Identification and Characterization of Two Se6OMTs from <i>Stephania epigaea</i> Offer Novel Insights into the Biosynthetic Pathway of Cepharanthine by Jingyi Gan, Wenlong Shi, Qishuang Li, Xinyi Li, Xingyu Zhao, Junhao Tang, Ying Ma, Jian Wang, Shukun Gong, Xiaohui Ma, Juan Guo

“…Results: Two <i>O</i>-methyltransferases, Se6OMT1 and Se6OMT3, showed efficient catalytic activity at the C6 position of both (<i>R</i>)- and (<i>S</i>)-norcoclaurine. …”
Get full text

Development and Validation of an Incident Hypertension Risk Prediction Model for Young Adults by Jaejin An, Heidi Fischer, Liang Ni, Mengying Xia, Soon Kyu Choi, Kerresa L. Morrissette, Rong Wei, Kristi Reynolds, Paul Muntner, Lisandro D. Colantonio, Andrew E. Moran, Brandon K. Bellows, Monika M. Safford, Norrina B. Allen, Vanessa Xanthakis, Carmen R. Isasi, Linda C. Gallo, Krista M. Perreira, Yiyi Zhang

“…Conclusions Compared with the US Preventive Services Task Force, the hypertension risk prediction model may be a more efficient tool to identify high‐risk young adults for early intervention.…”
Get full text

Precise prediction of choke oil rate in critical flow condition via surface data by Qing Wang, Muntadher Abed Hussein, Bhavesh Kanabar, Anupam Yadav, Asha Rajiv, Aman Shankhyan, Sachin Jaidka, Mehul Manu, Issa Mohammed Kadhim, Zainab Jamal Hamoodah, Fadhil Faez, Mohammad Mahtab Alam, Hojjat Abbasi

“…The novelty of this study lies in the comprehensive comparison of machine learning methods applied to real-world oil production data, with a particular focus on the impact of key well parameters on production efficiency. …”
Get full text

Assessing the economic performance of agrivoltaic systems in vineyards – framework development, simulated scenarios and directions for future research by Larissa Strub, Maximilian Wittke, Max Trommsdorff, Max Trommsdorff, Manfred Stoll, Claudia Kammann, Simone Loose

“…For AVS systems to achieve economic sustainability, substantial reductions in installation costs, increases in energy prices, or technological advances in efficiency are required. Promising configurations combining multiple favorable changes suggest a pathway toward economic feasibility but highlight the need for further development and innovation. …”
Get full text

Correlation between quality traits of kernels, hard semolina, pasta of durum winter wheat by N. E. Samofalova, N. P. Ilichkina, T. S. Bezuglaya, N. S. Kravchenko, A. S. Ivanisova, N. V. Kabanova, О. А. Dubinina

“…Correlation analysis, which makes it possible to identify practically positive and negative factors, minimize the most unfavorable ones, accelerate, and increase the efficiency of the breeding process, is one of them.The purpose of the current work was to study the correlation between quality traits of winter durum wheat and to determine the most accessible and informative ones as selection criteria in the breeding process.The field and laboratory (determination of grain quality parameters, rheological properties of dough and pasta) study was carried out on the basis of the FSBSI “ARC “Donskoy”, from 2014 to 2020. …”
Get full text

Evidence of SARS‐CoV‐2 Exposure in Cats and Dogs From Households in Romania and Long‐Term Specific Seroconversion in Cats by Luanda Elena Oslobanu, Luciana Alexandra Crivei, Gheorghe Savuta, Laro Gómez‐Marcos, Pablo Nogales‐Altozano, José M. Rojas, Noemí Sevilla

“…This study aimed to evaluate the presence of SARS‐CoV‐2 specific antibodies in household dogs and cats in Romania during the COVID‐19 pandemic. Methods The study was conducted at a veterinary clinic in Iasi City, Romania, from March 2020 to December 2022. …”
Get full text

Comparison of wind farm control strategies under realistic offshore wind conditions: turbine quantities of interest by J. A. Frederik, E. Simley, K. A. Brown, G. R. Yalla, L. C. Cheung, P. A. Fleming

“…<p>Wind farm flow control is a strategy to increase the efficiency and therefore lower the levelized cost of energy of a wind farm. …”
Get full text

Function and mechanism of cancer-testis antigen CT63 in chronic myeloid leukemia by KONG Ruxin, ZHOU Yaqun, WEI Tingyi, LEI Ming

“…Objective·To explore the effects of the cancer-testis antigen (CTA) family member CT63 on proliferation, differentiation, and tumorigenicity of chronic myeloid leukemia (CML) cells, and uncover the underlying molecular mechanisms.Methods·The link between CT63 expression and the prognosis of myeloid leukemia patients was analyzed using bioinformatics methods (TCGA database). …”
Get full text

Institutional Traps in the Scientific and Educational Sphere: Nature and Mechanism of Elimination by Е. V. Romanov

“…Methodology and research methods. The current research was carried out on the basis of a systematic approach. …”
Get full text

Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…Conclusions We successfully isolated and established NCM, RPE, and MutCM cell lines. We describe efficient methods for the isolation and growth of NCMs and report their phenotypic, proteomic, and transcriptomic characteristics, which will facilitate the investigation of UM development and progression. …”
Get full text

Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer by Chuan Wang, Kaïdre Bendjama, Stephen Schoenberger, Oliver Wood, Gareth Thomas, Pandurangan Vijayanand, Tilman Sanchez-Elsner, Nathalie Silvestre, Natalia Savelyeva, Christian Ottensmeier, Katy McCann, Adrian von Witzleben, Jaya Thomas, Divya Singh, Konstantinos Boukas, Finn Cilius Nielsen, Jason Greenbaum, Bjoern Peters

