Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro by Bo Pan, JianPeng Qin, KunLin Du, LuYao Zhang, GongXue Jia, JiangFeng Ye, QiuXia Liang, QiEn Yang, GuangBin Zhou

“…Objectives: To enhance the developmental competence of sheep oocytes, this study aimed to identify and supplement essential metabolites that were deficient in the culture systems. Methods: The metabolic characteristics of oocytes and embryos were determined using ultrasensitive metabolomics analysis on trace samples and single-cell RNA-seq. …”
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Aircraft Multi-stage Altitude Prediction Under Satellite Signal Loss by Mengchan HUANG, Qiang MIAO

“…This study proposes a multi-stage altitude prediction model using attention mechanisms and temporal convolutional neural networks (TCNs).Methods The aircraft’s flight stages are determined to facilitate targeted altitude prediction for different flight phases. …”
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Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes by D. V. Ivashchenko, A. S. Osipov, E. V. Nazarova, M. A. Ovchinnikova, N. I. Buromskaya, V. V. Smirnov, P. V. Shimanov, R. V. Deitch, T. A. Fainshtein, E. N. Shagovenko, K. A. Akmalova, A. A. Kachanova, E. A. Grishina, L. M. Savchenko, Yu. S. Shevchenko, D. A. Sychev

“…The CGAS, PANSS, UKU SERS, SAS, and BARS scales were used to evaluate the efficiency and safety of the therapy on day 14. The activity of CYP3A and CYP2D6 isoenzymes was measured by determining the metabolic ratios of the concentrations of endogenous substrates of the isoenzymes and their metabolites in a morning urine sample on days 1 and 14 of the study. …”
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The Relationship Between Supply Environment, Supply Chain Integration and Performance Considering Opportunistic Behaviors by Abbas َAsadi, safanaz Heidari

“…By holding training courses, managers and officials should increase the chain members' knowledge about the factors affecting the supply chain management of the project to enhance operational efficiency. This can be achieved by outlining a series of actions related to social responsibility towards the environment and employees, which may include: increased attention and investment in training employees focusing on skill development and behavioral improvement, determining rewards and welfare facilities appropriate to the performance of employees, career development and the possibility of promotion at all organizational levels, equality and job justice at all organizational levels, involving employees in decision-making, creating a cheerful, clean and safe environment for employees, and improving productivity and accordingly, performance in this environment.…”
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Detection of Invasive Species (Siam Weed) Using Drone-Based Imaging and YOLO Deep Learning Model by Deepak Gautam, Zulfadli Mawardi, Louis Elliott, David Loewensteiner, Timothy Whiteside, Simon Brooks

“…The study demonstrates the feasibility of using YOLO models to detect invasive species in natural landscapes, providing a safe alternative to the current method involving human spotters in helicopters. Future research will focus on developing tools to merge duplicates, gather georeference data, and report detections from large image datasets more efficiently, providing valuable insights for practical applications in environmental management at the catchment scale.…”
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Classifying and Localizing Abnormalities in Brain MRI Using Channel Attention Based Semi-Bayesian Ensemble Voting Mechanism and Convolutional Auto-Encoder by Syed Muhammad Ahmed Hassan Shah, Asad Ullah, Jawaid Iqbal, Sami Bourouis, Syed Sajid Ullah, Saddam Hussain, Muhammad Qasim Khan, Yaser Ali Shah, Ghulam Mustafa

“…The CAD system will involve two primary tasks: tumor classification, which determines the type of tumor depicted in the image, and tumor segmentation, which involves accurately determine the tumor region from the surrounding healthy tissue. …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…We demonstrated the utility of this method for determining the streamlined large-scale spatial proteomic features of gliomas. …”
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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and ma... by Leanne J Robinson, Rahel Wampfler, Inoni Betuela, Stephan Karl, Michael T White, Connie S N Li Wai Suen, Natalie E Hofmann, Benson Kinboro, Andreea Waltmann, Jessica Brewster, Lina Lorry, Nandao Tarongka, Lornah Samol, Mariabeth Silkey, Quique Bassat, Peter M Siba, Louis Schofield, Ingrid Felger, Ivo Mueller

“…The inclusion of a directly observed 20-d treatment regime maximises the efficiency of hypnozoite clearance but limits the generalisability of results to real-world MDA programmes.…”
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Genetic transformation of Lentil (Lens culinaris M.) and production of transgenic fertile plants by Fatemeh zaker tavallaie, Behzad Ghareyazie, Abdorreza Bagheri, Kiran Komar Sharma

“…The codA gene from Arthrobacter globiformis bacteria encodes choline oxidase enzyme that catalyzes synthesis of glycine betaine from choline. The efficiency of biotechnology techniques, especially tissue culture and gene transformation is noticeable in this aspect. …”
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The Effect of Deficit Irrigation on Yield and Its Related Traits in Promising Chiti Bean (Phaseolus vulgaris L.) Genotypes under Zanjan Province Climatic Condition by Seyedeh Soudabeh Shobeiri, Ali Akbar Asadi

“…Despite the desire of farmers to maximize the use of irrigation to increase production in dry and semi-arid conditions, even in the absence of water restrictions, excessive irrigation is not logical; therefore, in such a situation, the efficiency of water consumption in the farm should be optimized. …”
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Evaluation of the effectiveness of combined treatment of coronary heart disease – coronary artery bypass grafting, transplantation of autologous bone marrow mononuclear cells: a ra... by V. V. Komok, N. S. Bunenkov, S. A. Beliy, V. M. Pizin, V. M. Kondratev, A. V. Dulaev, A. E. Kobak, T. S. Maksimova, I. P. Sergienko, E. V. Parusova, L. A. Smirnova, E. V. Babenko, B. V. Afanasev, A. S. Nemkov, G. G. Khubulava

