Neuro-fuzzy inference system and white shark optimization of coagulation-flocculation of aquaculture wastewater treatment by A.F. Mohamed, H. Rezk

“…Therefore, the objective of this study is determining the optimal operating condition of coagulation-flocculation through optimizing the values of the three input parameters.METHODS: Artificial intelligence and recent optimzation algorithms are integrated to achieve the purpose of this study work. …”
Get full text

Skin melanoma cells produce diverse gelsolin (GSN) isoforms, which play non-redundant roles in cells’ proliferation and motility by Ewa Mazurkiewicz-Stanek, Aleksandra Makowiecka, Iryna Kopernyk, Michał Majkowski, Anna Boguszewska-Czubara, Tomasz Trombik, Paweł Karpiński, Piotr Donizy, Antonina J. Mazur

“…We discovered that cells producing GSN-A invade more efficiently, while cells producing GSN-C form the longest filipodia and migrate the best in 2D conditions. …”
Get full text

Polymer-Functionalized Magnetic Nanoparticles for Targeted Quercetin Delivery: A Potential Strategy for Colon Cancer Treatment by Júlia Borges de Macedo, Julia Narayana Schoroeder Bueno, Carla Cristine Kanunfre, José Ricardo de Arruda Miranda, Andris Figueiroa Bakuzis, Priscileila Colerato Ferrari

“…Optimized formulations had hydrodynamic diameters of 122.32 ± 8.56 nm, Zeta potentials of +30.78 ± 0.8 mV, and loading efficiencies of 80.45% (MNP-CS-Q) and 54.4% (MNP-FA-CS-Q). …”
Get full text

Simplified clinical algorithm for identifying patients eligible for immediate initiation of antiretroviral therapy for HIV (SLATE): protocol for a randomised evaluation by Mhairi Maskew, Bruce A Larson, Isaac Tsikhutsu, Margaret Bii, Peter D Ehrenkranz, Sydney Rosen, Matthew P Fox, Alana T Brennan, WD Francois Venter

“…For this policy of ‘treat all’ to succeed, millions of new patients must be initiated on ART as efficiently as possible. Studies have documented high losses of treatment-eligible patients from care before they receive their first dose of antiretrovirals (ARVs), due in part to a cumbersome, resource-intensive process for treatment initiation, requiring multiple clinic visits over a several-week period.Methods and analysis The Simplified Algorithm for Treatment Eligibility (SLATE) study is an individually randomised evaluation of a simplified clinical algorithm for clinicians to reliably determine a patient’s eligibility for immediate ART initiation without waiting for laboratory results or additional clinic visits. …”
Get full text

The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs by Entsar Shehata Mohammed, Seham Mohammed Elmwafie, Fatma Sayed Abdelaziz Mohamed, Safaa Salah Ismail

“…Abstract Background Preterm neonates often undergo invasive procedures during the period spent in neonatal intensive care units (NICUs), yet their ability to deal with pain is limited due to their immature nervous systems. Managing pain efficiently in this age is crucial, as recurrent or improperly controlled pain can have over-time influences on their neurological and physiological development. …”
Get full text

LiDAR Sensor Parameter Augmentation and Data-Driven Influence Analysis on Deep-Learning-Based People Detection by Lukas Haas, Florian Sanne, Johann Zedelmeier, Subir Das, Thomas Zeh, Matthias Kuba, Florian Bindges, Martin Jakobi, Alexander W. Koch

“…However, to design these systems cost- and energy-efficiently, the relationship between the measurement data and final object detection output with deep neural networks (DNNs) has to be elaborated. …”
Get full text

Subcellular mass spectrometric detection unveils hyperglycemic memory in the diabetic heart by Jiabing Zhan, Yufei Zhou, Yifan Chen, Kunying Jin, Zhaoyang Chen, Chen Chen, Huaping Li, Dao Wen Wang

“…Pathway analysis revealed that the peroxisome, PPAR pathway, and fatty acid metabolism could be efficiently rescued by glycemic control. However, dysregulation of oxidative phosphorylation and reactive oxygen species persisted even after normalization of hyperglycemia. …”
Get full text

Group Authentication Key Agreement Protocol Based on Certificateless Cryptography in UAV Network by Yuecheng WANG, Youwen ZHU, Zhiqiang ZHANG

