Development and study of mucoadhesive microcapsules for the nasal levodopa delivery by D. S. Gordeeva, V. V. Khutoryanskiy, R. I. Moustafine

“…A method for MC preparation was developed, the device parameters and the optimal composition of microparticles were selected. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Results Improved conditions for sEV transport studies included the application of membrane inserts with 1 µm pore size and of 1% BSA in the receiver compartment. Efficiency of LNCaP- and DU145-derived sEV uptake by hCMEC/D3 cells revealed an inverse correlation between uptake of sEVs and paracellular barrier integrity (TEER). …”
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Exploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in ch... by Yadong Li, Mingjie Li, Chenye Lin, Wentao Tang, Qiuyu Tang, Feng Cheng

“…Besides, PCT presented the highest diagnostic efficiency among the single-item detections, with an AUC of 0.862 (95% CI: 0.819–0.906). …”
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Experience with long-term infliximab therapy in patients with ankylosing spondylitis by Oksana Alekseevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov, Oksana Alekseyevna Rumyantseva, A G Bochkova, K Kh Kuzikyants, A V Levshakova, Sh F Erdes, E L Nasonov

“…The duration of continuous use of infliximab is more than 8 years in patients with ankylosing spondylitis (AS). The efficiency of the drug persists in most patients during its long-term regular therapy. …”
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INVESTIGATION OF IMMUNOGENICITY AND SAFETY OF 23-VALENT POLYSACCHARIDE PNEUMOCOCCAL VACCINE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS by G. M. Tarasova, B. S. Belov, D. V. Bukhanova, M. V. Cherkasova, S. K. Solovyev, E. A. Aseeva, T. M. Reshetnyak, T. V. Popkova

“…The overall clinical efficiency of vaccination was 93.3%. Conclusion. Thus, PPV-23 shows a good tolerability and a sufficient immunogenicity in patients with SLE. …”
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Robot-assisted laparoscopic ureteropelvic junction plasty in children using the da Vinci Xi robotic system: a Russian first experience by V. V. Sizonov, A. G. Makarov, S. M. Pakus, D. G. Kvaratskhelia, E. V. Orlova, S. G. Piskunova, M. I. Kogan

“…This prior expertise facilitates the optimization of console time duration and enables the rapid attainment of the performance plateau, achieving optimal surgical efficiency in the shortest possible timeframe.…”
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CHANGES OF CYTOKINE LEVELS DURING THERAPY WITH METHOTREXATE AND ADALIMUMAB IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS (REMARCA STUDY) by A. S. Avdeeva, A. A. Novikov, E. N. Aleksandrova, D. E. Karateev, E. L. Luchikhina, E. L. Nasonov

“…Serum cytokine concentrations were determined using the xMAP multiplexing technology before and 12 and 24 weeks after therapy. …”
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The Impact of Investors' Emotional Decision Patterns on Firm Performance by Seyed Abbas Hashemi, Alireza Rahrovi Dastjerdi, Mohammad Heydarian

“…Objective: The efficient market hypothesis is based on the assumption that investors behave rationally, but studies in behavioral finance have contradicted this notion. …”
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AI-Enhanced 3D Models in Global Virtual Reality Case Conferences for Surgical Care in a Low-Income Country: Exploratory Study by Miriam Obst, Jan Arensmeyer, Henrik Bonsmann, Andreas Kolbinger, Joel Kigenyi, Francis Oneka, Benard Owere, Joachim Schmidt, Philipp Feodorovici, Jan Wynands

“…The process was time-efficient, with a total of under 8 minutes per case for data acquisition and model creation, and resource-efficient with surgeons reporting sufficient quality of smartphone-derived models. …”
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From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody by Shuyuan Cao, Bo Sun, Feng Gao, Feng Gao, Feng Gao

“…This study uses molecular dynamics (MD) simulations to analyze the immune evasion mechanisms of class 1 nanobodies against emerging SARS-CoV-2 variants, and to develop an efficient in silico pipeline for rapid affinity optimization.MethodsWe employed MD simulations and binding free energy calculations to investigate the immune evasion mechanisms of four class 1 nanobodies (R14, DL4, VH ab6, and Nanosota9) against wild-type (WT) and Omicron variants, including BA.2, JN.1, and KP.3/XEC. …”
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A Distributed Pseudonym Management Scheme in VANETs by Xiaoling Zhu, Yang Lu, Benhong Zhang, Zhengfeng Hou

“…Moreover, the performance analysis shows that it is efficient in VANETs.…”
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Impact of Phenomenon-Based Learning on High School Physics Education in Shymkent, Kazakhstan by Bayan Ualikhanova, Ganya Ormanova, Dauletbay Berdaliyev, Nurken Mussakhan, Bakdaulet Anas, Ertan Güdekli

