Enhanced Intranasal Delivery of Atorvastatin via Superparamagnetic Iron-Oxide-Loaded Nanocarriers: Cytotoxicity and Inflammation Evaluation and In Vivo, In Silico, and Network Phar... by Kristina Zarif Attalla, Doaa H. Hassan, Mahmoud H. Teaima, Carol Yousry, Mohamed A. El-Nabarawi, Mohamed A. Said, Sammar Fathy Elhabal

“…<b>Objective</b>: This study aims to develop an intranasal (IN) delivery system for glioblastoma multiforme (GBM) management using repurposed superparamagnetic iron-oxide (SPION) loaded with atorvastatin (ATO)-nanostructured lipid carrier (NLC). <b>Methods</b>: Emulsification and ultrasonication were used to formulate ATO-NLCs, and the best formula was loaded with SPION to make the final atorvastatin/superparamagnetic iron oxide-loaded nanostructured lipid carrier (ASN) formulation. …”
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Investigating the relationship between Pfkelch13 mutations and response to artemisinin-based treatment for uncomplicated falciparum malaria: a protocol for a systematic review and... by Prabin Dahal, Philippe Guerin, Farhad Shokraneh, James A Watson, Karen I Barnes, Aboubakar Soma, Stephanie van Wyk, Chistevy Vouvoungui, Dhol S Ayuen

“…ART-R has been causally linked to specific mutations in the Pfkelch13 gene.Methods and analysis The systematic review and associated meta-analysis aim to determine the correlation between Pfkelch13 (alleles present in the Kelch13 gene region of the P. falciparum parasite) genotypes and clinical and parasitological response to ACTs from a globally representative data set pooling individual patient data (IPD) from eligible published and unpublished studies. …”
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Combining genetic and non-genetic factors to predict the risk of pancreatic cancer in patients with new-onset diabetes mellitus by Yu Zhou, Zhuo Wu, Liangtang Zeng, Rufu Chen

“…We developed a NODM-PC risk prediction model to stratify PC risk in patients with NODM. Methods This study utilized data from the UK Biobank, including 238 NODM-PC cases and 14,825 cancer-free T2DM controls. …”
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Factors influencing value-based care application among medical students and postgraduate in Thailand by Phoomjai Sornsenee, Kittisakdi Choomalee, Kamonlak Sanphet, Kanyarat Keereerak, Techin Wongwatthanawisit, Tanyamon Wongtabpabud, Panpim Tipphayawong, Panupong Khunjun, Suppanita Tularak, Kanisorn Sungkaro, Theepat Wongkittithaworn

“…Abstract Background The adoption of Value-Based Care (VBC) is essential for enhancing healthcare quality and efficiency, with implications for future healthcare delivery. …”
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A clinical study of efficacy and safety of the Carry Life UF system in continuous ambulatory peritoneal dialysis patients: protocol for a prospective, multicenter, randomized, cros... by Martin Wilkie, Charlotte de Leon, Ola Carlsson, Jörgen Hegbrant, Olof Heimbürger

“…The aim of this study is to compare efficacy and safety of the Carry Life UF system with a standard CAPD prescription in the home setting. Methods A prospective, multicenter, randomized, crossover study of 19 adult subjects at up to 12 sites in Italy, Sweden and the UK will complete the investigation. …”
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RITUXIMAB THERAPY MONITORING IN PATIENTS WITH RHEUMATOID ARTHRITIS HROUGH PERIPHERAL BLOOD GENE EXPRESSION ANALYSIS by E. V. Chetina, A. V. Pivanova, K. Kh. Kuzikyants, A. Yu. Devyataikina, G. V. Lukina, E. Yu. Samarkina, A. P. Aleksankin, E. N. Aleksandrova

“…Objective: to determine the predictors of the efficiency of rituximab (RTM) therapy through analysis of blood gene expressions in patients with rheumatoid arthritis (RA). …”
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Adalimumab in Focus: Evaluating Effectiveness and Safety in Non-Infectious Uveitis at a Tertiary Referral Center in Türkiye by Berru Yargı Özkoçak, Çiğdem Altan, Burcu Kemer Atik, Berna Başarır

“…BCVA was monitored at baseline and subsequent months to determine the onset of functional efficiency of ADA treatment. …”
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Intelligent algorithm-based model for predicting mass transfer performance in CO2 absorption within a rotating packed bed by Wei Zhang, Hao Chen, Ke Huang, Xing Shu, Cheng Fu, Bin Huang

“…The findings of this study suggest that the integration of intelligent optimization algorithms with LSSVM offers a promising alternative to conventional methods for predicting the mass transfer coefficient in RPB systems, thereby enhancing the efficiency and reliability of CO2 absorption processes.…”
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Unplanned re-attendance to emergency department of patients with systemic inflammatory response syndrome: a situational analysis by Siwapon Srikeaw, Ketsarin Utriyaprasit, Wanlaya Thampanichawat, Siriorn Sindhu, Chukiat Viwatwongkasem, Thitipong Tankumpuan

