THE FIRST RUSSIAN STRATEGIC STUDY OF PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS (REMARCA TRIAL): RESULTS OF 12-MONTH TREATMENT IN 130 PATIENTS by D. E. Karateev, E. L. Luchikhina, N. V. Demidova, G. S. Gridneva, M. A. Kanonirova, Yu. V. Muravyev, G. V. Lukina, Yu. A. Olyunin, K. A. Kasumova, E. N. Aleksandrova, A. A. Novikov, A. A. Avdeeva, T. V. Popkova, D. S. Novikova, A. V. Smirnov, A. V. Volkov, E. L. Nasonov

“…To introduce treat-to-target recommendations is an important task of modern rheumatology; however, there is still a diversity of serious problems relating to a scientific rationale and a clinical one for this strategy and to the possibilities of its implementation in real clinical practice, in the rheumatology service of the Russian Federation in particular, by taking into account the specific features of funding for high-tech medical care. Objective: to determine the efficiency and safety of combined therapy with subcutaneous methotrexate (MT) and biological agents (BA) when using the treat-to-target strategy in patients with active early and extended-stage rheumatoid arthritis (RA) who have risk factors for a poor prognosis. …”
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Exploration and morphological characteristics evaluation of a tetraploid seedling from periclinal graft chimera Hongrou Huyou (Citrus unshiu + C. aurantium) by JIANG Nan, WANG Gang, ZHANG Xiaoqin, CHEN Xiang, ZHANG Min, ZHANG Chi

“…Polyembryony hampers the efficiency of sexual hybridization in citrus, and seedlings from citrus chimera can additionally exhibit characteristics closer to the features of the donor of cell layer contributed to the gamete origination. …”
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Penentuan Musim Penangkapan Ikan Ekor Kuning (Blonch, 1791): Studi Perairan Karimunjawa, Indonesia by Pranata Candra Perdana Putra, Setyo Tri Wahyudi, Abu Bakar Sambah, Aida Sartimbul

“…One approach that can be applied is determining the fishing season index, which considers fishing patterns so that fishing activities can occur effectively and efficiently. …”
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The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine by Kiyoumars Roushangar, Mohammad Hosseini, Saman Shahnazi

“…Since intelligent methods are applied for various rivers with different flow conditions, it is necessary to evaluate the accuracy of these methods in quantification of bed load under varied hydraulic conditions. …”
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Effects of Fagopyrum dibotrys rhizoma meal supplementation on productive performance, egg quality, egg nutritional value, and serum biochemical parameters of Shanma laying ducks by Pingwen Xiong, Pingwen Xiong, Pingwen Xiong, Gaoxiang Ai, Gaoxiang Ai, Jiang Chen, Jiang Chen, Wenjing Song, Wenjing Song, Weide Su, Weide Su, Dongyou Yu, Qiongli Song, Qiongli Song, Chuanhui Xu, Chuanhui Xu, Zhiheng Zou, Zhiheng Zou, Qipeng Wei, Qipeng Wei, Xiaolian Chen, Xiaolian Chen, Lizhen Hu, Lizhen Hu

“…This experiment was conducted to assess the impacts of FDRM supplementation in Shanma laying ducks diet by determining productive performance, egg quality, egg nutritional value, and serum biochemical parameters.MethodsWith similar laying performance (80.88 ± 5.17%) and body weight (1.24 ± 0.02 kg), 512 healthy 32-week-old Shanma laying ducks were randomly assigned to four groups consisting of eight replicates (16 ducks per replicate). …”
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A novel machine learning models for meteorological drought forecasting in the semi-arid climate  region by Chaitanya Baliram Pande, Dinesh Kumar Vishwakarma, Aman Srivastava, Kanak N. Moharir, Fahad Alshehri, Norashidah Md Din, Lariyah Mohd Sidek, Bojan Đurin, Abebe Debele Tolche

