Cecilia Dobrecky, Claudia A. Ortega, Laura S. Favier, Valeria A. Cianchino, Sabrina Flor, Silvia Lucangioli

“…The properties of powder mixtures were evaluated before direct compression and pharmacotechnical tests were performed on the final formulation. The determination of the API content, uniformity of dosage, and physicochemical stability studies were analyzed by an HPLC-UV method. …”
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Dual SPE–HPLC–MS/MS Platform for Cross-Class Antiparasitic Surveillance: Simultaneous Quantification of Oxyclozanide and Levamisole Hydrochloride in Ovine Tissues with Applications... by Guonian Dai, Xuzheng Zhou, Weiwei Wang, Bintao Zhai, Jiang Li, Yangling Liu, Yong Zhang, Jiyu Zhang

“…This study presents a novel high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method for simultaneous determination of oxyclozanide (OXY) and levamisole hydrochloride (LEV) residues in ovine tissues, addressing the critical gap in cross-class antiparasitic drug monitoring. …”
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AI-assisted diagnosis of vulvovaginal candidiasis using cascaded neural networks by Zhongxiao Wang, Ruliang Wang, Haichun Guo, Qiannan Zhao, Huijun Ren, Jumin Niu, Ying Wang, Wei Wu, Bingbing Liang, Xin Yi, Xiaolei Zhang, Shiqi Xu, Xianling Dong, Liqun Wang, Qinping Liao

“…Timely and accurate diagnosis is crucial. Traditional methods, relying on clinical evaluation and manual microscopic examination, have limitations. …”
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Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants by Tonia T. Kam, Christine H. T. Bui, Hin-Wo Yeung, Peter C. H. Wong, Alex W. H. Chin, John M. Nicholls, Malik Peiris, Kenrie P. Y. Hui, Leo L. M. Poon, Michael C. W. Chan

“…Given that the canine respiratory tract is susceptible to a wide range of influenza viruses, it is of interest whether H3N2-CIV are likely to reassort with human and avian IAVs to generate reassortants with increased zoonotic potential. Methods We conducted a co-infection study in canine tracheal explants. …”
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Using Ultrasonic Acoustics to Detect Cryptic Flying Squirrels: Effects of Season and Habitat Quality by Corinne A. Diggins, L. Michelle Gilley, Christine A. Kelly, W. Mark Ford

“…The use of ultrasonic acoustic detectors to survey for flying squirrels (Glaucomys spp.) is a novel method that is more efficient than traditional methods. …”
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<p><strong>Morphological, optical and thermal properties of </strong>α and γ-<strong>aluminum nanoparticles: Assessment of their biological activities against storage mites and myc... by Marwa Barghout, Hoda Kabary, Asmaa Ismail, Ahmed Samy

“…The growth of fungi was assessed to determine the fungicidal concentrations in PDB cultures by Mycelium Dry Weights Method. …”
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Fistula Tract Laser Closure (FiLac) versus Standard Fistulectomy in the Treatment of Simple Perianal Fistula: A Prospective Interventional Study by Shreethi Sasidharan Pillai, D Balaji, Harshwanth Chandhar, G Tilak Ramu, K Shanmugapriya

“…Aim: To compare short-term (postoperative pain, bleeding, mean hospital stay) and intermediate-term (wound healing) outcomes between FiLaC and standard fistulectomy in the treatment of simple perianal fistulas. Materials and Methods: A prospective interventional study was conducted at SRM Medical College Hospital and Research Centre, Chengalpettu, Tamil Nadu, India, in the Department of General Surgery over a period of 18 months, involving 108 patients randomised into FiLaC (group A) and standard fistulectomy (group B). …”
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Dynamics of Kidney Function in Patients with Chronic Kidney Disease and Atrial Fibrillation Who Receive Dabigatran by N. A. Novikova, Z. K. Salpagarova, M. I. Chashkina, A. A. Bykova, Z. A. Alimova, А. S. Yadykina, D. F. Mesitskaya, N. A. Babakova, D. A. Andreev

“…Currently, there are scarce studies into the use of direct oral anticoagulants in patients with atrial fibrillation and chronic kidney disease (in case of Glomerular Filtration Rate (GFR) below 45 ml/min/1.73 m2).Aim. To determine the dynamics of GFR in patients with AF and CKD (in case of GFR below 45 ml/min/1.73 m2).Material and Methods. …”
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The effect of tofacitinib on function and quality of life indicators in patients with rheumatoid arthritis resistant to synthetic and biological disease-modifying antirheumatic dru... by D. E. Karateev, D. E. Abdulganieva, A. R. Babaeva, A. A. Baranov, L. P. Evstigneeva, O. N. Ivanova, G. V. Lukina, E. L. Luchikhina, V. I. Mazurov, A. S. Misiyuk, O. V. Semagina, A. E. Sizikov, V. N. Sorotskaya

