Preparation of Trop2-targeted chimeric antigen receptor T cells and study of their exhaustion status in vitro by LIU Xiuying, LI Xinzhan, ZHU Jingjing, ZHU Jingjing

“…Objective‍　‍To design and construct chimeric antigen receptor (CAR) T cells targeting Trop2, establish an in vitro cell exhaustion model through continuous antigen stimulation, and investigate their anti-tumor activity and exhaustion characteristics. Methods‍　‍The second-generation CAR plasmid was constructed based on the single-chain variable fragment (scFv) sequence of Sacituzumab Govitecan targeting Trop2. …”
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SC134-deruxtecan, a fucosyl-GM1 targeting ADC for small cell lung cancer therapy by Bryony Heath, Bubacarr G. Kaira, Dhruma Thakker, Omar J. Mohammed, Ruhul Choudhury, Foram Dave, Poonam Vaghela, Elena Dubinina, Tina Parsons, Lindy Durrant, Mireille Vankemmelbeke

“…We have developed SC134-deruxtecan, an antibody drug conjugate (ADC) targeting FucGM1 in SCLC, and characterized its preclinical activity. Methods SC134 binding specificity and affinity were tested through enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), flow cytometry against several SCLC cell lines, and immunohistochemistry (IHC) of clinical samples and animal tissues. …”
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Exploring the Benefits of Representing Multiplayer Game Data in a Coordinate System by Mekdad Slime, Mohammed El Kamli, Abdellah Ould Khal

“…This approach offers numerous advantages when compared to other methods. For instance, the Nash equilibrium can be readily identified within a game without requiring an extensive duration to exhaustively examine all strategies for its determination. …”
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Trust among millennial generation domestic travelers in staying at eco-friendly hotels by Mayang Fitri Anggani, I Gusti Agung Febrianto

“…This research aims to determine the beliefs of millennial domestic tourists regarding their intention to stay at an environmentally friendly hotel. …”
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Optimization of Photonic Nanocrystals for Invisibility Using Artificial Intelligence by Z. Dorrani

“…However, the design and optimization of these structures, especially with new methods like deep learning, have not been thoroughly investigated. …”
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AGRICULTURAL LAND, RENT SEEKING AND TRANSACTION COSTS by Minko GEORGIEV, Dafinka, GROZDANOVA, Boryana IVANOVA, Rositsa BELUHOVA-UZUNOVA, Mariyana SHISHKOVA

“…On the other hand, rents can positively contribute to the mobility of other factors and, hence, the more efficient allocation of the resources. The transaction costs represent a positive effect of the risk distribution associated with the use of resources, which determines their positive role in protecting property rights. …”
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Evaluation of Mechanical Properties Considering Uncertainties for Hairpin Coils in Electric Vehicle Motor Manufacturing by Young-Dae Shim, Jihun Kim, Changhyeon Kim, Jihyun Park, Dong-Wook Yang, Eun-Ho Lee

“…This study investigates uncertainties in mechanical property evaluation using a combination of tensile tests, analytic solutions, numerical simulations, and a present double-sided four-point bending method. The results show significant variations in the Young’s modulus, which affect the determination of yield stress in tensile tests. …”
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Modelling the infiltration rates of different soil under field conditions by Shubham Kindo, Narendra Agrawal, Aryak Shori, M.P Tripathi

“…Comparison of the Nash-Sutcliffe efficiency, coefficient of determination, and root mean square error (NSE, R², and RMSE) statistics used to assess the model's effectiveness with R², NSE, and RMSE values ranging from 0.8211-0.9719, 0.443-0.957, and 1.4694-6.0569, respectively, the results show that Philip’s model was the most reliable; it consistently outperformed other models in accuracy across various test scenarios. …”
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Characterization and treatment monitoring of ureagenesis disorders using stable isotopes by Gabriella Allegri, Martin Poms, Nadia Zürcher, Véronique Rüfenacht, Nicole Rimann, Déborah Mathis, Beat Thöny, Matthias Gautschi, Ralf A. Husain, Daniela Karall, Karolina Orchel-Szastak, Francesco Porta, Dominique Roland, Barbara Siri, Carlo Dionisi-Vici, René Santer, Johannes Häberle

“…There were no adverse events, and only minimal amounts of tracer and samples required with a short sample preparation time and analysis. Thus, the method proved to be safe and efficient to monitor UCD patients of variable severity pre- and post-therapy, being suitable as physiological endpoint for development of therapies.…”
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Wind energy resource assessment based on joint wolf pack intelligent optimization algorithm. by Jiayuan Wang

