Production and analysis of the biological properties of recombinant human granulocyte colony stimulating factor chimeric form by M. B. Pykhtina, V. P. Romanov, S. M. Miroshnichenko, A. B. Beklemishev

“…The aim of this work was to design and study biological properties of the recombinant human granulocyte colony stimulating factor (G-CSF), «linked» to apolipoprotein A-I (apoA-I) by a peptide linker, for obtaining in perspective a prolong form of the drug based on this cytokine.Material and methods. The nucleotide sequences of the genes encoding G-CSF and apoA-I were designed and optimized for expression in Pichia pastoris yeast using several computer programs. …”
Get full text

Potential evaluation and development utilization technology of geothermal resources in the Jining Coalfield by Qipeng SHI, Jianguo FAN, Fengfeng SHI, Xuesen WANG, Huiming ZHENG, Jia MENG, Shuailiang SONG

“…The study utilized thermal reservoir and recovery rate methods to calculate the quantity of geothermal resources and the recoverable reserves for each mine within the coalfield, evaluating their development and utilization potential. …”
Get full text

Precision Target Spraying System Integrated with Remote Deep Learning Recognition Model for Cabbage Plant Centers by ZHANG Hui, HU Jun, SHI Hang, LIU Changxi, WU Miao

“…Moreover, the research provides insights into how to maintain consistent spraying effectiveness and optimize pesticide utilization efficiency by dynamically adjusting the spraying system as the operating speed varies. …”
Get full text

ASSOCIATION OF BLOOD GENE EXPRESSIONS IN RHEUMATOID ARTHRITIS PATIENTS WITH CLINICAL AND LABORATORY PARAMETERS BEFORE AND AFTER METHOTREXATE THERAPY by E. V. Chetina, N. V. Demidova, D. E. Karateev, G. A. Markova, M. A. Makarov, V. V. Kolomatsky, A. L. Logunov, E. A. Naryshkin, M. M. Lipina, S. A. Makarov, A. N. Kuzin

“…The genes, the high basic expression of which indicates the efficiency of methotrexate (MTX) therapy in relieving joint inflammation and destruction in patients with rheumatoid arthritis (RA), have been defined.Objective: to find an association between the initial expression of the genes: mTOR (mammalian target of rapamycin), a major regulator of cell growth and proliferation; ULK1 (an autophagy marker 1); p21 (a cyclin-dependent kinase inhibitor); kaspase-3 (an apoptosis activity indicator); MMP-9 (matrix metalloproteinase 9), and cathepsin K, which are involved in joint destruction, and the cytokines: TNF-α (tumor necrosis factor-α), TGFβ1 (transforming growth factor β1) and Runx2 (Runt-related transcription factor 2) in the blood of RA patients with disease activity and joint destruction before and after MTX therapy during 24 months.Subjects and methods. …”
Get full text

Molecular characteristics of hepatitis B virus among students and pregnant women in Chad by Nalda Debsikréo, Nafissatou Leye, Gora Lo, Maire Dehainsala, Odan Debsikréo, Ndeye Aminata Diaw, Diao Ba, Diabou Diagne, Abdoulaye Souare, Ndeye Dieynaba Diouf, N’da Kouamé Nazaire Kouadio, Isaac Darko Otchere, Ali Mahamat Moussa, Ndèye Coumba Toure-Kane, Françoise Lunel-Fabiani

“…Methods Venous blood samples were collected from pregnant women and students in the capital of Chad between April and August 2021. …”
Get full text

Pneumatic Compliant End-effector Using Multi-compensation Integrated Nonlinear Active Disturbance Rejection Control by ZHANG Shuzhong, WU Qianxin, DAI Fuquan, WANG Yabing, ZHANG Gong

“…Therefore, the performance of this control directly affects the quality and efficiency of the polishing process. Among various end-effector mechanisms, the pneumatic type is widely adopted due to its lightweight structure, low cost, robustness, and ease of maintenance. …”
Get full text

Can open source large language models be used for tumor documentation in Germany?—An evaluation on urological doctors’ notes by Stefan Lenz, Arsenij Ustjanzew, Marco Jeray, Meike Ressing, Torsten Panholzer

“…Advances in information extraction techniques that build on large language models (LLMs) could have the potential for enhancing the efficiency and reliability of this process. Evaluating LLMs in the German medical domain, especially their ability to interpret specialized language, is essential to determine their suitability for the use in clinical documentation. …”
Get full text

MANAGEMENT OF COMPETITIVE ADVANTAGES IN CONFECTIONERY INDUSTRY ENTERPRISES: A CASE STUDY OF SLOVAKIA AND UKRAINE by Nataliia Parkhomenko, Lucia Vilčeková, Peter Štarchoň

“…To compare the competitive advantages of confectionery enterprises in both countries, the authors used methods such as diagnostic analysis, statistical data analysis, and case studies were employed. …”
Get full text

Analysis of latent profiles and influencing factors of sleep in first-trimester pregnant women by Liu Siqi, Cai Shu, Liang Yunfang, Tan Yingyao

“…Then the sleep profiles were identified through latent profile analysis， and the robust mixture regression model was employed to determine the influencing factors of sleep profiles.ResultsA 3-profile solution showed the best fit： 732 cases （68.67%） of good sleep quality group， 87 cases （8.16%） of low sleep efficiency group， and 247 cases （23.17%） of daytime dysfunction group. …”
Get full text