“…In testing, the SVM model bettered  in SPI-3 and SPI-6 forecasting (MSE = 0.5735, 0.8479; RMSE = 0.7573, 0.9208; MAE = 0.5882, 0.5300; MARE = − 0.5638, − 0.3621; NSE = 0.8676, 0.8601; R = 0.9317, 0.9275; R2 = 0.8680, 0.8603). The ensemble method played a novel and crucial role in significantly improving the accuracy of drought forecasting by developing ML models based on various algorithms that operate more efficiently, require fewer inputs, and exhibit less complexity than precise models, proving highly effective for drought warning systems. …”
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IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment by Gilbert Aaron Lee, Justin Bo-Kai Hsu, Yu-Wei Chang, Li-Chun Hsieh, Yi-Tien Li, Ying Chieh Wu, Cheng-Ying Chu, Yung-Hsiao Chiang, Wan-Yuo Guo, Chih-Chun Wu, Liang-Wei Chen, Hung-Wen Kao, Wan-Li Lin, Li‑Wen Tseng, Ting-Wei Weng, Duen-Pang Kuo, Sho-Jen Cheng, Yung-Chieh Chen, Shiu-Wen Huang, Hsing-Jien Kung, Cheng-Yu Chen

“…Targeting GBM-mediated immunosuppressive and invasive properties is a promising strategy to improve clinical outcomes. Methods We utilized clinical and genomic data from the Taiwan GBM cohort and The Cancer Genome Atlas (TCGA) to analyze RNA sequencing data from patient tumor samples, determining the association of interleukin-19 (Il-19) expression with survival and immunosuppressive activity. …”
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How aromatic dissolved organic matter differs in competitiveness against organic micropollutant adsorption by Qi Wang, Oliver J. Lechtenfeld, Luuk C. Rietveld, Jonas Schuster, Mathias Ernst, Roberta Hofman-Caris, Jan Kaesler, Chunmiao Wang, Min Yang, Jianwei Yu, Frederik Zietzschmann

“…Although the aromaticity-related metrics, such as UV254, of low MW DOM were proposed to correlate with DOM competitiveness, the method suffers from limitations in understanding the interplay of polarity and aromaticity in determining DOM competitiveness. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Volume-based reimbursement schemes prioritize efficiency, regardless of these major bioethical principles. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…Volume-based reimbursement schemes prioritize efficiency, regardless of these major bioethical principles. …”
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Utility of Cell Blocks from Lymph Node Aspirates to Improve the Diagnostic Accuracy of Fine Needle Aspiration Cytology: A Cross-sectional Observational Study from Eastern India by Upajna Pal, Abhinandan Bayen, Debajyoti Nanda, Manisha Sarkar, Dipanwita Nag

“…Conclusion: Cell blocks can be efficiently utilised from lymph node aspirates to improve the diagnostic accuracy of lymph node FNAC, even before an excision biopsy is performed in patients who are unfit for invasive surgical procedures. …”
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An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…We highlight that sysMPRA effectively uncovers regulatory effects stemming from the disruption of MEF2C transcription factor binding sites, single-nucleotide polymorphisms, and the consequences of genetic variations associated with late-onset Alzheimer‘s disease.Conclusion: SysMPRA is an effective library delivering method that simultaneously determines the transcriptional functions of hundreds of enhancers in vivo across multiple tissues.…”
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Energy requirements of Dorper×thin-tailed Han crossbred ewes during non-pregnancy and lactation by Can LOU, Bing-wen SI, Kai-dong DENG, Tao MA, Cheng-gang JIANG, Yan TU, Nai-feng ZHANG, Shou-kun JI, Dan-dan CHEN, Qi-yu DIAO

“…The maintenance requirements of NE, ME, and the efficiencies of ME utilisation for maintenance during the stages of non-pregnancy and early, middle and late lactation were 215.5, 253.1, 247.7, and 244.7 kJ kg−1 BW0.75 d, and 372.4, 327.1, 320.9, and 362.0 kJ kg−1 BW0.75 d, and 0.58, 0.77, 0.77, and 0.68, respectively. …”
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Mechanism of exogenous methyl jasmonate mediated AsA-GSH cycle in Summer Black grape against low temperature stress by ZHANG Shaowei, ZHU Qianyan, ZHAO Xiaogai, ZHOU Bing, LI Peng, LI Guirong