“…With this in mind, there are ongoing studies everywhere, which are aimed at investigating new techniques in order to boost the efficiency of existing standards. One of such promising techniques is cell/regenerative therapy with autologous bone marrow mononuclear cells (ABMMCs). …”
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Comparative efficacy studies of nine Chinese traditional patent medicines for the treatment of post-myocardial infarction heart failure: A Bayesian network by Fuyun Jia, Shengwei Gao, Qiaochu Zhu, Opoku Bonsu Francis, Rui Liu, Yadong Wang, Rui Zhang, Shichuan Chen, Zilian Zhan, Xi Zhang, Qiang Xu

“…This network meta-analysis aimed to assess the effectiveness of nine different Chinese traditional patent medicines (CTPMs) in the treatment of heart failure developing after acute myocardial infarction. Methods: Determine the eligibility criteria for inclusion and exclusion in advance. …”
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The effect of using red algae powder on growth indices, some serum and mucus indices, and mucus protein patterns in common carp (Cyprinus carpio) fry by Fatemeh Abdollahnejad, Seyed Hossein Hoseinifar, Hamed Paknejad, Abdolmajid Hajimoradlou, Mohamdreza Imanpuor

“…Studies have shown that the use of dried algae as an immune stimulant in the aquaculture industry improves the physiological responses of fish to stress and disease, and as an immune stimulant in aquaculture, they increase growth, food efficiency, and biochemical quality of carcasses in various aquatic animals. …”
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<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

“…Treatment with EHVG efficiently improved the survival of the larvae after lethal infection (60%), probably due to the reduction in CFUs. …”
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Research Progress on Information Model of Urban Green Space by Wei ZHANG, Yahan YAN

“…ObjectiveWith the rapid development of urban information models, 3D virtual scenes, and digital twin cities, the methods and standards for city information modeling have been widely adopted. …”
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A Sociological study of the Relationship between Smartphone Addiction and Phubbing Case Study18-29 Year Old Females of Ramhormoz City by Ali Boudaghi, Ali Hossein Hosseinzadeh, Sayedeh Sara Mousavi Moghadam

“…It is better to prevent the spread of this behavior by efficient planning of the women's leisure time and their sports. …”
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Effect of complex microbial inoculation on growth, nitrogen and phosphorus uptake of maize and soybean in intercropping system by Huozhi HUANG, Yang LIU, Kang CHEN, Xiurong WANG

“…ObjectiveTo investigate the effects of inoculation with synthetic microbial communities on growth, nitrogen (N) and phosphorus (P) uptake of monocultured or intercropped maize and soybean, and provide a theoretical basis for utilizing efficiently microbial inoculants to enhance crop yield.MethodUsing unsterilized soil in monoculture and intercropping systems of maize and soybean, a pot experiment, including eight treatments of non-inoculated control (CK), single inoculation with arbuscular mycorrhizal fungi (AM fungi, A), rhizobia (R) or Bacillus (B), dual inoculation with AM fungi and rhizobia (A+R), AM fungi and Bacillus (A+B), or rhizobia and Bacillus (R+B), and triple inoculation with AM fungi, rhizobia and Bacillus (A+R+B), was conducted to determine plant dry weight, N and P contents, root traits, mycorrhizal colonization rate, nodule traits, pH and acid phosphatase activity in the rhizosphere.ResultThe different combinations of dual inoculation exhibited better inoculation effects. …”
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Apparent Digestibility Coefficients of Black Soldier Fly (Hermetia illucens), Yellow Mealworm (Tenebrio molitor), and Blue Bottle Fly (Calliphora vicina) Insects for Juvenile Afric... by Zsuzsanna J. Sándor, Vojislav Banjac, Strahinja Vidosavljević, Jenő Káldy, Robert Egessa, Éva Lengyel-Kónya, Rita Tömösközi-Farkas, Zsolt Zalán, Nóra Adányi, Balázs Libisch, Janka Biró

“…A digestibility trial was conducted with African catfish hybrid juveniles in order to determine the apparent digestibility coefficients (ADCs) of different nutrients. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…RNA interference (RNAi) represents the only method currently available for manipulating gene-specific expression in Schistosoma spp., although application of this technology as a functional genomic profiling tool has yet to be explored. …”
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THE FIRST RUSSIAN STRATEGIC STUDY OF PHARMACOTHERAPY FOR RHEUMATOID ARTHRITIS (REMARCA TRIAL): RESULTS OF 12-MONTH TREATMENT IN 130 PATIENTS by D. E. Karateev, E. L. Luchikhina, N. V. Demidova, G. S. Gridneva, M. A. Kanonirova, Yu. V. Muravyev, G. V. Lukina, Yu. A. Olyunin, K. A. Kasumova, E. N. Aleksandrova, A. A. Novikov, A. A. Avdeeva, T. V. Popkova, D. S. Novikova, A. V. Smirnov, A. V. Volkov, E. L. Nasonov

“…To introduce treat-to-target recommendations is an important task of modern rheumatology; however, there is still a diversity of serious problems relating to a scientific rationale and a clinical one for this strategy and to the possibilities of its implementation in real clinical practice, in the rheumatology service of the Russian Federation in particular, by taking into account the specific features of funding for high-tech medical care.Objective: to determine the efficiency and safety of combined therapy with subcutaneous methotrexate (MT) and biological agents (BA) when using the treat-to-target strategy in patients with active early and extended-stage rheumatoid arthritis (RA) who have risk factors for a poor prognosis.Subjects and methods.The results of the REMARCA (Russian InvEstigation of MethotrexAte and biologicals in eaRly aCtive inflammatory Arthritis) trial of 130 patients followed up for 12 months or more were given. …”
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