In-Memory Versus Disk-Based Computing with Random Forest for Stock Analysis: A Comparative Study by Chitra Joshi, Chitrakant Banchorr, Omkaresh Kulkarni, Kirti Wanjale

“…The effectiveness of these frameworks plays a crucial role in determining data processing speed, model training efficiency and predictive accuracy. …”
Get full text

Individual-psychological factors and perception of social support in burnout syndrome by Jovanović Vesna R., Hinić Darko, Džamonja-Ignjatović Tamara, Stamatović-Gajić Branka, Gajić Tomislav, Mihajlović Goran

“…The most important predictors of burnout in special education teachers were: for emotional exhaustion (self-esteem, efficiency of class management and seniority); for depersonalization (self-esteem, efficiency of class management and social support); for a sense of lower personal accomplishment (assertiveness, effective student learning and class management). …”
Get full text

Dynamic of end-tidal carbon dioxide pressure during cardiopulmonary exercise testing before and after heart transplantation by I. Yu. Loginova, O. V. Kamenskaya, A. M. Chernyavskiy, D. V. Doronin, S. A. Alsov, V. N. Lomivorotov

“…Aim: to assess the dynamic and prognostic significance of the end-tidal carbon dioxide pressure (PetCO2) during cardiopulmonary exercise testing in recipients before and after heart transplantation (HT).Materials and methods. The study included 55 patients with severe chronic heart failure (CHF) from the HT waiting list. …”
Get full text

Investigation of printing turn angle effects on structural deformation and stress in selective laser melting by Ruqing Bai, Shengbo Shi, Jingzhe Wang, Jun Luo, Huayan Pu, Wenhan Lyu, Hakim Naceur, Daniel Coutellier, Li Wang, Yangkun Du

“…The primary challenge in path planning is to determine a printing turn angle that ensures uniform thermal distribution, thereby minimizing structural deformation while maintaining printing efficiency. …”
Get full text

Recovery of sodium from alumina-extracted fly ash using concentrated sodium carbonate solution by Wang Z., Zheng S., Ma S., Ding J., Wang X.

“…A novel method for the recovery of sodium from alumina-extracted fly ash (AEFA) using concentrated Na2CO3 solution is presented. …”
Get full text

VITA-D: A Radiomic Web Tool for Predicting Vitamin D Deficiency Levels by Yuliana Jiménez-Gaona, Oscar Vivanco-Galván, Darwin Castillo-Malla, Israel Vivanco-Gualán, Patricia Díaz-Guzmán

“…Conclusions: The “VITA-D” web application was used to monitor and predict vitamin D levels and deficiency factor risk based on clinical and sociodemographic data, providing an efficient and cost-effective alternative to traditional vitamin D testing methods.…”
Get full text

Pharmacoeconomic analysis of the use of tocilizumab in therapy for rheumatoid arthritis:imitation simulation by Dmitry Vladimirovich Goryachev, Sh F Erdes, E L Nasonov

“…Heavy economic expenses for treatment with genetic engineering biologicals (GEB) in patients with rheumatoid arthritis (RA) determine what strategies are most optimal in terms of both their clinical efficiency and economic constituent should be sought for. …”
Get full text

Civil Structural Health Monitoring and Machine Learning: A Comprehensive Review by Asraar Anjum, Meftah Hrairi, Abdul Aabid, Norfazrina Yatim, Maisarah Ali

“…This comprehensive review aims to clarify the array of ML-based methods employed in civil engineering, specifically focusing on their efficacy in strengthening energy efficiency and cost-effectiveness. …”
Get full text

Anti-Virulence Efficacy of Chinese Dragon’s Blood Against Pseudomonas aeruginosa Isolated from Wound Infections by Shen Y, Gu Z, Li Y, Zhou H, Zhu S, Sheng L, Qiang X, Zheng X

“…Antimicrobial susceptibility profiles were determined using the agar dilution method. Biofilm formation and eradication assays, quantitative real-time PCR (RT-qPCR), and bacterial motility assays were performed to evaluate the efficacy of CDB on biofilm formation, mature biofilm eradication, and motility ability of P. aeruginosa isolates.Results: Minimal inhibitory concentration (MIC) values of CDB against P. aeruginosa isolates were ≥ 1024 μg/mL. …”
Get full text

The predictive value of conventional MRI combined with radiomics in the immediate ablation rate of HIFU treatment for uterine fibroids by Chao Wei, Naiyu Li, Bin Shi, Chuanbin Wang, Yaoyuan Wu, Tingting Lin, Yulan Chen, Yaqiong Ge, Yongqiang Yu, Jiangning Dong

“…Objective This study aimed to assess the predictive value of conventional magnetic resonance imaging (MRI) combined with radiomics in determining the nonperfused volume ratio (NPVR) following high-intensity focused ultrasound (HIFU) ablation for uterine fibroids.Methods and materials A total of 216 symptomatic uterine fibroids in 216 women were subjected to HIFU ablation from October 2015 to March 2020. …”
Get full text

Socioeconomic Inequality in Chronic Complications of Type 2 Diabetes Mellitus in Iran: Concentration Index and Decomposition Approach by Sedigheh Mafakheri, Erfan Ayubi, Shiva Borzouei, Vajiheh Ramezani Doroh, Salman Khazaei

“…SES is a complex construct and its impact on the health outcomes should be evaluated in an efficient and flexible way. The purpose of this study is to examine SES inequality in chronic complications among T2DM patients using methods of decomposing inequality. …”
Get full text