“…Ensuring that the UAV group negotiates the session key safely and efficiently becomes a key issue in the process. This study presents a group authentication key negotiation protocol based on a certificateless key system to meet the requirements of identity authentication and data privacy in UAV network communication. …”
Get full text

Effects of Legume–Grass Mixture Combinations and Planting Ratios on Forage Productivity and Nutritional Quality in Typical Sand-Fixing Vegetation Areas of the Mu Us Sandy Land by Yuqing Mi, Hongbin Xu, Lei Zhang, Ruihua Pan, Shengnan Zhang, Haiyan Gao, Haibing Wang, Chunying Wang

“…Monoculture and legume–grass mixed cropping are the two most common planting methods, with mixed cropping generally demonstrating higher hay yield and superior nutritional quality compared to monoculture. …”
Get full text

Genomic analyses revealed low genetic variation in the intron-exon boundary of the doublesex gene within the natural populations of An. gambiae s.l. in Burkina Faso by Mahamadi Kientega, Ioanna Morianou, Nouhoun Traoré, Nace Kranjc, Honorine Kaboré, Odette N Zongo, Abdoul-Azize Millogo, Patric Stephane Epopa, Franck A. Yao, Adrien M G Belem, Austin Burt, Abdoulaye Diabaté

“…Conclusion These findings will guide the implementation of doublesex-targeted gene drives to support the current control tools in malaria elimination efforts. Our methods can be applied to efficiently monitor the evolution of any sequence of interest in a natural population via pooled amplicon sequencing, surpassing the need for WGS.…”
Get full text

In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protoc... by Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

“…However, in patients with obstructive respiratory diseases, altered or dysregulated T-cell responses to HRV may not only fail to efficiently eliminate the virus but can also exacerbate inflammation and airway remodeling. …”
Get full text

Identification and validation of reference genes for qPCR of Pseudomonas aeruginosa L10 under varying n-hexadecane concentrations by Huan Wang, Xiaobing Wang, Juntao Chen, Yumiao Zhang, Junhua Liu, Fangliang Xia, Jian Li, Tao Wu, Longxiang Liu

“…Abstract Pseudomonas aeruginosa can efficiently degrades petroleum hydrocarbons, but its degradation rate is affected by hydrocarbon pollutant concentrations, which must be neither too high nor too low. …”
Get full text

Ending preventable maternal deaths in Malawi: the stakeholders consensus approach to identify maternal health needs priorities by Mtisunge Joshua Gondwe, Leonard Mndala, Chifundo Kondoni, Annie Kuyere Khumalo, Bertha Maseko, Laura Munthali, Catherine Bamuya, Rosemary Bilesi, Henry Phiri, Fannie Kachale, Malangizo Mbewe, Jennifer Riches, Maria Lisa Odland, Effie Chipeta, Elizabeth Chodzaza, David Lissauer, Alinane Linda Nyondo-Mipando

“…Priority setting is a crucial concept that can benefit the healthcare system in Malawi by efficiently distributing limited resources and maximising gains in maternal healthcare. …”
Get full text

Patient-informed outpatient intervention to improve pregnancy outcomes through connections to social services: protocol for the BETTER randomised controlled trial by William A Grobman, Laura J Rush, Ann Scheck McAlearney, Anna Bartholomew, Timothy R Huerta, Sarah R MacEwan, Nicole R Thomas, Lindsey N Sova, Leah Roth, Kaprea F Johnson

“…Maternal anaemia is an upstream factor associated with severe maternal morbidity, maternal mortality and other APOs and is also associated with adverse SDoH. Effectively and efficiently addressing social needs arising from adverse SDoH in the obstetric setting can be difficult due to varying patient preferences, resource accessibility and clinic workflows. …”
Get full text

RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer by Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei

“…Methods The subcellular proportion of ALYREF was detected in samples from patients with TNBC using immunohistochemistry to analyze the relationship between ALYREF distribution and paclitaxel response. …”
Get full text

Unlocking data: Decision-maker perspectives on cross-sectoral data sharing and linkage as part of a whole-systems approach to public health policy and practice by Emily Tweed, Kristina Cimova, Peter Craig, Mirjam Allik, Denise Brown, Mhairi Campbell, David Henderson, Charlie Mayor, Petra Meier, Nick Watson

“…Recommendations included a considered approach to which data sets should be shared; standardising oversight of data sharing; using existing data sets efficiently for different research purposes; investing in staff training; and promoting a public conversation about data sharing and linkage, and its benefits and risks.…”
Get full text