Simplified clinical algorithm for identifying patients eligible for immediate initiation of antiretroviral therapy for HIV (SLATE): protocol for a randomised evaluation by Mhairi Maskew, Bruce A Larson, Isaac Tsikhutsu, Margaret Bii, Peter D Ehrenkranz, Sydney Rosen, Matthew P Fox, Alana T Brennan, WD Francois Venter

“…For this policy of ‘treat all’ to succeed, millions of new patients must be initiated on ART as efficiently as possible. Studies have documented high losses of treatment-eligible patients from care before they receive their first dose of antiretrovirals (ARVs), due in part to a cumbersome, resource-intensive process for treatment initiation, requiring multiple clinic visits over a several-week period.Methods and analysis The Simplified Algorithm for Treatment Eligibility (SLATE) study is an individually randomised evaluation of a simplified clinical algorithm for clinicians to reliably determine a patient’s eligibility for immediate ART initiation without waiting for laboratory results or additional clinic visits. …”
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The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs by Entsar Shehata Mohammed, Seham Mohammed Elmwafie, Fatma Sayed Abdelaziz Mohamed, Safaa Salah Ismail

“…Abstract Background Preterm neonates often undergo invasive procedures during the period spent in neonatal intensive care units (NICUs), yet their ability to deal with pain is limited due to their immature nervous systems. Managing pain efficiently in this age is crucial, as recurrent or improperly controlled pain can have over-time influences on their neurological and physiological development. …”
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Presenting the entrepreneurship development model in the national oil refining industry with the approach of environmental damage prevention by Jalal Abdi, Reza Yousefi Saeedabadi, Maryam Taghvaee Yazdi

“…Knowing the needs of entrepreneurs and businesses that need support, it seems that the government is in the best position to determine policy and design programs aimed at encouraging entrepreneurship. …”
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Analysis of Factors Influencing the Development of Community-Based Tourism in Rural Areas, Case Study: Villages Targeted by Tourism in the Markazi Province by Hamid Afshari, Behrouz Mohammadi Yeganeh, Hossein Farahani, Mehdi Cheraghi

“…To determine the research samples, the purposeful and snowball sampling methods were used and the sampling was done in a period of 2 months. …”
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Identification and leveling of factors affecting the acceptance of excellence model in Islamic Azad University by Seyedeh Somayeh Mousavi Siah Deleh, Samad Jabbari Asl, Musa Rezvani Chaman Zamin

“…In order to analyze the data, the theme analysis method was used, and in order to level the identified criteria, the interpretive structural modeling method was used in MACMIC software. …”
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Merging of the Fukushima Health Management Survey With the National and Local Cancer Registry to Refine the Detection of Thyroid Cancer Cases After the 2011 Fukushima Daiichi Nucle... by Reiko Kimura‐Tsuchiya, Masanori Nagao, Shigehira Saji, Fumikazu Hayashi, Tetsuya Ohira, Hiroki Shimura, Fumihiko Furuya, Satoru Suzuki, Satoshi Suzuki, Tetsuo Ishikawa, Susumu Yokoya, Hitoshi Ohto, Seiji Yasumura

“…This indicates that the NCR captured the cases more efficiently than the FPCR. Conclusion Merging data from the FHMS and CRs at the individual level is necessary to capture thyroid cancer cases more accurately after the 2011 nuclear accident.…”
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LiDAR Sensor Parameter Augmentation and Data-Driven Influence Analysis on Deep-Learning-Based People Detection by Lukas Haas, Florian Sanne, Johann Zedelmeier, Subir Das, Thomas Zeh, Matthias Kuba, Florian Bindges, Martin Jakobi, Alexander W. Koch

“…However, to design these systems cost- and energy-efficiently, the relationship between the measurement data and final object detection output with deep neural networks (DNNs) has to be elaborated. …”
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Subcellular mass spectrometric detection unveils hyperglycemic memory in the diabetic heart by Jiabing Zhan, Yufei Zhou, Yifan Chen, Kunying Jin, Zhaoyang Chen, Chen Chen, Huaping Li, Dao Wen Wang

“…Pathway analysis revealed that the peroxisome, PPAR pathway, and fatty acid metabolism could be efficiently rescued by glycemic control. However, dysregulation of oxidative phosphorylation and reactive oxygen species persisted even after normalization of hyperglycemia. …”
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Effects of Legume–Grass Mixture Combinations and Planting Ratios on Forage Productivity and Nutritional Quality in Typical Sand-Fixing Vegetation Areas of the Mu Us Sandy Land by Yuqing Mi, Hongbin Xu, Lei Zhang, Ruihua Pan, Shengnan Zhang, Haiyan Gao, Haibing Wang, Chunying Wang