“…Tofacitinib (TOFA), a representative of a new class of targeted synthetic disease-modifying antirheumatic drugs (s-DMARD), is a promising drug for treating rheumatoid arthritis (RA) and other immune inflammatory diseases.Objective: to evaluate the efficiency and safety of therapy with TOFA in combination with methotrexate (MTX) and other s-DMARDs in real clinical practice in patients with active RA and previous ineffective therapy.Patients and methods. …”
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Strategy for prophylactic application of peripheral va-ecmo in transplantation involving expected extremely prolonged ischemia time by V. N. Poptsov, V. M. Zakharevich, E. A. Spirina, A. I. Skokova, A. K. Solodovnikova, A. S. Ignatkina, A. A. Kuznetsova, G. B. Glinkin

“…Materials and methods. Thirty-eight recipients (33 (86.8%) males and 5 (13.2%) females), age 11–66 (44.7 ± 12.0) years (median 48.0 years) were examined. …”
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The diagnostic of PAX1 gene methylation in cervical lesions and its role in the triage of non-16/18 HR-HPV positive by Meng-Meng Chen, Meng-Meng Chen, Bing-Qiang Zhang, Bing-Qiang Zhang, Yan-Song Luan, Guo-Long Sun, Yun-Yuan Zhang, Xiao-Yan Zhou, Xi-Feng Zhang, Feng-Chun Gao, Jun-Mei Yu

“…ObjectiveThis study aims to systematically evaluate the application value of PAX1 gene methylation detection in cervical lesion screening and its potential advantages in the triage of non-16/18 high-risk human papillomavirus (HR-HPV) positive patients.Materials and methodsThis study enrolled 1,619 HPV-positive female patients who visited the Affiliated Hospital of Qingdao University from December 2023 to March 2025, with 989 patients ultimately meeting the inclusion criteria. …”
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Poisoning Epidemiology, Clinical Outcomes and Management Decisions for General Public Calls: A Cross-Sectional Analysis of a Nationwide Telehealth Toxicology Consultation Service D... by Abdullah A. Alharbi, Mohammed A. Muaddi, Meshary S. Binhotan, Ahmad Y. Alqassim, Ali K. Alsultan, Mohammed S. Arafat, Abdulrahman Aldhabib, Yasser A. Alaska, Eid B. Alwahbi, Meshari A. Almutairi, Mobarak Alharthi, M. Mahmud Khan, Mohammed Alabdulaali, Nawfal A. Aljerian

“…Methods We conducted a retrospective analysis of all public calls to the national TCS hotline between January 1 and December 31, 2023. …”
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Design of a Modular Wall-Climbing Robot with Multi-Plane Transition and Cleaning Capabilities by Boyu Wang, Weijian Zhang, Jianghan Luo, Qingsong Xu

“…It provides a new approach for wall-climbing robots to collaborate during wall transitions through a quick attachment-and-disassembly device and an efficient wall detection method.…”
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Oxygen heterocyclic compounds (OHCs) in lemon oils are important markers in targeted HPLC analyses for authentication by Siyu Liu, Shiming Li, Chi-Tang Ho

“…This study provided a reliable and efficient method in determining the authenticity of lemon oils.…”
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An Effective Algorithm for Video-Based Parking and Drop Event Detection by Gang Li, Huansheng Song, Zheng Liao

“…The method is based on the matching of the three-dimensional structure of the vehicle body. …”
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Inversion Study of Hydrogeological Parameters for Metro Foundation Pit Confined Aquifiers Based on Surrogate Modeling by YE Ru, DI Honggui, ZHU Zhitai, ZHU Yilong, JIANG Bin, XIANG Longsheng, CHAI Dongsheng, YAO Qiyu

“…When these parameters are input into the numerical seepage model, the calculated data closely matches the measured data in all process, including the stage of rapid water level drop in the initial pumping, the stage of gradual change during the stabilization period, and the stage of water level gradual recovery after pumping stops, validating the feasibility of the inversion method. The use of deep learning-based surrogate modeling combined with optimization algorithms enables efficient and accurate inversion analysis of groundwater parameters.…”
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Effects of Iron-Calcium and Organic Matter Matrix on Cadmium Detection in Soil by Energy Dispersive X-Ray Fluorescence Spectroscopy by Aosong JIANG, Longhua WU, Tong ZHOU, Zhu LI, Jingjing WANG, Yujuan HUANG

“…This study demonstrates that the application potential of EDXRF technology in different types of soil through reasonable correction measures can be significantly improved, and an efficient, convenient and accurate detection method for environmental monitoring can be established.…”
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Light Stable Isotopes and Their Ratios in Honey Components by Lev A. Oganesyants, Alexander L. Panasyuk, Dmitriy A. Sviridov, Mikhail Yu. Ganin, Alexey A. Shilkin, Oksana V. Serebryakova

“…The research resulted in a patent (RU2809285C1) for a new method of determining exogenous sugar-containing substances in honey.…”
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Detail-preserving denoising of CT and MRI images via adaptive clustering and non-local means algorithm by Mohit Sharma, Ayush Dogra, Bhawna Goyal, Anita Gupta, Manob Jyoti Saikia

“…The method integrates a cluster-wise principal component analysis (PCA) thresholding approach guided by the Marchenko–Pastur (MP) law from random matrix theory and a non-local means algorithm. …”
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Circular Dichroism in Study of Drug Chirality by G. N. Gildeeva, I. G. Smirnova

“…It was shown that circular dichroism provided rapid and highly efficient determination of the optic isomers and could be recommended as a method for control of drug quality.…”
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