“…Following vaccination of HHD mice, de novo T-cell responses were generated to 4/18 (22%) mutated gene variants; T cells reactive against two variants were also evident in the autologous setting. Subsequently, we determined the major histocompatibility complex restriction of the T-cell responses and used in silico prediction tools to determine the likely neoepitopes.Conclusions Our study demonstrates the feasibility of efficiently identifying tumor-specific neoantigens that can be targeted by vaccination in tumors with a low mutational burden, promising successful clinical exploitation, with trials currently underway.…”
Get full text

Ethanol consumption during gestation promotes placental alterations in IGF-1 deficient mouse placentas [version 3; peer review: 1 approved, 2 approved with reservations, 1 not appr... by Mario Bermúdez De León, Diego Rodríguez-Mendoza, Carolina Zertuche-Mery, Inma Castilla-Cortázar, Oscar R Fajardo-Ramírez, Fabiola Castorena-Torres, Marcela Galindo-Rangel, Patricio Gómez-Álvarez, Irene Martín-Estal, Andrea Leal López

“…Results IGF-1 deficiency and ethanol consumption during pregnancy altered placental morphology, and decreased placental efficiency and AAH expression in placentas from all genotypes. …”
Get full text

Evaluating spectral indices for water extraction: Limitations and contextual usage recommendations by Chuanwu Zhao, Haishuo Wei, Gudina Legese Feyisa, Thiaggo de Castro Tayer, Gelilan Ma, Hanyi Wu, Yaozhong Pan

“…This study offers valuable guidance for the selection and use of water body indices in practical application, helping to enhance the accuracy and efficiency of fine-scale monitoring of water bodies.…”
Get full text

AI-powered machine learning models for monitoring and optimization of biodrying process by Abhisit Bhatsada, Panida Payomthip, Tanik Itsarathorn, Ye Nyi Nyi Lwin, Eka Wahyanti, Sirintornthep Towprayoon, Suthum Patumsawad, Chart Chiemchaisri, Komsilp Wangyao

“…This study integrates machine learning and deep learning techniques to develop predictive models to capture these complex relationships and improving biodrying efficiency. Experimental data were collected from four distinct waste types: fluff RDF, coarse RDF, fresh municipal solid waste, and market waste. …”
Get full text

Construction and application of a TCN-LSTM-SVM-based time series prediction model for water inflow in coal seam roofs by Xuan LIU, Yadong JI, Kaipeng ZHU, Chunhu ZHAO, Kai LI, Chaofeng LI, Chenhan YUAN, Panpan LI, Pengzhen YAN

“…BackgroundThe accurate prediction of mine water inflow plays a significant role in the prevention and control of water hazards and the safe and efficient production in coal mines. MethodsTo construct a prediction model of water inflow in mines under threat of water hazards from extremely thick sandstones aquifer in West China, this study investigated a typical mine (also referred to as the studied mine) severely affected by such water hazards in the Binchang mining area of Shaanxi Province. …”
Get full text

Abstract 054: Transradial Thrombectomy Using "Sheathless PV" Guide Catheter in Armenia: Three‐Year Institutional Experience in 103 Cases by David Sahakyan, Anna Isahakyan, David Marqaryan, Aleksan Petrosyan, Mikayel Grigoryan

“…It offers numerous advantages and stimulated development of long flexible large lumen guiding catheters as well as adoption of existing cost‐efficient alternatives used in cardiac and peripheral interventions (2,3). …”
Get full text

Gestational Diabetes Management and Outcomes in South Jordan: Metformin Alone vs. Metformin-Insulin Therapy, A Retrospective Cohort Study by Ahlam M. Al-Kharabsheh, Seham M. Abufraijeh, Ashwaq K. Al-Tarawneh, Hana K. Al-Masarwah, Omar H. Abu Azzam

“…The primary goal was to develop an efficient management system that reduces hospital admissions and improves outpatient care for pregnant women with diabetes. …”
Get full text

Large-scale annotation of biochemically relevant pockets and tunnels in cognate enzyme–ligand complexes by O. Vavra, J. Tyzack, F. Haddadi, J. Stourac, J. Damborsky, S. Mazurenko, J. M. Thornton, D. Bednar

“…Abstract Tunnels in enzymes with buried active sites are key structural features allowing the entry of substrates and the release of products, thus contributing to the catalytic efficiency. Targeting the bottlenecks of protein tunnels is also a powerful protein engineering strategy. …”
Get full text

AI-Driven Integrated System for Burn Depth Prediction With Electronic Medical Records: Algorithm Development and Validation by Md Masudur Rahman, Mohamed El Masry, Surya C Gnyawali, Yexiang Xue, Gayle Gordillo, Juan P Wachs

“…Traditional diagnostic methods primarily rely on visual inspection by experienced burn surgeons. …”
Get full text

FACTORS OF SOCIO-PSYCHOLOGICAL ADAPTATION AND ANXIETY OF REFUGEES DURING THE WAR by Harkusha Inesa, Dubinskyi Serhii

“…The purpose of the article is to review and analyse the factors of socio-psychological adaptation and anxiety of refugees in terms of war, as well as psychological techniques to develop in them a new attitude to stress reactions as a resource that can strengthen immunity to traumatization. The study used the methods of terminological, substantive and statistical analysis in determining the content and essence of anxiety as a state and process of experiencing, as well as modelling and projecting methods to find factors of social and psychological adaptation and reducing the level of anxiety of refugees during the war. …”
Get full text