“…Monoculture and legume–grass mixed cropping are the two most common planting methods, with mixed cropping generally demonstrating higher hay yield and superior nutritional quality compared to monoculture. …”
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Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso by Mahamadi Kientega, Ioanna Morianou, Nouhoun Traoré, Nace Kranjc, Honorine Kaboré, Odette N Zongo, Abdoul-Azize Millogo, Patric Stephane Epopa, Franck A. Yao, Adrien M G Belem, Austin Burt, Abdoulaye Diabaté

“…Conclusion These findings will guide the implementation of doublesex-targeted gene drives to support the current control tools in malaria elimination efforts. Our methods can be applied to efficiently monitor the evolution of any sequence of interest in a natural population via pooled amplicon sequencing, surpassing the need for WGS.…”
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Nested PCR and the TaqMan SNP Genotyping Assay enhanced the sensitivity of drug resistance testing of Mycobacterium leprae using clinical specimens of leprosy patients. by Xiaohua Chen, Jun He, Jian Liu, Yuangang You, Lianchao Yuan, Yan Wen

“…<h4>Background</h4>Although leprosy is efficiently treated by multidrug therapy, resistance to first-line (dapsone, rifampin) and second-line (fluoroquinolones) drugs has been described worldwide. …”
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Frog Skin Peptides Hylin-a1, AR-23, and RV-23: Promising Tools Against Carbapenem-Resistant <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Infections by Annalisa Chianese, Annalisa Ambrosino, Rosa Giugliano, Francesca Palma, Preetu Parimal, Marina Acunzo, Alessandra Monti, Nunzianna Doti, Carla Zannella, Massimiliano Galdiero, Anna De Filippis

“…A microdilution assay evaluated the antibacterial effect, determining the peptides’ minimum inhibitory concentration (MIC). …”
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The Effectiveness of Wisdom Training on Academic Emotions, Academic Motivation and Subjective Vitality in Students by Masoomeh Azizi, Abolghasem Yaghoobi

“…Previous studies show that negative emotions lead to distraction and reduced efficiency in the learning process, but positive emotions contribute to better learning and students’ psychological well-being (Lou & Xu, 2022). …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Volume-based reimbursement schemes prioritize efficiency, regardless of these major bioethical principles. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Volume-based reimbursement schemes prioritize efficiency, regardless of these major bioethical principles. …”
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Patient Burden And Impact Of Moderate-to-Severe Atopic Dermatitis In the Spanish Healthcare System: The APOLO Cross-Sectional Study by Pablo De La Cueva Dobao, Laia Curto Barredo, Juan Francisco Silvestre Salvador, Esther Serra Baldrich, Pedro Herranz Pinto, Natalia Hernández Cano, Francisco Javier Ortiz De Frutos, Gastón Roustan Gullón, Rosa María Izu Belloso, Irene Arévalo Ortega, Alicia González Quesada, Manuel Galán Gutiérrez, Yolanda Gilaberte Calzada, Daniel Arumi Torredemer, Noelia Llevat Felius, Irene Hernández Martín, Francisco José Rebollo Laserna

“…This study emphasizes the need for more effective treatment strategies and an improved understanding of the AD burden to utilize public healthcare resources more efficiently. …”
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A novel machine learning models for meteorological drought forecasting in the semi-arid climate  region by Chaitanya Baliram Pande, Dinesh Kumar Vishwakarma, Aman Srivastava, Kanak N. Moharir, Fahad Alshehri, Norashidah Md Din, Lariyah Mohd Sidek, Bojan Đurin, Abebe Debele Tolche

“…In testing, the SVM model bettered  in SPI-3 and SPI-6 forecasting (MSE = 0.5735, 0.8479; RMSE = 0.7573, 0.9208; MAE = 0.5882, 0.5300; MARE = − 0.5638, − 0.3621; NSE = 0.8676, 0.8601; R = 0.9317, 0.9275; R2 = 0.8680, 0.8603). The ensemble method played a novel and crucial role in significantly improving the accuracy of drought forecasting by developing ML models based on various algorithms that operate more efficiently, require fewer inputs, and exhibit less complexity than precise models, proving highly effective for drought warning systems. …”
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In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protoc... by Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

“…However, in patients with obstructive respiratory diseases, altered or dysregulated T-cell responses to HRV may not only fail to efficiently eliminate the virus but can also exacerbate inflammation and airway remodeling. …”
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Effects of forage feeding to calves on performance, rumen fermentation, and nutrient digestibility: A meta-analysis by Jianxin Xiao, Jia Tian, Yingqi Peng, Rui Hu, Quanhui Peng, Lizhi Wang, Bai Xue, Zhisheng Wang

“…The results of the mixed-effects model analysis indicated that calves can be efficiently fed 12% of DM as forage during the preweaning period to support their growth and development. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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