“…[Objective] The aim of this study was to explore the response mechanism of the exogenous Methyl jasmonate (MeJA) regulating the ascorbic acid-glutathione (AsA-GSH) cycle of Vitis vinifera Summer Black grape to low-temperature stress. [Methods] One-year-old Summer Black grape plants were used as materials, and different concentrations of MeJA treatment groups and low-temperature stress treatment groups were set up. (1) MeJA treatment: the selected 1-year-old Summer Black grape plants were randomly divided into 5 groups, with 10 plants in each group.0 (CK), 50, 100, 150, 200 μmol·L-1 MeJA solution were sprayed on the leaves, and the spraying amount was suitable for the uniform wetting of the leaf surface without water dripping. …”
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Implementation of the mini-CEX in a paediatric emergency department by Iris Alonso Sánchez, Sandra Morán Moya, Gemma Claret Teruel, Roser Garrido Romero, David Muñoz Santanach, Victoria Trenchs Sainz de la Maza, Carles Luaces Cubells

“…Material and methods: Inclusion criteria: paediatrics residents in the first (MIR1) and second (MIR2) year of residency. …”
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Garlic-Derived Exosome-Like Nanovesicles: A Promising Natural Nanotherapy for Periodontitis via PHGDH/PI3K/AKT-Mediated Metabolic and Inflammatory Regulation by Yu C, Liu Y, Yu X, Liu J, Cao P, Liu G, Cai Y, Zhang Y, Luan Q

“…In vitro, GaELNs were efficiently internalized by human gingival fibroblasts, significantly enhancing their proliferation, migration, and VEGF expression, while markedly reducing LPS-induced oxidative stress and pro-inflammatory factor expression. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…A cost-effectiveness analysis assessed possible efficiency gains. An NHS perspective was used, and relevant direct medical costs were collected. …”
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Demographic Linkages between Rural and Urban Areas and Its Impact on Creating Social Capital (Case study: Damavand, Firouzkoh, Shemiranat) by Nasrin Kazemi, Mohammad Salmani, Seyed Ali Badri, Sharif Motavaf

“…The samples of this study were selected radomly from 7 districts and 26 villages located in Damavand, Firuzkoh, and Shemiranat. The main methods to analyze the collected data were network analysis and cross- impact analysis; the results of these methods led to the determination of impacts demographic linkages on creation of social capital. …”
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Rheumatoid arthritis in real clinical practice: initiation of therapy with biological agents. Results of the «Computer Terminals of Self-Assessment for Patients with Rheumatic Dise... by V. N. Amirdzhanova, E. Yu. Pogozheva, A. E. Karateev, O. V. Antipova, I. B. Vinogradova, A. Yu. Kazankova, R. G. Mukhina, A. G. Vasilyev, O. B. Nesmeyanova, E. A. Bogdanova, R. R. Samigullina, A. A. Vasilenko, I. B. Bashkova, T. S. Salnikova, I. N. Dashkov, N. E. Nikulenkova, V. Yu. Manokhin, I. P. Afanasyeva, O. N. Anoshenkova, T. V. Plaksina, M. R. Spitsina, L. V. Solodovnikova, A. V. Petrov, O. P. Slyusar, E. V. Papichev, E. V. Ivanova, L. V. Masneva, L. P. Evstigneeva, I. V. Kolotilina, E. N. Otteva, I. A. Cherentsova, I. N. Shchendrygin, S. A. Derevenskikh, I. G. Bannikova, N. K. Delyavskaya, I. N. Danilova, I. M. Marusenko

“…The efficiency of the therapy was analyzed 6 months after the start of the study according to the standard procedures.Results and discussion. …”
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Spatial Analysis of the Concentration of Knowledge-Based Firms in Iran by Najmoddin Yazdi, Mahdi Fateh-rad, Jamal Kadkhodapour, Siamak Tahmasbi

“…Geographic concentration is essential for regional development as it enhances efficiency and fosters innovation among firms. However, some studies have also highlighted its negative aspects, such as the exacerbation of regional inequality. …”
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