“…Methods This study employed a cross-sectional and prospective cohort study design. …”
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Demonstration of accurate ID-VG characteristics modeling in SiC mosfets using separated artificial neural networks with small training dataset by Manopat Chankla, Bang-Ren Chen, Shivendra Kumar Singh, Yogesh Singh Chauhan, Wen-Jay Lee, Nan-Yow Chen, Songphol Kanjanachuchai, Tian-Li Wu

“…A transition layer is also used to model the transition between the ON- and OFF-states. We evaluated our method on training datasets of various sizes. This method achieved a coefficient of determination (R 2) exceeding 99.96% on 3000 I D –V G curves when training was conducted using only 150 randomly selected curves, with a modeling time of less than 10 s. …”
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Caracterización de los deportistas Paralímpicos de Goalball Chilenos y asociación entre variables Antropométricas, de Composición Corporal y Fuerza en el Lanzamiento del Balón (Cha... by Luis Felipe Castelli Correia de Campos, Cristian Eduardo Luarte rocha, Luiz Gustavo Teixeira Fabricio dos Santos, Jerusa Petróvna Resende Lara, Raúl Smith Plaza, Kevin Campos-Campos, Juan Gajardo-Oñate

“…Conclusion: In relation to the data obtained in the present study, there is a very high and significant correlation between estimated maximum strength and shorter times in the launch of the Goalball, which shows that strength is a determining quality in offensive actions, whereas anthropometric measures are not, since they did not influence throwing efficiency. …”
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Job recommender systems: a systematic literature review, applications, open issues, and challenges by Duygu Çelik Ertuğrul, Selin Bitirim

“…Conclusion As a result, JRSs are still under development and need further improvements, particularly in reducing bias and increasing efficiency in HR processes through advanced AI technologies. …”
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Experimental measurement of the size distribution of microbubbles prepared by reciprocating syringe technique by Zhengbin Pan, Yiting Xiao, Yijian He, Bo Kong, Yiyi Liang

“…The shadow imaging method was used to explore the influence of the equipment operation parameters on the experimental system's microbubble flow process. …”
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Complete auricular avulsion and reconstruction techniques: a literature review by Manar A. Awad, Mahmoud A. Deshisha, Yasmin Z. Salam, Hadir M. Abou Mostafa, Mohamed G. Ibrahim, Ihab M. Nada

“…It also aimed to help the surgeon choose the best total reconstruction method considering the available materials and to assess the advantages and disadvantages of each technique. …”
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Designing a sustainable-resilient humanitarian supply chain for post-disaster relief process, an earthquake case study in Haiti by Hossein Shakibaei, Seyyed Amirmohammad Moosavi, Amir Aghsami, Masoud Rabbani

“…Originality/value – Ultimately, the model provides the optimal quantities of each product to be shipped and determines the appropriate mode of transportation. Additionally, the application of the epsilon constraint method results in a set of Pareto optimal solutions. …”
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Predicting the uplift capacity of circular anchors in frictional-cohesive soils using Kolmogorov-Arnold networks by Tran Vu-Hoang, Tan Nguyen, Jim Shiau, Hung-Thinh Pham-Tran, Trung Nguyen-Thoi

“…Additionally, a closed-form solution for stability factors is derived through KAN, providing an efficient method for predicting bearing capacity. The optimized models exhibit high coefficient of determination (R²) values and low root mean square errors (RMSE) for training and testing datasets. …”
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Hybrid Vehicle Battery Health State Estimation Based on Intelligent Regenerative Braking Control by Chellappan Kavitha, Gupta Gautam, Ravi Sudeep, Chidambaram Kannan, Bragadeshwaran Ashok

“…In this study, a fuzzy logic estimation method is deployed to determine the tire road friction coefficient (TRFC) and various control strategies are adopted to establish regenerative cut-off points. …”
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BACTERIAL PATTERNS AND URINE CULTURE SENSITIVITY DESCRIPTION OF UROLOGY PATIENTS IN THE PAEDIATRIC POPULATION AT TERTIARY HOSPITAL by Veryne Ayu Permata, Johan Renaldo, Naritha Vermasari

“…Material & Methods: Medical record data and the microbiology laboratory database were studied retrospectively using a descriptive method. …”
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Injection well site optimization of carbon geological sequestration based on dynamic programming by Bin LIU, Chunsheng SHI

“…Geological storage of carbon dioxide (CO2) is one of the most effective methods for reducing carbon emissions and mitigating the greenhouse effect, critical challenges in combating climate change. …”
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Optimization of software project evaluation system by Li ding .

“…An improved particle swarm optimization algorithm is introduced to solve the problem of determining the connection weight coefficient of the evaluation model accurately and efficiently. …”
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