“… Traditional teaching methods have become obsolete in modern society, and require people with high efficiency, cooperation, and active participation. …”
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Non-Destructive Testing for Evaluation of Young’s Modulus by Using Free Vibration Response of Composite Materials by Mirela-Roxana Apsan, Ana-Maria Mitu, Catalin-Andrei Neagoe, Nicolae Pop, Tudor Sireteanu

“…This article presents a non-destructive method, based on the response to free vibrations, which can be used with efficiency and reliability to determine the Young’s modulus of polymer composite materials reinforced with natural or synthetic fibers. …”
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Classifying fermionic states via many-body correlation measures by Mykola Semenyakin, Yevheniia Cheipesh, Yaroslav Herasymenko

“…For fermionic systems, correlations can be defined as deviations from Slater determinant states. The link between fermionic correlations and efficient computational physics methods is actively studied but remains ambiguous. …”
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Optimization of Coulomb energies in gigantic configurational spaces of multi-element ionic crystals by Konstantin Köster, Tobias Binninger, Payam Kaghazchi

“…Thus, GOAC provides an efficient method for constructing low-energy atomistic models for ionic multi-element materials with gigantic configurational spaces.…”
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The Processing of Biological Waste from the Pharmaceutical Industry by Aleksandra Petrovic, Klemen Rola, Sven Gruber, Neža Santl, Saša Sankovic, Lidija Cucek, Darko Goricanec, Danijela Urbancl

“…The aim of this research is to investigate the microfiltration (MF) method for the treatment of pharmaceutical waste mycelia (fermentation residue) and to test different operating conditions (different permeate flows, operating pressures, and treatment times) to identify and determine the optimum setting conditions. …”
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Spectroscopic Properties and Continuous Wave Laser Performances at 1064 nm of Nd3+: LuAG Transparent Ceramic by Chaoyang Ma, Jiangfeng Zhu, Zhongqi Hu, Zicheng Wen, Jiaqi Long, Xuanyi Yuan, Yongge Cao

“…A transparent 2 at&#x0025; Nd^3&#x002B;-doped Lu₃Al₅O₁₂ (LuAG) ceramic was fabricated by using tape-casting method and solid-state sintering technology. Based on the room temperature absorption spectrum, the three J&#x2013;O intensity parameters were calculated with Judd&#x2013;Ofelt analysis, and then, the radiative transition rates and branching ratios of transitions from ⁴<bold>F</bold>_3&#x002F;2 manifold to the <inline-formula><tex-math notation="LaTeX">${}^4{{\rm {\mathbf I}}_{ \mathbf{{J}^{\prime}}}}$ </tex-math></inline-formula> (<inline-formula><tex-math notation="LaTeX">$\mathbf{{ J}^{\prime}} = \ 13/2,\;11/2,\;9/2$ </tex-math></inline-formula>) lower lying multiple manifolds were determined. …”
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Formation of an Integrated Approach to Conducting Financial Analysis of the Company's Equity Based on Aspects of Information Management by Nataliia Kuprina, Tetiana Markova, Khrystyna Baraniuk, Maryna Stupnytska

“…To solve the problems of the study we used the method of structural-logical analysis, methods of theoretical generalization and comparative analysis, synthesis and method of grouping of absolute and relative values, graphical method and information management methods. …”
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Simulation of the of the DeepLabv3 neural network learning process for the agricultural fields segmentation by A. F. Rogachev, I. S. Belousov

“…The constructed DNN family based on DeepLabV3 with ResNet50 showed the efficiency of recognition and sufficient speed in determining the state of crops.Conclusions. …”
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HypE-GA based study on optimal design of standard floor facade windowing of high-rise office buildings facing energy saving in heating, cooling and lighting. by Weixiang Zhang, Jieli Sui

“…Therefore, this paper takes the standard floor of a high-rise office building as the research object in cold region-Yantai, facing façade windowing design, the three building performance objectives of each office unit-Annual Cooling Energy Consumption (AC), Annual Heating Energy Consumption (AH) and Annual Lighting Energy Consumption (AL)-are simulated and single/multi-objective optimized by relying on Ladybug and Honeybee (LB + HB) platform and Hypervolume Estimation Genetic Algorithm (HypE-GA) to obtain the genome of Pareto-Window-to-Wall Ratio (WWR), Window Height (WH) and Sill Height (SH)-at the lowest of each performance objective in order to determine the most energy-efficient façade windowing expression. …”
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