“…And the research method can effectively evaluate the status of wind energy resources, with low time complexity at different data scales, taking no more than 5 seconds, and improving operational efficiency. …”
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Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs by Çağrı Çevrim, Béryl Laplace-Builhé, Ko Sugawara, Maria Lorenza Rusciano, Nicolas Labert, Jacques Brocard, Alba Almazán, Michalis Averof

“…The method is optimised to limit light exposure while maximising tracking efficiency. …”
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Optimal D-STATCOM placement and sizing using a novel bird swarm operated exploitation of elephant herd algorithm by V. Tejaswini, D. Susitra

“…The proposed Hybrid Algorithm, named Bird Swarm Operated Exploitation of Elephant Herd (BSOEEH), is tested under four different scenarios to determine its effectiveness compared to traditional optimization methods. …”
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System analysis of mathematical models of placement of transport and logistics facilities of different levels by O. V. Moskvichev, E. E. Moskvicheva

“…One of the most important tasks in the implementation of this project in the context of limited investment resources is the correct justification of the number and choice of locations for the transport and logistics centres of the overarching network in the Russian Federation, as well as the locations of transport and logistics centres in the constituent entities of the Russian Federation.Materials and methods. This article provides an evaluation analysis of the classical methods for finding optimal centres on a plane and some construction of mathematical quantitative models for the optimal placement of transport and logistics facilities.Results. …”
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Initial validation of the powered mobility device autonomy residential screen (PoMoDARS) by Natalie C. Dickson, Apeksha R. Gohil, Carolyn A. Unsworth

“…The PoMoDARS is context specific, time efficient and promotes resident autonomy and safety.Aims To (i) undertake initial face and content validation of the PoMoDARS, and (ii) use the research findings to make any modifications.Methods A mixed-methods study design, underpinned by Classical Test Theory. …”
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Ocular neuromodulation as a novel treatment for retinitis pigmentosa: identifying rod responders and predictors of visual improvement by Ismail M Musallam

“…Abstract Purpose To evaluate the safety and efficacy of ophthalmic nerve stimulation (ONS), combined with ascorbic acid (AA) in the treatment of retinitis pigmentosa (RP). Methods Forty participants with RP were enrolled in a prospective open-label single-armed intervention. …”
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Optimization of carbon dioxide adsorption from industrial flue gas using zeolite 13X: A simulation study with Aspen Adsorption and response surface methodology by Narges Sadat Nazari, Fatemeh Afshari, Mahdi Mahmoudkhani, Ahad Ghaemi

“…One of the best ways to prevent further warming of the planet and reduce pollutants is to remove or adsorb and recover carbon dioxide gas from the exit of cement factory exhaust. So far, several methods have been proposed for this; In this research, zeolite 13X adsorbent is used considering the operational conditions. …”
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Causal relationships of vegetation productivity with root zone water availability and atmospheric dryness at the catchment scale by G. W. Abeshu, H.-Y. Li, M. Shi, L. R. Leung

“…Seasonal climatic, hydrological, and vegetation characteristics were represented using the Horton index, ecological aridity index, evaporative fraction index, and carbon uptake efficiency. Statistical methods, including circularity statistics, correlation analysis, and causality tests, were employed to determine the complex interactions between catchment wetness, atmospheric dryness, and vegetation carbon uptake. …”
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Fingerprint Classification Based on Multilayer Extreme Learning Machines by Axel Quinteros, David Zabala-Blanco

“…Fingerprint recognition is one of the most effective and widely adopted methods for person identification. However, the computational time required for the querying of large databases is excessive. …”
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Prevalence of symptoms of sick building syndrome and its associated factors in intensive care nurses in Kerman University of medical sciences educational hospitals by MT Ghaneian, MA Morovvati Sharif Abad, MH Ehrampoosh, M Haj Hosseini

“…Conclusion: According to high prevalence of sick building syndrome in nurses and its relationship to environment noise and unpleasant smell work, more attention to improvement of environment conditions, such as increasing the efficiency of air conditioning and fresh air to enhance the quality of work life for nurses segments and increase the efficiency of motivation of the working environment is needed.…”
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DUAL THERAPY WITH BIOLOGICALS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS by A. A. Mesnyankina, S. K. Solovyev, E. N. Aleksandrova, A. P. Aleksankin, E. A. Aseeva, E. L. Nasonov

“…Objective: to determine the efficiency of dual anti-B cell therapy in patients with active systemic lupus erythematosus (SLE).Subjects and methods. …”
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